{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:40:51Z","timestamp":1787020851470,"version":"build-2736575974"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"DOI":"10.1186\/s13256-025-05221-2","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T04:56:40Z","timestamp":1746507400000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exercise hemodynamic evaluation in the management of dasatinib-related pulmonary arterial hypertension: a case report"],"prefix":"10.1186","volume":"19","author":[{"given":"Shuhei","family":"Yamashita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Hiraide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Shiraishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Katsumata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaharu","family":"Kataoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Fukui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiyuki","family":"Kawakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsuke","family":"Yuasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Ieda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,6]]},"reference":[{"key":"5221_CR1","doi-asserted-by":"publisher","first-page":"2128","DOI":"10.1161\/CIRCULATIONAHA.111.079921","volume":"125","author":"D Montani","year":"2012","unstructured":"Montani D, Bergot E, G\u00fcnther S, Savale L, Bergeron A, Bourdin A, et\u00a0al. Pulmonary arterial hypertension in patients treated by dasatinib. Circulation. 2012;125:2128\u201337.","journal-title":"Circulation"},{"key":"5221_CR2","doi-asserted-by":"publisher","first-page":"229","DOI":"10.5045\/br.2021.2021117","volume":"56","author":"Z Nekoukar","year":"2021","unstructured":"Nekoukar Z, Moghimi M, Salehifar E. A narrative review on adverse effects of dasatinib with a focus on pharmacotherapy of dasatinib-induced pulmonary toxicities. Blood Res. 2021;56:229\u201342.","journal-title":"Blood Res"},{"key":"5221_CR3","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1177\/2045893217716659","volume":"7","author":"A Jose","year":"2017","unstructured":"Jose A, Rafei H, Ahari J. Combination targeted pulmonary hypertension therapy in the resolution of Dasatinib-associated pulmonary arterial hypertension. Pulm Circ. 2017;7:803\u20137.","journal-title":"Pulm Circ"},{"key":"5221_CR4","doi-asserted-by":"publisher","first-page":"1700217","DOI":"10.1183\/13993003.00217-2017","volume":"50","author":"J Weatherald","year":"2017","unstructured":"Weatherald J, Chaumais MC, Savale L, Ja\u00efs X, Seferian A, Canuet M, et\u00a0al. Long-term outcomes of dasatinib-induced pulmonary arterial hypertension: a population-based study. Eur Respir J. 2017;50:1700217.","journal-title":"Eur Respir J"},{"key":"5221_CR5","first-page":"3618","volume":"43","author":"M Humbert","year":"2022","unstructured":"Humbert M, Kovacs G, Hoeper MM, Badagliacca R, Berger RMF, Brida M, et\u00a0al. 2022 ESC\/ERS guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Respir J. 2022;43:3618\u2013731.","journal-title":"Eur Respir J"},{"key":"5221_CR6","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.1161\/CIRCULATIONAHA.108.787101","volume":"118","author":"JJ Tolle","year":"2008","unstructured":"Tolle JJ, Waxman AB, Van Horn TL, Pappagianopoulos PP, Systrom DM. Exercise-induced pulmonary arterial hypertension. Circulation. 2008;118:2183\u20139.","journal-title":"Circulation"},{"key":"5221_CR7","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1183\/09031936.00061015","volume":"46","author":"R Naeije","year":"2015","unstructured":"Naeije R, Vonk Noordegraaf A, Kovacs G. Exercise-induced pulmonary hypertension: at last! Eur Respir J. 2015;46:583\u20136.","journal-title":"Eur Respir J"},{"key":"5221_CR8","doi-asserted-by":"publisher","first-page":"2489","DOI":"10.1093\/eurheartj\/ehr160","volume":"32","author":"EM Lau","year":"2011","unstructured":"Lau EM, Manes A, Celermajer DS, Gali\u00e8 N. Early detection of pulmonary vascular disease in pulmonary arterial hypertension: time to move forward. Eur Heart J. 2011;32:2489\u201398.","journal-title":"Eur Heart J"},{"key":"5221_CR9","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1161\/CIRCULATIONAHA.112.000667","volume":"128","author":"GD Lewis","year":"2013","unstructured":"Lewis GD, Bossone E, Naeije R, Gr\u00fcnig E, Saggar R, Lancellotti P, et\u00a0al. Pulmonary vascular hemodynamic response to exercise in cardiopulmonary diseases. Circulation. 2013;128:1470\u20139.","journal-title":"Circulation"},{"key":"5221_CR10","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.120.007555","volume":"14","author":"C Baratto","year":"2021","unstructured":"Baratto C, Caravita S, Soranna D, Faini A, Dewachter C, Zambon A, et\u00a0al. Current limitations of invasive exercise hemodynamics for the diagnosis of heart failure with preserved ejection fraction. Circ Heart Fail. 2021;14: e007555.","journal-title":"Circ Heart Fail"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-025-05221-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-025-05221-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-025-05221-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T04:56:41Z","timestamp":1746507401000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-025-05221-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,6]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["5221"],"URL":"https:\/\/doi.org\/10.1186\/s13256-025-05221-2","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,6]]},"assertion":[{"value":"11 April 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of Keio University hospital. We obtained informed consent from the patient.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Authors declare no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"209"}}