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The clinical symptoms are atypical or completely absent. Angiosarcomas of the adrenal gland are therefore often discovered incidentally, and the diagnosis is made histologically after resection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 46-year-old white Spanish male who was a previous smoker and nondrinker and was slightly overweight (92\u00a0kg, 176\u00a0cm, body mass index 29.7\u00a0kg\/m<jats:sup>2<\/jats:sup>) with no relevant medical history presented to the internal medicine emergency department of our hospital with an unclear 12\u00a0cm tumor of the right adrenal gland. Prior to the computed tomography scan, he had had persistent evening fevers for 4\u00a0months and unintentional weight loss of 5\u00a0kg. The laboratory results showed anemia and an elevated C-reactive protein, but no hormone production. We performed an open adrenalectomy of the right adrenal gland. Finally, the histologic findings revealed an angiosarcoma of the adrenal gland.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Even though angiosarcomas of the adrenal gland are rare, the differential diagnosis of an angiosarcoma should be considered if a malignant tumor of the adrenal gland is suspected. Treatment decisions should be made on an interdisciplinary basis and preferably in a specialized center. Owing to the rarity of angiosarcomas of the adrenal gland, it is necessary to continue to share clinical experience to gain a better understanding of this particular tumor entity.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s13256-024-04583-3","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:02:06Z","timestamp":1716508926000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Recurrent fever leading to the diagnosis of an angiosarcoma of the adrenal gland: a case report"],"prefix":"10.1186","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7984-9530","authenticated-orcid":false,"given":"Ann-Kathrin","family":"Lederer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Zimmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rabea","family":"Margies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Krettek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"Musholt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,5,24]]},"reference":[{"key":"4583_CR1","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1177\/10668969211020099","volume":"30","author":"A Ladenheim","year":"2022","unstructured":"Ladenheim A, Tian M, Afify A, Campbell M, Kamangar E. 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