{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:21:35Z","timestamp":1792725695041,"version":"4.5.0"},"reference-count":7,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Introduction<\/jats:title>\n                <jats:p>Vaginal metastasis from colorectal cancer is a rare occurrence, typically associated with other metastatic lesions. Isolated metastasis is exceedingly uncommon, with only a few cases documented in the literature. Vaginal involvement in colorectal cancer primarily results from direct contiguous spread from the primary tumor.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We present the case of a 70-year-old African woman diagnosed with adenocarcinoma of the middle rectum. She underwent chemotherapy, radiotherapy, and subsequent anterior resection. After 2\u00a0months, an isolated metastasis of rectal cancer was identified in the lower third of the left vaginal wall, confirmed by biopsy. Colonoscopy ruled out colorectal recurrence. Thoraco-abdominal computed tomography scan showed no distant metastases. The patient underwent abdominoperineal resection, removing the lateral and posterior vaginal wall with free macroscopic margins and a definitive colostomy. The final histopathological analysis confirmed the diagnosis of moderately differentiated adenocarcinoma of the vagina, measuring 5\u2009\u00d7\u20094.5\u00a0cm. The rectal wall was extrinsically invaded by the tumor down to the muscularis propria while respecting the rectal mucosa. Resection margins were negative. The patient was discharged 1\u00a0week postoperation with no complications. Adjuvant chemotherapy was indicated, and the patient is currently tolerating the treatment well.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Vaginal metastases from colorectal cancer are extremely rare. A vigilant gynecological examination is recommended during the follow-up of colorectal cancer patients. Diagnosis can be challenging, especially if the metastatic lesion is small and asymptomatic, even after standard radiological examination. Surgical resection followed by chemotherapy is a valid option for patients with early isolated metastases.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-024-04501-7","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T23:02:13Z","timestamp":1714604533000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["An isolated vaginal metastasis from rectal cancer: a case report"],"prefix":"10.1186","volume":"18","author":[{"given":"Saida","family":"Sakhri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Zemni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Ali","family":"Ayadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayoub","family":"Ghazouani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Boujelbene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek","family":"Ben Dhiab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,2]]},"reference":[{"issue":"3","key":"4501_CR1","doi-asserted-by":"publisher","first-page":"527","DOI":"10.12998\/wjcc.v8.i3.527","volume":"8","author":"SK Kwon","year":"2020","unstructured":"Kwon SK, Yu CS, Lee SW, Kim J, Song I, Lee JL, et\u00a0al. Isolated vaginal metastasis from stage I colon cancer: a case report. World J Clin Cases. 2020;8(3):527\u201334.","journal-title":"World J Clin Cases."},{"issue":"10","key":"4501_CR2","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1016\/j.ijsu.2013.09.004","volume":"11","author":"HJ Ng","year":"2013","unstructured":"Ng HJ, Aly EH. Vaginal metastases from colorectal cancer. Int J Surg. 2013;11(10):1048\u201355.","journal-title":"Int J Surg"},{"key":"4501_CR3","doi-asserted-by":"crossref","unstructured":"Ansari S, Liao Y, Dewdney S, Wang D, Barry P. Vaginal oligometastatic disease of colorectal primary: report of a novel therapeutic approach. Rare Tumors. 2021;13:20363613211044570.","DOI":"10.1177\/20363613211044566"},{"issue":"4","key":"4501_CR4","doi-asserted-by":"publisher","first-page":"3457","DOI":"10.4103\/jmas.JMAS_182_18","volume":"15","author":"E G\u00fcndo\u011fan","year":"2019","unstructured":"G\u00fcndo\u011fan E, Cicek E, Sumer F, Kayaalp C. A case of vaginal recurrence following laparoscopic left-sided colon cancer resection combined with transvaginal specimen extraction. J Minimal Access Surg. 2019;15(4):3457.","journal-title":"J Minimal Access Surg"},{"issue":"1","key":"4501_CR5","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s43046-021-00058-4","volume":"33","author":"M Korkmaz","year":"2021","unstructured":"Korkmaz M, Ery\u0131lmaz MK, Kerimo\u011flu \u00dc, Karaa\u011fa\u00e7 M, Demirk\u0131ran A, Demir ET, et\u00a0al. Vaginal metastasis in solid tumours: our four cases and review of the literature. J Egypt Natl Cancer Inst. 2021;33(1):3.","journal-title":"J Egypt Natl Cancer Inst."},{"issue":"6","key":"4501_CR6","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1097\/RLU.0000000000002573","volume":"44","author":"R Wang","year":"2019","unstructured":"Wang R, Fan Q, Liu H, Su M. Isolated vaginal recurrence of early-stage rectal cancer detected by 18F-FDG PET\/CT. Clin Nucl Med. 2019;44(6):499.","journal-title":"Clin Nucl Med"},{"key":"4501_CR7","doi-asserted-by":"publisher","unstructured":"Alawneh F, Chaar MKA. Metastatic solitary vaginal nodule from a primary rectal tumor. https:\/\/doi.org\/10.21203\/rs.3.rs-53505\/v1","DOI":"10.21203\/rs.3.rs-53505\/v1"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-024-04501-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-024-04501-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-024-04501-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T23:02:26Z","timestamp":1714604546000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-024-04501-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,2]]},"references-count":7,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["4501"],"URL":"https:\/\/doi.org\/10.1186\/s13256-024-04501-7","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,2]]},"assertion":[{"value":"25 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest and declare that this work was done with all due respect to the code of ethics under the supervision of the medical and ethics committee of the Salah Azaiez Institute.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"233"}}