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Additional bone marrow samples were obtained with Brigham and Women\u2019s Hospital\/Partners Institutional Review Board (Boston, MA) approval (IRB protocol #1999P001235) and annual review, as femoral tissue discarded during total hip replacement for non-inflammatory osteoarthritis. Criteria for exclusion were rheumatoid arthritis, cancer, and other comorbid conditions that could affect skeletal metabolism including renal insufficiency, alcoholism, active liver disease, malabsorption, hyperthyroidism, ankylosing spondylitis, aseptic necrosis, hyperparathyroidism, morbid obesity, and diabetes. Also excluded were patients who were taking medications that may influence skeletal metabolism (e.g., thyroid hormone, glucocorticoids, nonsteroidal anti-inflammatory drugs, and bisphosphonates).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"KCO is the inventor listed on a patent application entitled \u201cCell-surface marker of early MSC aging\u201d that has been filed on behalf of Tulane University and is under review in Australia, Canada, Europe, and the US. All other authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher's Note"}}],"article-number":"201"}}