{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T12:32:17Z","timestamp":1777897937269,"version":"3.51.4"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Stevens\u2013Johnson syndrome epitomizes an acute, exceptionally rare, and capricious immunological phenomenon marked by potentially life-threatening skin reactions, involvement of mucous membranes, and concomitant systemic manifestations. Most cases of Stevens\u2013Johnson syndrome have been attributed to being triggered by drugs, while a minority have implicated infectious agents such as\u00a0Mycoplasma pneumoniae and Coxsackie virus A6 as their cause. We present a case report on the rare occurrence of Mycoplasma-pneumoniae-induced Stevens\u2013Johnson Syndrome in a 25-year-old Sri Lankan male adult.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case presentation<\/jats:title>\n            <jats:p>A 25-year-old Sri Lankan male adult sought medical attention at our institution, presenting a constellation of symptoms composed of fever with chills, dyspnea, pleuritic chest pain, cough producing reddish sputum, and sore throat, persisting over a 4-day period; 2 days following the onset of the respiratory symptoms, he experienced ocular congestion with purulent discharge and painful oral lesions. He had associated generalized body ache and fatigue.<\/jats:p>\n            <jats:p>Stevens-Johnson syndrome is diagnosed by skin biopsy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Stevens\u2013Johnson syndrome is an acute and debilitating condition that requires prompt and timely management to ensure minimum morbidity of the patient. The similarities and overlap of features between Stevens\u2013Johnson syndrome caused due to infectious and drug-related etiologies pose a diagnostic challenge for the physicians, which needs to be subdued using systematic research and evaluation with subsequent formulation of an evidence-based assessment and management plan to ensure safe and efficacious medical care for the patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s13256-024-04758-y","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T09:18:35Z","timestamp":1740561515000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mycoplasma-pneumonia-induced Stevens\u2013Johnson syndrome in an adult: a case report"],"prefix":"10.1186","volume":"19","author":[{"given":"Fathima Thesleem","family":"Yoosuf","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6858-3375","authenticated-orcid":false,"given":"Bassem","family":"Al Hariri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Memon Noor","family":"Illahi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Sharif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Yousaf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Gaafar","family":"Mohamedali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muayad Kasim","family":"Khalid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"key":"4758_CR1","volume-title":"Medical Microbiology","author":"S Razin","year":"1996","unstructured":"Razin S. Mycoplasmas. In: Baron S, editor. Medical Microbiology. 4th ed. Galveston: University of Texas Medical Branch at Galveston; 1996.","edition":"4"},{"issue":"12","key":"4758_CR2","doi-asserted-by":"publisher","first-page":"2326","DOI":"10.3390\/microorganisms10122326","volume":"10","author":"N Garin","year":"2022","unstructured":"Garin N, Marti C, SkaliLami A, Prendki V. Atypical pathogens in adult community-acquired pneumonia, and implications for empiric antibiotic treatment: a narrative review. Microorganisms. 2022;10(12):2326.","journal-title":"Microorganisms"},{"key":"4758_CR3","unstructured":"Oakley AM, Krishnamurthy K. Stevens-Johnson Syndrome. Treasure Island (FL): StatPearls Publishing; 2024"},{"issue":"8","key":"4758_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.644871","volume":"26","author":"T Imatoh","year":"2021","unstructured":"Imatoh T, Saito Y. Associations between Stevens-Johnson syndrome and Infection: overview of pharmacoepidemiological studies. Front Med. 2021;26(8): 644871.","journal-title":"Front Med"},{"issue":"2","key":"4758_CR5","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.jaad.2014.06.026","volume":"72","author":"TN Canavan","year":"2015","unstructured":"Canavan TN, Mathes EF, Frieden I, Shinkai K. Mycoplasma pneumoniae-induced rash and mucositis as a syndrome distinct from Stevens-Johnson syndrome and erythema multiforme: a systematic review. J Am Acad Dermatol. 2015;72(2):239\u201345.","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"4758_CR6","doi-asserted-by":"publisher","first-page":"525","DOI":"10.2332\/allergolint.11-OA-0309","volume":"60","author":"Y Kunimi","year":"2011","unstructured":"Kunimi Y, Hirata Y, Aihara M, Yamane Y, Ikezawa Z. Statistical analysis of Stevens-Johnson syndrome caused by Mycoplasma pneumonia infection in Japan. Allergol Int. 2011;60(4):525\u201332.","journal-title":"Allergol Int"},{"key":"4758_CR7","unstructured":"Mathes E.,\u00a0Kittler N.W. Reactive infectious mucocutaneous eruption (RIME). (Updated Feb 2024). UpToDate. Retrieved March 28, 2024."},{"key":"4758_CR8","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3389\/fmicb.2016.00023","volume":"7","author":"M Narita","year":"2016","unstructured":"Narita M. Classification of extrapulmonary manifestations due to Mycoplasma pneumoniae infection on the basis of possible pathogenesis. Front Microbiol. 2016;7:23.","journal-title":"Front Microbiol"},{"key":"4758_CR9","unstructured":"Frantz GF, McAninch SA. 2024 Mycoplasma pneumoniae\u2013Induced Rash and Mucositis (MIRM). StatPearls Publishin: Treasure Island (FL)."},{"issue":"2","key":"4758_CR10","doi-asserted-by":"publisher","first-page":"131","DOI":"10.4065\/mcp.2009.0379","volume":"85","author":"DA Wetter","year":"2010","unstructured":"Wetter DA, Camilleri MJ. Clinical, etiologic, and histopathologic features of Stevens-Johnson syndrome during an 8-year period at Mayo Clinic. Mayo Clin Proc. 2010;85(2):131\u20138.","journal-title":"Mayo Clin Proc"},{"issue":"2","key":"4758_CR11","doi-asserted-by":"publisher","first-page":"e386","DOI":"10.1542\/peds.2015-0278","volume":"136","author":"D Olson","year":"2015","unstructured":"Olson D, Watkins LK, Demirjian A, Lin X, Robinson CC, Pretty K, Benitez AJ, Winchell JM, Diaz MH, Miller LA, Foo TA, Mason MD, Lauper UL, Kupfer O, Kennedy J, Glod\u00e9 MP, Kutty PK, Dominguez SR. Outbreak of mycoplasma pneumoniae-associated Stevens-Johnson syndrome. Pediatrics. 2015;136(2):e386\u201394.","journal-title":"Pediatrics"},{"key":"4758_CR12","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1111\/j.1365-4632.2009.04154.x","volume":"48","author":"PC Schalock","year":"2009","unstructured":"Schalock PC, Dinulos JGH. Mycoplasma pneumoniae-induced cutaneous disease. Int J Dermatol. 2009;48:673\u201381.","journal-title":"Int J Dermatol"},{"key":"4758_CR13","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.24748.1","author":"A Hasegawa","year":"2020","unstructured":"Hasegawa A, Abe R. Recent advances in managing and understanding Stevens-Johnson syndrome and toxic epidermal necrolysis. F1000Res. 2020. https:\/\/doi.org\/10.12688\/f1000research.24748.1.","journal-title":"F1000Res"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-024-04758-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-024-04758-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-024-04758-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T09:18:38Z","timestamp":1740561518000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-024-04758-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,26]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4758"],"URL":"https:\/\/doi.org\/10.1186\/s13256-024-04758-y","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,26]]},"assertion":[{"value":"30 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This case report was subject to review and approval from the Institutional Review Board (IRB) of the Medical Research Center (MRC) at Hamad Medical Corporation and is in full conformance with the principles of the Declaration of Helsinki, Good Clinical Practice (GCP), and within the laws and regulations of MoPH in Qatar. IRB of Hamad Medical Corporation waived the need for informed consent due to the retrospective nature of the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have declared that no competing interests exist.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"74"}}