{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:11:05Z","timestamp":1791486665128,"version":"4.3.4"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Extraskeletal osteosarcoma is an extremely rare malignancy that accounts for 1% of soft tissue sarcoma and 4.3% of all osteosarcoma. Extraskeletal osteosarcoma can develop in a patient between the ages of 48 and 60 years. The incidence of extraskeletal osteosarcoma is slightly higher in male patients than in females.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 50-year-old Caucasian male patient presented with a 6-month history of intermittent lower-left back pain that limits his activity. Prior ultrasonography and abdominal computed tomography scan showed a diagnosis of kidney stone and tumor in the lower-left abdomen. The computed tomography urography with contrast revealed a mass suspected as a left retroperitoneal malignant tumor. Hence, the tumor was resected through laparotomy and the patient continued with histopathological and immunohistochemistry examination with the result of extraskeletal osteosarcoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Extraskeletal osteosarcoma presents diagnostic challenges requiring multimodal examination, including histological and immunohistochemistry analyses. This case underscores the aggressive nature and poor prognosis despite undergoing the current suggested treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13256-024-04608-x","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T20:04:07Z","timestamp":1720555447000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Extraskeletal osteosarcoma infiltrating pancreas, spleen, gastric, and left kidney: a case report"],"prefix":"10.1186","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2194-1304","authenticated-orcid":false,"given":"Wifanto Saditya","family":"Jeo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintia","family":"Christina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel Jason","family":"Zacharia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalikul","family":"Razi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,10]]},"reference":[{"issue":"7","key":"4608_CR1","doi-asserted-by":"publisher","first-page":"825","DOI":"10.2217\/fon-2020-0802","volume":"17","author":"AK Kattepur","year":"2021","unstructured":"Kattepur AK, Gulia A, Jones RL, Rastogi S. Extraskeletal osteosarcomas: current update. Future Oncol. 2021;17(7):825\u201335.","journal-title":"Future Oncol"},{"issue":"7","key":"4608_CR2","first-page":"15","volume":"7","author":"M Hoch","year":"2013","unstructured":"Hoch M, Ali S, Agrawal S, Wang C, Khurana JS. Extraskeletal osteosarcoma: a case report and review of the literature. J Radiol Case Rep. 2013;7(7):15\u201323.","journal-title":"J Radiol Case Rep"},{"key":"4608_CR3","doi-asserted-by":"publisher","first-page":"203636131774965","DOI":"10.1177\/2036361317749651","volume":"10","author":"H Wang","year":"2018","unstructured":"Wang H, Miao R, Jacobson A, Harmon D, Choy E, Hornicek F, et al. Extraskeletal osteosarcoma: a large series treated at a single institution. Rare Tumors. 2018;10:2036361317749651.","journal-title":"Rare Tumors"},{"issue":"11","key":"4608_CR4","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.1002\/1097-0142(19951201)76:11<2253::AID-CNCR2820761112>3.0.CO;2-8","volume":"76","author":"JS Lee","year":"1995","unstructured":"Lee JS, Fetsch JF, Wasdhal DA, Lee BP, Pritchard DJ, Nascimento AG. A review of 40 patients with extraskeletal osteosarcoma. Cancer. 1995;76(11):2253\u20139.","journal-title":"Cancer"},{"issue":"1","key":"4608_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-019-41089-1","volume":"9","author":"Z Liao","year":"2019","unstructured":"Liao Z, Qiu M, Yang J, Yang Y, Zhu L, Yang B, et al. Outcomes of surgery and\/or combination chemotherapy for extraskeletal osteosarcoma: a single-center retrospective study from China. Sci Rep. 2019;9(1):1\u20138.","journal-title":"Sci Rep"},{"issue":"1","key":"4608_CR6","doi-asserted-by":"publisher","first-page":"W31","DOI":"10.2214\/AJR.11.6927","volume":"198","author":"G Mc Auley","year":"2012","unstructured":"Mc Auley G, Jagannathan J, O\u2019Regan K, Krajewski KM, Hornick JL, Butrynski J, et al. Extraskeletal osteosarcoma: spectrum of imaging findings. Am J Roentgenol. 2012;198(1):W31\u20137.","journal-title":"Am J Roentgenol"},{"key":"4608_CR7","unstructured":"Mudgal P, Kang O. Extraskeletal osteosarcoma. Radiopaediaorg. 2018. https:\/\/radiopaedia.org\/articles\/27393."},{"issue":"2","key":"4608_CR8","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s00590-012-1097-6","volume":"23","author":"A Gulia","year":"2013","unstructured":"Gulia A, Puri A, Jain S, Rekhi B, Juvekar S. Extraskeletal osteosarcoma with synchronous regional lymph node and soft tissue metastasis: a rare presentation of an uncommon tumour. Eur J Orthop Surg Traumatol. 2013;23(2):317\u201322.","journal-title":"Eur J Orthop Surg Traumatol"},{"issue":"1\u20132","key":"4608_CR9","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1111\/ans.18761","volume":"94","author":"J Thomas","year":"2024","unstructured":"Thomas J, Jerome A, Marr G, De Boo DW, Gani J. Surgeons versus radiologists: do we care what they think? ANZ J Surg. 2024;94(1\u20132):103\u20137.","journal-title":"ANZ J Surg"},{"key":"4608_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpr.2022.300639","volume":"28","author":"LN Yenwongfai","year":"2022","unstructured":"Yenwongfai LN, Liu J, Wang C, Bocklage TJ. Extraskeletal osteosarcoma and its histological mimics. Hum Pathol Rep. 2022;28: 300639.","journal-title":"Hum Pathol Rep"},{"issue":"9","key":"4608_CR11","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1097\/COC.0000000000000397","volume":"41","author":"J Paludo","year":"2018","unstructured":"Paludo J, Fritchie K, Haddox CL, Rose PS, Arndt CAS, Marks RS, et al. Extraskeletal osteosarcoma: outcomes and the role of chemotherapy. Am J Clin Oncol. 2018;41(9):832\u20137.","journal-title":"Am J Clin Oncol"},{"issue":"8","key":"4608_CR12","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1007\/s00432-005-0687-7","volume":"131","author":"SY Goldstein-Jackson","year":"2005","unstructured":"Goldstein-Jackson SY, Gosheger G, Delling G, Berdel WE, Gulrich E, Jundt G, et al. Extraskeletal osteosarcoma has a favorable prognosis when treated like conventional osteosarcoma. J Cancer Res Clin Oncol. 2005;131(8):520\u20136.","journal-title":"J Cancer Res Clin Oncol"},{"issue":"5","key":"4608_CR13","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1007\/s00776-007-1164-8","volume":"12","author":"T Torigoe","year":"2007","unstructured":"Torigoe T, Yazawa Y, Takagi T, Terakado A, Kurosawa H. Extraskeletal osteosarcoma in Japan: multiinstitutional study of 20 patients from the Japanese Musculoskeletal Oncology Group. J Orthop Sci. 2007;12(5):424\u20139.","journal-title":"J Orthop Sci"},{"key":"4608_CR14","first-page":"98","volume":"36","author":"LM Nystrom","year":"2016","unstructured":"Nystrom LM, Reimer NB, Reith JD, Scarborough MT, Gibbs CP Jr. The treatment and outcomes of extraskeletal osteosarcoma: institutional experience and review of the literature. Iowa Orthop J. 2016;36:98\u2013103.","journal-title":"Iowa Orthop J"},{"issue":"10","key":"4608_CR15","doi-asserted-by":"publisher","first-page":"2559","DOI":"10.3390\/cancers14102559","volume":"14","author":"S Tsukamoto","year":"2022","unstructured":"Tsukamoto S, Mavrogenis AF, Angelelli L, Righi A, Filardo G, Kido A, et al. The effect of adjuvant chemotherapy on localized extraskeletal osteosarcoma: a systematic review. Cancers. 2022;14(10):2559.","journal-title":"Cancers"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-024-04608-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-024-04608-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-024-04608-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T20:04:33Z","timestamp":1720555473000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-024-04608-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,10]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["4608"],"URL":"https:\/\/doi.org\/10.1186\/s13256-024-04608-x","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,10]]},"assertion":[{"value":"18 January 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethics approval for this study was obtained from the ethics committee of the Faculty of Medicine, University of Indonesia. The patient provided written informed consent to participate in the study. All patient data was kept confidential and securely stored under applicable privacy regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have nothing to disclose, and there are no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"332"}}