{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T21:38:57Z","timestamp":1794433137862,"version":"4.9.1"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T00:00:00Z","timestamp":1510704000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T00:00:00Z","timestamp":1510704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["U19AI067773"],"award-info":[{"award-number":["U19AI067773"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["K08HL103780, NCI R01CA197792"],"award-info":[{"award-number":["K08HL103780, NCI R01CA197792"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13287-017-0711-2","type":"journal-article","created":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T12:30:40Z","timestamp":1510749040000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Thioredoxin mitigates radiation-induced hematopoietic stem cell injury in mice"],"prefix":"10.1186","volume":"8","author":[{"given":"Pasupathi","family":"Sundaramoorthy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqun","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benny J.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuong L.","family":"Doan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson J.","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubin","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,15]]},"reference":[{"key":"711_CR1","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.7326\/0003-4819-140-12-200406150-00015","volume":"140","author":"JK Waselenko","year":"2004","unstructured":"Waselenko JK, MacVittie TJ, Blakely WF, Pesik N, Wiley AL, Dickerson WE, et al. Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group. Ann Intern Med. 2004;140:1037\u201351.","journal-title":"Ann Intern Med"},{"key":"711_CR2","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/S0301-472X(02)00802-0","volume":"30","author":"N Dainiak","year":"2002","unstructured":"Dainiak N. Hematologic consequences of exposure to ionizing radiation. Exp Hematol. 2002;30:513\u201328.","journal-title":"Exp Hematol"},{"key":"711_CR3","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1056\/NEJMra000365","volume":"346","author":"FA Mettler Jr","year":"2002","unstructured":"Mettler Jr FA, Voelz GL. Major radiation exposure\u2014what to expect and how to respond. N Engl J Med. 2002;346:1554\u201361.","journal-title":"N Engl J Med"},{"key":"711_CR4","doi-asserted-by":"publisher","first-page":"eaal2408","DOI":"10.1126\/scitranslmed.aal2408","volume":"9","author":"W Fendler","year":"2017","unstructured":"Fendler W, Malachowska B, Meghani K, Konstantinopoulos PA, Guha C, Singh VK, et al. Evolutionarily conserved serum microRNAs predict radiation-induced fatality in nonhuman primates. Sci Transl Med. 2017;9:eaal2408.","journal-title":"Sci Transl Med"},{"key":"711_CR5","first-page":"323","volume":"23","author":"JS Greenberger","year":"2009","unstructured":"Greenberger JS. Radioprotection. In Vivo. 2009;23:323\u201336.","journal-title":"In Vivo"},{"key":"711_CR6","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.freeradbiomed.2015.05.045","volume":"87","author":"G Xu","year":"2015","unstructured":"Xu G, Wu H, Zhang J, Li D, Wang Y, Wang Y, et al. Metformin ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice. Free Radic Biol Med. 2015;87:15\u201325.","journal-title":"Free Radic Biol Med"},{"key":"711_CR7","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1182\/blood-2005-04-1418","volume":"107","author":"Y Wang","year":"2006","unstructured":"Wang Y, Schulte BA, LaRue AC, Ogawa M, Zhou D. Total body irradiation selectively induces murine hematopoietic stem cell senescence. Blood. 2006;107:358\u201366.","journal-title":"Blood"},{"key":"711_CR8","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1089\/ars.2013.5635","volume":"20","author":"L Shao","year":"2014","unstructured":"Shao L, Luo Y, Zhou D. Hematopoietic stem cell injury induced by ionizing radiation. Antioxid Redox Signal. 2014;20:1447\u201362.","journal-title":"Antioxid Redox Signal"},{"key":"711_CR9","doi-asserted-by":"publisher","first-page":"29","DOI":"10.2174\/157339807779941767","volume":"3","author":"JS Greenberger","year":"2007","unstructured":"Greenberger JS, Epperly MW. Antioxidant therapeutic approaches toward amelioration of the pulmonary pathophysiological damaging effects of ionizing irradiation. Curr Respiratory Med Rev. 2007;3:29\u201337.","journal-title":"Curr Respiratory Med Rev"},{"key":"711_CR10","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1097\/HP.0000000000000279","volume":"108","author":"VK Singh","year":"2015","unstructured":"Singh VK, Romaine PL, Seed TM. Medical countermeasures for radiation exposure and related injuries: characterization of medicines, FDA-approval status and inclusion into the strategic national stockpile. Health Phys. 2015;108:607.","journal-title":"Health Phys"},{"key":"711_CR11","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.cyto.2014.08.003","volume":"71","author":"VK Singh","year":"2015","unstructured":"Singh VK, Newman VL, Seed TM. Colony-stimulating factors for the treatment of the hematopoietic component of the acute radiation syndrome (H-ARS): a review. Cytokine. 2015;71:22\u201337.","journal-title":"Cytokine"},{"key":"711_CR12","doi-asserted-by":"publisher","first-page":"2501","DOI":"10.1182\/blood-2011-11-394304","volume":"120","author":"SA Peslak","year":"2012","unstructured":"Peslak SA, Wenger J, Bemis JC, Kingsley PD, Koniski AD, McGrath KE, Palis J. EPO-mediated expansion of late-stage erythroid progenitors in the bone marrow initiates recovery from sublethal radiation stress. Blood. 2012;120:2501\u201311.","journal-title":"Blood"},{"key":"711_CR13","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1016\/j.ijrobp.2012.08.014","volume":"85","author":"D Zhou","year":"2013","unstructured":"Zhou D, Deoliveira D, Kang Y, Choi SS, Li Z, Chao NJ, et al. Insulin-like growth factor 1 mitigates hematopoietic toxicity after lethal total body irradiation. Int J Radiat Oncol Biol Phys. 2013;85:1141\u20138.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"711_CR14","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1200\/JCO.1994.12.4.661","volume":"12","author":"G Spitzer","year":"1994","unstructured":"Spitzer G, Adkins DR, Spencer V, Dunphy FR, Petruska PJ, Velasquez WS, et al. Randomized study of growth factors post-peripheral-blood stem-cell transplant: neutrophil recovery is improved with modest clinical benefit. J Clin Oncol. 1994;12:661\u201370.","journal-title":"J Clin Oncol"},{"key":"711_CR15","doi-asserted-by":"crossref","unstructured":"Reeves G. Overview of use of G-CSF and GM-CSF in the treatment of acute radiation injury. Health Phys. 2014;106:699\u2013703.","DOI":"10.1097\/HP.0000000000000090"},{"key":"711_CR16","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1001\/dmp.2011.68","volume":"5","author":"N Dainiak","year":"2011","unstructured":"Dainiak N, Gent RN, Carr Z, Schneider R, Bader J, Buglova E, et al. First global consensus for evidence-based management of the hematopoietic syndrome resulting from exposure to ionizing radiation. Disaster Med Public Health Prep. 2011;5:202\u201312.","journal-title":"Disaster Med Public Health Prep"},{"key":"711_CR17","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1002\/stem.5530160716","volume":"16","author":"G Wagemaker","year":"1998","unstructured":"Wagemaker G, Neelis KJ, Hartong SC, Wognum AW, Thomas GR, Fielder PJ, et al. The efficacy of recombinant TPO in murine and nonhuman primate models for myelosuppression and stem cell transplantation. Stem Cells. 1998;16:127\u201341.","journal-title":"Stem Cells"},{"key":"711_CR18","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1016\/j.exphem.2013.08.004","volume":"41","author":"N An","year":"2013","unstructured":"An N, Janech M, Bland A, Lazarchick J, Arthur JM, Kang Y. Proteomic analysis of murine bone marrow niche microenvironment identifies thioredoxin as a novel agent for radioprotection and for enhancing donor cell reconstitution. Exp Hematol. 2013;41:944\u201356.","journal-title":"Exp Hematol"},{"key":"711_CR19","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1089\/ars.2010.3114","volume":"13","author":"JF Collet","year":"2010","unstructured":"Collet JF, Messens J. Structure, function, and mechanism of thioredoxin proteins. Antioxid Redox Signal. 2010;13:1205\u201316.","journal-title":"Antioxid Redox Signal"},{"key":"711_CR20","volume-title":"Redox and cancer: advances in cancer research","author":"N An","year":"2014","unstructured":"An N, Kang Y. Thioredoxin and hematological malignancies. In: Townsend Tew K, editor. Redox and cancer: advances in cancer research. 2014."},{"key":"711_CR21","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1089\/ars.2011.4322","volume":"18","author":"S Lee","year":"2013","unstructured":"Lee S, Kim SM, Lee RT. Thioredoxin and thioredoxin target proteins: from molecular mechanisms to functional significance. Antioxid Redox Signal. 2013;18:1165\u2013207.","journal-title":"Antioxid Redox Signal"},{"key":"711_CR22","doi-asserted-by":"publisher","first-page":"e11056","DOI":"10.1371\/journal.pone.0011056","volume":"5","author":"BJ Chen","year":"2010","unstructured":"Chen BJ, Deoliveira D, Spasojevic I, Sempowski GD, Jiang C, Owzar K, et al. Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates. PLoS One. 2010;5:e11056.","journal-title":"PLoS One"},{"key":"711_CR23","doi-asserted-by":"publisher","first-page":"37305","DOI":"10.1038\/srep37305","volume":"6","author":"K Venkateswaran","year":"2016","unstructured":"Venkateswaran K, Shrivastava A, Agrawala PK, Prasad A, Kalra N, Pandey PR, et al. Mitigation of radiation-induced hematopoietic injury by the polyphenolic acetate 7, 8-diacetoxy-4-methylthiocoumarin in mice. Sci Rep. 2016;6:37305.","journal-title":"Sci Rep"},{"key":"711_CR24","doi-asserted-by":"crossref","unstructured":"Kiang JG, Jiao W, Cary L, Mog S, Elliott T, Pellmar T, et al. Wound trauma increases radiation-induced mortality by increasing iNOS, cytokine concentrations, and bacterial infections. Radiat Res. 2010;173(3):319\u201332.","DOI":"10.1667\/RR1892.1"},{"key":"711_CR25","first-page":"5414","volume":"63","author":"A Meng","year":"2003","unstructured":"Meng A, Wang Y, Van Zant G, Zhou D. Ionizing radiation and busulfan induce premature senescence in murine bone marrow hematopoietic cells. Cancer Res. 2003;63:5414\u20139.","journal-title":"Cancer Res"},{"key":"711_CR26","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1182\/blood-2010-04-279349","volume":"117","author":"J Cho","year":"2011","unstructured":"Cho J, Shen H, Yu H, Li H, Cheng T, Lee SB, et al. Ewing sarcoma gene Ews regulates hematopoietic stem cell senescence. Blood. 2011;117:1156\u201366.","journal-title":"Blood"},{"key":"711_CR27","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1016\/j.stemcr.2014.10.005","volume":"3","author":"M Hilpert","year":"2014","unstructured":"Hilpert M, Legrand C, Bluteau D, Balayn N, Betems A, Bluteau O, et al. p19 INK4d controls hematopoietic stem cells in a cell-autonomous manner during genotoxic stress and through the microenvironment during aging. Stem Cell Rep. 2014;3:1085\u2013102.","journal-title":"Stem Cell Rep"},{"key":"711_CR28","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s11010-014-2053-z","volume":"393","author":"JG Kiang","year":"2014","unstructured":"Kiang JG, Garrison BR, Smith JT, Fukumoto R. Ciprofloxacin as a potential radio-sensitizer to tumor cells and a radio-protectant for normal cells: differential effects on \u03b3-H2AX formation, p53 phosphorylation, Bcl-2 production, and cell death. Mol Cell Biochem. 2014;393:133\u201343.","journal-title":"Mol Cell Biochem"},{"key":"711_CR29","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1097\/HP.0000000000000108","volume":"106","author":"JG Kiang","year":"2014","unstructured":"Kiang JG, Fukumoto R. Ciprofloxacin increases survival after ionizing irradiation combined injury: \u03b3-H2AX formation, cytokine\/chemokine, and red blood cells. Health Phys. 2014;106:720-26.","journal-title":"Health Phys"},{"key":"711_CR30","doi-asserted-by":"publisher","first-page":"e79541","DOI":"10.1371\/journal.pone.0079541","volume":"8","author":"LG Mariotti","year":"2013","unstructured":"Mariotti LG, Pirovano G, Savage KI, Ghita M, Ottolenghi A, Prise KM, et al. Use of the gamma-H2AX assay to investigate DNA repair dynamics following multiple radiation exposures. PLoS One. 2013;8:e79541.","journal-title":"PLoS One"},{"key":"711_CR31","unstructured":"Kuo LJ, Yang L-X. \u03b3-H2AX-a novel biomarker for DNA double-strand breaks. In vivo. 2008;22:305\u20139."},{"key":"711_CR32","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1126\/science.1095956","volume":"304","author":"CN Coleman","year":"2004","unstructured":"Coleman CN, Stone HB, Moulder JE, Pellmar TC. Modulation of radiation injury. Science. 2004;304:693\u20134.","journal-title":"Science"},{"key":"711_CR33","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13287-016-0464-3","volume":"8","author":"X-L Xue","year":"2017","unstructured":"Xue X-L, Han X-D, Li Y, Chu X-F, Miao W-M, Zhang J-L, et al. Astaxanthin attenuates total body irradiation-induced hematopoietic system injury in mice via inhibition of oxidative stress and apoptosis. Stem Cell Res Ther. 2017;8:7.","journal-title":"Stem Cell Res Ther"},{"key":"711_CR34","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.freeradbiomed.2012.10.530","volume":"54","author":"H Zhang","year":"2013","unstructured":"Zhang H, Zhai Z, Wang Y, Zhang J, Wu H, Wang Y, et al. Resveratrol ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice. Free Radic Biol Med. 2013;54:40\u201350.","journal-title":"Free Radic Biol Med"},{"key":"711_CR35","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1016\/S0360-3016(98)00477-5","volume":"43","author":"MA Mouthon","year":"1999","unstructured":"Mouthon MA, Van der Meeren A, Gaugler MH, Visser TP, Squiban C et al. Thrombopoietin promotes hematopoietic recovery and survival after high-dose whole body irradiation. Int J Radiat Oncol Biol Phys. 1999;43:867\u201375.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"711_CR36","doi-asserted-by":"publisher","first-page":"25692","DOI":"10.1074\/jbc.M800517200","volume":"283","author":"S Yalcin","year":"2008","unstructured":"Yalcin S, Zhang X, Luciano JP, Mungamuri SK, Marinkovic D, Vercherat C, et al. Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells. J Biol Chem. 2008;283:25692\u2013705.","journal-title":"J Biol Chem"},{"key":"711_CR37","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.cell.2007.01.003","volume":"128","author":"Z Tothova","year":"2007","unstructured":"Tothova Z, Kollipara R, Huntly BJ, Lee BH, Castrillon DH, Cullen DE, et al. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell. 2007;128:325\u201339.","journal-title":"Cell"},{"key":"711_CR38","first-page":"105","volume":"8","author":"JF Ward","year":"1987","unstructured":"Ward JF, Evans JW, Limoli CL, Calabro-Jones PM. Radiation and hydrogen peroxide induced free radical damage to DNA. Br J Cancer Suppl. 1987;8:105\u201312.","journal-title":"Br J Cancer Suppl"},{"key":"711_CR39","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1089\/ars.2013.5668","volume":"21","author":"WL Santivasi","year":"2014","unstructured":"Santivasi WL, Xia F. Ionizing radiation-induced DNA damage, response, and repair. Antioxid Redox Signal. 2014;21:251\u20139.","journal-title":"Antioxid Redox Signal"},{"key":"711_CR40","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1016\/j.exphem.2003.08.014","volume":"31","author":"A Meng","year":"2003","unstructured":"Meng A, Wang Y, Brown SA, Van Zant G, Zhou D. Ionizing radiation and busulfan inhibit murine bone marrow cell hematopoietic function via apoptosis-dependent and -independent mechanisms. Exp Hematol. 2003;31:1348\u201356.","journal-title":"Exp Hematol"},{"key":"711_CR41","first-page":"156","volume":"21","author":"S Neben","year":"1993","unstructured":"Neben S, Hellman S, Montgomery M, Ferrara J, Mauch P. Hematopoietic stem cell deficit of transplanted bone marrow previously exposed to cytotoxic agents. Exp Hematol. 1993;21:156\u201362.","journal-title":"Exp Hematol"},{"key":"711_CR42","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1182\/blood.V92.6.1950","volume":"92","author":"R van Os","year":"1998","unstructured":"van Os R, Robinson S, Sheridan T, Mislow JM, Dawes D, Mauch PM. Granulocyte colony-stimulating factor enhances bone marrow stem cell damage caused by repeated administration of cytotoxic agents. Blood. 1998;92:1950\u20136.","journal-title":"Blood"},{"key":"711_CR43","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1667\/RR2727.1","volume":"176","author":"Y Wang","year":"2011","unstructured":"Wang Y, Liu L, Zhou D. Inhibition of p38 MAPK attenuates ionizing radiation-induced hematopoietic cell senescence and residual bone marrow injury. Radiat Res. 2011;176:743\u201352.","journal-title":"Radiat Res"},{"key":"711_CR44","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/0360-3016(77)90028-1","volume":"2","author":"S Hellman","year":"1977","unstructured":"Hellman S, Botnick LE. Stem cell depletion: an explanation of the late effects of cytotoxins. Int J Radiat Oncol Biol Phys. 1977;2:181\u20134.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"711_CR45","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1089\/15230860260220201","volume":"4","author":"A Mitsui","year":"2002","unstructured":"Mitsui A, Hamuro J, Nakamura H, Kondo N, Hirabayashi Y, Ishizaki-Koizumi S, et al. Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span. Antioxid Redox Signal. 2002;4:693\u20136.","journal-title":"Antioxid Redox Signal"},{"key":"711_CR46","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.febslet.2005.12.046","volume":"580","author":"A Miranda-Vizuete","year":"2006","unstructured":"Miranda-Vizuete A, Gonz\u00e1lez JCF, Gahmon G, Burghoorn J, Navas P, Swoboda P. Lifespan decrease in a Caenorhabditis elegans mutant lacking TRX-1, a thioredoxin expressed in ASJ sensory neurons. FEBS Lett. 2006;580:484\u201390.","journal-title":"FEBS Lett"},{"key":"711_CR47","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.bbrc.2010.01.026","volume":"392","author":"JJ Young","year":"2010","unstructured":"Young JJ, Patel A, Rai P. Suppression of thioredoxin-1 induces premature senescence in normal human fibroblasts. Biochem Biophys Res Commun. 2010;392:363\u20138.","journal-title":"Biochem Biophys Res Commun"},{"key":"711_CR48","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1111\/j.1872-034X.2012.00973.x","volume":"42","author":"T Zhang","year":"2012","unstructured":"Zhang T, Liu H, Zhu C, Briggs K, Ya K, Fleming JA, et al. Silencing thioredoxin induces liver cancer cell senescence under hypoxia. Hepatol Res. 2012;42:706\u201313.","journal-title":"Hepatol Res"},{"key":"711_CR49","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1111\/j.1474-9726.2009.00489.x","volume":"8","author":"Y Liu","year":"2009","unstructured":"Liu Y, Sanoff HK, Cho H, Burd CE, Torrice C, Ibrahim JG, et al. Expression of p16INK4a in peripheral blood T\u2010cells is a biomarker of human aging. Aging Cell. 2009;8:439\u201348.","journal-title":"Aging Cell"},{"key":"711_CR50","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1038\/nm1388","volume":"12","author":"K Ito","year":"2006","unstructured":"Ito K, Hirao A, Arai F, Takubo K, Matsuoka S, Miyamoto K, et al. Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nat Med. 2006;12:446\u201351.","journal-title":"Nat Med"},{"key":"711_CR51","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1056\/NEJM198809083191001","volume":"319","author":"KS Antman","year":"1988","unstructured":"Antman KS, Griffin JD, Elias A, Socinski MA, Ryan L, Cannistra SA, et al. Effect of recombinant human granulocyte-macrophage colony-stimulating factor on chemotherapy-induced myelosuppression. N Engl J Med. 1988;319:593\u20138.","journal-title":"N Engl J Med"},{"key":"711_CR52","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1126\/science.275.5296.90","volume":"275","author":"H Ichijo","year":"1997","unstructured":"Ichijo H, Nishida E, Irie K, ten Dijke P, Saitoh M, Moriguchi T, et al. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK\/JNK and p38 signaling pathways. Science. 1997;275:90\u20134.","journal-title":"Science"},{"key":"711_CR53","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/S0079-6603(08)60611-X","volume":"35","author":"J Ward","year":"1988","unstructured":"Ward J. DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability. Prog Nucleic Acid Res Mol Biol. 1988;35:95\u2013125.","journal-title":"Prog Nucleic Acid Res Mol Biol"},{"key":"711_CR54","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/sj.bjc.6604208","volume":"98","author":"N Bucher","year":"2008","unstructured":"Bucher N, Britten C. G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer. Br J Cancer. 2008;98:523\u20138.","journal-title":"Br J Cancer"},{"key":"711_CR55","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1002\/jcb.24694","volume":"115","author":"MA Chaudhry","year":"2014","unstructured":"Chaudhry MA. Radiation\u2010induced microRNA: discovery, functional analysis, and cancer radiotherapy. J Cell Biochem. 2014;115:436\u201349.","journal-title":"J Cell Biochem"},{"key":"711_CR56","doi-asserted-by":"publisher","first-page":"4662","DOI":"10.1074\/jbc.M006206200","volume":"276","author":"KC Das","year":"2001","unstructured":"Das KC. c-Jun NH2-terminal kinase-mediated redox-dependent degradation of I\u03baB: role of thioredoxin in NF-\u03baB activation. J Biol Chem. 2001;276:4662\u201370.","journal-title":"J Biol Chem"},{"key":"711_CR57","doi-asserted-by":"publisher","first-page":"e844","DOI":"10.1038\/cddis.2013.338","volume":"4","author":"J Hou","year":"2013","unstructured":"Hou J, Han Z, Jing Y, Yang X, Zhang S, Sun K, et al. Autophagy prevents irradiation injury and maintains stemness through decreasing ROS generation in mesenchymal stem cells. Cell Death Dis. 2013;4:e844.","journal-title":"Cell Death Dis"},{"key":"711_CR58","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/S0891-5849(00)00313-0","volume":"29","author":"G Powis","year":"2000","unstructured":"Powis G, Mustacich D, Coon A. The role of the redox protein thioredoxin in cell growth and cancer. Free Radic Biol Med. 2000;29:312\u201322.","journal-title":"Free Radic Biol Med"},{"key":"711_CR59","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1006\/cyto.1996.0002","volume":"8","author":"H Blum","year":"1996","unstructured":"Blum H, R\u00f6llinghoff M, Gessner A. Expression and co-cytokine function of murine thioredoxin\/adult T cell leukaemia-derived factor (ADF). Cytokine. 1996;8:6\u201313.","journal-title":"Cytokine"},{"key":"711_CR60","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s10565-006-0042-z","volume":"22","author":"M Moon","year":"2006","unstructured":"Moon M, Kim J, Kim T, Yum J, Cho E, Kim I. Polyamine depletion partially reduces the radiation-induced cell death via cell cycle delay mediated by thioredoxin. Cell Biol Toxicol. 2006;22:137\u201347.","journal-title":"Cell Biol Toxicol"},{"key":"711_CR61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mrfmmm.2013.10.002","volume":"751","author":"HL Kim","year":"2013","unstructured":"Kim HL, Koedrith P, Lee SM, Kim YJ, Seo YR. Base excision DNA repair defect in thioredoxin-1 (Trx1)-deficient cells. Mutat Res. 2013;751:1\u20137.","journal-title":"Mutat Res"},{"key":"711_CR62","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1016\/j.yexcr.2007.01.004","volume":"313","author":"Z Song","year":"2007","unstructured":"Song Z, Saghafi N, Gokhale V, Brabant M, Meuillet EJ. Regulation of the activity of the tumor suppressor PTEN by thioredoxin in Drosophila melanogaster. Exp Cell Res. 2007;313:1161\u201371.","journal-title":"Exp Cell Res"},{"key":"711_CR63","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1016\/j.cell.2008.04.041","volume":"133","author":"T Ago","year":"2008","unstructured":"Ago T, Liu T, Zhai P, Chen W, Li H, Molkentin JD, et al. A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy. Cell. 2008;133:978\u201393.","journal-title":"Cell"},{"key":"711_CR64","doi-asserted-by":"publisher","first-page":"3821","DOI":"10.1093\/nar\/20.15.3821","volume":"20","author":"JR Matthews","year":"1992","unstructured":"Matthews JR, Wakasugi N, Yodoi J, Hay RT. Thioredoxin regulates the DNA binding activity of NF-kB by reduction of a disulphide bond involving cysteine 62. Nucleic Acids Res. 1992;20:3821\u201330.","journal-title":"Nucleic Acids Res"}],"container-title":["Stem Cell Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-017-0711-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13287-017-0711-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-017-0711-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T14:01:43Z","timestamp":1589551303000},"score":1,"resource":{"primary":{"URL":"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/s13287-017-0711-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,15]]},"references-count":64,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["711"],"URL":"https:\/\/doi.org\/10.1186\/s13287-017-0711-2","relation":{},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,15]]},"assertion":[{"value":"9 August 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All our studies were performed in accordance with Duke University Institutional Animal Care and Use Committee approved procedures (A096-17-04).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"263"}}