{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:45:06Z","timestamp":1776905106374,"version":"3.51.2"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":38,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Somatostatin analogs such as octreotide are frequently used in the prevention of carcinoid syndrome in the perioperative period following neuroendocrine tumor resection. This is the first reported case of ventricular asystole associated with postoperative intravenous octreotide infusion in a patient with previous congenital cardiac surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We present the case of a 62-year-old white British male patient with a history of previous congenital cardiac surgery who sustained multiple episodes of ventricular asystole and associated loss of cardiac output during octreotide infusion. Recurrent asystole ceased following discontinuation of the octreotide infusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Physicians caring for patients receiving intravenous octreotide should be aware of the potential arrhythmogenic adverse effects. While specific risk factors for octreotide-associated arrhythmias are not generally understood, previous cardiac surgery could potentially be one of these. Risk stratification guidance regarding patient groups requiring heightened monitoring while receiving intravenous octreotide is required. Monitoring recommendations may involve invasive blood pressure monitoring and telemetry in these cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13256-026-05958-4","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:54:57Z","timestamp":1773662097000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Recurrent ventricular asystole during octreotide infusion in a patient with pancreatic neuroendocrine tumor: a case report"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6992-6098","authenticated-orcid":false,"given":"Nicholaos","family":"Mansolas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Nesbitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"issue":"12","key":"5958_CR1","doi-asserted-by":"publisher","first-page":"3049","DOI":"10.3390\/ijms20123049","volume":"20","author":"AK Stueven","year":"2019","unstructured":"Stueven AK, Kayser A, Wetz C, Amthauer H, Wree A, Tacke F, Wiedenmann B, Roderburg C, Jann H. Somatostatin analogues in the treatment of neuroendocrine tumors: past, present and future. Int J Mol Sci. 2019;20(12):3049. https:\/\/doi.org\/10.3390\/ijms20123049.","journal-title":"Int J Mol Sci"},{"issue":"6","key":"5958_CR2","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1002\/ags3.12396","volume":"4","author":"K Eto","year":"2020","unstructured":"Eto K, Yoshida N, Iwagami S, Iwatsuki M, Baba H. Surgical treatment for gastrointestinal neuroendocrine tumors. Ann Gastroenterol Surg. 2020;4(6):652\u20139. https:\/\/doi.org\/10.1002\/ags3.12396.","journal-title":"Ann Gastroenterol Surg"},{"issue":"1","key":"5958_CR3","doi-asserted-by":"publisher","DOI":"10.1530\/EO-22-0077","volume":"3","author":"J George","year":"2023","unstructured":"George J, Ramage J, White B, Srirajaskanthan R. The role of serotonin inhibition within the treatment of carcinoid syndrome. Endocrine Oncol. 2023;3(1): e220077. https:\/\/doi.org\/10.1530\/EO-22-0077.","journal-title":"Endocrine Oncol"},{"issue":"12","key":"5958_CR4","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1530\/EC-18-0324","volume":"7","author":"M Fouch\u00e9","year":"2018","unstructured":"Fouch\u00e9 M, Bouffard Y, Le Goff MC, Prothet J, Malavieille F, Sagnard P, Christin F, Hayi-Slayman D, Pasquer A, Poncet G, Walter T, Rimmel\u00e9 T. Intraoperative carcinoid syndrome during small-bowel neuroendocrine tumour surgery. Endocr Connect. 2018;7(12):1245\u201350. https:\/\/doi.org\/10.1530\/EC-18-0324.","journal-title":"Endocr Connect"},{"issue":"12","key":"5958_CR5","doi-asserted-by":"publisher","first-page":"2966","DOI":"10.3390\/cancers14122966","volume":"14","author":"A Xu","year":"2022","unstructured":"Xu A, Suz P, Reljic T, Are AC, Kumar A, Powers B, Strosberg J, Denbo JW, Fleming JB, Anaya DA. Perioperative carcinoid crisis: a systematic review and meta-analysis. Cancers Basel. 2022;14(12):2966. https:\/\/doi.org\/10.3390\/cancers14122966.","journal-title":"Cancers Basel"},{"key":"5958_CR6","unstructured":"British National Formulary (BNF), n.d. Octreotide. [online] https:\/\/bnf.nice.org.uk\/drugs\/octreotide\/. Accessed 7 Aug 2025"},{"issue":"4","key":"5958_CR7","first-page":"24","volume":"29","author":"OE Osadchi\u012d","year":"1998","unstructured":"Osadchi\u012d OE, Pokrovski\u012d VM. Somatostatin as a regulator of cardiovascular system functions. Usp Fiziol Nauk. 1998;29(4):24\u201341 ((In Russian)).","journal-title":"Usp Fiziol Nauk"},{"issue":"4","key":"5958_CR8","first-page":"258","volume":"38","author":"R Bubi\u0144ski","year":"1993","unstructured":"Bubi\u0144ski R, Ku\u015b W, Goch J. Effect of somatostatin on the conduction system of the heart. Kardiol Pol. 1993;38(4):258\u201362 ((In Polish)).","journal-title":"Kardiol Pol"},{"issue":"3","key":"5958_CR9","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/0143-4179(93)90102-g","volume":"25","author":"E Preston","year":"1993","unstructured":"Preston E, Courtice GP. Cardiac vagal effects in the toad are attenuated by repetitive vagal stimulation. Neuropeptides. 1993;25(3):193\u20138. https:\/\/doi.org\/10.1016\/0143-4179(93)90102-g.","journal-title":"Neuropeptides"},{"issue":"5","key":"5958_CR10","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/0143-4179(81)90019-6","volume":"1","author":"F Rioux","year":"1981","unstructured":"Rioux F, K\u00e9rouac R, St-Pierre S. Somatostatin: interaction with the sympathetic nervous system in guinea pigs. Neuropeptides. 1981;1(5):319\u201327.","journal-title":"Neuropeptides"},{"issue":"12","key":"5958_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/life13122278","volume":"13","author":"G Ganea","year":"2023","unstructured":"Ganea G, Cintez\u0103 EE, Filip C, Iancu MA, Balta MD, V\u0103t\u0103\u0219escu R, Vasile CM, C\u00eerstoveanu C, B\u0103lgr\u0103dean M. Postoperative cardiac arrhythmias in pediatric and neonatal patients with congenital heart disease\u2014a narrative review. Life. 2023;13(12): 2278. https:\/\/doi.org\/10.3390\/life13122278.","journal-title":"Life"},{"issue":"2","key":"5958_CR12","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/j.athoracsur.2008.11.018","volume":"87","author":"S Buz","year":"2009","unstructured":"Buz S, Alexi-Meskishvili V, Villavicencio-Lorini F, Yigitbasi M, H\u00fcbler M, Weng Y, Berger F, Hetzer R. Analysis of arrhythmias after correction of partial anomalous pulmonary venous connection. Ann Thorac Surg. 2009;87(2):580\u20133.","journal-title":"Ann Thorac Surg"},{"issue":"1","key":"5958_CR13","doi-asserted-by":"publisher","first-page":"95","DOI":"10.5152\/eurasianjmed.2018.18064","volume":"51","author":"YK Icen","year":"2019","unstructured":"Icen YK, Urgun OD, Sumbul HE, Koc M. Complete heart block due to octreotide infusion in patient with cryptogenic cirrhosis. Eurasian J Med. 2019;51(1):95\u20137. https:\/\/doi.org\/10.5152\/eurasianjmed.2018.18064.","journal-title":"Eurasian J Med"},{"issue":"6","key":"5958_CR14","doi-asserted-by":"publisher","first-page":"e18","DOI":"10.1016\/j.hrtlng.2012.04.010","volume":"41","author":"LSO Yuhico","year":"2012","unstructured":"Yuhico LSO, Gundu V, Lenox R. Octreotide-induced asystolic events in an intensive care unit patient with gastrointestinal bleeding. 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Anesth Analg. 2004;98(2):318\u201320. https:\/\/doi.org\/10.1213\/01.ANE.0000097170.27056.08.","journal-title":"Anesth Analg"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13256-026-05958-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-026-05958-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-026-05958-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T23:56:42Z","timestamp":1776902202000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13256-026-05958-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,16]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["5958"],"URL":"https:\/\/doi.org\/10.1186\/s13256-026-05958-4","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,16]]},"assertion":[{"value":"12 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Local departmental authorization for the write up of this case report was sought and obtained. The patient gave their consent to the writing of this case report. This consent form is available on enquiry.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"216"}}