{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:30:45Z","timestamp":1788780645245,"version":"build-2803163510"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["ITMS code: 26240220023"],"award-info":[{"award-number":["ITMS code: 26240220023"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13287-017-0622-2","type":"journal-article","created":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T21:41:30Z","timestamp":1499809290000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Improvement in asymmetric dimethylarginine and oxidative stress in patients with limb salvage after autologous mononuclear stem cell application for critical limb ischemia"],"prefix":"10.1186","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1326-2336","authenticated-orcid":false,"given":"Juraj","family":"Madaric","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Valachovicova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovit","family":"Paulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Pribojova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Mateova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Sebekova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luba","family":"Postulkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terezia","family":"Madaricova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Bucova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Mistrik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Vulev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,7,12]]},"reference":[{"key":"622_CR1","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1161\/ATVBAHA.110.215640","volume":"31","author":"P Zhang","year":"2011","unstructured":"Zhang P, Hu X, Xu X, Chen Y, Bache RJ. Dimethylarginine dimethylaminohydrolase 1 modulates endothelial cell growth through nitric oxide and Akt. Arterioscler Thromb Vasc Biol. 2011;31:890\u20137.","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"622_CR2","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1161\/01.CIR.102.12.1414","volume":"102","author":"JJ Jang","year":"2000","unstructured":"Jang JJ, Ho HK, Kwan HH, Fajardo LF, Cooke JP. Angiogenesis is impaired by hypercholesterolemia: role of asymmetric dimethylarginine. Circulation. 2000;102:1414\u20139.","journal-title":"Circulation."},{"key":"622_CR3","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1161\/CIRCULATIONAHA.108.838268","volume":"119","author":"RH Boger","year":"2009","unstructured":"Boger RH, Sullivan LM, Schwedhelm E, Wang TJ, Maas R, Benjamin EJ, Schulze F, Xanthakis V, Benndorf RA, Vasan RS. Plasma asymmetric dimethylarginine and incidence of cardiovascular disease and death in the community. Circulation. 2009;119:1592\u2013600.","journal-title":"Circulation."},{"key":"622_CR4","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.ijcard.2016.06.254","volume":"220","author":"F Mangiacapra","year":"2016","unstructured":"Mangiacapra F, Conte M, Demartini C, Muller O, Delrue L, Dierickx K, Di Sciascio G, Trimarco B, De Bruyne B, Wijns W, Bartunek J, Barbato E. Relationship of asymmetric dimethylarginine (ADMA) with extent and functional severity of coronary atherosclerosis. Int J Cardiol. 2016;220:629\u201333.","journal-title":"Int J Cardiol."},{"key":"622_CR5","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1161\/01.ATV.0000242801.38419.48","volume":"26","author":"F Mittermayer","year":"2006","unstructured":"Mittermayer F, Krzyzanowska K, Exner M, Mlekusch W, Amighi J, Sabeti S, Minar E, M\u00fcller M, Wolzt M, Schillinger M. Asymmetric dimethylarginine predicts major adverse cardiovascular events in patients with advanced peripheral artery disease. Arterioscler Thromb Vasc Biol. 2006;26:2536\u201340.","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"622_CR6","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S1567-5688(03)00033-3","volume":"4","author":"K Sydow","year":"2003","unstructured":"Sydow K, M\u00fcnzel T. ADMA and oxidative stress. Atheroscler Suppl. 2003;4:41\u201351. Review.","journal-title":"Atheroscler Suppl."},{"key":"622_CR7","doi-asserted-by":"crossref","first-page":"13527","DOI":"10.1073\/pnas.212269799","volume":"99","author":"J Leiper","year":"2002","unstructured":"Leiper J, Murray-Rust J, McDonald N, Valance P. S-nitrosylatio of dimethylarginine dimethylaminohydrolase regulates enzyme activity: further interactions between nitric oxide synthase and dimethylarginine dimethylaminodyhdrolase. Proc Natl Acad Sci U S A. 2002;99:13527\u201332.","journal-title":"Proc Natl Acad Sci U S A."},{"key":"622_CR8","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1093\/eurheartj\/ehp061","volume":"30","author":"C Antoniades","year":"2009","unstructured":"Antoniades C, Shirodaria C, Leeson P, Antonopoulos A, Warrick N, Van-Assche T, Cunnington C, Tousoulis D, Pillai R, Ratnatunga C, Stefanadis C, Channon KM. Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis. Eur Heart J. 2009;30:1142\u201350.","journal-title":"Eur Heart J."},{"key":"622_CR9","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1097\/FJC.0b013e31812564e4","volume":"50","author":"F Nigris de","year":"2007","unstructured":"de Nigris F, Balestrieri ML, Williams-Ignarro S, D\u2019Armiento FP, Lerman LO, Byrns R, Crimi E, Palagiano A, Fatigati G, Ignarro LJ, Napoli C. Therapeutic effects of autologous bone marrow cells and metabolic intervention in the ischemic hindlimb of spontaneously hypertensive rats involve reduced cell senescence and CXCR4\/Akt\/eNOS pathways. J Cardiovasc Pharmacol. 2007;50:424\u201333.","journal-title":"J Cardiovasc Pharmacol."},{"key":"622_CR10","doi-asserted-by":"crossref","first-page":"17202","DOI":"10.1073\/pnas.0508534102","volume":"102","author":"C Napoli","year":"2005","unstructured":"Napoli C, Williams-Ignarro S, de Nigris F, de Rosa G, Lerman LO, Farzati B, Matarazzo A, Sica G, Botti C, Fiore A, Byrns RE, Sumi D, Sica V, Ignarro LJ. Beneficial effects of concurrent autologous bone marrow cell therapy and metabolic intervention in ischemia-induced angiogenesis in the mouse hindlimb. Proc Natl Acad Sci U S A. 2005;102:17202\u20136.","journal-title":"Proc Natl Acad Sci U S A."},{"key":"622_CR11","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.4161\/cc.5.24.3568","volume":"5","author":"V Sica","year":"2006","unstructured":"Sica V, Williams-Ignarro S, de Nigris F, D\u2019Armiento FP, Lerman LO, Balestrieri ML, Maione C, Palagiano A, Rossiello L, Ignarro LJ, Napoli C. Autologous bone marrow cell therapy and metabolic intervention in ischemia-induced angiogenesis in the diabetic mouse hindlimb. Cell Cycle. 2006;5:2903\u20138.","journal-title":"Cell Cycle."},{"issue":"Suppl 1","key":"622_CR12","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.ejvs.2006.09.024","volume":"33","author":"L Norgren","year":"2007","unstructured":"Norgren L, Hiatt WR, Dormandy JA, Nehler MR, Harris KA, Fowkes FG, TASC II Working Group, Bell K, Caporusso J, Durand-Zaleski I, Komori K, Lammer J, Liapis C, Novo S, Razavi M, Robbs J, Schaper N, Shigematsu H, Sapoval M, White C, White J, Clement D, Creager M, Jaff M, Mohler 3rd E, Rutherford RB, Sheehan P, Sillesen H, Rosenfield K. Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II). Eur J Vasc Endovasc Surg. 2007;33 Suppl 1:S1\u201375.","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"622_CR13","doi-asserted-by":"crossref","first-page":"371","DOI":"10.3727\/096368909788534942","volume":"18","author":"B Amann","year":"2009","unstructured":"Amann B, Luedemann C, Ratei R, Schmidt-Lucke JA. Autologous bone marrow cell transplantation increases leg perfusion and reduces amputations in patients with advanced critical limb ischemia due to peripheral artery disease. Cell Transplant. 2009;18:371\u201380.","journal-title":"Cell Transplant."},{"key":"622_CR14","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.3727\/096368910X514170","volume":"19","author":"V Proch\u00e1zka","year":"2010","unstructured":"Proch\u00e1zka V, Gumulec J, Jal\u016fvka F, Salounov\u00e1 D, Jonszta T, Czern\u00fd D, Kraj\u010da J, Urbanec R, Klement P, Martinek J, Klement GL. Cell therapy, a new standard in management of chronic critical limb ischemia and foot ulcer. Cell Transplant. 2010;19:1413\u201324.","journal-title":"Cell Transplant."},{"key":"622_CR15","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.3727\/000000007783472363","volume":"16","author":"PC Hermann","year":"2008","unstructured":"Hermann PC, Huber SL, Herrler T, von Hesler C, Andrassy J, Kevy SV, Jacobson MS, Heeschen C. Concentration of bone marrow total nucleated cells by a point-of-care device provides a high yield and preserves their functional activity. Cell Transplant. 2008;16:1059\u201369.","journal-title":"Cell Transplant."},{"key":"622_CR16","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0741-5214(97)70045-4","volume":"26","author":"RB Rutherford","year":"1997","unstructured":"Rutherford RB, Baker JD, Ernst C, Johnston KW, Porter JM, Ahn S, Jones DN. Recommended standards for reports dealing with lower extremity ischemia: revised version. J Vasc Surg. 1997;26:517\u201338.","journal-title":"J Vasc Surg."},{"issue":"3","key":"622_CR17","doi-asserted-by":"crossref","first-page":"545","DOI":"10.3727\/096368912X636777","volume":"22","author":"E Benoit","year":"2013","unstructured":"Benoit E, O'Donnell TF, Patel AN. Safety and efficacy of autologous cell therapy in critical limb ischemia: a systematic review. Cell Transplant. 2013;22(3):545\u201362.","journal-title":"Cell Transplant"},{"issue":"9","key":"622_CR18","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.3727\/096368912X636948","volume":"21","author":"A Klepanec","year":"2012","unstructured":"Klepanec A, Mistrik M, Altaner C, Valachovicova M, Olejarova I, Slysko R, Balazs T, Urlandova T, Hladikova D, Liska B, Tomka J, Vulev I, Madaric J. No difference in intra-arterial and intramuscular delivery of autologous bone marrow cells in patients with advanced critical limb ischemia. Cell Transplant. 2012;21(9):1909\u201318.","journal-title":"Cell Transplant"},{"key":"622_CR19","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/j.jacc.2005.04.066","volume":"46","author":"T Thum","year":"2005","unstructured":"Thum T, Tsikas D, Stein S, Schultheiss M, Eigenthaler M, Anker SD, Poole-Wilson PA, Ertl G, Bauersachs J. Suppression of endothelial progenitor cells in human coronary artery disease by the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine. J Am Coll Cardiol. 2005;46:1693\u2013701.","journal-title":"J Am Coll Cardiol."},{"key":"622_CR20","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.jacc.2006.10.068","volume":"49","author":"H Konishi","year":"2007","unstructured":"Konishi H, Sydow K, Cooke JP. Dimethylarginine dimethylaminohydrolase promotes endothelial repair after vascular injury. J Am Coll Cardiol. 2007;49:1099\u2013105.","journal-title":"J Am Coll Cardiol."},{"key":"622_CR21","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.vph.2008.01.004","volume":"48","author":"GG Zhang","year":"2008","unstructured":"Zhang GG, Bai YP, Chen MF, Shi RZ, Jiang DJ, Fu QM, Tan GS, Li YJ. Asymmetric dimethylarginine induces TNF-alpha production via ROS\/NF-kappaB dependent pathway in human monocytic cells and the inhibitory effect of reinioside C. Vascul Pharmacol. 2008;48:115\u201321.","journal-title":"Vascul Pharmacol."}],"container-title":["Stem Cell Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-017-0622-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T21:41:36Z","timestamp":1499809296000},"score":1,"resource":{"primary":{"URL":"http:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/s13287-017-0622-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,12]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["622"],"URL":"https:\/\/doi.org\/10.1186\/s13287-017-0622-2","relation":{},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,12]]},"article-number":"165"}}