{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:42:40Z","timestamp":1792788160648,"version":"4.5.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Ruhr-Universit\u00e4t Bochum","id":[{"id":"https:\/\/ror.org\/04tsk2644","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Drug-induced aseptic meningitis (DIAM) is a neurological disorder that requires specialized diagnostic pathways and an in-depth patient history to prevent inaccurate diagnoses and unnecessary procedures. Amoxicillin has been reported as one of the drugs causing recurrent DIAM, with a total of 22 patients described in the literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We report two cases involving patients of Mediterranean ethnicity \u2014a father (69-years-old) and his daughter (47-years-old)\u2014who presented to our neurology department at different time points with severe headache persisting for several days. Both patients disclosed recent use of amoxicillin to treat bronchitis and otitis. In both cases, examination of cerebrospinal fluid (CSF) revealed leukocytosis with lymphocytic predominance, while no causative pathogens were identified. After extensive investigations to rule out other causes of secondary headache, a diagnosis of amoxicillin-induced aseptic meningitis (AIAM) was established. Notably, the daughter experienced two similar episodes, both temporally associated with amoxicillin intake.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Amoxicillin-induced aseptic meningitis is a rare adverse reaction that should be considered in patients presenting with severe headache in the absence of an identifiable pathogen. A thorough patient history combined with comprehensive diagnostic evaluation is essential to establish the diagnosis and to avoid unnecessary or excessive treatment. Additionally, potential genetic predispositions, as suggested in other forms of drug-induced aseptic meningitis, may play a role and should be considered in selected cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13256-026-06579-7","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T13:33:12Z","timestamp":1789738392000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Like father, like daughter: amoxicillin-induced aseptic meningitis in a female patient and her father: a case report"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1579-8416","authenticated-orcid":false,"given":"Ibrahim","family":"Farhood","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Seidel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Kaeder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Sch\u00f6nlau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinna","family":"Seliger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"issue":"31","key":"6579_CR1","doi-asserted-by":"publisher","first-page":"5793","DOI":"10.1016\/j.vaccine.2007.04.058","volume":"25","author":"T Tapiainen","year":"2007","unstructured":"Tapiainen T, Prevots R, Izurieta HS, Abramson J, Bilynsky R, Bonhoeffer J, et al. Aseptic meningitis: case definition and guidelines for collection, analysis and presentation of immunization safety data. Vaccine. 2007;25(31):5793\u2013802.","journal-title":"Vaccine"},{"issue":"5","key":"6579_CR2","first-page":"314","volume":"96","author":"HR Mount","year":"2017","unstructured":"Mount HR, Boyle SD. Aseptic and Bacterial Meningitis: Evaluation, Treatment, and Prevention. Am Fam Physician. 2017;96(5):314\u201322.","journal-title":"Am Fam Physician"},{"issue":"11","key":"6579_CR3","doi-asserted-by":"publisher","first-page":"2540","DOI":"10.1111\/bcp.14073","volume":"85","author":"K Bihan","year":"2019","unstructured":"Bihan K, Weiss N, Th\u00e9ophile H, Funck-Brentano C, Lebrun-Vignes B. Drug-induced aseptic meningitis: 329 cases from the French pharmacovigilance database analysis. 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Copies of signed consent forms are available for editorial review.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from both patients to publish the case report. Copies of signed consent forms are available for editorial review.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"551"}}