{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T23:08:42Z","timestamp":1784070522171,"version":"3.55.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":55,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pyodermatitis vegetans (PDV) is a rare, chronic inflammatory dermatosis associated with inflammatory bowel disease (IBD), particularly ulcerative colitis. Though PDV has been documented globally, it remains rare in pediatric populations and under-reported in Pakistan. This case highlights an adolescent male with suspected IBD presenting with extensive cutaneous manifestations consistent with PDV. A 17-year-old male presented with a 10-year history of recurrent vegetative skin lesions, which initially started behind the left ear and then involved the face, axillae, back, chest, buttocks, gluteal cleft, and genitals. He also reported red, itchy, ring-like lesions on the limbs with systemic complaints, including nausea, anorexia, constipation, painful defecation, and fresh rectal bleeding. Physical examination revealed multiple verrucous plaques, nodular eruptions, crusted lesions, and acne scars. Blood workup showed microcytic hypochromic anemia and elevated serum IgE (1375\u00a0IU\/mL). Histopathological examination of the skin biopsy shows features diagnostic of PDV, including hyperkeratosis, parakeratosis, follicular plugging, elongation of rete ridges, and dermal fibrosis with lymphocytic infiltration. Considering the clinical features and laboratory findings, the final diagnosis made is pyodermatitis vegetans. This study emphasizes how crucial it is to treat PDV as an uncommon extraintestinal sign of IBD in teenagers who exhibit persistent vegetative skin lesions. Accurate diagnosis, mimicking exclusion, and prompt therapy intervention to address underlying systemic connections all depend on multidisciplinary collaboration and teamwork.<\/jats:p>","DOI":"10.1186\/s13256-026-06136-2","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T12:34:26Z","timestamp":1779366866000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A rare case report of pyodermatitis vegetans linked with inflammatory bowel disease in juvenile population"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4277-8078","authenticated-orcid":false,"given":"Pakeezah","family":"Tabasum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9351-0520","authenticated-orcid":false,"given":"Waleed","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. N. U.","family":"Simran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0751-2830","authenticated-orcid":false,"given":"Mir Raza","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmeen","family":"Sufi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5283-016X","authenticated-orcid":false,"given":"Leina","family":"Elomeiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"6136_CR1","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1590\/S0365-05962011000700036","volume":"86","author":"FdAT Matias","year":"2011","unstructured":"Matias FdAT, Rosa DJdF, Carvalho MTFd, Casta\u00f1on MCMN. Pyodermatitis-pyostomatitis vegetans: case report and review of medical literature. An Bras Dermatol. 2011;86:137\u201340.","journal-title":"An Bras Dermatol"},{"issue":"3","key":"6136_CR2","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1016\/j.jaad.2016.03.047","volume":"75","author":"LG Clark","year":"2016","unstructured":"Clark LG, Tolkachjov SN, Bridges AG, Camilleri MJ. Pyostomatitis vegetans (PSV)-pyodermatitis vegetans (PDV): a clinicopathologic study of 7 cases at a tertiary referral center. J Am Acad Dermatol. 2016;75(3):578\u201384.","journal-title":"J Am Acad Dermatol"},{"key":"6136_CR3","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.jdcr.2021.11.031","volume":"21","author":"SB Reddy","year":"2022","unstructured":"Reddy SB, Wang S, Graham LV. Successful treatment of pyoderma vegetans with doxycycline. 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Med Oral Patol Oral Cir Bucal. 2009;14(3):E114\u20137.","journal-title":"Med Oral Patol Oral Cir Bucal"},{"issue":"1","key":"6136_CR7","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1159\/000327221","volume":"3","author":"F Canpolat","year":"2011","unstructured":"Canpolat F, Cemil B\u00c7, Y\u0131lmazer D, Ye\u015filli O, Eskio\u011flu F. Pyoderma vegetans associated with ulcerative colitis: a case with good response to steroids. Case Rep Dermatol. 2011;3(1):80\u20134.","journal-title":"Case Rep Dermatol"},{"issue":"5","key":"6136_CR8","doi-asserted-by":"publisher","DOI":"10.5070\/D3265048779","volume":"26","author":"M Gheisari","year":"2020","unstructured":"Gheisari M, Zerehpoosh FB, Zaresharifi S. Pyodermatitis-pyostomatitis vegetans: a case report and review of literature. Dermatol Online J. 2020;26(5): 13030\/qt5871q750.","journal-title":"Dermatol Online J"},{"issue":"3","key":"6136_CR9","first-page":"250","volume":"7","author":"S Nigen","year":"2003","unstructured":"Nigen S, Poulin Y, Rochette L, L\u00e9vesque MH, Gagn\u00e9 E. Pyodermatitis-pyostomatitis vegetans: two cases and a review of the literature. J Cutan Med Surg. 2003;7(3):250\u20135.","journal-title":"J Cutan Med Surg"},{"key":"6136_CR10","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01059","volume":"10","author":"AV Marzano","year":"2019","unstructured":"Marzano AV, Ortega-Loayza AG, Heath M, Morse D, Genovese G, Cugno M. Mechanisms of inflammation in neutrophil-mediated skin diseases. Front Immunol. 2019;10: 1059.","journal-title":"Front Immunol"},{"issue":"1","key":"6136_CR11","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-025-01064-7","volume":"47","author":"C Moltrasio","year":"2025","unstructured":"Moltrasio C, Romagnuolo M, Tavoletti G, Maronese CA, Marzano AV. Pyoderma gangrenosum: pathogenetic mechanisms and their implications for treatment. Semin Immunopathol. 2025;47(1): 38. https:\/\/doi.org\/10.1007\/s00281-025-01064-7.","journal-title":"Semin Immunopathol"},{"issue":"35","key":"6136_CR12","doi-asserted-by":"publisher","first-page":"3954","DOI":"10.3748\/wjg.v30.i35.3954","volume":"30","author":"H Lv","year":"2024","unstructured":"Lv H, Li HY, Zhang HN, Liu Y. Delayed diagnosis in inflammatory bowel disease: time to consider solutions. World J Gastroenterol. 2024;30(35):3954\u20138. https:\/\/doi.org\/10.3748\/wjg.v30.i35.3954.","journal-title":"World J Gastroenterol"},{"issue":"2","key":"6136_CR13","doi-asserted-by":"publisher","first-page":"236","DOI":"10.5009\/gnl20337","volume":"16","author":"J Jang","year":"2022","unstructured":"Jang J, Lee SH, Jeong IS, et al. Clinical characteristics and long-term outcomes of pediatric ulcerative colitis: a single-center experience in Korea. 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A copy of the completed consent form would available on request for review by the Editor-in-Chief of this journal.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interest.","order":3,"name":"Ethics","label":"Competing interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"396"}}