{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T02:21:44Z","timestamp":1782440504517,"version":"3.54.5"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":39,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atypical lobular endocervical glandular hyperplasia is an infrequent precursor to gastric-type cervical adenocarcinoma, often posing diagnostic challenges owing to its occult nature and high misdiagnosis rate. The synchronous presentation in both the cervix and endometrium, a form of synchronous mucinous metaplasia and neoplasia of the female genital tract, is even rarer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We report the case of a 53-year-old Chinese woman with increased vaginal discharge and postmenopausal bleeding, initially misdiagnosed as cervical and endometrial polyps. Postoperative pathology following hysteroscopy revealed synchronous atypical lobular endocervical glandular hyperplasia of the cervix and endometrium. Notably, while atypical lobular endocervical glandular hyperplasia is typically an occult finding diagnosed after cervical conization, hysteroscopy in this case enabled direct visualization and targeted biopsy, overcoming a significant diagnostic hurdle.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case underscores the insidious clinical presentation of synchronous atypical lobular endocervical glandular hyperplasia and highlights the pivotal role of hysteroscopy as a diagnostic tool. It can facilitate the early and accurate identification of these occult lesions, thereby preventing potential misdiagnosis and guiding appropriate management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13256-026-05906-2","type":"journal-article","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T15:53:58Z","timestamp":1772726038000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synchronous atypical lobular endocervical glandular hyperplasia of the cervix and endometrium: a clinicopathologic case report and review of literature"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6182-7842","authenticated-orcid":false,"given":"Ziqi","family":"Ge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zili","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junmin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"issue":"4","key":"5906_CR1","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1046\/j.1365-2559.2001.01239.x","volume":"39","author":"Y Mikami","year":"2001","unstructured":"Mikami Y, Hata S, Melamed J, Fujiwara K, Manabe T. Lobular endocervical glandular hyperplasia is a metaplastic process with a pyloric gland phenotype. Histopathology. 2001;39(4):364\u201372. https:\/\/doi.org\/10.1046\/j.1365-2559.2001.01239.x.","journal-title":"Histopathology"},{"issue":"10","key":"5906_CR2","first-page":"785","volume":"57","author":"J Zhang","year":"2022","unstructured":"Zhang J. New progress in pathological diagnosis of cervical adenocarcinoma and its precancerous lesions. Chin J Obstet Gynecol. 2022;57(10):785\u20138.","journal-title":"Chin J Obstet Gynecol"},{"key":"5906_CR3","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1097\/00000478-199908000-00005","volume":"23","author":"MR Nucci","year":"1999","unstructured":"Nucci MR, Clement PB, Young RT. Lobular endocervical glandular hyperplasia, not otherwise specified. Am J Surg Pathol. 1999;23:886\u201391. https:\/\/doi.org\/10.1097\/00000478-199908000-00005.","journal-title":"Am J Surg Pathol"},{"key":"5906_CR4","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1038\/modpathol.3800148","volume":"17","author":"Y Mikami","year":"2004","unstructured":"Mikami Y, Kiyokawa T, Hata S, Fujiwara K, Moriya T, Sasano H, et\u00a0al. Gastrointestinal immunophenotype in adenocarcinomas of the uterine cervix and related glandular lesions: a possible link between lobular endocervical glandular hyperplasia\/pyloric gland metaplasia and \u201cadenoma malignum.\u201d Mod Pathol. 2004;17:962\u201372. https:\/\/doi.org\/10.1038\/modpathol.3800148.","journal-title":"Mod Pathol"},{"issue":"10","key":"5906_CR5","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1136\/ijgc-2020-001612","volume":"30","author":"H Kobara","year":"2020","unstructured":"Kobara H, Miyamoto T, Ando H, et\u00a0al. Limited frequency of malignant change in lobular endocervical glandular hyperplasia. Int J Gynecol Cancer. 2020;30(10):1480\u20137. https:\/\/doi.org\/10.1136\/ijgc-2020-001612.","journal-title":"Int J Gynecol Cancer"},{"key":"5906_CR6","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1097\/PAP.0000000000000266","volume":"27","author":"S Stolnicu","year":"2020","unstructured":"Stolnicu S, Talia KL, McCluggage WG. The evolving spectrum of precursor lesions of cervical adenocarcinomas. Adv Anat Pathol. 2020;27:278\u201393. https:\/\/doi.org\/10.1097\/PAP.0000000000000266.","journal-title":"Adv Anat Pathol"},{"issue":"8","key":"5906_CR7","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1097\/PAS.0000000000000855","volume":"41","author":"KL Talia","year":"2017","unstructured":"Talia KL, Stewart C, Howitt BE, et\u00a0al. HPV-negative gastric type adenocarcinoma in situ of the cervix: a spectrum of rare lesions exhibiting gastric and intestinal differentiation. Am J Surg Pathol. 2017;41(8):1023\u201333. https:\/\/doi.org\/10.1097\/PAS.0000000000000855.","journal-title":"Am J Surg Pathol"},{"key":"5906_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.gore.2020.100571","volume":"32","author":"H Kobara","year":"2020","unstructured":"Kobara H, Miyamoto T, Otsuki T, Ohya A, Shiozawa T. Worsening cytology and lesion enlargement are useful indicators for malignant transformation of lobular endocervical glandular hyperplasia during follow-up: a case report. Gynecol Oncol Rep. 2020;32: 100571. https:\/\/doi.org\/10.1016\/j.gore.2020.100571.","journal-title":"Gynecol Oncol Rep"},{"issue":"12","key":"5906_CR9","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1097\/PAS.0b013e3181883722","volume":"32","author":"S Kawauchi","year":"2008","unstructured":"Kawauchi S, Kusuda T, Liu XP, et\u00a0al. Is lobular endocervical glandular hyperplasia a cancerous precursor of minimal deviation adenocarcinoma?: a comparative molecular-genetic and immunohistochemical study. Am J Surg Pathol. 2008;32(12):1807\u201315. https:\/\/doi.org\/10.1097\/PAS.0b013e3181883722.","journal-title":"Am J Surg Pathol"},{"key":"5906_CR10","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1038\/s41379-020-00726-1","volume":"34","author":"P Selenica","year":"2021","unstructured":"Selenica P, Alemar B, Matrai C, Talia KL, Veras E, Hussein Y, et\u00a0al. Massively parallel sequencing analysis of 68 gastric-type cervical adenocarcinomas reveals mutations in cell cycle-related genes and potentially targetable mutations. Mod Pathol. 2021;34:1213\u201325. https:\/\/doi.org\/10.1038\/s41379-020-00726-1.","journal-title":"Mod Pathol"},{"issue":"7","key":"5906_CR11","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1097\/IGC.0b013e31821f746c","volume":"21","author":"A Takatsu","year":"2011","unstructured":"Takatsu A, Shiozawa T, Miyamoto T, et\u00a0al. Preoperative differential diagnosis of minimal deviation adenocarcinoma and lobular endocervical glandular hyperplasia of the uterine cervix: a multicenter study of clinicopathology and magnetic resonance imaging findings. Int J Gynecol Cancer. 2011;21(7):1287\u201396. https:\/\/doi.org\/10.1097\/IGC.0b013e31821f746c.","journal-title":"Int J Gynecol Cancer"},{"issue":"2","key":"5906_CR12","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1111\/jog.13528","volume":"44","author":"A Ohya","year":"2018","unstructured":"Ohya A, Asaka S, Fujinaga Y, Kadoya M. Uterine cervical adenocarcinoma associated with lobular endocervical glandular hyperplasia: radiologic-pathologic correlation. J Obstet Gynaecol Res. 2018;44(2):312\u201322. https:\/\/doi.org\/10.1111\/jog.13528.","journal-title":"J Obstet Gynaecol Res"},{"key":"5906_CR13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0221088","volume":"14","author":"M Omori","year":"2019","unstructured":"Omori M, Kondo T, Tagaya H, Watanabe Y, Fukasawa H, Kawai M, et\u00a0al. Utility of imaging modalities for predicting carcinogenesis in lobular endocervical glandular hyperplasia. PLoS ONE. 2019;14: e0221088. https:\/\/doi.org\/10.1371\/journal.pone.0221088.","journal-title":"PLoS ONE"},{"issue":"3","key":"5906_CR14","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1111\/j.1365-2559.2009.03346.x","volume":"55","author":"Y Mikami","year":"2009","unstructured":"Mikami Y, Kojima A, Kiyokawa T, et\u00a0al. Ki67 labelling index and p53 status indicate neoplastic nature of atypical lobular endocervical glandular hyperplasia (ALEGH). Histopathology. 2009;55(3):362\u20134. https:\/\/doi.org\/10.1111\/j.1365-2559.2009.03346.x.","journal-title":"Histopathology"},{"issue":"6","key":"5906_CR15","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1159\/000509667","volume":"64","author":"S Ishii","year":"2020","unstructured":"Ishii S, Ito T, Yamada M, et\u00a0al. Characteristic cytological findings of lobular endocervical glandular hyperplasia associated with adenocarcinoma of the uterine cervix. Acta Cytol. 2020;64(6):556\u201362. https:\/\/doi.org\/10.1159\/000509667.","journal-title":"Acta Cytol"},{"issue":"3","key":"5906_CR16","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s00428-018-2381-6","volume":"473","author":"K Yamanoi","year":"2018","unstructured":"Yamanoi K, Ishii K, Tsukamoto M, Asaka S, Nakayama J. Gastric gland mucin-specific O-glycan expression decreases as tumor cells progress from lobular endocervical gland hyperplasia to cervical mucinous carcinoma, gastric type. Virchows Arch. 2018;473(3):305\u201311. https:\/\/doi.org\/10.1007\/s00428-018-2381-6.","journal-title":"Virchows Arch"},{"issue":"1","key":"5906_CR17","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s00428-018-2469-z","volume":"474","author":"S Asaka","year":"2019","unstructured":"Asaka S, Nakajima T, Momose M, Miyamoto T, Uehara T, Ota H. Trefoil factor family 2 protein: a potential immunohistochemical marker for aiding diagnosis of lobular endocervical glandular hyperplasia and gastric-type adenocarcinoma of the uterine cervix. Virchows Arch. 2019;474(1):79\u201386. https:\/\/doi.org\/10.1007\/s00428-018-2469-z.","journal-title":"Virchows Arch"},{"issue":"1","key":"5906_CR18","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1097\/01.lab.0000049821.16698.d0","volume":"83","author":"C Kuragaki","year":"2003","unstructured":"Kuragaki C, Enomoto T, Ueno Y, et\u00a0al. Mutations in the STK11 gene characterize minimal deviation adenocarcinoma of the uterine cervix. Lab Invest. 2003;83(1):35\u201345. https:\/\/doi.org\/10.1097\/01.lab.0000049821.16698.d0.","journal-title":"Lab Invest"},{"issue":"11","key":"5906_CR19","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1111\/jog.13083","volume":"42","author":"H Ando","year":"2016","unstructured":"Ando H, Miyamoto T, Kashima H, et\u00a0al. Usefulness of a management protocol for patients with cervical multicystic lesions: a retrospective analysis of 94 cases and the significance of GNAS mutation. J Obstet Gynaecol Res. 2016;42(11):1588\u201398. https:\/\/doi.org\/10.1111\/jog.13083.","journal-title":"J Obstet Gynaecol Res"},{"issue":"12","key":"5906_CR20","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.3760\/cma.j.cn112152-20240518-00201","volume":"46","author":"L Linghui","year":"2024","unstructured":"Linghui L, Yiqing C, Jing L, et\u00a0al. Clinical and pathological characteristics of mucinous metaplasia and tumors in multiple sites of the female reproductive tract at the same time. Chinese J Oncol. 2024;46(12):1195\u2013208. https:\/\/doi.org\/10.3760\/cma.j.cn112152-20240518-00201.","journal-title":"Chinese J Oncol"},{"issue":"2","key":"5906_CR21","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1111\/j.1365-2559.2008.03202.x","volume":"54","author":"Y Mikami","year":"2009","unstructured":"Mikami Y, Kiyokawa T, Sasajima Y, et\u00a0al. Reappraisal of synchronous and multifocal mucinous lesions of the female genital tract: a close association with gastric metaplasia. Histopathology. 2009;54(2):184\u201391. https:\/\/doi.org\/10.1111\/j.1365-2559.2008.03202.x.","journal-title":"Histopathology"},{"issue":"12","key":"5906_CR22","doi-asserted-by":"publisher","first-page":"3056","DOI":"10.1111\/jog.15441","volume":"48","author":"T Miyamoto","year":"2022","unstructured":"Miyamoto T, Kobara H, Shiozawa T. Biology and management of lobular endocervical glandular hyperplasia. J Obstet Gynaecol Res. 2022;48(12):3056\u201367. https:\/\/doi.org\/10.1111\/jog.15441.","journal-title":"J Obstet Gynaecol Res"},{"issue":"11","key":"5906_CR23","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.3390\/healthcare11111619","volume":"11","author":"R Shiro","year":"2023","unstructured":"Shiro R, Kotani Y, Ohta M, et\u00a0al. Diagnostic utility of hysteroscopic biopsy in suspected lobular endocervical glandular hyperplasia. Healthcare. 2023;11(11):1619. https:\/\/doi.org\/10.3390\/healthcare11111619.","journal-title":"Healthcare"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-026-05906-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-026-05906-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-026-05906-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T11:57:05Z","timestamp":1776081425000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13256-026-05906-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,5]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["5906"],"URL":"https:\/\/doi.org\/10.1186\/s13256-026-05906-2","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,5]]},"assertion":[{"value":"27 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Owing to the observational nature of this case report, which does not involve any interventions or experimental procedures, formal ethical approval was not required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"191"}}