{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T16:30:35Z","timestamp":1762878635727,"version":"3.45.0"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Datta Meghe Institute of Higher Education and Research"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Previously called giant cell reparative granuloma, central giant cell granuloma is an intraosseous lesion of unclear cause that is benign but may become aggressive. It frequently crosses the midline and typically affects the anterior area of the jaw, particularly in young females. Because the posterior mandibular lesion is uncommon, especially in middle-aged people, these presentations are difficult to diagnose and have clinical significance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A 37-year-old Indian female reported that she had been experiencing a painful, progressively growing bulge in her left posterior jaw for the previous 4\u00a0months. It was accompanied by paresthesia of lower left side of the face. Upon intraoral examination, a firm, nontender enlargement that stretched from the premolar to the molar region was discovered. A reactive bone lesion was suggested by a multilocular radiolucency found during radiographic assessment. Central giant cell granuloma was diagnosed after an incisional sample and histological examination. The patient had the affected side segmentally resected owing to the size and placement of the lesion. There was no recurrence observed during the follow-up period, and the postoperative recovery went smoothly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In contrast to the usual demographic and anatomical trends, this case illustrates a rare presentation of central giant cell granuloma in the posterior mandible of a middle-aged female. The significance of taking central giant cell granuloma into account when making a differential diagnosis for jaw swellings other than anterior region and in older age groups is highlighted by this atypical placement. By describing an uncommon site of involvement, the case contributes significantly to the limited literature on this atypical presentation. It also emphasizes the necessity of thorough clinical, radiographic, and histological correlation for precise diagnosis and treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13256-025-05613-4","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:53:51Z","timestamp":1762876431000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unveiling the mandibular mystery: a case of central giant cell granuloma in posterior mandibular region\u2014a case report"],"prefix":"10.1186","volume":"19","author":[{"given":"Aakanksha","family":"Tiwari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suwarna","family":"Dangore-Khasbage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"5613_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2020.151526","volume":"46","author":"VRV Melo-Muniz","year":"2020","unstructured":"Melo-Muniz VRV, Nunes FD, Cangussu MCT, et\u00a0al. Central giant cell granuloma: a clinicopathological and immunohistochemistry study of macrophages, blood vessels, lymphatic vessels, and regulatory proteins. Ann Diagn Pathol. 2020;46: 151526.","journal-title":"Ann Diagn Pathol"},{"key":"5613_CR2","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-019-0356-5","volume":"48","author":"Y Wang","year":"2019","unstructured":"Wang Y, Le A, El Demellawy D, et\u00a0al. An aggressive central giant cell granuloma in a pediatric patient: case report and review of literature. J Otolaryngol Head Neck Surg. 2019;48: 32.","journal-title":"J Otolaryngol Head Neck Surg"},{"issue":"1","key":"5613_CR3","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1186\/s13256-024-04571-7","volume":"18","author":"S Tabatabaei","year":"2024","unstructured":"Tabatabaei S, Paknahad M, Garmabi J, Ghorbani F. Central giant cell granuloma in the posterior region of mandible mimicking a fibro-osseous lesion and hemangioma: a case report. J Med Case Rep. 2024;18(1):255.","journal-title":"J Med Case Rep"},{"issue":"1\u20133","key":"5613_CR4","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1177\/26323273231224986","volume":"5","author":"G Singh","year":"2023","unstructured":"Singh G, Kumar S, Kumar A. Central giant cell granuloma of maxilla: a case report. Traumaxilla. 2023;5(1\u20133):38\u201341.","journal-title":"Traumaxilla"},{"issue":"112","key":"5613_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2023.108971","volume":"1","author":"M Ali","year":"2023","unstructured":"Ali M, Hamama M, Kheder K, Haidar O. Central giant cell granuloma formation in an edentulous area in the posterior portion of mandible: a case report. Int J Surg Case Rep. 2023;1(112): 108971.","journal-title":"Int J Surg Case Rep"},{"issue":"1","key":"5613_CR6","doi-asserted-by":"publisher","first-page":"37","DOI":"10.4103\/ams.ams_232_18","volume":"9","author":"P Jeyaraj","year":"2019","unstructured":"Jeyaraj P. Management of central giant cell granulomas of the jaws: an unusual case report with critical appraisal of existing literature. Annals Maxillofac Surg. 2019;9(1):37\u201347.","journal-title":"Annals Maxillofac Surg"},{"key":"5613_CR7","doi-asserted-by":"publisher","DOI":"10.1177\/23247096221123146","volume":"10","author":"BJ Shum","year":"2022","unstructured":"Shum BJ, Kim MS, Kondra K, Hammoudeh JA, Strom C, Ryabets-Lienhard A. A unique case of aggressive central giant cell granuloma in a 10-year-old boy with 16p13. 11 microdeletion syndrome. J Investig Med High Impact Case Rep. 2022;10: 23247096221123146.","journal-title":"J Investig Med High Impact Case Rep"},{"key":"5613_CR8","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.57729","author":"OV Desai","year":"2024","unstructured":"Desai OV, Kshirsagar R, Singh V, Nair VS, Sane V, Jain S, Agarwal R. Central giant cell granuloma of the mandible: a case report. Cureus. 2024. https:\/\/doi.org\/10.7759\/cureus.57729.","journal-title":"Cureus"},{"issue":"1","key":"5613_CR9","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.ajoms.2024.04.018","volume":"37","author":"YB How","year":"2024","unstructured":"How YB, Telang A, Telang L, Tilakaratne WM. An unusual case of central giant cell granuloma. J Oral Maxillofac Surg Med Patho. 2024;37(1):239\u201342.","journal-title":"J Oral Maxillofac Surg Med Patho"},{"issue":"Suppl 2","key":"5613_CR10","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1007\/s12070-021-02794-4","volume":"74","author":"VI Patel","year":"2022","unstructured":"Patel VI, Amrutha GM. Central giant cell granuloma of Maxilla: a case report. Indian J Otolaryngol Head & Neck Surg. 2022;74(Suppl 2):1661\u20134.","journal-title":"Indian J Otolaryngol Head & Neck Surg"},{"issue":"4","key":"5613_CR11","doi-asserted-by":"publisher","first-page":"118","DOI":"10.18231\/j.ijmi.2020.029","volume":"6","author":"A Deshpande","year":"2021","unstructured":"Deshpande A, Munde A, Mishra S, Kawsankar K, Sawade R, Nayak P. Aggressive giant cell granuloma of mandible: a case report. IP Int J Maxillofac Imaging. 2021;6(4):118\u201321.","journal-title":"IP Int J Maxillofac Imaging"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-025-05613-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-025-05613-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-025-05613-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:53:52Z","timestamp":1762876432000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-025-05613-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,11]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["5613"],"URL":"https:\/\/doi.org\/10.1186\/s13256-025-05613-4","relation":{},"ISSN":["1752-1947"],"issn-type":[{"type":"electronic","value":"1752-1947"}],"subject":[],"published":{"date-parts":[[2025,11,11]]},"assertion":[{"value":"28 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"580"}}