{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:56:25Z","timestamp":1771548985804,"version":"3.50.1"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T00:00:00Z","timestamp":1726272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T00:00:00Z","timestamp":1726272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"DOI":"10.1186\/s13256-024-04755-1","type":"journal-article","created":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T00:01:56Z","timestamp":1726272116000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A case of basal cell carcinoma of skin with bone metastasis: a case report"],"prefix":"10.1186","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1867-1609","authenticated-orcid":false,"given":"Azadeh","family":"Khayyat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MohammadAli Esmaeil","family":"Pour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid","family":"Nasrollahi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Mehdi","family":"Mehrabi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Amir","family":"Zohouri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bita","family":"Geramizadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,14]]},"reference":[{"key":"4755_CR1","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1016\/j.mayocp.2017.02.015","volume":"92","author":"JG Muzic","year":"2017","unstructured":"Muzic JG, Schmitt AR, Wright AC, et\u00a0al. Incidence and trends of basal cell carcinoma and cutaneous squamous cell carcinoma: a population-based study in Olmsted County, Minnesota, 2000 to 2010. Mayo Clin Proc. 2017;92:890\u20138. https:\/\/doi.org\/10.1016\/j.mayocp.2017.02.015.","journal-title":"Mayo Clin Proc"},{"key":"4755_CR2","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1158\/1055-9965.EPI-13-0821","volume":"23","author":"S Wu","year":"2014","unstructured":"Wu S, Han J, Laden F, Qureshi AA. Long-term ultraviolet flux, other potential risk factors, and skin cancer risk: a cohort study. Cancer Epidemiol Biomarkers Prev. 2014;23:1080\u20139. https:\/\/doi.org\/10.1158\/1055-9965.EPI-13-0821.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"4755_CR3","doi-asserted-by":"publisher","first-page":"2967","DOI":"10.2217\/fon.15.180","volume":"11","author":"X Wu","year":"2015","unstructured":"Wu X, Elkin EE, Marghoob AA. Burden of basal cell carcinoma in USA. Future Oncol. 2015;11:2967\u201374. https:\/\/doi.org\/10.2217\/fon.15.180.","journal-title":"Future Oncol"},{"key":"4755_CR4","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.amepre.2014.08.036","volume":"48","author":"GP Guy Jr","year":"2015","unstructured":"Guy GP Jr, Machlin SR, Ekwueme DU, Yabroff KR. Prevalence and costs of skin cancer treatment in the U.S., 2002\u20132006 and 2007\u20132011. Am J Prev Med. 2015;48:183\u20137. https:\/\/doi.org\/10.1016\/j.amepre.2014.08.036.","journal-title":"Am J Prev Med."},{"key":"4755_CR5","first-page":"568","volume":"12","author":"TP Wu","year":"2013","unstructured":"Wu TP, Stein JA. Nonmelanoma skin cancer in young women. J Drugs Dermatol. 2013;12:568\u201372.","journal-title":"J Drugs Dermatol"},{"key":"4755_CR6","doi-asserted-by":"publisher","first-page":"200","DOI":"10.2174\/138955711795049871","volume":"11","author":"A Gould","year":"2011","unstructured":"Gould A, Missailidis S. Targeting the hedgehog pathway: the development of cyclopamine and the development of anti-cancer drugs targeting the hedgehog pathway. Mini Rev Med Chem. 2011;11:200\u201313. https:\/\/doi.org\/10.2174\/138955711795049871.","journal-title":"Mini Rev Med Chem"},{"key":"4755_CR7","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1001\/jamadermatol.2013.3064","volume":"149","author":"A Wysong","year":"2013","unstructured":"Wysong A, Aasi SZ, Tang JY. Update on metastatic basal cell carcinoma: a summary of published cases from 1981 through 2011. JAMA Dermatol. 2013;149:615\u20136. https:\/\/doi.org\/10.1001\/jamadermatol.2013.3064.","journal-title":"JAMA Dermatol"},{"key":"4755_CR8","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1016\/s0190-9622(84)80334-5","volume":"10","author":"H von Domarus","year":"1984","unstructured":"von Domarus H, Stevens PJ. Metastatic basal cell carcinoma. Report of five cases and review of 170 cases in the literature. J Am Acad Dermatol. 1984;10:1043\u201360. https:\/\/doi.org\/10.1016\/s0190-9622(84)80334-5.","journal-title":"J Am Acad Dermatol."},{"key":"4755_CR9","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1002\/tera.1420010103","volume":"1","author":"RF Keeler","year":"1968","unstructured":"Keeler RF, Binns W. Teratogenic compounds of Veratrum californicum (Durand). V. Comparison of cyclopian effects of steroidal alkaloids from the plant and structurally related compounds from other sources. Teratology. 1968;1:5\u201310. https:\/\/doi.org\/10.1002\/tera.1420010103.","journal-title":"Teratology"},{"key":"4755_CR10","doi-asserted-by":"publisher","first-page":"2743","DOI":"10.1101\/gad.1025302","volume":"1","author":"JK Chen","year":"2002","unstructured":"Chen JK, Taipale J, Cooper MK, Beachy PA. Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev. 2002;1:2743\u20138. https:\/\/doi.org\/10.1101\/gad.1025302.","journal-title":"Genes Dev"},{"key":"4755_CR11","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s10354-013-0193-5","volume":"163","author":"U Wollina","year":"2013","unstructured":"Wollina U, Tchernev G. Advanced basal cell carcinoma. Wien Med Wochenschr. 2013;163:347\u201353. https:\/\/doi.org\/10.1007\/s10354-013-0193-5.","journal-title":"Wien Med Wochenschr"},{"key":"4755_CR12","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1038\/nrc2503","volume":"8","author":"EH Epstein","year":"2008","unstructured":"Epstein EH. Basal cell carcinomas: attack of the hedgehog. Nat Rev Cancer. 2008;8:743\u201354. https:\/\/doi.org\/10.1038\/nrc2503.","journal-title":"Nat Rev Cancer"},{"key":"4755_CR13","doi-asserted-by":"publisher","first-page":"2543","DOI":"10.1002\/mc.22690","volume":"56","author":"A Bakshi","year":"2017","unstructured":"Bakshi A, Chaudhary SC, Rana M, et\u00a0al. Basal cell carcinoma pathogenesis and therapy involving hedgehog signaling and beyond. Mol Carcinog. 2017;56:2543\u201357. https:\/\/doi.org\/10.1002\/mc.22690.","journal-title":"Mol Carcinog"},{"key":"4755_CR14","doi-asserted-by":"publisher","first-page":"9522","DOI":"10.1200\/JCO.2016.34.15_SUPPL.9522","volume":"34","author":"JS Ross","year":"2016","unstructured":"Ross JS, Gay LG, Mihm MC, et\u00a0al. Deep sequencing of metastatic cutaneous basal cell and squamous cell carcinomas to reveal distinctive genomic profiles and new routes to targeted therapies. J Clin Oncol. 2016;34:9522\u20139522. https:\/\/doi.org\/10.1200\/JCO.2016.34.15_SUPPL.9522.","journal-title":"J Clin Oncol"},{"key":"4755_CR15","doi-asserted-by":"publisher","first-page":"2225","DOI":"10.1056\/NEJMe1202170","volume":"7","author":"JT Lear","year":"2012","unstructured":"Lear JT. Oral hedgehog-pathway inhibitors for basal-cell carcinoma. N Engl J Med. 2012;7:2225\u20136. https:\/\/doi.org\/10.1056\/NEJMe1202170.","journal-title":"N Engl J Med"},{"key":"4755_CR16","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.1056\/NEJMoa1113713","volume":"7","author":"A Sekulic","year":"2012","unstructured":"Sekulic A, Migden MR, Oro AE, et\u00a0al. Efficacy and safety of vismodegib in advanced basal-cell carcinoma. N Engl J Med. 2012;7:2171\u20139. https:\/\/doi.org\/10.1056\/NEJMoa1113713.","journal-title":"N Engl J Med"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-024-04755-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-024-04755-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-024-04755-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T00:02:47Z","timestamp":1726272167000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-024-04755-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,14]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["4755"],"URL":"https:\/\/doi.org\/10.1186\/s13256-024-04755-1","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,14]]},"assertion":[{"value":"6 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The patient provided written, informed consent for the publication of this case report and any accompanying images.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for the publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests concerning this case report.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"428"}}