{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T12:19:41Z","timestamp":1772540381104,"version":"3.50.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["404598"],"award-info":[{"award-number":["404598"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["303061"],"award-info":[{"award-number":["303061"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E26\/2014"],"award-info":[{"award-number":["E26\/2014"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006506","name":"Minist\u00e9rio da Sa\u00fade","doi-asserted-by":"publisher","award":["405036"],"award-info":[{"award-number":["405036"]}],"id":[{"id":"10.13039\/501100006506","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13287-017-0481-x","type":"journal-article","created":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T07:17:49Z","timestamp":1487143069000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Cardiosphere-derived cells do not improve cardiac function in rats with cardiac failure"],"prefix":"10.1186","volume":"8","author":[{"given":"Ta\u00eds Hanae","family":"Kasai-Brunswick","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9a Rodrigues da","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raiana Andrade Quintanilha","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruna","family":"Farjun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Cristina Paccola","family":"Mesquita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan\u00fabia","family":"Silva dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isalira Peroba","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grazielle","family":"Suhett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilherme Visconde","family":"Brasil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro Torrentes da","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Oscar R.","family":"Brito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana do Amaral","family":"Passipieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana Bastos","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Carlos","family":"Campos de Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,2,15]]},"reference":[{"key":"481_CR1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/eurheartj\/ehi555","volume":"27","author":"SJ Pocock","year":"2006","unstructured":"Pocock SJ, Wang D, Pfeffer MA, Yusuf S, McMurray JJ, Swedberg KB, Ostergren J, Michelson EL, Pieper KS, Granger CB. Predictors of mortality and morbidity in patients with chronic heart failure. Eur Heart J. 2006;27:65\u201375.","journal-title":"Eur Heart J."},{"key":"481_CR2","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0092-8674(03)00687-1","volume":"114","author":"AP Beltrami","year":"2003","unstructured":"Beltrami AP, Barlucchi L, Torella D, Baker M, Limana F, Chimenti S, Kasahara H, Rota M, Musso E, Urbanek K, Leri A, Kajstura J, Nadal-Ginard B, Anversa P. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell. 2003;114:763\u201376.","journal-title":"Cell."},{"key":"481_CR3","doi-asserted-by":"crossref","first-page":"14068","DOI":"10.1073\/pnas.0706760104","volume":"104","author":"C Bearzi","year":"2007","unstructured":"Bearzi C, Rota M, Hosoda T, Tillmanns J, Nascimbene A, De Angelis A, Yasuzawa-Amano S, Trofimova I, Siggins RW, Lecapitaine N, Cascapera S, Beltrami AP, D\u2019Alessandro DA, Zias E, Quaini F, Urbanek K, Michler RE, Bolli R, Kajstura J, Leri A, Anversa P. Human cardiac stem cells. Proc Natl Acad Sci U S A. 2007;104:14068\u201373.","journal-title":"Proc Natl Acad Sci U S A."},{"key":"481_CR4","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1161\/01.RES.0000147315.71699.51","volume":"95","author":"E Messina","year":"2004","unstructured":"Messina E, De Angelis L, Frati G, Morrone S, Chimenti S, Fiordaliso F, Salio M, Battaglia M, Latronico MV, Coletta M, Vivarelli E, Frati L, Cossu G, Giacomello A. Isolation and expansion of adult cardiac stem cells from human and murine heart. Circ Res. 2004;95:911\u201321.","journal-title":"Circ Res."},{"key":"481_CR5","doi-asserted-by":"crossref","first-page":"12313","DOI":"10.1073\/pnas.2132126100","volume":"100","author":"H Oh","year":"2003","unstructured":"Oh H, Bradfute SB, Gallardo TD, Nakamura T, Gaussin V, Mishina Y, Pocius J, Michael LH, Behringer RR, Garry DJ, Entman ML, Schneider MD. Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc Natl Acad Sci U S A. 2003;100:12313\u20138.","journal-title":"Proc Natl Acad Sci U S A."},{"key":"481_CR6","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1161\/CIRCULATIONAHA.106.655209","volume":"115","author":"RR Smith","year":"2007","unstructured":"Smith RR, Barile L, Cho HC, Leppo MK, Hare JM, Messina E, Giacomello A, Abraham MR, Marban E. Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens. Circulation. 2007;115:896\u2013908.","journal-title":"Circulation."},{"key":"481_CR7","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1161\/CIRCRESAHA.109.210682","volume":"106","author":"I Chimenti","year":"2010","unstructured":"Chimenti I, Smith RR, Li TS, Gerstenblith G, Messina E, Giacomello A, Marban E. Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice. Circ Res. 2010;106:971\u201380.","journal-title":"Circ Res."},{"key":"481_CR8","volume":"4","author":"DR Davis","year":"2009","unstructured":"Davis DR, Zhang Y, Smith RR, Cheng K, Terrovitis J, Malliaras K, Li TS, White A, Makkar R, Marban E. Validation of the cardiosphere method to culture cardiac progenitor cells from myocardial tissue. PLoS One. 2009;4, e7195.","journal-title":"PLoS One."},{"key":"481_CR9","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.yjmcc.2010.02.019","volume":"49","author":"DR Davis","year":"2010","unstructured":"Davis DR, Kizana E, Terrovitis J, Barth AS, Zhang Y, Smith RR, Miake J, Marban E. Isolation and expansion of functionally-competent cardiac progenitor cells directly from heart biopsies. J Mol Cell Cardiol. 2010;49:312\u201321.","journal-title":"J Mol Cell Cardiol."},{"key":"481_CR10","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1161\/CIRCULATIONAHA.108.816058","volume":"120","author":"PV Johnston","year":"2009","unstructured":"Johnston PV, Sasano T, Mills K, Evers R, Lee ST, Smith RR, Lardo AC, Lai S, Steenbergen C, Gerstenblith G, Lange R, Marban E. Engraftment, differentiation, and functional benefits of autologous cardiosphere-derived cells in porcine ischemic cardiomyopathy. Circulation. 2009;120:1075\u201383. 7 p following 1083.","journal-title":"Circulation"},{"key":"481_CR11","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.jacc.2010.07.049","volume":"57","author":"ST Lee","year":"2011","unstructured":"Lee ST, White AJ, Matsushita S, Malliaras K, Steenbergen C, Zhang Y, Li TS, Terrovitis J, Yee K, Simsir S, Makkar R, Marban E. Intramyocardial injection of autologous cardiospheres or cardiosphere-derived cells preserves function and minimizes adverse ventricular remodeling in pigs with heart failure post-myocardial infarction. J Am Coll Cardiol. 2011;57:455\u201365.","journal-title":"J Am Coll Cardiol."},{"key":"481_CR12","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1016\/j.jacc.2008.06.052","volume":"52","author":"N Takehara","year":"2008","unstructured":"Takehara N, Tsutsumi Y, Tateishi K, Ogata T, Tanaka H, Ueyama T, Takahashi T, Takamatsu T, Fukushima M, Komeda M, Yamagishi M, Yaku H, Tabata Y, Matsubara H, Oh H. Controlled delivery of basic fibroblast growth factor promotes human cardiosphere-derived cell engraftment to enhance cardiac repair for chronic myocardial infarction. J Am Coll Cardiol. 2008;52:1858\u201365.","journal-title":"J Am Coll Cardiol."},{"key":"481_CR13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0001929","volume":"3","author":"LT Shenje","year":"2008","unstructured":"Shenje LT, Field LJ, Pritchard CA, Guerin CJ, Rubart M, Soonpaa MH, Ang KL, Galinanes M. Lineage tracing of cardiac explant derived cells. PLoS One. 2008;3, e1929.","journal-title":"PLoS One."},{"key":"481_CR14","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.jacc.2008.12.036","volume":"53","author":"Z Li","year":"2009","unstructured":"Li Z, Lee A, Huang M, Chun H, Chung J, Chu P, Hoyt G, Yang P, Rosenberg J, Robbins RC, Wu JC. Imaging survival and function of transplanted cardiac resident stem cells. J Am Coll Cardiol. 2009;53:1229\u201340.","journal-title":"J Am Coll Cardiol."},{"key":"481_CR15","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1002\/stem.72","volume":"27","author":"DC Andersen","year":"2009","unstructured":"Andersen DC, Andersen P, Schneider M, Jensen HB, Sheikh SP. Murine \u201ccardiospheres\u201d are not a source of stem cells with cardiomyogenic potential. Stem Cells. 2009;27:1571\u201381.","journal-title":"Stem Cells."},{"key":"481_CR16","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S0140-6736(12)60195-0","volume":"379","author":"RR Makkar","year":"2012","unstructured":"Makkar RR, Smith RR, Cheng K, Malliaras K, Thomson LE, Berman D, Czer LS, Marban L, Mendizabal A, Johnston PV, Russell SD, Schuleri KH, Lardo AC, Gerstenblith G, Marban E. Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial. Lancet. 2012;379:895\u2013904.","journal-title":"Lancet."},{"key":"481_CR17","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jacc.2013.08.724","volume":"63","author":"K Malliaras","year":"2014","unstructured":"Malliaras K, Makkar RR, Smith RR, Cheng K, Wu E, Bonow RO, Marban L, Mendizabal A, Cingolani E, Johnston PV, Gerstenblith G, Schuleri KH, Lardo AC, Marban E. Intracoronary cardiosphere-derived cells after myocardial infarction: evidence of therapeutic regeneration in the final 1-year results of the CADUCEUS trial (CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction). J Am Coll Cardiol. 2014;63:110\u201322.","journal-title":"J Am Coll Cardiol."},{"key":"481_CR18","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1161\/CIRCRESAHA.116.304346","volume":"116","author":"M Gyongyosi","year":"2015","unstructured":"Gyongyosi M, Wojakowski W, Lemarchand P, Lunde K, Tendera M, Bartunek J, Marban E, Assmus B, Henry TD, Traverse JH, Moye L, Suerder D, Corti R, Huikuri HV, Miettinen JA, Woehrle J, Obradovic S, Roncalli J, Malliaras K, Pokushalov E, Romanov A, Kastrup J, Bergmann MW, Atsma D, Diederichsen AC, Edes I, Benedek I, Benedek T, Pejkov H, Nyolczas N, Pavo N, Bergler-Klein J, Pavo IJ, Sylven C, Berti S, Navarese EP, Maurer GM. Meta-Analysis of Cell-based CaRdiac stUdiEs (ACCRUE) in patients with acute myocardial infarction based on individual patient data. Circ Res. 2015;116:1346\u201360.","journal-title":"Circ Res"},{"key":"481_CR19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0041691","volume":"7","author":"C Benavides-Vallve","year":"2012","unstructured":"Benavides-Vallve C, Corbacho D, Iglesias-Garcia O, Pelacho B, Albiasu E, Castano S, Munoz-Barrutia A, Prosper F, Ortiz-de-Solorzano C. New strategies for echocardiographic evaluation of left ventricular function in a mouse model of long-term myocardial infarction. PLoS One. 2012;7, e41691.","journal-title":"PLoS One."},{"key":"481_CR20","doi-asserted-by":"crossref","first-page":"6444","DOI":"10.1016\/j.biomaterials.2010.04.069","volume":"31","author":"YC Yeh","year":"2010","unstructured":"Yeh YC, Lee WY, Yu CL, Hwang SM, Chung MF, Hsu LW, Chang Y, Lin WW, Tsai MS, Wei HJ, Sung HW. Cardiac repair with injectable cell sheet fragments of human amniotic fluid stem cells in an immune-suppressed rat model. Biomaterials. 2010;31:6444\u201353.","journal-title":"Biomaterials."},{"key":"481_CR21","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/scrt490","volume":"5","author":"JA Passipieri","year":"2014","unstructured":"Passipieri JA, Kasai-Brunswick TH, Suhett G, Martins AB, Brasil GV, Campos DB, Rocha NN, Ramos IP, Mello DB, Rodrigues DC, Christie BB, Silva-Mendes BJ, Balduino A, Sa RM, Lopes LM, Goldenberg RC, Campos de Carvalho AC, Carvalho AB. Improvement of cardiac function by placenta-derived mesenchymal stem cells does not require permanent engraftment and is independent of the insulin signaling pathway. Stem Cell Res Ther. 2014;5:102.","journal-title":"Stem Cell Res Ther."},{"key":"481_CR22","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1161\/CIRCULATIONAHA.111.042598","volume":"125","author":"K Malliaras","year":"2012","unstructured":"Malliaras K, Li TS, Luthringer D, Terrovitis J, Cheng K, Chakravarty T, Galang G, Zhang Y, Schoenhoff F, Van Eyk J, Marban L, Marban E. Safety and efficacy of allogeneic cell therapy in infarcted rats transplanted with mismatched cardiosphere-derived cells. Circulation. 2012;125:100\u201312.","journal-title":"Circulation."},{"key":"481_CR23","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1161\/CIRCULATIONAHA.110.971622","volume":"123","author":"R Mishra","year":"2011","unstructured":"Mishra R, Vijayan K, Colletti EJ, Harrington DA, Matthiesen TS, Simpson D, Goh SK, Walker BL, Almeida-Porada G, Wang D, Backer CL, Dudley Jr SC, Wold LE, Kaushal S. Characterization and functionality of cardiac progenitor cells in congenital heart patients. Circulation. 2011;123:364\u201373.","journal-title":"Circulation."},{"key":"481_CR24","volume":"3","author":"K Cheng","year":"2014","unstructured":"Cheng K, Ibrahim A, Hensley MT, Shen D, Sun B, Middleton R, Liu W, Smith RR, Marban E. Relative roles of CD90 and c-kit to the regenerative efficacy of cardiosphere-derived cells in humans and in a mouse model of myocardial infarction. J Am Heart Assoc. 2014;3, e001260.","journal-title":"J Am Heart Assoc."},{"key":"481_CR25","volume":"6","author":"CA Carr","year":"2011","unstructured":"Carr CA, Stuckey DJ, Tan JJ, Tan SC, Gomes RS, Camelliti P, Messina E, Giacomello A, Ellison GM, Clarke K. Cardiosphere-derived cells improve function in the infarcted rat heart for at least 16\u00a0weeks\u2014an MRI study. PLoS One. 2011;6, e25669.","journal-title":"PLoS One."},{"key":"481_CR26","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jchf.2013.08.008","volume":"2","author":"K Cheng","year":"2014","unstructured":"Cheng K, Malliaras K, Smith RR, Shen D, Sun B, Blusztajn A, Xie Y, Ibrahim A, Aminzadeh MA, Liu W, Li TS, De Robertis MA, Marban L, Czer LS, Trento A, Marban E. Human cardiosphere-derived cells from advanced heart failure patients exhibit augmented functional potency in myocardial repair. JACC Heart Fail. 2014;2:49\u201361.","journal-title":"JACC Heart Fail."},{"key":"481_CR27","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1002\/stem.2101","volume":"33","author":"Y Zhang","year":"2015","unstructured":"Zhang Y, Sivakumaran P, Newcomb AE, Hernandez D, Harris N, Khanabdali R, Liu GS, Kelly DJ, Pebay A, Hewitt AW, Boyle A, Harvey R, Morrison WA, Elliott DA, Dusting GJ, Lim SY. Cardiac repair with a novel population of mesenchymal stem cells resident in the human heart. Stem Cells. 2015;33:3100\u201313.","journal-title":"Stem Cells."}],"container-title":["Stem Cell Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-017-0481-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,25]],"date-time":"2017-06-25T06:36:21Z","timestamp":1498372581000},"score":1,"resource":{"primary":{"URL":"http:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/s13287-017-0481-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,15]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["481"],"URL":"https:\/\/doi.org\/10.1186\/s13287-017-0481-x","relation":{},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,15]]},"article-number":"36"}}