{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T21:03:51Z","timestamp":1778533431484,"version":"3.51.4"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Parotid gland agenesis is a rare, congenital, usually asymptomatic disorder. Until now, only 24 cases with unilateral, incidentally found, parotid gland agenesis have been described. Here, we present the first reported case of an ipsilateral preauricular neoplasm in a patient with unilateral parotid gland agenesis. During surgery, the position of the greater auricular- and facial nerves was documented. Furthermore, we performed the first sialendoscopy for this rare disorder to assess the number of duct branches, which might be indicative of the abundance of parotid tissue. Moreover, we looked for sialendoscopic characteristic features that could aid in identifying these patients in the ambulatory setting.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 50-year-old Greek man presented with a painless, slowly enlarging mass in the right parotid space. Magnetic resonance imaging revealed a complete absence of the right parotid gland without accessory parotid tissue. The right parotid gland was replaced by fatty tissue and the radiologist suggested a benign parotid tumor. Fine needle aspiration was indicative of a reactive lymph node. Sialendoscopy revealed only two branches within the right parotid duct. Surgical resection was performed through a conventional lateral parotidectomy. This revealed typical anatomic position of the greater auricular- and facial nerves despite the parotid tissue agenesis. Histopathology revealed a small lymphocytic lymphoma.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Surgeons should feel confident to resect tumors of the parotid space in patients with parotid gland agenesis. Reduced branching observed during sialendoscopy might indicate parotid gland agenesis. Physicians should be even more cautious than usual with the watch and wait strategy in patients with tumors of parotid gland agenesis, since the probability of a tumor being a benign salivary gland tumor might be lower than usual.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-024-04553-9","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T23:01:55Z","timestamp":1714690915000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lymphoma presenting as preauricular tumor in unilateral parotid gland agenesis: a case report and review of literature"],"prefix":"10.1186","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4162-4261","authenticated-orcid":false,"given":"Aris I.","family":"Giotakis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Masaoutis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Delides","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evangelos I.","family":"Giotakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,5,3]]},"reference":[{"key":"4553_CR1","doi-asserted-by":"publisher","first-page":"2672496","DOI":"10.1155\/2016\/2672496","volume":"2016","author":"A Teymoortash","year":"2016","unstructured":"Teymoortash A, Hoch S. Congenital unilateral agenesis of the parotid gland: a case report and review of the literature. Case Rep Dent. 2016;2016:2672496. https:\/\/doi.org\/10.1155\/2016\/2672496.","journal-title":"Case Rep Dent"},{"issue":"11","key":"4553_CR2","doi-asserted-by":"publisher","first-page":"3453","DOI":"10.1016\/j.radcr.2021.07.096","volume":"16","author":"IK Sgantzou","year":"2021","unstructured":"Sgantzou IK, Vassiou K, Gkrinia E, Maiou C, Agrotis G, Vlychou M. Asymptomatic unilateral aplasia of the left parotid gland: an unusual entity and case report. Radiol Case Rep. 2021;16(11):3453\u20136. https:\/\/doi.org\/10.1016\/j.radcr.2021.07.096.","journal-title":"Radiol Case Rep"},{"issue":"3","key":"4553_CR3","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1007\/s11604-009-0401-9","volume":"28","author":"BH Lee","year":"2010","unstructured":"Lee BH. Unilateral agenesis of the parotid gland associated with a pleomorphic adenoma in the ipsilateral buccal space. Jpn J Radiol. 2010;28(3):224\u20136. https:\/\/doi.org\/10.1007\/s11604-009-0401-9.","journal-title":"Jpn J Radiol"},{"issue":"1","key":"4553_CR4","doi-asserted-by":"publisher","first-page":"E13","DOI":"10.1177\/014556131309200120","volume":"92","author":"AB Seith","year":"2013","unstructured":"Seith AB, Gadodia A, Sharma R, Parshad R. Unilateral parotid agenesis associated with pleomorphic adenoma of ipsilateral accessory parotid gland. Ear Nose Throat J. 2013;92(1):E13-15. https:\/\/doi.org\/10.1177\/014556131309200120.","journal-title":"Ear Nose Throat J"},{"issue":"1","key":"4553_CR5","first-page":"9","volume":"102","author":"W Gruber","year":"1885","unstructured":"Gruber W. Congenitaler Mangel beider Glandulae submaxillares bei einem wohlgebildeten, erwachsenen Subjecte. Archiv f\u00fcr pathologische Anatomie und Physiologie und f\u00fcr klinische Medicin. 1885;102(1):9\u201311.","journal-title":"Archiv f\u00fcr pathologische Anatomie und Physiologie und f\u00fcr klinische Medicin"},{"issue":"6","key":"4553_CR6","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/0266-4356(90)90041-i","volume":"28","author":"SA Kelly","year":"1990","unstructured":"Kelly SA, Black MJ, Soames JV. Unilateral enlargement of the parotid gland in a patient with sialosis and contralateral parotid aplasia. Br J Oral Maxillofac Surg. 1990;28(6):409\u201312. https:\/\/doi.org\/10.1016\/0266-4356(90)90041-i.","journal-title":"Br J Oral Maxillofac Surg"},{"issue":"5","key":"4553_CR7","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1258\/0022215053945741","volume":"119","author":"O Karakoc","year":"2005","unstructured":"Karakoc O, Akcam T, Kocaoglu M, Yetiser S. Agenesis of the unilateral parotid gland associated with pleomorphic adenoma of the contralateral parotid gland. J Laryngol Otol. 2005;119(5):409\u201311. https:\/\/doi.org\/10.1258\/0022215053945741.","journal-title":"J Laryngol Otol"},{"issue":"5","key":"4553_CR8","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1007\/s00405-011-1902-6","volume":"269","author":"P Capaccio","year":"2012","unstructured":"Capaccio P, Luca N, Sigismund PE, Pignataro L. Recurrent inflammation of accessory parotid tissue associated with unilateral parotid gland aplasia: diagnostic and therapeutic implications. Eur Arch Otorhinolaryngol. 2012;269(5):1551\u20134. https:\/\/doi.org\/10.1007\/s00405-011-1902-6.","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"11","key":"4553_CR9","doi-asserted-by":"publisher","first-page":"e162","DOI":"10.1097\/RLU.0b013e318219b2b9","volume":"36","author":"D Udall","year":"2011","unstructured":"Udall D, Cho SY. Congenital agenesis of right parotid gland confounds MIBG scan interpretation in craniocervical neuroblastoma. Clin Nucl Med. 2011;36(11):e162-164. https:\/\/doi.org\/10.1097\/RLU.0b013e318219b2b9.","journal-title":"Clin Nucl Med"},{"issue":"4","key":"4553_CR10","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/j.otohns.2007.05.062","volume":"137","author":"A Bozzato","year":"2007","unstructured":"Bozzato A, Zenk J, Greess H, Hornung J, Gottwald F, Rabe C, Iro H. Potential of ultrasound diagnosis for parotid tumors: analysis of qualitative and quantitative parameters. Otolaryngol Head Neck Surg. 2007;137(4):642\u20136. https:\/\/doi.org\/10.1016\/j.otohns.2007.05.062.","journal-title":"Otolaryngol Head Neck Surg"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-024-04553-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-024-04553-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-024-04553-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T23:02:11Z","timestamp":1714690931000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-024-04553-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,3]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["4553"],"URL":"https:\/\/doi.org\/10.1186\/s13256-024-04553-9","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,3]]},"assertion":[{"value":"23 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The ethical committee of Metropolitan General approved the study (358\/18072022).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"231"}}