{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T11:12:30Z","timestamp":1767611550291,"version":"3.37.3"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100008967","name":"Philipps-Universit\u00e4t Marburg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008967","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Yellow nail syndrome is characterized by a yellow discoloration of the nails, respiratory symptoms,\u00a0and lymphedema. It was first described in 1964 and has an estimated prevalence of less than 1:1.000.000. Despite its diverse manifestations affecting different organ systems and a wide range of associated diseases, yellow nail syndrome is most commonly related to impaired lymphatic drainage. The treatment depends on whether the underlying pathology can be identified and includes dietary, pharmacological, interventional, and surgical approaches.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We report the case of a 73-year-old Caucasian male patient presenting with exertional shortness of breath and orthopnea, nonpitting edema of his distal extremities, and yellow discoloration of both his finger and toe nails. The diagnostic workup, which included the drainage of a large chylous pleural effusion, computed tomography of the chest, and lymphangiography, led to the diagnosis of yellow nail syndrome, presumably caused by a mediastinal lipoma compressing the thoracic duct. Treatment-wise, a percutaneous lymphatic embolization was performed after conservative treatment did not lead to a significant improvement of symptoms.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>While demonstrating the specific diagnostic findings of this case, we try to point out common pathogenetic aspects of the disorder and present the currently available treatment options.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-024-04962-w","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:02:13Z","timestamp":1733875333000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Yellow nail syndrome linked to a mediastinal lipoma: a case report"],"prefix":"10.1186","volume":"18","author":[{"given":"Christoph","family":"M\u00fcller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingo","family":"Stricker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Hykel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominic","family":"Dellweg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"issue":"4","key":"4962_CR1","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1111\/j.1365-2133.1964.tb14499.x","volume":"76","author":"PD Samman","year":"1964","unstructured":"Samman PD, White WF. The \u201cyellow nail\u201d syndrome. Br J Dermatol. 1964;76(4):153\u20137. https:\/\/doi.org\/10.1111\/j.1365-2133.1964.tb14499.x.","journal-title":"Br J Dermatol"},{"key":"4962_CR2","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-017-0594-4","author":"S Vignes","year":"2017","unstructured":"Vignes S, Baran R. Yellow nail syndrome: a review. Orphanet J Rare Dis. 2017. https:\/\/doi.org\/10.1186\/s13023-017-0594-4.","journal-title":"Orphanet J Rare Dis"},{"issue":"7","key":"4962_CR3","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1111\/resp.12357","volume":"19","author":"L Vald\u00e9s","year":"2014","unstructured":"Vald\u00e9s L, Huggins JT, Gude F, et\u00a0al. Characteristics of patients with yellow nail syndrome and pleural effusion. 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A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare to have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"599"}}