{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:35:19Z","timestamp":1722472519909},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Primary central nervous system lymphoma is rare, and primary central nervous system T cell lymphoma is relatively uncommon, contributing to\u2009&lt;\u20095% of all cases. Lymphomatosis cerebri, a rare subtype of primary central nervous system lymphoma, is characterized by extensive white-matter lesions on magnetic resonance imaging and nonspecific symptoms, such as cognitive decline and depression. Reports of lymphomatosis cerebri in adult T cell leukemia\/lymphoma are limited.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 49-year-old Japanese man gradually developed insomnia, anorexia, and weight loss over a 2-month period following work-related promotion. Initially diagnosed with depression, his condition rapidly deteriorated with cognitive decline and motor dysfunction. Despite various treatments, his symptoms persisted within a month. Upon admission, the presence of neurological abnormalities suggestive of a central nervous system disorder raised suspicion of a cerebral lesion. Diagnostic tests revealed extensive brain lesions on imaging and the presence of atypical lymphocytes (flower cells) in the cerebrospinal fluid. The patient was diagnosed with lymphomatosis cerebri due to adult T cell leukemia\/lymphoma, a rare presentation in the literature. Due to irreversible brainstem damage and poor neurological prognosis, aggressive treatment was not initiated, and the patient died, with an autopsy confirming the diagnosis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Lymphomatosis cerebri with adult T cell leukemia\/lymphoma is very rare. It is crucial to promptly consider lymphomatosis cerebri as a differential diagnosis, particularly in cases of rapid cognitive decline and poor treatment response. Recognition of lymphomatosis cerebri as an important differential diagnosis for cognitive decline, and depression is necessary for timely intervention and management. Further research is required to better understand this unique and rare presentation in adult T cell leukemia\/lymphoma.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-024-04666-1","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:02:03Z","timestamp":1722384123000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lymphomatosis cerebri caused by adult T cell leukemia\/lymphoma: a differential diagnosis for depression: a case report"],"prefix":"10.1186","volume":"18","author":[{"given":"Satoshi","family":"Inaba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masataka","family":"Kudo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Kamano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Ohishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Kiyasu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Watari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,7,31]]},"reference":[{"issue":"Suppl 5","key":"4666_CR1","doi-asserted-by":"publisher","first-page":"v1","DOI":"10.1093\/neuonc\/noac202","volume":"24","author":"QT Ostrom","year":"2022","unstructured":"Ostrom QT, Price M, Neff C, Cioffi G, Waite KA, Kruchko C, et\u00a0al. CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2015\u20132019. Neuro Oncol. 2022;24(Suppl 5):v1\u201395. https:\/\/doi.org\/10.1093\/neuonc\/noac202.","journal-title":"Neuro Oncol"},{"key":"4666_CR2","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1200\/JCO.2003.09.139","volume":"21","author":"AJ Ferreri","year":"2003","unstructured":"Ferreri AJ, Blay JY, Reni M, Pasini F, Spina M, Ambrosetti A, et\u00a0al. Prognostic scoring system for primary CNS lymphomas: the International Extranodal Lymphoma Study Group experience. J Clin Oncol. 2003;21:266\u201372. https:\/\/doi.org\/10.1200\/JCO.2003.09.139.","journal-title":"J Clin Oncol"},{"key":"4666_CR3","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1159\/000017116","volume":"10","author":"R Bakshi","year":"1999","unstructured":"Bakshi R, Mazziotta JC, Mischel PS, Jahan R, Seligson DB, Vinters HV. Lymphomatosis cerebri presenting as a rapidly progressive dementia: clinical, neuroimaging and pathologic findings. Dement Geriatr Cogn Disord. 1999;10:152\u20137. https:\/\/doi.org\/10.1159\/000017116.","journal-title":"Dement Geriatr Cogn Disord"},{"key":"4666_CR4","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1093\/neuonc\/nov197","volume":"18","author":"C Izquierdo","year":"2016","unstructured":"Izquierdo C, Velasco R, Vidal N, S\u00e1nchez JJ, Argyriou AA, Besora S, et\u00a0al. Lymphomatosis cerebri: a rare form of primary central nervous system lymphoma. Analysis of 7 cases and systematic review of the literature. Neuro Oncol. 2016;18:707\u201315. https:\/\/doi.org\/10.1093\/neuonc\/nov197.","journal-title":"Neuro Oncol"},{"key":"4666_CR5","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s10014-011-0064-y","volume":"29","author":"R Kitai","year":"2012","unstructured":"Kitai R, Hashimoto N, Yamate K, Ikawa M, Yoneda M, Nakajima T, et\u00a0al. Lymphomatosis cerebri: clinical characteristics, neuroimaging, and pathological findings. Brain Tumor Pathol. 2012;29:47\u201353. https:\/\/doi.org\/10.1007\/s10014-011-0064-y.","journal-title":"Brain Tumor Pathol"},{"key":"4666_CR6","doi-asserted-by":"publisher","first-page":"bcr0820080752","DOI":"10.1136\/bcr.08.2008.0752","volume":"2009","author":"J Lewerenz","year":"2009","unstructured":"Lewerenz J, Ding XQ, Matschke J, Schnabel C, Emami P, von Borczyskowski D, et\u00a0al. Dementia and leukoencephalopathy due to lymphomatosis cerebri. BMJ Case Rep. 2009;2009:bcr0820080752. https:\/\/doi.org\/10.1136\/bcr.08.2008.0752.","journal-title":"BMJ Case Rep"},{"key":"4666_CR7","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.3892\/ol.2018.8839","volume":"16","author":"L Li","year":"2018","unstructured":"Li L, Rong JH, Feng J. Neuroradiological features of lymphomatosis cerebri: a systematic review of the English literature with a new case report. Oncol Lett. 2018;16:1463\u201374. https:\/\/doi.org\/10.3892\/ol.2018.8839.","journal-title":"Oncol Lett"},{"key":"4666_CR8","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/j.1365-2990.1997.tb01184.x","volume":"23","author":"J Wanschitz","year":"1997","unstructured":"Wanschitz J, Hainfellner JA, Simonitsch I, Schnizer M, Deisenhammer E, Terunuma H, et\u00a0al. Non-HTLV-I associated pleomorphic T-cell lymphoma of the brain mimicking post-vaccinal acute inflammatory demyelination. Neuropathol Appl Neurobiol. 1997;23:43\u20139.","journal-title":"Neuropathol Appl Neurobiol"},{"key":"4666_CR9","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s00701-009-0433-z","volume":"152","author":"AJ Clark","year":"2010","unstructured":"Clark AJ, Lee K, Broaddus WC, Martin MJ, Ghatak NR, Grossman CE, et\u00a0al. Primary brain T-cell lymphoma of the lymphoblastic type presenting as altered mental status. Acta Neurochir (Wien). 2010;152:163\u20138. https:\/\/doi.org\/10.1007\/s00701-009-0433-z.","journal-title":"Acta Neurochir (Wien)"},{"key":"4666_CR10","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s10014-012-0094-0","volume":"30","author":"T Sugino","year":"2013","unstructured":"Sugino T, Mikami T, Akiyama Y, Wanibuchi M, Hasegawa T, Mikuni N. Primary central nervous system anaplastic large-cell lymphoma mimicking lymphomatosis cerebri. Brain Tumor Pathol. 2013;30:61\u20135. https:\/\/doi.org\/10.1007\/s10014-012-0094-0.","journal-title":"Brain Tumor Pathol"},{"key":"4666_CR11","doi-asserted-by":"publisher","first-page":"531","DOI":"10.2188\/jea.JE20220147","volume":"33","author":"M Nakajima","year":"2023","unstructured":"Nakajima M, Okada Y, Sonoo T, Goto T. Development and validation of a novel method for converting the Japan coma scale to Glasgow Coma Scale. J Epidemiol. 2023;33:531\u20135. https:\/\/doi.org\/10.2188\/jea.JE20220147.","journal-title":"J Epidemiol"},{"key":"4666_CR12","doi-asserted-by":"publisher","first-page":"5034","DOI":"10.1200\/JCO.2005.13.524","volume":"23","author":"LE Abrey","year":"2005","unstructured":"Abrey LE, Batchelor TT, Ferreri AJ, Gospodarowicz M, Pulczynski EJ, Zucca E, et\u00a0al. Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma. J Clin Oncol. 2005;23:5034\u201343. https:\/\/doi.org\/10.1200\/JCO.2005.13.524.","journal-title":"J Clin Oncol"},{"key":"4666_CR13","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s13054-019-2718-9","volume":"24","author":"S Benghanem","year":"2020","unstructured":"Benghanem S, Mazeraud A, Azabou E, Chhor V, Shinotsuka CR, Claassen J, et\u00a0al. Brainstem dysfunction in critically ill patients. Crit Care. 2020;24:5. https:\/\/doi.org\/10.1186\/s13054-019-2718-9.","journal-title":"Crit Care"},{"key":"4666_CR14","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.resuscitation.2015.07.018","volume":"95","author":"JP Nolan","year":"2015","unstructured":"Nolan JP, Soar J, Cariou A, Cronberg T, Moulaert VRM, Deakin CD, et\u00a0al. European resuscitation council and European society of intensive care medicine guidelines for post-resuscitation care 2015: section 5 of the European resuscitation council guidelines for resuscitation 2015-section 5. Resuscitation. 2015;95:202\u201322. https:\/\/doi.org\/10.1016\/j.resuscitation.2015.07.018.","journal-title":"Resuscitation"},{"key":"4666_CR15","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.jns.2011.10.024","volume":"314","author":"I Lotan","year":"2012","unstructured":"Lotan I, Khlebtovsky A, Inbar E, Strenov J, Djaldetti R, Steiner I. Primary brain T-cell lymphoma in an HTLV-1 serologically positive male. J Neurol Sci. 2012;314:163\u20135. https:\/\/doi.org\/10.1016\/j.jns.2011.10.024.","journal-title":"J Neurol Sci"},{"key":"4666_CR16","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s00401-007-0243-4","volume":"114","author":"DN Louis","year":"2007","unstructured":"Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, et\u00a0al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 2007;114:97\u2013109. https:\/\/doi.org\/10.1007\/s00401-007-0243-4.","journal-title":"Acta Neuropathol"},{"key":"4666_CR17","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1002\/1097-0142(19900115)65:2<327::aid-cncr2820650224>3.0.co;2-w","volume":"65","author":"T Teshima","year":"1990","unstructured":"Teshima T, Akashi K, Shibuya T, Taniguchi S, Okamura T, Harada M, et\u00a0al. Central nervous system involvement in adult T-cell leukemia\/lymphoma. Cancer. 1990;65:327\u201332. https:\/\/doi.org\/10.1002\/1097-0142(19900115)65:2%3c327::aid-cncr2820650224%3e3.0.co;2-w.","journal-title":"Cancer"},{"key":"4666_CR18","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/s0022-510x(98)00111-7","volume":"158","author":"AG Marshall","year":"1998","unstructured":"Marshall AG, Pawson R, Thom M, Schulz TF, Scaravilli F, Rudge P. HTLV-I associated primary CNS T-cell lymphoma. J Neurol Sci. 1998;158:226\u201331. https:\/\/doi.org\/10.1016\/s0022-510x(98)00111-7.","journal-title":"J Neurol Sci"},{"key":"4666_CR19","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1002\/1097-0142(19930101)71:1<133::aid-cncr2820710121>3.0.co;2-g","volume":"71","author":"H Taguchi","year":"1993","unstructured":"Taguchi H, Sonobe H, Yamato K, Takeuchi T, Ookawa K, Kodama H, et\u00a0al. Central nervous system involvement of adult T-cell leukemia-lymphoma with multinucleated giant cells in the brain, skin, and kidney. Cancer. 1993;71:133\u20137. https:\/\/doi.org\/10.1002\/1097-0142(19930101)71:1%3c133::aid-cncr2820710121%3e3.0.co;2-g.","journal-title":"Cancer"},{"key":"4666_CR20","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1002\/cncr.10480","volume":"96","author":"L Dahmoush","year":"2002","unstructured":"Dahmoush L, Hijazi Y, Barnes E, Stetler-Stevenson M, Abati A. Adult T-cell leukemia\/lymphoma: a cytopathologic, immunocytochemical, and flow cytometric study. Cancer. 2002;96:110\u20136. https:\/\/doi.org\/10.1002\/cncr.10480.","journal-title":"Cancer"},{"key":"4666_CR21","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1002\/ana.21430","volume":"64","author":"MD Geschwind","year":"2008","unstructured":"Geschwind MD, Shu H, Haman A, Sejvar JJ, Miller BL. Rapidly progressive dementia. Ann Neurol. 2008;64:97\u2013108. https:\/\/doi.org\/10.1002\/ana.21430.","journal-title":"Ann Neurol"},{"key":"4666_CR22","doi-asserted-by":"publisher","first-page":"759","DOI":"10.12740\/PP\/113013","volume":"54","author":"B Remberk","year":"2020","unstructured":"Remberk B, Szostakiewicz \u0141, Ka\u0142wa A, Bogucka-Bonikowska A, Borowska A, Racicka E. What exactly is catatonia in children and adolescents. Psychiatr Pol. 2020;54:759\u201375. https:\/\/doi.org\/10.12740\/PP\/113013.","journal-title":"Psychiatr Pol"},{"key":"4666_CR23","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3390\/geriatrics3030037","volume":"3","author":"J Serra-Mestres","year":"2018","unstructured":"Serra-Mestres J, Jaimes-Albornoz W. Recognizing catatonia in medically hospitalized older adults: why it matters. Geriatrics (Basel). 2018;3:37. https:\/\/doi.org\/10.3390\/geriatrics3030037.","journal-title":"Geriatrics (Basel)"},{"key":"4666_CR24","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s13030-018-0122-3","volume":"12","author":"A Koyama","year":"2018","unstructured":"Koyama A, Ohtake Y, Yasuda K, Sakai K, Sakamoto R, Matsuoka H, et\u00a0al. Avoiding diagnostic errors in psychosomatic medicine: a case series study. Biopsychosoc Med. 2018;12:4. https:\/\/doi.org\/10.1186\/s13030-018-0122-3.","journal-title":"Biopsychosoc Med"},{"key":"4666_CR25","doi-asserted-by":"publisher","first-page":"778","DOI":"10.5692\/clinicalneurol.cn-001076","volume":"57","author":"Y Takeuchi","year":"2017","unstructured":"Takeuchi Y, Kaga T, Ieda M, Kojima Y, Ochiai J, Mabuchi C. Symmetrical lesions of the cerebral peduncles and internal capsules on MRI in a patient with extranodal NK\/T cell lymphoma. Rinsho Shinkeigaku. 2017;57:778\u201381. https:\/\/doi.org\/10.5692\/clinicalneurol.cn-001076.","journal-title":"Rinsho Shinkeigaku"},{"key":"4666_CR26","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1212\/wnl.51.1.319","volume":"51","author":"JH Veldink","year":"1998","unstructured":"Veldink JH, Scheltens P, Jonker C, Launer LJ. Progression of cerebral white matter hyperintensities on MRI is related to diastolic blood pressure. Neurology. 1998;51:319\u201320. https:\/\/doi.org\/10.1212\/wnl.51.1.319.","journal-title":"Neurology"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-024-04666-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-024-04666-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-024-04666-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:02:13Z","timestamp":1722384133000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-024-04666-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,31]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["4666"],"URL":"https:\/\/doi.org\/10.1186\/s13256-024-04666-1","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,31]]},"assertion":[{"value":"6 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The institution does not require ethical approval for the publication of a single case report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient\u2019s next-of-kin for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that there has been no conflict of interest in the development or publication of this manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"348"}}