{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:05:52Z","timestamp":1790438752677,"version":"4.1.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T00:00:00Z","timestamp":1561593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T00:00:00Z","timestamp":1561593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s13287-019-1295-9","type":"journal-article","created":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T14:02:57Z","timestamp":1561644177000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Bone marrow vs Wharton\u2019s jelly mesenchymal stem cells in experimental sepsis: a comparative study"],"prefix":"10.1186","volume":"10","author":[{"given":"Caroline","family":"Laroye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Boufenzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Jolly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisiane","family":"Cunat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corentine","family":"Alauzet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Merlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9mence","family":"Yguel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dani\u00e8le","family":"Bensoussan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo\u00efc","family":"Reppel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Gibot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,6,27]]},"reference":[{"key":"1295_CR1","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1002\/stem.2695","volume":"35","author":"C Laroye","year":"2017","unstructured":"Laroye C, Gibot S, Reppel L, Bensoussan D. Concise review: mesenchymal stromal\/stem cells: a new treatment for sepsis and septic shock?: MSCs in the treatment for sepsis and septic shock. Stem Cells. 2017;35:2331\u20139.","journal-title":"Stem Cells"},{"key":"1295_CR2","doi-asserted-by":"publisher","first-page":"2459","DOI":"10.2174\/1381612811319130015","volume":"19","author":"L de Girolamo","year":"2013","unstructured":"de Girolamo L, Lucarelli E, Alessandri G, Antonietta Avanzini M, Ester Bernardo M, Biagi E, et al. Mesenchymal stem\/stromal cells: a new \u201ccells as drugs\u201d paradigm. Efficacy and critical aspects in cell therapy. Curr Pharm Des. 2013;19:2459\u201373.","journal-title":"Curr Pharm Des"},{"key":"1295_CR3","doi-asserted-by":"publisher","first-page":"e47559","DOI":"10.1371\/journal.pone.0047559","volume":"7","author":"MM Lalu","year":"2012","unstructured":"Lalu MM, McIntyre L, Pugliese C, Fergusson D, Winston BW, Marshall JC, et al. Safety of cell therapy with mesenchymal stromal cells (SafeCell): a systematic review and meta-analysis of clinical trials. PLoS One. 2012;7:e47559 Beltrami AP, editor.","journal-title":"PLoS One"},{"key":"1295_CR4","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.tibtech.2006.01.010","volume":"24","author":"JK Fraser","year":"2006","unstructured":"Fraser JK, Wulur I, Alfonso Z, Hedrick MH. Fat tissue: an underappreciated source of stem cells for biotechnology. Trends Biotechnol. 2006;24:150\u20134.","journal-title":"Trends Biotechnol"},{"key":"1295_CR5","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/S0140-6736(05)66916-4","volume":"366","author":"MJ Griffiths","year":"2005","unstructured":"Griffiths MJ, Bonnet D, Janes SM. Stem cells of the alveolar epithelium. Lancet. 2005;366:249\u201360.","journal-title":"Lancet"},{"key":"1295_CR6","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/S0092-8674(03)00687-1","volume":"114","author":"AP Beltrami","year":"2003","unstructured":"Beltrami AP, Barlucchi L, Torella D, Baker M, Limana F, Chimenti S, et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell. 2003;114:763\u201376.","journal-title":"Cell."},{"key":"1295_CR7","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/j.biocel.2008.01.007","volume":"40","author":"Y Chen","year":"2008","unstructured":"Chen Y, Shao J-Z, Xiang L-X, Dong X-J, Zhang G-R. Mesenchymal stem cells: a promising candidate in regenerative medicine. Int J Biochem Cell Biol. 2008;40:815\u201320.","journal-title":"Int J Biochem Cell Biol"},{"key":"1295_CR8","doi-asserted-by":"publisher","first-page":"67","DOI":"10.4252\/wjsc.v2.i4.67","volume":"2","author":"C Sancricca","year":"2010","unstructured":"Sancricca C. Mesenchymal stem cells: molecular characteristics and clinical applications. World J Stem Cells. 2010;2:67.","journal-title":"World J Stem Cells"},{"key":"1295_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/901821","volume":"2013","author":"F Rossignoli","year":"2013","unstructured":"Rossignoli F, Caselli A, Grisendi G, Piccinno S, Burns JS, Murgia A, et al. Isolation, characterization, and transduction of endometrial decidual tissue multipotent mesenchymal stromal\/stem cells from menstrual blood. Biomed Res Int. 2013;2013:1\u201314.","journal-title":"Biomed Res Int"},{"key":"1295_CR10","first-page":"1","volume-title":"Bioreact Syst Tissue Eng II [Internet]","author":"S Wolbank","year":"2010","unstructured":"Wolbank S, Griensven M, Grillari-Voglauer R, Peterbauer-Scherb A. Alternative sources of adult stem cells: human amniotic membrane. In: Kasper C, Griensven M, P\u00f6rtner R, editors. Bioreact Syst Tissue Eng II [Internet]. Berlin, Heidelberg: Springer Berlin Heidelberg; 2010. p. 1\u201327. [cited 2016 Mar 31]. Available from: \n                    http:\/\/link.springer.com\/10.1007\/10_2010_71\n                    \n                  ."},{"key":"1295_CR11","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1634\/stemcells.2004-0058","volume":"22","author":"PS In \u2019t Anker","year":"2004","unstructured":"In \u2019t Anker PS, Scherjon SA, Kleijburg-van der Keur C, de Groot-Swings GMJS, Claas FHJ, Fibbe WE, et al. Isolation of mesenchymal stem cells of fetal or maternal origin from human placenta. Stem Cells. 2004;22:1338\u201345.","journal-title":"Stem Cells"},{"key":"1295_CR12","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1634\/stemcells.22-4-625","volume":"22","author":"K Bieback","year":"2004","unstructured":"Bieback K, Kern S, Kl\u00fcter H, Eichler H. Critical parameters for the isolation of mesenchymal stem cells from umbilical cord blood. Stem Cells. 2004;22:625\u201334.","journal-title":"Stem Cells"},{"key":"1295_CR13","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1634\/stemcells.2004-0013","volume":"22","author":"H-S Wang","year":"2004","unstructured":"Wang H-S, Hung S-C, Peng S-T, Huang C-C, Wei H-M, Guo Y-J, et al. Mesenchymal stem cells in the Wharton\u2019s jelly of the human umbilical cord. Stem Cells. 2004;22:1330\u20137.","journal-title":"Stem Cells"},{"key":"1295_CR14","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1080\/14653240600855905","volume":"8","author":"M Dominici","year":"2006","unstructured":"Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini FC, Krause DS, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006;8:315\u20137.","journal-title":"Cytotherapy."},{"key":"1295_CR15","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1186\/s13287-015-0192-0","volume":"6","author":"F Alcayaga-Miranda","year":"2015","unstructured":"Alcayaga-Miranda F, Cuenca J, Martin A, Contreras L, Figueroa FE, Khoury M. Combination therapy of menstrual derived mesenchymal stem cells and antibiotics ameliorates survival in sepsis. Stem Cell Res Ther. 2015;6:199.","journal-title":"Stem Cell Res Ther"},{"key":"1295_CR16","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1634\/stemcells.2004-0024","volume":"22","author":"RA Panepucci","year":"2004","unstructured":"Panepucci RA, Siufi JLC, Silva WA, Proto-Siquiera R, Neder L, Orellana M, et al. Comparison of gene expression of umbilical cord vein and bone marrow-derived mesenchymal stem cells. Stem Cells. 2004;22:1263\u201378.","journal-title":"Stem Cells"},{"key":"1295_CR17","doi-asserted-by":"publisher","first-page":"695","DOI":"10.3892\/ijmm.2014.1821","volume":"34","author":"X Li","year":"2014","unstructured":"Li X, Bai J, Ji X, Li R, Xuan Y, Wang Y. Comprehensive characterization of four different populations of human mesenchymal stem cells as regards their immune properties, proliferation and differentiation. Int J Mol Med. 2014;34:695\u2013704.","journal-title":"Int J Mol Med"},{"key":"1295_CR18","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"M Singer","year":"2016","unstructured":"Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315:801.","journal-title":"JAMA."},{"key":"1295_CR19","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1001\/jama.2016.0289","volume":"315","author":"M Shankar-Hari","year":"2016","unstructured":"Shankar-Hari M, Phillips GS, Levy ML, Seymour CW, Liu VX, Deutschman CS, et al. Developing a new definition and assessing new clinical criteria for septic shock: for the third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315:775.","journal-title":"JAMA."},{"key":"1295_CR20","doi-asserted-by":"publisher","first-page":"e269","DOI":"10.1371\/journal.pmed.0040269","volume":"4","author":"SH Mei","year":"2007","unstructured":"Mei SH, McCarter SD, Deng Y, Parker CH, Liles WC, Stewart DJ. Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin 1. PLoS Med. 2007;4:e269.","journal-title":"PLoS Med"},{"key":"1295_CR21","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1164\/rccm.201001-0010OC","volume":"182","author":"SHJ Mei","year":"2010","unstructured":"Mei SHJ, Haitsma JJ, Dos Santos CC, Deng Y, Lai PFH, Slutsky AS, et al. Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis. Am J Respir Crit Care Med. 2010;182:1047\u201357.","journal-title":"Am J Respir Crit Care Med"},{"key":"1295_CR22","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1136\/gut.2008.168534","volume":"58","author":"E Gonzalez-Rey","year":"2009","unstructured":"Gonzalez-Rey E, Anderson P, Gonz\u00e1lez MA, Rico L, B\u00fcscher D, Delgado M. Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis. Gut. 2009;58:929\u201339.","journal-title":"Gut."},{"key":"1295_CR23","first-page":"719","volume":"63","author":"L Pedrazza","year":"2014","unstructured":"Pedrazza L, Lunardelli A, Luft C, Cruz CU, de Mesquita FC, Bitencourt S, et al. Mesenchymal stem cells decrease splenocytes apoptosis in a sepsis experimental model. Inflamm Res Off J Eur Histamine Res Soc Al. 2014;63:719\u201328.","journal-title":"Inflamm Res Off J Eur Histamine Res Soc Al"},{"key":"1295_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2172-15-1","volume":"15","author":"H Kim","year":"2014","unstructured":"Kim H, Darwish I, Monroy M-F, Prockop DJ, Liles WC, Kain KC. Mesenchymal stromal (stem) cells suppress pro-inflammatory cytokine production but fail to improve survival in experimental staphylococcal toxic shock syndrome. BMC Immunol. 2014;15:1.","journal-title":"BMC Immunol"},{"key":"1295_CR25","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1038\/nm.1905","volume":"15","author":"K N\u00e9meth","year":"2009","unstructured":"N\u00e9meth K, Leelahavanichkul A, Yuen PST, Mayer B, Parmelee A, Doi K, et al. Bone marrow stromal cells attenuate sepsis via prostaglandin E2\u2013dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med. 2009;15:42\u20139.","journal-title":"Nat Med"},{"key":"1295_CR26","doi-asserted-by":"publisher","first-page":"823","DOI":"10.3727\/096368910X508942","volume":"19","author":"H Yagi","year":"2010","unstructured":"Yagi H, Soto-Gutierrez A, Kitagawa Y, Tilles AW, Tompkins RG, Yarmush ML. Bone marrow mesenchymal stromal cells attenuate organ injury induced by LPS and burn. Cell Transplant. 2010;19:823\u201330.","journal-title":"Cell Transplant"},{"key":"1295_CR27","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1165\/rcmb.2004-0330OC","volume":"33","author":"M Rojas","year":"2005","unstructured":"Rojas M, Xu J, Woods CR, Mora AL, Spears W, Roman J, et al. Bone marrow\u2013derived mesenchymal stem cells in repair of the injured lung. Am J Respir Cell Mol Biol. 2005;33:145\u201352.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"1295_CR28","doi-asserted-by":"publisher","first-page":"10145","DOI":"10.1038\/ncomms10145","volume":"6","author":"P Rocheteau","year":"2015","unstructured":"Rocheteau P, Chatre L, Briand D, Mebarki M, Jouvion G, Bardon J, et al. Sepsis induces long-term metabolic and mitochondrial muscle stem cell dysfunction amenable by mesenchymal stem cell therapy. Nat Commun. 2015;6:10145.","journal-title":"Nat Commun"},{"key":"1295_CR29","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s40635-018-0194-1","volume":"6","author":"C Laroye","year":"2018","unstructured":"Laroye C, Lemari\u00e9 J, Boufenzer A, Labroca P, Cunat L, Alauzet C, et al. Clinical-grade mesenchymal stem cells derived from umbilical cord improve septic shock in pigs. Intensive Care Med Exp. 2018;6:24.","journal-title":"Intensive Care Med Exp"},{"key":"1295_CR30","doi-asserted-by":"publisher","first-page":"17986","DOI":"10.3390\/ijms140917986","volume":"14","author":"H Jin","year":"2013","unstructured":"Jin H, Bae Y, Kim M, Kwon S-J, Jeon H, Choi S, et al. Comparative analysis of human mesenchymal stem cells from bone marrow, adipose tissue, and umbilical cord blood as sources of cell therapy. Int J Mol Sci. 2013;14:17986\u20138001.","journal-title":"Int J Mol Sci"},{"key":"1295_CR31","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.tim.2011.01.001","volume":"19","author":"L Dejager","year":"2011","unstructured":"Dejager L, Pinheiro I, Dejonckheere E, Libert C. Cecal ligation and puncture: the gold standard model for polymicrobial sepsis? Trends Microbiol. 2011;19:198\u2013208.","journal-title":"Trends Microbiol"},{"key":"1295_CR32","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1084\/jem.20040708","volume":"200","author":"S Gibot","year":"2004","unstructured":"Gibot S. A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine Sepsis. J Exp Med. 2004;200:1419\u201326.","journal-title":"J Exp Med"},{"key":"1295_CR33","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1093\/cvr\/cvy018","volume":"114","author":"L Jolly","year":"2018","unstructured":"Jolly L, Carrasco K, Derive M, Lemari\u00e9 J, Boufenzer A, Gibot S. Targeted endothelial gene deletion of triggering receptor expressed on myeloid cells-1 protects mice during septic shock. Cardiovasc Res. 2018;114:907\u201318.","journal-title":"Cardiovasc Res"},{"key":"1295_CR34","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1002\/stem.1270","volume":"31","author":"SRR Hall","year":"2013","unstructured":"Hall SRR, Tsoyi K, Ith B, Padera RF, Lederer JA, Wang Z, et al. Mesenchymal stromal cells improve survival during sepsis in the absence of heme oxygenase-1: the importance of neutrophils. Stem Cells. 2013;31:397\u2013407.","journal-title":"Stem Cells"},{"key":"1295_CR35","first-page":"439","volume":"6","author":"H-H Chen","year":"2014","unstructured":"Chen H-H, Chang C-L, Lin K-C, Sung P-H, Chai H-T, Zhen Y-Y, et al. Melatonin augments apoptotic adipose-derived mesenchymal stem cell treatment against sepsis-induced acute lung injury. Am J Transl Res. 2014;6:439.","journal-title":"Am J Transl Res"},{"key":"1295_CR36","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.exphem.2015.10.009","volume":"44","author":"K Mareschi","year":"2016","unstructured":"Mareschi K, Castiglia S, Sanavio F, Rustichelli D, Muraro M, Defedele D, et al. Immunoregulatory effects on T lymphocytes by human mesenchymal stromal cells isolated from bone marrow, amniotic fluid, and placenta. Exp Hematol. 2016;44:138\u2013150.e1.","journal-title":"Exp Hematol"},{"key":"1295_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/583984","volume":"2015","author":"RN B\u00e1rcia","year":"2015","unstructured":"B\u00e1rcia RN, Santos JM, Filipe M, Teixeira M, Martins JP, Almeida J, et al. What makes umbilical cord tissue-derived mesenchymal stromal cells superior immunomodulators when compared to bone marrow derived mesenchymal stromal cells? Stem Cells Int. 2015;2015:1\u201314.","journal-title":"Stem Cells Int"},{"key":"1295_CR38","doi-asserted-by":"publisher","first-page":"e110338","DOI":"10.1371\/journal.pone.0110338","volume":"9","author":"Y-H Chao","year":"2014","unstructured":"Chao Y-H, Wu H-P, Wu K-H, Tsai Y-G, Peng C-T, Lin K-C, et al. An increase in CD3+CD4+CD25+ regulatory T cells after administration of umbilical cord-derived mesenchymal stem cells during sepsis. PLoS One. 2014;9:e110338 Zimmer J, editor.","journal-title":"PLoS One"},{"key":"1295_CR39","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.biocel.2016.08.013","volume":"79","author":"W Liu","year":"2016","unstructured":"Liu W, Gao Y, Li H, Wang H, Ye M, Jiang G, et al. Intravenous transplantation of mesenchymal stromal cells has therapeutic effects in a sepsis mouse model through inhibition of septic natural killer cells. Int J Biochem Cell Biol. 2016;79:93\u2013103.","journal-title":"Int J Biochem Cell Biol"},{"key":"1295_CR40","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1002\/stem.2891","volume":"36","author":"D Perlee","year":"2018","unstructured":"Perlee D, van Vught LA, Scicluna BP, Maag A, Lutter R, Kemper EM, et al. Intravenous infusion of human adipose mesenchymal stem cells modifies the host response to lipopolysaccharide in humans: a randomized, single-blind, parallel group, placebo controlled trial: mesenchymal stem cells in human endotoxemia. Stem Cells. 2018;36:1778\u201388.","journal-title":"Stem Cells"},{"key":"1295_CR41","doi-asserted-by":"publisher","first-page":"2430","DOI":"10.1002\/stem.1729","volume":"32","author":"G Moll","year":"2014","unstructured":"Moll G, Alm JJ, Davies LC, von Bahr L, Heldring N, Stenbeck-Funke L, et al. Do cryopreserved mesenchymal stromal cells display impaired immunomodulatory and therapeutic properties?: therapeutic efficacy of fresh versus thawed MSCs. Stem Cells. 2014;32:2430\u201342.","journal-title":"Stem Cells"},{"key":"1295_CR42","doi-asserted-by":"publisher","first-page":"147","DOI":"10.3109\/14653249.2011.623691","volume":"14","author":"M Fran\u00e7ois","year":"2012","unstructured":"Fran\u00e7ois M, Copland IB, Yuan S, Romieu-Mourez R, Waller EK, Galipeau J. Cryopreserved mesenchymal stromal cells display impaired immunosuppressive properties as a result of heat-shock response and impaired interferon-\u03b3 licensing. Cytotherapy. 2012;14:147\u201352.","journal-title":"Cytotherapy."},{"key":"1295_CR43","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.jcyt.2014.10.018","volume":"17","author":"J Luetzkendorf","year":"2015","unstructured":"Luetzkendorf J, Nerger K, Hering J, Moegel A, Hoffmann K, Hoefers C, et al. Cryopreservation does not alter main characteristics of good manufacturing process\u2013grade human multipotent mesenchymal stromal cells including immunomodulating potential and lack of malignant transformation. Cytotherapy. 2015;17:186\u201398.","journal-title":"Cytotherapy."},{"key":"1295_CR44","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.jcyt.2016.11.008","volume":"19","author":"RN B\u00e1rcia","year":"2017","unstructured":"B\u00e1rcia RN, Santos JM, Teixeira M, Filipe M, Pereira ARS, Ministro A, et al. Umbilical cord tissue\u2013derived mesenchymal stromal cells maintain immunomodulatory and angiogenic potencies after cryopreservation and subsequent thawing. Cytotherapy. 2017;19:360\u201370.","journal-title":"Cytotherapy."},{"key":"1295_CR45","doi-asserted-by":"publisher","first-page":"339","DOI":"10.3389\/fimmu.2017.00339","volume":"8","author":"F Alcayaga-Miranda","year":"2017","unstructured":"Alcayaga-Miranda F, Cuenca J, Khoury M. Antimicrobial activity of mesenchymal stem cells: current status and new perspectives of antimicrobial peptide-based therapies. Front Immunol. 2017;8:339.","journal-title":"Front Immunol"},{"key":"1295_CR46","doi-asserted-by":"publisher","first-page":"2210","DOI":"10.1002\/stem.2372","volume":"34","author":"MV Jackson","year":"2016","unstructured":"Jackson MV, Morrison TJ, Doherty DF, McAuley DF, Matthay MA, Kissenpfennig A, et al. Mitochondrial transfer via tunneling nanotubes (TNT) is an important mechanism by which mesenchymal stem cells enhance macrophage phagocytosis in the in vitro and in vivo models of ARDS: mitochondrial transfer from MSC to macrophages. Stem Cells. 2016;34:2210\u201323.","journal-title":"Stem Cells"},{"key":"1295_CR47","doi-asserted-by":"publisher","first-page":"L1003","DOI":"10.1152\/ajplung.00180.2011","volume":"302","author":"A Krasnodembskaya","year":"2012","unstructured":"Krasnodembskaya A, Samarani G, Song Y, Zhuo H, Su X, Lee J-W, et al. Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytes. AJP Lung Cell Mol Physiol. 2012;302:L1003\u201313.","journal-title":"AJP Lung Cell Mol Physiol"},{"key":"1295_CR48","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1164\/rccm.201705-1006OC","volume":"197","author":"LA McIntyre","year":"2018","unstructured":"McIntyre LA, Stewart DJ, Mei SHJ, Courtman D, Watpool I, Granton J, et al. Cellular immunotherapy for septic shock. A phase I clinical trial. Am J Respir Crit Care Med. 2018;197:337\u201347.","journal-title":"Am J Respir Crit Care Med"},{"key":"1295_CR49","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.trsl.2018.04.006","volume":"199","author":"X He","year":"2018","unstructured":"He X. Umbilical cord-derived mesenchymal stem (stromal) cells for treatment of severe sepsis: a phase 1 clinical trial. Transl Res. 2018;199:10.","journal-title":"Transl Res"},{"key":"1295_CR50","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/s13287-017-0555-9","volume":"8","author":"AK Batsali","year":"2017","unstructured":"Batsali AK, Pontikoglou C, Koutroulakis D, Pavlaki KI, Damianaki A, Mavroudi I, et al. Differential expression of cell cycle and WNT pathway-related genes accounts for differences in the growth and differentiation potential of Wharton\u2019s jelly and bone marrow-derived mesenchymal stem cells. Stem Cell Res Ther. 2017;8:102.","journal-title":"Stem Cell Res Ther"},{"key":"1295_CR51","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1186\/s13287-017-0609-z","volume":"8","author":"L Avercenc-L\u00e9ger","year":"2017","unstructured":"Avercenc-L\u00e9ger L, Guerci P, Virion J-M, Cauchois G, Hupont S, Rahouadj R, et al. Umbilical cord-derived mesenchymal stromal cells: predictive obstetric factors for cell proliferation and chondrogenic differentiation. Stem Cell Res Ther. 2017;8:161.","journal-title":"Stem Cell Res Ther"},{"key":"1295_CR52","doi-asserted-by":"publisher","first-page":"e0164269","DOI":"10.1371\/journal.pone.0164269","volume":"11","author":"I Sammour","year":"2016","unstructured":"Sammour I, Somashekar S, Huang J, Batlahally S, Breton M, Valasaki K, et al. The effect of gender on mesenchymal stem cell (MSC) efficacy in neonatal hyperoxia-induced lung injury. PLoS One. 2016;11:e0164269 Kirchmair R, editor.","journal-title":"PLoS One"},{"key":"1295_CR53","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1479-5876-12-8","volume":"12","author":"MS Choudhery","year":"2014","unstructured":"Choudhery MS, Badowski M, Muise A, Pierce J, Harris DT. Donor age negatively impacts adipose tissue-derived mesenchymal stem cell expansion and differentiation. J Transl Med. 2014;12:8.","journal-title":"J Transl Med"},{"key":"1295_CR54","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1002\/sctm.17-0060","volume":"6","author":"JM Greenberg","year":"2017","unstructured":"Greenberg JM, Carballosa CM, Cheung HS. Concise review: the deleterious effects of cigarette smoking and nicotine usage and mesenchymal stem cell function and implications for cell-based therapies: cigarette smoking, nicotine, and MSC function. Stem Cells Transl Med. 2017;6:1815\u201321.","journal-title":"Stem Cells Transl Med"},{"key":"1295_CR55","doi-asserted-by":"publisher","first-page":"647","DOI":"10.2337\/db15-0849","volume":"65","author":"KE Boyle","year":"2016","unstructured":"Boyle KE, Patinkin ZW, Shapiro ALB, Baker PR, Dabelea D, Friedman JE. Mesenchymal stem cells from infants born to obese mothers exhibit greater potential for adipogenesis: the healthy start BabyBUMP project. Diabetes. 2016;65:647\u201359.","journal-title":"Diabetes."},{"issue":"1","key":"1295_CR56","doi-asserted-by":"publisher","first-page":"103","DOI":"10.2174\/1875043501104010103","volume":"4","author":"Laura Pierdomenico","year":"2011","unstructured":"Pierdomenico L, Lanuti P, Lachmann R, Grifone G, Cianci E, Gial\u00f2 L, et al. Diabetes mellitus during pregnancy interferes with the biological characteristics of Wharton\u2019s jelly mesenchymal stem cells. Open Tissue Eng Regen Med J. 2011;4 [cited 2017 Aug 2]. Available from: \n                    https:\/\/benthamopen.com\/ABSTRACT\/TOTERMJ-4-103\n                    \n                  .","journal-title":"The Open Tissue Engineering and Regenerative Medicine Journal"}],"container-title":["Stem Cell Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-019-1295-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13287-019-1295-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-019-1295-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T23:15:48Z","timestamp":1593126948000},"score":1,"resource":{"primary":{"URL":"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/s13287-019-1295-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,27]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1295"],"URL":"https:\/\/doi.org\/10.1186\/s13287-019-1295-9","relation":{},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,27]]},"assertion":[{"value":"9 April 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 May 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was carried out in accordance with the recommendations of the French national legislation regarding human sample collection, manipulation, and personal data protection with written informed consent from all subjects. All subjects gave written informed consent in accordance with the Declaration of Helsinki. The protocol was approved by the Nancy Hospital ethics committee and French ministry of research (No. DC-2014-2114).This study was carried out in accordance with the recommendations of the National Institute of Health guidelines on the Use of Laboratory Animals. The protocol was approved by the University Animal Care Committee (Comit\u00e9 d\u2019\u00c9thique Lorrain en Mati\u00e8re d\u2019Exp\u00e9rimentation Animale (CELMEA - CE2A-66)).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"192"}}