{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:56:15Z","timestamp":1770252975118,"version":"3.49.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"DOI":"10.1186\/s13256-025-05782-2","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T14:17:13Z","timestamp":1767881833000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful 15-year management of a 97-year-old woman with acromegaly: a case report and review of the literature"],"prefix":"10.1186","volume":"20","author":[{"given":"Youhei","family":"Takeuchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7622-1270","authenticated-orcid":false,"given":"Tomohiro","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohisa","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshikazu","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidenori","family":"Endo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"5782_CR1","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1007\/s11102-015-0701-2","volume":"19","author":"T Burton","year":"2016","unstructured":"Burton T, Le Nestour E, Neary M, Ludlam WH. Incidence and prevalence of acromegaly in a large US health plan database. Pituitary. 2016;19:262\u20137. https:\/\/doi.org\/10.1007\/s11102-015-0701-2.","journal-title":"Pituitary"},{"key":"5782_CR2","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s42000-020-00235-5","volume":"20","author":"F Ceccato","year":"2021","unstructured":"Ceccato F, Barbot M, Lizzul L, Cuccarollo A, Selmin E, Boschin IM, et\u00a0al. Clinical presentation and management of acromegaly in elderly patients. Hormones. 2021;20:143\u201350. https:\/\/doi.org\/10.1007\/s42000-020-00235-5.","journal-title":"Hormones"},{"key":"5782_CR3","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1530\/EJE-18-0015","volume":"178","author":"D Esposito","year":"2018","unstructured":"Esposito D, Ragnarsson O, Granfeldt D, Marlow T, Johannsson G, Olsson DS. Decreasing mortality and changes in treatment patterns in patients with acromegaly from a nationwide study. Eur J Endocrinol. 2018;178:459\u201369. https:\/\/doi.org\/10.1530\/EJE-18-0015.","journal-title":"Eur J Endocrinol"},{"key":"5782_CR4","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1111\/j.1365-2265.2009.03619.x","volume":"72","author":"R Kauppinen-M\u00e4kelin","year":"2010","unstructured":"Kauppinen-M\u00e4kelin R, Sane T, V\u00e4lim\u00e4ki MJ, Markkanen H, Niskanen L, Ebeling T, et\u00a0al. Increased cancer incidence in acromegaly\u2014A nationwide survey. Clin Endocrinol (Oxf). 2010;72:278\u20139. https:\/\/doi.org\/10.1111\/j.1365-2265.2009.03619.x.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"5782_CR5","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s11102-023-01360-1","volume":"27","author":"A Giustina","year":"2024","unstructured":"Giustina A, Biermasz N, Casanueva FF, Fleseriu M, Mortini P, Strasburger C, et\u00a0al. Consensus on criteria for acromegaly diagnosis and remission. Pituitary. 2024;27:7\u201322. https:\/\/doi.org\/10.1007\/s11102-023-01360-1.","journal-title":"Pituitary"},{"key":"5782_CR6","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1507\/endocrj.EJ23-0274","volume":"70","author":"T Isojima","year":"2023","unstructured":"Isojima T, Shimatsu A. Proposed reference intervals of serum insulin-like growth factor-1 (IGF-1) levels in older Japanese populations. Endocr J. 2023;70:1023\u20137. https:\/\/doi.org\/10.1507\/endocrj.EJ23-0274.","journal-title":"Endocr J"},{"key":"5782_CR7","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s12020-020-02206-7","volume":"68","author":"MR Ambrosio","year":"2020","unstructured":"Ambrosio MR, Gagliardi I, Chiloiro S, Ferreira AG, Bondanelli M, Giampietro A, et\u00a0al. Acromegaly in the elderly patients. Endocrine. 2020;68:16\u201331. https:\/\/doi.org\/10.1007\/s12020-020-02206-7.","journal-title":"Endocrine"},{"key":"5782_CR8","doi-asserted-by":"publisher","first-page":"599","DOI":"10.2176\/nmc.ra.2014-0088","volume":"54","author":"I Fukuda","year":"2014","unstructured":"Fukuda I, Hizuka N, Muraoka T, Ichihara A. Adult growth hormone deficiency: current concepts. Neurol Med Chir Tokyo. 2014;54:599\u2013605.","journal-title":"Neurol Med Chir Tokyo"},{"key":"5782_CR9","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1159\/000183771","volume":"40","author":"KKY Ho","year":"1993","unstructured":"Ho KKY, Hoffman DM. Aging and growth hormone. Horm Res. 1993;40:80\u20136.","journal-title":"Horm Res"},{"key":"5782_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1054\/ghir.2001.0263","volume":"12","author":"H Simpson","year":"2002","unstructured":"Simpson H, Savine R, S\u00f6nksen P, Bengtsson BA, Carlsson L, Christiansen JS, et\u00a0al. Growth hormone replacement therapy for adults: into the new millennium. Growth Horm IGF Res. 2002;12:1\u201333. https:\/\/doi.org\/10.1054\/ghir.2001.0263.","journal-title":"Growth Horm IGF Res"},{"key":"5782_CR11","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/s41572-019-0071-6","volume":"5","author":"A Colao","year":"2019","unstructured":"Colao A, Grasso LFS, Giustina A, Melmed S, Chanson P, Pereira AM, et\u00a0al. Acromegaly. Nat Rev Dis Primers. 2019;5:20. https:\/\/doi.org\/10.1038\/s41572-019-0071-6.","journal-title":"Nat Rev Dis Primers"},{"key":"5782_CR12","doi-asserted-by":"publisher","first-page":"3933","DOI":"10.1210\/jc.2014-2700","volume":"99","author":"L Katznelson","year":"2014","unstructured":"Katznelson L, Laws ER Jr, Melmed S, Molitch ME, Murad MH, Utz A, et\u00a0al. Acromegaly: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2014;99:3933\u201351. https:\/\/doi.org\/10.1210\/jc.2014-2700.","journal-title":"J Clin Endocrinol Metab"},{"key":"5782_CR13","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1210\/er.2018-00115","volume":"40","author":"MR Gadelha","year":"2019","unstructured":"Gadelha MR, Kasuki L, Lim DST, Fleseriu M. Systemic complications of acromegaly and the impact of the current treatment landscape: an update. Endocr Rev. 2019;40:268\u2013332.","journal-title":"Endocr Rev"},{"key":"5782_CR14","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1210\/er.2018-00115","volume":"53","author":"H Nishioka","year":"2021","unstructured":"Nishioka H. Growth hormone deficiency in treated acromegaly. Diabetes Endocrinol Metab. 2021;53:201\u20134. https:\/\/doi.org\/10.1210\/er.2018-00115.","journal-title":"Diabetes Endocrinol Metab"},{"key":"5782_CR15","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1530\/EJE-11-0657","volume":"165","author":"S Yamada","year":"2011","unstructured":"Yamada S, Fukuhara N, Nishioka H, Takeshita A, Suzuki H, Miyakawa M, et\u00a0al. GH deficiency in patients after cure of acromegaly by surgery alone. Eur J Endocrinol. 2011;165:873\u20139. https:\/\/doi.org\/10.1530\/EJE-11-0657.","journal-title":"Eur J Endocrinol"},{"key":"5782_CR16","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1007\/s11102-012-0424-6","volume":"16","author":"S Fujio","year":"2013","unstructured":"Fujio S, Tokimura H, Hirano H, Hanaya R, Kubo F, Yunoue S, et\u00a0al. Severe growth hormone deficiency is rare in surgically-cured acromegalics. Pituitary. 2013;16:326\u201332. https:\/\/doi.org\/10.1007\/s11102-012-0424-6.","journal-title":"Pituitary"},{"key":"5782_CR17","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1530\/EJE-14-0304","volume":"171","author":"CR Ku","year":"2014","unstructured":"Ku CR, Hong JW, Kim EH, Kim SH, Lee EJ. Clinical predictors of GH deficiency in surgically cured acromegalic patients. Eur J Endocrinol. 2014;171:379\u201387. https:\/\/doi.org\/10.1530\/EJE-14-0304.","journal-title":"Eur J Endocrinol"},{"key":"5782_CR18","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.tem.2014.10.005","volume":"26","author":"G Mazziotti","year":"2015","unstructured":"Mazziotti G, Marzullo P, Doga M, Aimaretti G, Giustina A. Growth hormone deficiency in treated acromegaly. Trends Endocrinol Metab. 2015;26:11\u201321. https:\/\/doi.org\/10.1016\/j.tem.2014.10.005.","journal-title":"Trends Endocrinol Metab"},{"key":"5782_CR19","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1111\/j.0954-6820.1988.tb15881.x","volume":"223","author":"BA Bengtsson","year":"1988","unstructured":"Bengtsson BA, Ed\u00e9n S, Ernest I, Od\u00e9n A, Sj\u00f6gren B. Epidemiology and long-term survival in acromegaly. A study of 166 cases diagnosed between 1955 and 1984. Acta Med Scand. 1988;223:327\u201335. https:\/\/doi.org\/10.1111\/j.0954-6820.1988.tb15881.x.","journal-title":"Acta Med Scand"},{"key":"5782_CR20","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/s0889-8529(05)70206-1","volume":"30","author":"BD Anawalt","year":"2001","unstructured":"Anawalt BD, Merriam GR. Neuroendocrine aging in men. Andropause and somatopause. Endocrinol Metab Clin North Am. 2001;30:647\u201369. https:\/\/doi.org\/10.1016\/s0889-8529(05)70206-1.","journal-title":"Endocrinol Metab Clin North Am"},{"key":"5782_CR21","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1001\/jama.288.18.2282","volume":"288","author":"MR Blackman","year":"1996","unstructured":"Blackman MR, Sorkin JD, M\u00fcnzer T, Bellantoni MF, Busby-Whitehead J, Stevens TE, et\u00a0al. Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial. JAMA. 1996;288:2209\u201315. https:\/\/doi.org\/10.1001\/jama.288.18.2282.","journal-title":"JAMA"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-025-05782-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-025-05782-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-025-05782-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T11:50:43Z","timestamp":1770205843000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13256-025-05782-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,8]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["5782"],"URL":"https:\/\/doi.org\/10.1186\/s13256-025-05782-2","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,8]]},"assertion":[{"value":"17 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by Ethics Committee of Kohnan hospital (approval ID: 2023\u20130118-02). Moreover, the informed consent was obtained from the patient.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"61"}}