{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T15:02:16Z","timestamp":1771599736862,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":23,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary neuroendocrine carcinoma (small-cell carcinoma) of the breast is a rare tumor; most cases are reported in women. Small-cell carcinoma is a type of neuroendocrine tumor characterized by high-grade, poorly differentiated, and aggressive behavior, which are common features regardless of the tumor\u2019s location. Here, we present a rare case of primary small-cell carcinoma of the breast in a male patient treated successfully with neoadjuvant chemotherapy followed by surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 47-year-old Syrian man presented with a left breast mass. Further histopathological investigation revealed the diagnosis of high-grade small-cell carcinoma of the breast. Computed tomography imaging excluded other potential primary origins. The patient was treated with neoadjuvant chemotherapy (cisplatin and etoposide), followed by a modified radical mastectomy. After 18\u00a0months of diagnosis, the patient is under surveillance and doing well.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This report presents a rare case of male breast cancer with the uncommon histological diagnosis of small-cell carcinoma. It highlights a successful therapeutic approach in the absence of established treatment guidelines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13256-025-05780-4","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T05:15:59Z","timestamp":1769577359000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A complete pathological response to preoperative chemotherapy in a male patient with primary neuroendocrine breast cancer: a case report"],"prefix":"10.1186","volume":"20","author":[{"given":"Maher","family":"Saifo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahaf","family":"Hussein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Awad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad","family":"Al Chikh Youssef","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9132-1384","authenticated-orcid":false,"given":"Mousa","family":"Alali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"issue":"3","key":"5780_CR1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, et\u00a0al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229\u201363. https:\/\/doi.org\/10.3322\/caac.21834.","journal-title":"CA Cancer J Clin"},{"key":"5780_CR2","doi-asserted-by":"publisher","unstructured":"Muhammad M, Alali M, Saifo M. Clinicopathological features, treatment patterns, and survival outcomes among Syrian patients with advanced breast cancer. Front Oncol. 2024;14 [online]. Available: https:\/\/doi.org\/10.3389\/fonc.2024.1417053","DOI":"10.3389\/fonc.2024.1417053"},{"issue":"5","key":"5780_CR3","doi-asserted-by":"publisher","first-page":"e997","DOI":"10.1016\/j.clbc.2018.06.013","volume":"18","author":"N Liu","year":"2018","unstructured":"Liu N, Johnson KJ, Ma CX. Male breast cancer: an updated surveillance, epidemiology, and end results data analysis. 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A copy of the written consent is available for review by the Editor-in-Chief of the journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"111"}}