{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T18:37:23Z","timestamp":1781980643864,"version":"3.54.5"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81100646"],"award-info":[{"award-number":["81100646"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Tianjin Municipal Science and Technology Commission Grants","award":["11JCYBJC26000"],"award-info":[{"award-number":["11JCYBJC26000"]}]},{"name":"Tianjin Municipal Science and Technology Commission Grants","award":["13JCYBJC23300"],"award-info":[{"award-number":["13JCYBJC23300"]}]},{"name":"The Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry","award":["No.48"],"award-info":[{"award-number":["No.48"]}]},{"name":"Science and Technology Foundation of Beichen District of Tianjin","award":["BC2014-10"],"award-info":[{"award-number":["BC2014-10"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13287-017-0593-3","type":"journal-article","created":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T13:35:29Z","timestamp":1496669729000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Mesenchymal stem cells for treating autoimmune dacryoadenitis"],"prefix":"10.1186","volume":"8","author":[{"given":"Xiaoxiao","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xilian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Nian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruihua","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,6,5]]},"reference":[{"key":"593_CR1","first-page":"S102","volume":"14","author":"SC Pflugfelder","year":"2008","unstructured":"Pflugfelder SC. Prevalence, burden, and pharmacoeconomics of dry eye disease. Am J Manage Care. 2008;14:S102\u20136.","journal-title":"Am J Manage Care"},{"key":"593_CR2","doi-asserted-by":"crossref","first-page":"250230","DOI":"10.1155\/2014\/250230","volume":"2014","author":"E Beyazyildiz","year":"2014","unstructured":"Beyazyildiz E, Pinarli FA, Beyazyildiz O, et al. Efficacy of topical mesenchymal stem cell therapy in the treatment of experimental dry eye syndrome model. Stem Cells Int. 2014;2014:250230.","journal-title":"Stem Cells Int"},{"key":"593_CR3","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/s12016-007-8011-8","volume":"32","author":"GE Katsifis","year":"2007","unstructured":"Katsifis GE, Moutsopoulos NM, Wahl SM. T lymphocytes in Sjogren's syndrome: contributors to and regulators of pathophysiology. Clin Rev Allergy Immunol. 2007;32:252\u201364.","journal-title":"Clin Rev Allergy Immunol"},{"key":"593_CR4","doi-asserted-by":"crossref","first-page":"986789","DOI":"10.1155\/2013\/986789","volume":"2013","author":"SK Bedoya","year":"2013","unstructured":"Bedoya SK, Lam B, Lau K, Larkin 3rd J. Th17 cells in immunity and autoimmunity. Clin Dev Immunol. 2013;2013:986789.","journal-title":"Clin Dev Immunol"},{"key":"593_CR5","doi-asserted-by":"crossref","first-page":"130763","DOI":"10.1155\/2013\/130763","volume":"2013","author":"A Sohni","year":"2013","unstructured":"Sohni A, Verfaillie CM. Mesenchymal stem cells migration homing and tracking. Stem Cells Int. 2013;2013:130763.","journal-title":"Stem Cells Int"},{"key":"593_CR6","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","volume":"284","author":"MF Pittenger","year":"1999","unstructured":"Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284:143\u20137.","journal-title":"Science"},{"key":"593_CR7","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.medcli.2014.01.014","volume":"144","author":"I Sanchez-Berna","year":"2015","unstructured":"Sanchez-Berna I, Santiago-Diaz C, Jimenez-Alonso J. Immunomodulatory properties of stem mesenchymal cells in autoimmune diseases. Med Clin. 2015;144:88\u201391.","journal-title":"Med Clin"},{"key":"593_CR8","doi-asserted-by":"crossref","first-page":"574","DOI":"10.2174\/156652412800619950","volume":"12","author":"MP Miguel De","year":"2012","unstructured":"De Miguel MP, Fuentes-Julian S, Blazquez-Martinez A, et al. Immunosuppressive properties of mesenchymal stem cells: advances and applications. Curr Mol Med. 2012;12:574\u201391.","journal-title":"Curr Mol Med"},{"key":"593_CR9","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ajog.2003.07.022","volume":"190","author":"C Gotherstrom","year":"2004","unstructured":"Gotherstrom C, Ringden O, Tammik C, et al. Immunologic properties of human fetal mesenchymal stem cells. Am J Obstet Gynecol. 2004;190:239\u201345.","journal-title":"Am J Obstet Gynecol"},{"key":"593_CR10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0897.2011.01069.x","volume":"67","author":"E Soleymaninejadian","year":"2012","unstructured":"Soleymaninejadian E, Pramanik K, Samadian E. Immunomodulatory properties of mesenchymal stem cells: cytokines and factors. Am J Reprod Immunol. 2012;67:1\u20138.","journal-title":"Am J Reprod Immunol"},{"key":"593_CR11","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s12015-011-9311-1","volume":"8","author":"EJ Bassi","year":"2012","unstructured":"Bassi EJ, de Almeida DC, Moraes-Vieira PM, Camara NO. Exploring the role of soluble factors associated with immune regulatory properties of mesenchymal stem cells. Stem Cell Rev. 2012;8:329\u201342.","journal-title":"Stem Cell Rev"},{"key":"593_CR12","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1365-2249.2010.04178.x","volume":"161","author":"FR Li","year":"2010","unstructured":"Li FR, Wang XG, Deng CY, et al. Immune modulation of co-transplantation mesenchymal stem cells with islet on T and dendritic cells. Clin Exp Immunol. 2010;161:357\u201363.","journal-title":"Clin Exp Immunol"},{"key":"593_CR13","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ymeth.2015.09.016","volume":"99","author":"J Kobolak","year":"2016","unstructured":"Kobolak J, Dinnyes A, Memic A, et al. Mesenchymal stem cells: Identification, phenotypic characterization, biological properties and potential for regenerative medicine through biomaterial micro-engineering of their niche. Methods. 2016;99:62\u20138.","journal-title":"Methods"},{"key":"593_CR14","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.3109\/14653249.2012.706705","volume":"14","author":"R Shohara","year":"2012","unstructured":"Shohara R, Yamamoto A, Takikawa S, et al. Mesenchymal stromal cells of human umbilical cord Wharton's jelly accelerate wound healing by paracrine mechanisms. Cytotherapy. 2012;14:1171\u201381.","journal-title":"Cytotherapy"},{"key":"593_CR15","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.bbrc.2012.09.129","volume":"427","author":"E Biver","year":"2012","unstructured":"Biver E, Soubrier AS, Thouverey C, et al. Fibroblast growth factor 2 inhibits up-regulation of bone morphogenic proteins and their receptors during osteoblastic differentiation of human mesenchymal stem cells. Biochem Biophys Res Commun. 2012;427:737\u201342.","journal-title":"Biochem Biophys Res Commun"},{"key":"593_CR16","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1749-6632.2012.06727.x","volume":"1270","author":"C Cabrera","year":"2012","unstructured":"Cabrera C, Carriquiry G, Pierinelli C, et al. The role of biologically active peptides in tissue repair using umbilical cord mesenchymal stem cells. Ann N Y Acad Sci. 2012;1270:93\u20137.","journal-title":"Ann N Y Acad Sci"},{"key":"593_CR17","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.yjmcc.2008.01.004","volume":"45","author":"E Chavakis","year":"2008","unstructured":"Chavakis E, Urbich C, Dimmeler S. Homing and engraftment of progenitor cells: a prerequisite for cell therapy. J Mol Cell Cardiol. 2008;45:514\u201322.","journal-title":"J Mol Cell Cardiol"},{"key":"593_CR18","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.ultrasmedbio.2015.10.005","volume":"42","author":"G Wang","year":"2016","unstructured":"Wang G, Zhang Q, Zhuo Z, et al. Enhanced Homing of CXCR-4 Modified Bone Marrow-Derived Mesenchymal Stem Cells to Acute Kidney Injury Tissues by Micro-Bubble-Mediated Ultrasound Exposure. Ultrasound Med Biol. 2016;42:539\u201348.","journal-title":"Ultrasound Med Biol"},{"key":"593_CR19","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s12015-011-9293-z","volume":"8","author":"Y Wu","year":"2012","unstructured":"Wu Y, Zhao RC. The role of chemokines in mesenchymal stem cell homing to myocardium. Stem Cell Rev. 2012;8:243\u201350.","journal-title":"Stem Cell Rev"},{"key":"593_CR20","doi-asserted-by":"crossref","first-page":"419","DOI":"10.3109\/14653249.2010.536213","volume":"13","author":"DD Carrade","year":"2011","unstructured":"Carrade DD, Owens SD, Galuppo LD, et al. Clinicopathologic findings following intra-articular injection of autologous and allogeneic placentally derived equine mesenchymal stem cells in horses. Cytotherapy. 2011;13:419\u201330.","journal-title":"Cytotherapy"},{"key":"593_CR21","doi-asserted-by":"crossref","first-page":"4817","DOI":"10.1182\/blood-2006-01-0057","volume":"107","author":"JL Chan","year":"2006","unstructured":"Chan JL, Tang KC, Patel AP, et al. Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-gamma. Blood. 2006;107:4817\u201324.","journal-title":"Blood"},{"key":"593_CR22","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S0301-472X(01)00769-X","volume":"30","author":"A Bartholomew","year":"2002","unstructured":"Bartholomew A, Sturgeon C, Siatskas M, et al. Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol. 2002;30:42\u20138.","journal-title":"Exp Hematol"},{"key":"593_CR23","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.biologicals.2016.01.002","volume":"44","author":"MR Sam","year":"2016","unstructured":"Sam MR, Azadbakhsh AS, Farokhi F, et al. Genetic modification of bone-marrow mesenchymal stem cells and hematopoietic cells with human coagulation factor IX-expressing plasmids. Biologicals. 2016;44:170\u20137.","journal-title":"Biologicals"},{"key":"593_CR24","first-page":"15528","volume":"8","author":"XW Ma","year":"2015","unstructured":"Ma XW, Cui DP, Zhao DW. Vascular endothelial growth factor\/bone morphogenetic protein-2 bone marrow combined modification of the mesenchymal stem cells to repair the avascular necrosis of the femoral head. Int J Clin Exp Med. 2015;8:15528\u201334.","journal-title":"Int J Clin Exp Med"},{"key":"593_CR25","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3892\/mmr.2015.4553","volume":"13","author":"Y Hu","year":"2016","unstructured":"Hu Y, Zhang Y, Tian K, et al. Effects of nerve growth factor and basic fibroblast growth factor dual gene modification on rat bone marrow mesenchymal stem cell differentiation into neuron-like cells in vitro. Mol Med Rep. 2016;13:49\u201358.","journal-title":"Mol Med Rep"},{"key":"593_CR26","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1182\/blood-2005-04-1496","volume":"106","author":"E Zappia","year":"2005","unstructured":"Zappia E, Casazza S, Pedemonte E, et al. Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy. Blood. 2005;106:1755\u201361.","journal-title":"Blood"},{"key":"593_CR27","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/ar3105","volume":"12","author":"C Jorgensen","year":"2010","unstructured":"Jorgensen C. Mesenchymal stem cells in arthritis: role of bone marrow microenvironment. Arthritis Res Ther. 2010;12:135.","journal-title":"Arthritis Res Ther"},{"key":"593_CR28","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/S0140-6736(08)60690-X","volume":"371","author":"K Blanc Le","year":"2008","unstructured":"Le Blanc K, Frassoni F, Ball L, et al. Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet. 2008;371:1579\u201386.","journal-title":"Lancet"},{"key":"593_CR29","doi-asserted-by":"crossref","first-page":"e38615","DOI":"10.1371\/journal.pone.0038615","volume":"7","author":"S Khalili","year":"2012","unstructured":"Khalili S, Liu Y, Kornete M, et al. Mesenchymal stromal cells improve salivary function and reduce lymphocytic infiltrates in mice with Sjogren's-like disease. PLoS One. 2012;7:e38615.","journal-title":"PLoS One"},{"key":"593_CR30","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1001\/jama.299.8.925","volume":"299","author":"RK Burt","year":"2008","unstructured":"Burt RK, Loh Y, Pearce W, et al. Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases. JAMA. 2008;299:925\u201336.","journal-title":"JAMA"},{"key":"593_CR31","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1167\/iovs.03-1055","volume":"45","author":"S Barabino","year":"2004","unstructured":"Barabino S, Dana MR. Animal models of dry eye: a critical assessment of opportunities and limitations. Investig Ophthalmol Vis Sci. 2004;45:1641\u20136.","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"593_CR32","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/0090-1229(79)90052-7","volume":"12","author":"FW Quimby","year":"1979","unstructured":"Quimby FW, Schwartz RS, Poskitt T, Lewis RM. A disorder of dogs resembling Sjogren's syndrome. Clin Immunol Immunopathol. 1979;12:471\u20136.","journal-title":"Clin Immunol Immunopathol"},{"key":"593_CR33","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1016\/j.jcyt.2013.06.009","volume":"15","author":"SA Park","year":"2013","unstructured":"Park SA, Reilly CM, Wood JA, et al. Safety and immunomodulatory effects of allogeneic canine adipose-derived mesenchymal stromal cells transplanted into the region of the lacrimal gland, the gland of the third eyelid and the knee joint. Cytotherapy. 2013;15:1498\u2013510.","journal-title":"Cytotherapy"},{"key":"593_CR34","doi-asserted-by":"crossref","first-page":"527926","DOI":"10.1155\/2015\/527926","volume":"2015","author":"AJ Villatoro","year":"2015","unstructured":"Villatoro AJ, Fernandez V, Claros S, et al. Use of adipose-derived mesenchymal stem cells in keratoconjunctivitis sicca in a canine model. BioMed Res Int. 2015;2015:527926.","journal-title":"BioMed Res Int"},{"key":"593_CR35","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1001\/archophthalmol.2011.364","volume":"130","author":"W Stevenson","year":"2012","unstructured":"Stevenson W, Chauhan SK, Dana R. Dry eye disease: an immune-mediated ocular surface disorder. Arch Ophthalmol. 2012;130:90\u2013100.","journal-title":"Arch Ophthalmol"},{"key":"593_CR36","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1089\/scd.2007.0153","volume":"17","author":"JW Kang","year":"2008","unstructured":"Kang JW, Kang KS, Koo HC, et al. Soluble factors-mediated immunomodulatory effects of canine adipose tissue-derived mesenchymal stem cells. Stem Cells Dev. 2008;17:681\u201393.","journal-title":"Stem Cells Dev"},{"key":"593_CR37","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/mt.2014.159","volume":"23","author":"MJ Lee","year":"2015","unstructured":"Lee MJ, Ko AY, Ko JH, et al. Mesenchymal stem\/stromal cells protect the ocular surface by suppressing inflammation in an experimental dry eye. Mol Ther. 2015;23:139\u201346.","journal-title":"Mol Ther"},{"key":"593_CR38","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1038\/mt.2012.208","volume":"20","author":"J Weng","year":"2012","unstructured":"Weng J, He C, Lai P, et al. Mesenchymal stromal cells treatment attenuates dry eye in patients with chronic graft-versus-host disease. Mol Ther. 2012;20:2347\u201354.","journal-title":"Mol Ther"},{"key":"593_CR39","doi-asserted-by":"crossref","first-page":"e30842","DOI":"10.1371\/journal.pone.0030842","volume":"7","author":"L Yao","year":"2012","unstructured":"Yao L, Li ZR, Su WR, et al. Role of mesenchymal stem cells on cornea wound healing induced by acute alkali burn. PLoS One. 2012;7:e30842.","journal-title":"PLoS One"},{"key":"593_CR40","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jtos.2015.11.005","volume":"14","author":"M Hirayama","year":"2016","unstructured":"Hirayama M, Kawakita T, Tsubota K, Shimmura S. Challenges and Strategies for Regenerating the Lacrimal Gland. Ocular Surf. 2016;14:135\u201343.","journal-title":"Ocular Surf"},{"key":"593_CR41","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1634\/stemcells.2005-0046","volume":"24","author":"Y Ma","year":"2006","unstructured":"Ma Y, Xu Y, Xiao Z, et al. Reconstruction of chemically burned rat corneal surface by bone marrow-derived human mesenchymal stem cells. Stem Cells. 2006;24:315\u201321.","journal-title":"Stem Cells"},{"key":"593_CR42","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1097\/00003226-200310001-00004","volume":"22","author":"Y Ogawa","year":"2003","unstructured":"Ogawa Y, Kuwana M. Dry eye as a major complication associated with chronic graft-versus-host disease after hematopoietic stem cell transplantation. Cornea. 2003;22:S19\u201327.","journal-title":"Cornea"},{"key":"593_CR43","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0140-6736(05)66990-5","volume":"366","author":"RI Fox","year":"2005","unstructured":"Fox RI. Sjogren\u2019s syndrome. Lancet. 2005;366:321\u201331.","journal-title":"Lancet"},{"key":"593_CR44","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1182\/blood-2011-11-391144","volume":"120","author":"J Xu","year":"2012","unstructured":"Xu J, Wang D, Liu D, et al. Allogeneic mesenchymal stem cell treatment alleviates experimental and clinical Sjogren syndrome. Blood. 2012;120:3142\u201351.","journal-title":"Blood"},{"key":"593_CR45","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1093\/rheumatology\/keu316","volume":"54","author":"R Liu","year":"2015","unstructured":"Liu R, Su D, Zhou M, et al. Umbilical cord mesenchymal stem cells inhibit the differentiation of circulating T follicular helper cells in patients with primary Sjogren's syndrome through the secretion of indoleamine 2,3-dioxygenase. Rheumatology. 2015;54:332\u201342.","journal-title":"Rheumatology"},{"key":"593_CR46","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1038\/bmt.2010.195","volume":"45","author":"JY Weng","year":"2010","unstructured":"Weng JY, Du X, Geng SX, et al. Mesenchymal stem cell as salvage treatment for refractory chronic GVHD. Bone Marrow Transplant. 2010;45:1732\u201340.","journal-title":"Bone Marrow Transplant"},{"key":"593_CR47","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/ICO.0b013e3181e2ecf0","volume":"30","author":"KR Koch","year":"2011","unstructured":"Koch KR, Joussen AM, Huber KK. Ocular involvement in chronic graft-versus-host disease: therapeutic approaches to complicated courses. Cornea. 2011;30:107\u201313.","journal-title":"Cornea"},{"key":"593_CR48","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/ICO.0b013e3181e9b3bf","volume":"30","author":"CS Sales","year":"2011","unstructured":"Sales CS, Johnston LJ, Ta CN. Long-term clinical course of dry eye in patients with chronic graft-versus-host disease referred for eye examination. Cornea. 2011;30:143\u20139.","journal-title":"Cornea"},{"key":"593_CR49","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1182\/blood-2007-02-069716","volume":"110","author":"AJ Nauta","year":"2007","unstructured":"Nauta AJ, Fibbe WE. Immunomodulatory properties of mesenchymal stromal cells. Blood. 2007;110:3499\u2013506.","journal-title":"Blood"},{"key":"593_CR50","first-page":"1356","volume":"41","author":"F Brignole","year":"2000","unstructured":"Brignole F, Pisella PJ, Goldschild M, et al. Flow cytometric analysis of inflammatory markers in conjunctival epithelial cells of patients with dry eyes. Investig Ophthalmol Vis Sci. 2000;41:1356\u201363.","journal-title":"Investig Ophthalmol Vis Sci"}],"container-title":["Stem Cell Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-017-0593-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T04:36:16Z","timestamp":1659069376000},"score":1,"resource":{"primary":{"URL":"http:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/s13287-017-0593-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,5]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["593"],"URL":"https:\/\/doi.org\/10.1186\/s13287-017-0593-3","relation":{},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,5]]},"article-number":"126"}}