{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:14:34Z","timestamp":1792631674633,"version":"4.5.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T00:00:00Z","timestamp":1547164800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T00:00:00Z","timestamp":1547164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472087"],"award-info":[{"award-number":["81472087"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1 AR066539"],"award-info":[{"award-number":["RO1 AR066539"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["1508085MC45"],"award-info":[{"award-number":["1508085MC45"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s13287-018-1107-7","type":"journal-article","created":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T11:18:12Z","timestamp":1547205492000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["BMP-dependent, injury-induced stem cell niche as a mechanism of heterotopic ossification"],"prefix":"10.1186","volume":"10","author":[{"given":"Chen","family":"Kan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiazhao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenya","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammy L.","family":"McGuire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haimei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keqin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana M. Palila","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Kessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Kan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,1,11]]},"reference":[{"key":"1107_CR1","doi-asserted-by":"publisher","first-page":"194","DOI":"10.3389\/fphys.2017.00194","volume":"8","author":"OG Davies","year":"2017","unstructured":"Davies OG, Liu Y, Player DJ, Martin NRW, Grover LM, Lewis MP. Defining the balance between regeneration and pathological ossification in skeletal muscle following traumatic injury. Front Physiol. 2017;8:194.","journal-title":"Front Physiol"},{"issue":"4","key":"1107_CR2","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.rehab.2016.03.009","volume":"59","author":"W Almangour","year":"2016","unstructured":"Almangour W, Schnitzler A, Salga M, Debaud C, Denormandie P, Genet F. Recurrence of heterotopic ossification after removal in patients with traumatic brain injury: a systematic review. Ann Phys Rehabil Med. 2016;59(4):263\u20139.","journal-title":"Ann Phys Rehabil Med"},{"issue":"1","key":"1107_CR3","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1097\/TA.0000000000000883","volume":"80","author":"CT Kraft","year":"2016","unstructured":"Kraft CT, Agarwal S, Ranganathan K, Wong VW, Loder S, Li J, et al. Trauma-induced heterotopic bone formation and the role of the immune system: a review. J Trauma Acute Care Surg. 2016;80(1):156\u201365.","journal-title":"J Trauma Acute Care Surg"},{"issue":"4","key":"1107_CR4","first-page":"230","volume":"12","author":"VI Sakellariou","year":"2012","unstructured":"Sakellariou VI, Grigoriou E, Mavrogenis AF, Soucacos PN, Papagelopoulos PJ. Heterotopic ossification following traumatic brain injury and spinal cord injury: insight into the etiology and pathophysiology. J Musculoskelet Neuronal Interact. 2012;12(4):230\u201340.","journal-title":"J Musculoskelet Neuronal Interact"},{"issue":"Suppl 2","key":"1107_CR5","first-page":"437","volume":"10","author":"RJ Pignolo","year":"2013","unstructured":"Pignolo RJ, Shore EM, Kaplan FS. Fibrodysplasia ossificans progressiva: diagnosis, management, and therapeutic horizons. Pediatr Endocrinol Rev. 2013;10(Suppl 2):437\u201348.","journal-title":"Pediatr Endocrinol Rev"},{"issue":"4","key":"1107_CR6","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1016\/S0002-9440(10)63372-X","volume":"165","author":"L Kan","year":"2004","unstructured":"Kan L, Hu M, Gomes WA, Kessler JA. Transgenic mice overexpressing BMP4 develop a fibrodysplasia ossificans progressiva (FOP)-like phenotype. Am J Pathol. 2004;165(4):1107\u201315.","journal-title":"Am J Pathol"},{"issue":"10","key":"1107_CR7","doi-asserted-by":"publisher","first-page":"2759","DOI":"10.1002\/jcb.23259","volume":"112","author":"L Kan","year":"2011","unstructured":"Kan L, Lounev VY, Pignolo RJ, Duan L, Liu Y, Stock SR, et al. Substance P signaling mediates BMP-dependent heterotopic ossification. J Cell Biochem. 2011;112(10):2759\u201372.","journal-title":"J Cell Biochem"},{"issue":"3","key":"1107_CR8","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s00011-013-0690-4","volume":"63","author":"L Kan","year":"2014","unstructured":"Kan L, Mutso AA, McGuire TL, Apkarian AV, Kessler JA. Opioid signaling in mast cells regulates injury responses associated with heterotopic ossification. Inflamm Res. 2014;63(3):207\u201315.","journal-title":"Inflamm Res"},{"issue":"8","key":"1107_CR9","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1053\/hupa.2001.26464","volume":"32","author":"FH Gannon","year":"2001","unstructured":"Gannon FH, Glaser D, Caron R, Thompson LD, Shore EM, Kaplan FS. Mast cell involvement in fibrodysplasia ossificans progressiva. Hum Pathol. 2001;32(8):842\u20138.","journal-title":"Hum Pathol"},{"key":"1107_CR10","doi-asserted-by":"publisher","first-page":"76","DOI":"10.3389\/fnins.2011.00076","volume":"5","author":"M Llorens-Martin","year":"2011","unstructured":"Llorens-Martin M, Trejo JL. Multiple birthdating analyses in adult neurogenesis: a line-up of the usual suspects. Front Neurosci. 2011;5:76.","journal-title":"Front Neurosci"},{"issue":"7166","key":"1107_CR11","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/nature06293","volume":"450","author":"J Livet","year":"2007","unstructured":"Livet J, Weissman TA, Kang H, Draft RW, Lu J, Bennis RA, et al. Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system. Nature. 2007;450(7166):56\u201362.","journal-title":"Nature"},{"issue":"3","key":"1107_CR12","doi-asserted-by":"publisher","first-page":"652","DOI":"10.2106\/JBJS.H.01177","volume":"91","author":"VY Lounev","year":"2009","unstructured":"Lounev VY, Ramachandran R, Wosczyna MN, Yamamoto M, Maidment AD, Shore EM, et al. Identification of progenitor cells that contribute to heterotopic skeletogenesis. J Bone Joint Surg Am. 2009;91(3):652\u201363.","journal-title":"J Bone Joint Surg Am"},{"issue":"5","key":"1107_CR13","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1002\/jbmr.1562","volume":"27","author":"MN Wosczyna","year":"2012","unstructured":"Wosczyna MN, Biswas AA, Cogswell CA, Goldhamer DJ. Multipotent progenitors resident in the skeletal muscle interstitium exhibit robust BMP-dependent osteogenic activity and mediate heterotopic ossification. J Bone Miner Res. 2012;27(5):1004\u201317.","journal-title":"J Bone Miner Res"},{"issue":"1","key":"1107_CR14","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.bone.2012.12.008","volume":"53","author":"L Kan","year":"2013","unstructured":"Kan L, Peng CY, McGuire TL, Kessler JA. Glast-expressing progenitor cells contribute to heterotopic ossification. Bone. 2013;53(1):194\u2013203.","journal-title":"Bone"},{"key":"1107_CR15","doi-asserted-by":"publisher","unstructured":"Kan C, Chen L, Hu Y, Ding N, Li Y, McGuire TL, Lu H, Kessler JA, Kan L. Gli1-labeled adult mesenchymal stem\/progenitor cells and hedgehog signaling contribute to endochondral heterotopic ossification. Bone. 2018;109:71\u201379. \n                    https:\/\/doi.org\/10.1016\/j.bone.2017.06.014\n                    \n                  . Epub 2017 Jun 21.","DOI":"10.1016\/j.bone.2017.06.014"},{"issue":"3","key":"1107_CR16","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1002\/gene.20162","volume":"43","author":"A Ivanova","year":"2005","unstructured":"Ivanova A, Signore M, Caro N, Greene ND, Copp AJ, Martinez-Barbera JP. In vivo genetic ablation by Cre-mediated expression of diphtheria toxin fragment A. Genesis. 2005;43(3):129\u201335.","journal-title":"Genesis"},{"key":"1107_CR17","doi-asserted-by":"publisher","unstructured":"Kan C, Chen L, Hu Y, Ding N, Lu H, Li Y, Kessler JA, Kan L. Conserved signaling pathways underlying heterotopic ossification. Bone. 2018;109:43\u201348. \n                    https:\/\/doi.org\/10.1016\/j.bone.2017.04.014\n                    \n                  . Epub 2017 Apr 25.","DOI":"10.1016\/j.bone.2017.04.014"},{"issue":"8","key":"1107_CR18","doi-asserted-by":"publisher","first-page":"996","DOI":"10.7150\/ijbs.19986","volume":"13","author":"P Wang","year":"2017","unstructured":"Wang P, Ying J, Luo C, Jin X, Zhang S, Xu T, et al. Osthole promotes bone fracture healing through activation of BMP signaling in chondrocytes. Int J Biol Sci. 2017;13(8):996\u20131007.","journal-title":"Int J Biol Sci"},{"issue":"6","key":"1107_CR19","first-page":"5424","volume":"14","author":"HD Fu","year":"2017","unstructured":"Fu HD, Wang HR, Li DH. BMP-7 accelerates the differentiation of rabbit mesenchymal stem cells into cartilage through the Wnt\/beta-catenin pathway. Exp Ther Med. 2017;14(6):5424\u20138.","journal-title":"Exp Ther Med"},{"issue":"1","key":"1107_CR20","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1634\/stemcells.2008-0576","volume":"27","author":"L Kan","year":"2009","unstructured":"Kan L, Liu Y, McGuire TL, Berger DM, Awatramani RB, Dymecki SM, et al. Dysregulation of local stem\/progenitor cells as a common cellular mechanism for heterotopic ossification. Stem Cells. 2009;27(1):150\u20136.","journal-title":"Stem Cells"},{"issue":"4","key":"1107_CR21","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.cell.2004.07.023","volume":"118","author":"S Ahn","year":"2004","unstructured":"Ahn S, Joyner AL. Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning. Cell. 2004;118(4):505\u201316.","journal-title":"Cell"},{"issue":"2","key":"1107_CR22","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1006\/dbio.2000.0106","volume":"230","author":"YY Kisanuki","year":"2001","unstructured":"Kisanuki YY, Hammer RE, Miyazaki J, Williams SC, Richardson JA, Yanagisawa M. Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo. Dev Biol. 2001;230(2):230\u201342.","journal-title":"Dev Biol"},{"issue":"1","key":"1107_CR23","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.cell.2010.09.016","volume":"143","author":"HJ Snippert","year":"2010","unstructured":"Snippert HJ, van der Flier LG, Sato T, van Es JH, van den Born M, Kroon-Veenboer C, et al. Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. Cell. 2010;143(1):134\u201344.","journal-title":"Cell"},{"issue":"1","key":"1107_CR24","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/nn.2467","volume":"13","author":"L Madisen","year":"2010","unstructured":"Madisen L, Zwingman TA, Sunkin SM, Oh SW, Zariwala HA, Gu H, et al. A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci. 2010;13(1):133\u201340.","journal-title":"Nat Neurosci"},{"issue":"4","key":"1107_CR25","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1016\/j.celrep.2014.04.018","volume":"7","author":"Y Rinkevich","year":"2014","unstructured":"Rinkevich Y, Montoro DT, Contreras-Trujillo H, Harari-Steinberg O, Newman AM, Tsai JM, et al. In vivo clonal analysis reveals lineage-restricted progenitor characteristics in mammalian kidney development, maintenance, and regeneration. Cell Rep. 2014;7(4):1270\u201383.","journal-title":"Cell Rep"},{"issue":"6","key":"1107_CR26","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1002\/stem.1681","volume":"32","author":"FJ Lv","year":"2014","unstructured":"Lv FJ, Tuan RS, Cheung KM, Leung VY. Concise review: the surface markers and identity of human mesenchymal stem cells. Stem Cells. 2014;32(6):1408\u201319.","journal-title":"Stem Cells"},{"issue":"12","key":"1107_CR27","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1097\/00005072-199612000-00009","volume":"55","author":"A Kendler","year":"1996","unstructured":"Kendler A, Golden JA. Progenitor cell proliferation outside the ventricular and subventricular zones during human brain development. J Neuropathol Exp Neurol. 1996;55(12):1253\u20138.","journal-title":"J Neuropathol Exp Neurol"},{"issue":"3","key":"1107_CR28","doi-asserted-by":"publisher","first-page":"E338","DOI":"10.1073\/pnas.1515397113","volume":"113","author":"S Agarwal","year":"2016","unstructured":"Agarwal S, Loder S, Brownley C, Cholok D, Mangiavini L, Li J, et al. Inhibition of Hif1alpha prevents both trauma-induced and genetic heterotopic ossification. Proc Natl Acad Sci U S A. 2016;113(3):E338\u201347.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"1107_CR29","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1002\/stem.2515","volume":"35","author":"S Agarwal","year":"2017","unstructured":"Agarwal S, Loder SJ, Cholok D, Peterson J, Li J, Breuler C, et al. Scleraxis-lineage cells contribute to ectopic bone formation in muscle and tendon. Stem Cells. 2017;35(3):705\u201310.","journal-title":"Stem Cells"},{"key":"1107_CR30","doi-asserted-by":"publisher","first-page":"74","DOI":"10.3389\/fendo.2017.00074","volume":"8","author":"HH Sung Hsieh","year":"2017","unstructured":"Sung Hsieh HH, Chung MT, Allen RM, Ranganathan K, Habbouche J, Cholok D, et al. Evaluation of salivary cytokines for diagnosis of both trauma-induced and genetic heterotopic ossification. Front Endocrinol (Lausanne). 2017;8:74.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"366","key":"1107_CR31","doi-asserted-by":"publisher","first-page":"366ra163","DOI":"10.1126\/scitranslmed.aaf1090","volume":"8","author":"D Dey","year":"2016","unstructured":"Dey D, Bagarova J, Hatsell SJ, Armstrong KA, Huang L, Ermann J, et al. Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification. Sci Transl Med. 2016;8(366):366ra163.","journal-title":"Sci Transl Med"},{"issue":"4","key":"1107_CR32","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1002\/sctm.16-0347","volume":"6","author":"EA Olmsted-Davis","year":"2017","unstructured":"Olmsted-Davis EA, Salisbury EA, Hoang D, Davis EL, Lazard Z, Sonnet C, et al. Progenitors in peripheral nerves launch heterotopic ossification. Stem Cells Transl Med. 2017;6(4):1109\u201319.","journal-title":"Stem Cells Transl Med"},{"issue":"7","key":"1107_CR33","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1111\/febs.13667","volume":"283","author":"C Zhang","year":"2016","unstructured":"Zhang C, Zhang Y, Zhong B, Luo CF. SMAD7 prevents heterotopic ossification in a rat Achilles tendon injury model via regulation of endothelial-mesenchymal transition. FEBS J. 2016;283(7):1275\u201385.","journal-title":"FEBS J"},{"issue":"14","key":"1107_CR34","doi-asserted-by":"publisher","first-page":"9924","DOI":"10.1074\/jbc.M112.409342","volume":"288","author":"H Hojo","year":"2013","unstructured":"Hojo H, Ohba S, Taniguchi K, Shirai M, Yano F, Saito T, et al. Hedgehog-Gli activators direct osteo-chondrogenic function of bone morphogenetic protein toward osteogenesis in the perichondrium. J Biol Chem. 2013;288(14):9924\u201332.","journal-title":"J Biol Chem"},{"key":"1107_CR35","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.bone.2015.09.002","volume":"81","author":"NH Kazmers","year":"2015","unstructured":"Kazmers NH, McKenzie JA, Shen TS, Long F, Silva MJ. Hedgehog signaling mediates woven bone formation and vascularization during stress fracture healing. Bone. 2015;81:524\u201332.","journal-title":"Bone"},{"issue":"52","key":"1107_CR36","doi-asserted-by":"publisher","first-page":"18117","DOI":"10.1073\/pnas.0408258102","volume":"101","author":"J Imitola","year":"2004","unstructured":"Imitola J, Raddassi K, Park KI, Mueller FJ, Nieto M, Teng YD, et al. Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha\/CXC chemokine receptor 4 pathway. Proc Natl Acad Sci U S A. 2004;101(52):18117\u201322.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"1107_CR37","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1038\/nbt751","volume":"20","author":"KI Park","year":"2002","unstructured":"Park KI, Teng YD, Snyder EY. The injured brain interacts reciprocally with neural stem cells supported by scaffolds to reconstitute lost tissue. Nat Biotechnol. 2002;20(11):1111\u20137.","journal-title":"Nat Biotechnol"},{"issue":"2","key":"1107_CR38","first-page":"173","volume":"148","author":"S Pluchino","year":"2010","unstructured":"Pluchino S, Cusimano M, Bacigaluppi M, Martino G. Remodelling the injured CNS through the establishment of atypical ectopic perivascular neural stem cell niches. Arch Ital Biol. 2010;148(2):173\u201383.","journal-title":"Arch Ital Biol"},{"issue":"4","key":"1107_CR39","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1097\/MOH.0000000000000265","volume":"23","author":"VW Yu","year":"2016","unstructured":"Yu VW, Scadden DT. Heterogeneity of the bone marrow niche. Curr Opin Hematol. 2016;23(4):331\u20138.","journal-title":"Curr Opin Hematol"},{"issue":"1","key":"1107_CR40","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1111\/nyas.13016","volume":"1370","author":"A Birbrair","year":"2016","unstructured":"Birbrair A, Frenette PS. Niche heterogeneity in the bone marrow. Ann N Y Acad Sci. 2016;1370(1):82\u201396.","journal-title":"Ann N Y Acad Sci"},{"issue":"1\u20132","key":"1107_CR41","first-page":"7","volume":"4","author":"R Schofield","year":"1978","unstructured":"Schofield R. The relationship between the spleen colony-forming cell and the haemopoietic stem cell. Blood Cells. 1978;4(1\u20132):7\u201325.","journal-title":"Blood Cells"},{"issue":"7159","key":"1107_CR42","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/nature06115","volume":"449","author":"MJ Kiel","year":"2007","unstructured":"Kiel MJ, He S, Ashkenazi R, Gentry SN, Teta M, Kushner JA, et al. Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU. Nature. 2007;449(7159):238\u201342.","journal-title":"Nature"}],"container-title":["Stem Cell Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-018-1107-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13287-018-1107-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-018-1107-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T13:24:31Z","timestamp":1589549071000},"score":1,"resource":{"primary":{"URL":"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/s13287-018-1107-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,11]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1107"],"URL":"https:\/\/doi.org\/10.1186\/s13287-018-1107-7","relation":{},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,11]]},"assertion":[{"value":"22 August 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All animal experiments in this study followed the guidelines approved by the Animal Care and Use Committees at Anhui Medical University (Protocol: LLSC20140042) and at Northwestern University (Protocol: IS00001002). The use of the deidentified human material was approved by the Medical Research Ethics Committee of Anhui Provincial Hospital (Serial number: P-023), the Primary Affiliated Hospital of China University of Science and Technology, Hefei, China. Due to the nature of the deidentified human material, we have relied on the IRB\/ethics committee to review the study and the consent process.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"14"}}