{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T20:56:54Z","timestamp":1781557014584,"version":"3.54.5"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Clear-cell carcinoma, a rare malignancy of the minor salivary gland of the soft palate, is diagnostically challenging neoplasm due to its rarity and overlapping features with other neoplasms. We report a case of atypical presentation, diagnostic challenges, and long-term follow-up post-surgical resection of the tumor, which adds valuable insights to literature on this rare malignancy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case presentation<\/jats:title>\n            <jats:p>A 34-years-old Pakistani female came to the hospital with a 2\u2009\u00d7\u20092\u00a0cm ulcerative lesion of soft palate. The lesion had no active bleeding and any associated discharge. However, during history taking, she reported pain and occasional bleeding from the lesion.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Diagnosis and therapeutic interventions<\/jats:title>\n            <jats:p>Excisional biopsy was performed, and the specimen was sent for histopathological examination and immunohistochemistry, which confirmed the diagnosis of clear-cell carcinoma. Later on, radiological evaluation confirmed the diagnosis of hyalinizing variant of clear-cell carcinoma. Long-term follow-up revealed no recurrence and postoperative complications.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>This case report highlights the importance of thorough diagnostic evaluation and long-term follow-up in management of a rare oral malignancy. Histopathological examination and immunohistochemistry are crucial in differentiating clear-cell carcinoma from other malignancies with overlapping features. Surgical excision remains the primary treatment modality, with a favorable prognosis if diagnosed and managed adequately.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s13256-025-05115-3","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T10:44:58Z","timestamp":1740739498000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clear-cell carcinoma of the soft palate: a case with atypical presentation and long-term follow-up: a case report"],"prefix":"10.1186","volume":"19","author":[{"given":"Sardar Noman","family":"Qayyum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayyed Muddasir","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irfan","family":"Ullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maleeka","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulmeena Aziz","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safi","family":"Ullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7195-2010","authenticated-orcid":false,"given":"Samim","family":"Noori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mudassir","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"issue":"2","key":"5115_CR1","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.ajoms.2018.09.002","volume":"31","author":"T Tsuji","year":"2019","unstructured":"Tsuji T, Kitada H, Abe S, Okita M, Otsuka N, Nakayama E. Clear cell carcinoma of the hard palate: a case report. J Oral Maxillofac Surg Med Pathol. 2019;31(2):113\u20137.","journal-title":"J Oral Maxillofac Surg Med Pathol"},{"issue":"2","key":"5115_CR2","doi-asserted-by":"publisher","first-page":"310","DOI":"10.4103\/jomfp.JOMFP_101_19","volume":"23","author":"TS Khan","year":"2019","unstructured":"Khan TS, Khan TA, Sharma M, Sharma GK. Clear cell carcinoma of soft palate\u2014a case report. J Oral Maxillofac Pathol. 2019;23(2):310.","journal-title":"J Oral Maxillofac Pathol"},{"issue":"3","key":"5115_CR3","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s12105-009-0124-3","volume":"3","author":"ED O\u2019Sullivan-Mejia","year":"2009","unstructured":"O\u2019Sullivan-Mejia ED, Massey HD, Faquin WC, Powers CN. Hyalinizing clear cell carcinoma: report of eight cases and a review of literature. Head Neck Pathol. 2009;3(3):179\u201385.","journal-title":"Head Neck Pathol"},{"key":"5115_CR4","unstructured":"Clear cell carcinoma of minor salivary gland origin: a case of mistaken identity. National Journal of Medical Research https:\/\/njmr.in\/index.php\/file\/article\/view\/497. Accessed 16 Sep 2024."},{"issue":"3","key":"5115_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.omsc.2022.100260","volume":"8","author":"S Alshehry","year":"2022","unstructured":"Alshehry S, Alnofaie H, Almusallam M, Alshuaibi H, Alodaini A. Clear cell carcinoma of soft palate in a young patient: a case report. Oral Maxillofac Surg Cases. 2022;8(3): 100260.","journal-title":"Oral Maxillofac Surg Cases"},{"issue":"2","key":"5115_CR6","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s12105-011-0244-4","volume":"5","author":"EA Bilodeau","year":"2011","unstructured":"Bilodeau EA, Hoschar AP, Barnes EL, Hunt JL, Seethala RR. Clear cell carcinoma and clear cell odontogenic carcinoma: a comparative clinicopathologic and immunohistochemical study. Head Neck Pathol. 2011;5(2):101\u20137.","journal-title":"Head Neck Pathol"},{"issue":"1","key":"5115_CR7","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1007\/s12105-013-0427-2","volume":"7","author":"J Tanguay","year":"2013","unstructured":"Tanguay J, Weinreb I. What the EWSR1-ATF1 fusion has taught us about hyalinizing clear cell carcinoma. Head Neck Pathol. 2013;7(1):28\u201334.","journal-title":"Head Neck Pathol"},{"key":"5115_CR8","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1007\/s12105-013-0466-8","volume":"1","author":"I Weinreb","year":"2013","unstructured":"Weinreb I. Hyalinizing clear cell carcinoma of salivary gland: a review and update. Head Neck Pathol. 2013;1:20\u20139.","journal-title":"Head Neck Pathol"},{"key":"5115_CR9","doi-asserted-by":"crossref","unstructured":"Research (IJHSR) IJ of HS and. Rare entity of clear cell carcinoma arising from the soft palate: a case report. Int J Health Sci Res. 2023 13(1).","DOI":"10.52403\/ijhsr.20230120"},{"issue":"6","key":"5115_CR10","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/j.ijom.2021.03.018","volume":"51","author":"A Desai","year":"2022","unstructured":"Desai A, Faquin WC, Iafrate AJ, Rivera MN, Jaquinet A, Troulis MJ. Clear cell carcinoma: a comprehensive literature review of 254 cases. Int J Oral Maxillofac Surg. 2022;51(6):705\u201312.","journal-title":"Int J Oral Maxillofac Surg"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-025-05115-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-025-05115-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-025-05115-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T10:45:06Z","timestamp":1740739506000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-025-05115-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,28]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["5115"],"URL":"https:\/\/doi.org\/10.1186\/s13256-025-05115-3","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,28]]},"assertion":[{"value":"19 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No ethical approval was required to report this case. However, consent was obtained from the patient before writing the case report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have no conflict of interest to declare.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"81"}}