{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T13:02:46Z","timestamp":1773838966063,"version":"3.50.1"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Lymphoid neoplasm is a common disease, arising from lymphoid cells. It is divided into Hodgkin lymphoma and non-Hodgkin lymphoma. Non-Hodgkin lymphoma can be intranodular or extranodular, which happens in 25% of primary cases. The most common locations of extranodular non-Hodgkin lymphoma are the skin and gastrointestinal tract. The genital tract is a rare location; most lymphomas arise from the cervix and vagina, while the uterine corpus is an extremely rare location. In our case, the patient was diagnosed with primary extranodular non-Hodgkin lymphoma in different locations of her genital tract.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 48-year-old nonparous Syrian woman complained of diffuse abdominal pain, fatigue, debility, high fever, vomiting, and urinary retention for a week. The last menstrual period of the patient was 5\u00a0years previously. The physical examination showed periodic abdominal pain with severe fatigue and increased abdominal size. The laboratory investigations were within normal limits except for a low level of hemoglobin and a high level of cancer antigen 125. The radiological investigations showed a uterine sizable lobulated mass with irregular borders and high and heterogeneous density, extending to the right and left ovaries, enlargement lymph nodes around the abdominal aortic and right iliac vessels, and severe right pleural effusion with right inferior lobe atelectasis. A total hysterectomy and oophorectomy were done. The histopathological examination showed that the patient had non-Hodgkin lymphoma (primary tumor).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Primary non-Hodgkin lymphoma in the female genital tract is an extremely rare disease. Fast diagnosis and treatment can improve the outcomes, so this differential diagnosis should be in our minds even in the absence of systematic manifestations of lymphoma. More studies are needed to explain the pathology of this disease and to put guidelines that determine the perfect methods for diagnosis and treatment.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-024-04657-2","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:02:01Z","timestamp":1721088121000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diffuse large B-cell lymphoma in the uterus with unexpected manifestations: a case report"],"prefix":"10.1186","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3045-2230","authenticated-orcid":false,"given":"Kenana","family":"Tawashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuka","family":"Hamasho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Al-Hussien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ameen","family":"Ammar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,7,16]]},"reference":[{"issue":"4","key":"4657_CR1","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1111\/cas.13962","volume":"110","author":"S Tanaka","year":"2019","unstructured":"Tanaka S, Sawada N, Yamaji T, Shimazu T, Goto A, Iwasaki M, et\u00a0al. Female reproductive factors and risk of lymphoid neoplasm: the Japan Public Health Center-based Prospective Study. Cancer Sci. 2019;110(4):1442\u201352.","journal-title":"Cancer Sci"},{"issue":"4","key":"4657_CR2","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.pop.2016.07.012","volume":"43","author":"EN Mugnaini","year":"2016","unstructured":"Mugnaini EN, Ghosh N. Lymphoma. Prim Care. 2016;43(4):661\u201375.","journal-title":"Prim Care"},{"issue":"10091","key":"4657_CR3","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/S0140-6736(16)32407-2","volume":"390","author":"JO Armitage","year":"2017","unstructured":"Armitage JO, Gascoyne RD, Lunning MA, Cavalli F. Non-Hodgkin lymphoma. Lancet. 2017;390(10091):298\u2013310.","journal-title":"Lancet"},{"issue":"1","key":"4657_CR4","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/s13256-017-1271-x","volume":"11","author":"N Ram","year":"2017","unstructured":"Ram N, Rashid O, Farooq S, Ulhaq I, Islam N. Primary adrenal non-Hodgkin lymphoma: a case report and review of the literature. J Med Case Rep. 2017;11(1):108.","journal-title":"J Med Case Rep"},{"issue":"1","key":"4657_CR5","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/modpathol.3880005","volume":"13","author":"R Vang","year":"2000","unstructured":"Vang R, Medeiros LJ, Ha CS, Deavers M. Non-Hodgkin\u2019s lymphomas involving the uterus: a clinicopathologic analysis of 26 cases. Mod Pathol. 2000;13(1):19\u201328.","journal-title":"Mod Pathol"},{"issue":"3","key":"4657_CR6","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1111\/j.1479-828X.2000.tb03353.x","volume":"40","author":"A Agrawal","year":"2000","unstructured":"Agrawal A, Ofili G, Allan TL, Mann BS. Malignant lymphoma of uterus: a case report with a review of the literature. Aust N Z J Obstet Gynaecol. 2000;40(3):358\u201360.","journal-title":"Aust N Z J Obstet Gynaecol"},{"issue":"1","key":"4657_CR7","doi-asserted-by":"publisher","first-page":"106","DOI":"10.3390\/medicina58010106","volume":"58","author":"C Capsa","year":"2022","unstructured":"Capsa C, Calustian LA, Antoniu SA, Bratucu E, Simion L, Prunoiu VM. Primary non-Hodgkin uterine lymphoma of the cervix: a literature review. Medicina (Kaunas). 2022;58(1):106.","journal-title":"Medicina (Kaunas)"},{"issue":"1","key":"4657_CR8","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0887-8994(00)00156-9","volume":"23","author":"B Marjanovi\u0107","year":"2000","unstructured":"Marjanovi\u0107 B, Vujani\u0107 GM, Zamurovi\u0107 D, Rasovi\u0107 N, Vuji\u0107 D. Non-Hodgkin\u2019s lymphoma of the uterus and CNS. Pediatr Neurol. 2000;23(1):69\u201372.","journal-title":"Pediatr Neurol"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-024-04657-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-024-04657-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-024-04657-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:02:03Z","timestamp":1721088123000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-024-04657-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,16]]},"references-count":8,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["4657"],"URL":"https:\/\/doi.org\/10.1186\/s13256-024-04657-2","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,16]]},"assertion":[{"value":"19 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No approval was required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"325"}}