{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T20:26:40Z","timestamp":1793996800501,"version":"4.8.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"national natural science foundation of china","doi-asserted-by":"publisher","award":["81903262"],"award-info":[{"award-number":["81903262"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"national natural science foundation of china","doi-asserted-by":"publisher","award":["82030056"],"award-info":[{"award-number":["82030056"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002767","name":"hunan provincial science and technology department","doi-asserted-by":"publisher","award":["2020SK51103"],"award-info":[{"award-number":["2020SK51103"]}],"id":[{"id":"10.13039\/501100002767","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Radiation-induced dermatitis is a serious side effect of radiotherapy, and very few effective treatments are currently available for this condition. We previously demonstrated that apoptosis is an important feature of radiation-induced dermatitis and adipose-derived stem cells (ADSCs) are one of the most promising types of stem cells that have a protective effect on acute radiation-induced dermatitis. Cathepsin F (CTSF) is a recently discovered protein that plays an important role in apoptosis. In this study, we investigated whether ADSCs affect chronic radiation-induced dermatitis, and the underlying mechanisms involved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>ADSCs were isolated from male Sprague-Dawley (SD) rats and characterized. For in vivo studies, rats were randomly divided into control and ADSC-treated groups, and cultured ADSCs were transplanted into radiation-induced dermatitis model rats. The effects of ADSC transplantation were determined by skin damage scoring, histopathological analysis, electron microscopy, immunohistochemical staining, and western blotting analysis of apoptosis-related proteins. To evaluate the effects of ADSCs in vitro, radiation-induced apoptotic cells were treated with ADSC culture supernatant, and apoptosis-related protein expression was investigated by TUNEL staining, flow cytometry, and western blotting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the in vivo studies, skin damage, inflammation, fibrosis, and apoptosis were reduced and hair follicle and sebaceous gland regeneration were enhanced in the ADSC group compared with the control group. Further,\n                      <jats:italic>CTSF<\/jats:italic>\n                      and downstream pro-apoptotic proteins (Bid, BAX, and caspase 9) were downregulated, while anti-apoptotic proteins (Bcl-2 and Bcl-XL) were upregulated. In vitro, ADSCs markedly attenuated radiation-induced apoptosis, downregulated\n                      <jats:italic>CTSF<\/jats:italic>\n                      and downstream pro-apoptotic proteins, and upregulated anti-apoptotic proteins.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      ADSCs protect against radiation-induced dermatitis by exerting an anti-apoptotic effect through inhibition of\n                      <jats:italic>CTSF<\/jats:italic>\n                      expression. ADSCs may be a good therapeutic candidate to prevent the development of radiation-induced dermatitis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13287-021-02516-1","type":"journal-article","created":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T04:03:24Z","timestamp":1628481804000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Adipose-derived stem cells alleviate radiation-induced dermatitis by suppressing apoptosis and downregulating cathepsin F expression"],"prefix":"10.1186","volume":"12","author":[{"given":"Chaoling","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiyan","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongyi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmeng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowu","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,9]]},"reference":[{"issue":"9","key":"2516_CR1","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1111\/ijd.13371","volume":"56","author":"F Hegedus","year":"2017","unstructured":"Hegedus F, Mathew LM, Schwartz RA. Radiation dermatitis: an overview. Int J Dermatol. 2017;56(9):909\u201314. https:\/\/doi.org\/10.1111\/ijd.13371.","journal-title":"Int J Dermatol"},{"issue":"3 Pt 2","key":"2516_CR2","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1038\/jid.2011.411","volume":"132","author":"JL Ryan","year":"2012","unstructured":"Ryan JL. Ionizing radiation: the good, the bad, and the ugly. J Invest Dermatol. 2012;132(3 Pt 2):985\u201393. https:\/\/doi.org\/10.1038\/jid.2011.411.","journal-title":"J Invest Dermatol"},{"issue":"10","key":"2516_CR3","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1097\/01.SMJ.0000140866.97278.87","volume":"97","author":"JL Harper","year":"2004","unstructured":"Harper JL, Franklin LE, Jenrette JM, Aguero EG. Skin toxicity during breast irradiation: pathophysiology and management. South Med J. 2004;97(10):989\u201393. https:\/\/doi.org\/10.1097\/01.SMJ.0000140866.97278.87.","journal-title":"South Med J"},{"issue":"10","key":"2516_CR4","doi-asserted-by":"publisher","first-page":"2933","DOI":"10.1007\/s00520-013-1896-2","volume":"21","author":"RK Wong","year":"2013","unstructured":"Wong RK, Bensadoun RJ, Boers-Doets CB, et al. Clinical practice guidelines for the prevention and treatment of acute and late radiation reactions from the MASCC Skin Toxicity Study Group. Support Care Cancer. 2013;21(10):2933\u201348. https:\/\/doi.org\/10.1007\/s00520-013-1896-2.","journal-title":"Support Care Cancer"},{"issue":"6","key":"2516_CR5","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1016\/j.bjps.2007.01.003","volume":"61","author":"I Hashimoto","year":"2008","unstructured":"Hashimoto I, Sedo H, Inatsugi K, Nakanishi H, Arase S. Severe radiation-induced injury after cardiac catheter ablation: a case requiring free anterolateral thigh flap and vastus lateralis muscle flap reconstruction on the upper arm. J Plast Reconstr Aesthet Surg. 2008;61(6):704\u20138. https:\/\/doi.org\/10.1016\/j.bjps.2007.01.003.","journal-title":"J Plast Reconstr Aesthet Surg"},{"issue":"5","key":"2516_CR6","doi-asserted-by":"publisher","first-page":"3178","DOI":"10.1111\/jcmm.14174","volume":"23","author":"X Sheng","year":"2019","unstructured":"Sheng X, Zhou Y, Wang H, Shen Y, Liao Q, Rao Z, et al. Establishment and characterization of a radiation-induced dermatitis rat model. J Cell Mol Med. 2019;23(5):3178\u201389. https:\/\/doi.org\/10.1111\/jcmm.14174.","journal-title":"J Cell Mol Med"},{"issue":"1","key":"2516_CR7","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/cr.2007.109","volume":"18","author":"MS Huen","year":"2008","unstructured":"Huen MS, Chen J. The DNA damage response pathways: at the crossroad of protein modifications. Cell Res. 2008;18(1):8\u201316. https:\/\/doi.org\/10.1038\/cr.2007.109.","journal-title":"Cell Res"},{"issue":"23","key":"2516_CR8","doi-asserted-by":"publisher","first-page":"9808","DOI":"10.1158\/0008-5472.CAN-10-1118","volume":"70","author":"PJ Coates","year":"2010","unstructured":"Coates PJ, Appleyard MV, Murray K, et al. Differential contextual responses of normal human breast epithelium to ionizing radiation in a mouse xenograft model. Cancer Res. 2010;70(23):9808\u201315. https:\/\/doi.org\/10.1158\/0008-5472.CAN-10-1118.","journal-title":"Cancer Res"},{"issue":"8","key":"2516_CR9","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1016\/j.freeradbiomed.2009.01.023","volume":"46","author":"JK Tak","year":"2009","unstructured":"Tak JK, Park JW. The use of ebselen for radioprotection in cultured cells and mice. Free Radic Biol Med. 2009;46(8):1177\u201385. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2009.01.023.","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"2516_CR10","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/s10555-017-9669-x","volume":"36","author":"S Gandhi","year":"2017","unstructured":"Gandhi S, Chandna S. Radiation-induced inflammatory cascade and its reverberating crosstalks as potential cause of post-radiotherapy second malignancies. Cancer Metastasis Rev. 2017;36(2):375\u201393. https:\/\/doi.org\/10.1007\/s10555-017-9669-x.","journal-title":"Cancer Metastasis Rev"},{"issue":"12","key":"2516_CR11","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1080\/09553000600568002","volume":"81","author":"VL Calveley","year":"2005","unstructured":"Calveley VL, Khan MA, Yeung IW, et al. Partial volume rat lung irradiation: temporal fluctuations of in-field and out-of-field DNA damage and inflammatory cytokines following irradiation. Int J Radiat Biol. 2005;81(12):887\u201399. https:\/\/doi.org\/10.1080\/09553000600568002.","journal-title":"Int J Radiat Biol"},{"issue":"1","key":"2516_CR12","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1210\/jc.2018-01171","volume":"104","author":"S Ezquerro","year":"2019","unstructured":"Ezquerro S, Mocha F, Fruhbeck G, et al. Ghrelin Reduces TNF-alpha-Induced Human Hepatocyte Apoptosis, Autophagy, and Pyroptosis: Role in Obesity-Associated NAFLD. J Clin Endocrinol Metab. 2019;104(1):21\u201337. https:\/\/doi.org\/10.1210\/jc.2018-01171.","journal-title":"J Clin Endocrinol Metab"},{"key":"2516_CR13","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.fsi.2017.05.030","volume":"66","author":"C Gao","year":"2017","unstructured":"Gao C, Fu Q, Su B, Song H, Zhou S, Tan F, et al. The involvement of cathepsin F gene (CTSF) in turbot (Scophthalmus maximus L.) mucosal immunity. Fish Shellfish Immunol. 2017;66:270\u20139. https:\/\/doi.org\/10.1016\/j.fsi.2017.05.030.","journal-title":"Fish Shellfish Immunol"},{"issue":"1","key":"2516_CR14","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3727\/096504017X14928634401204","volume":"26","author":"C Ji","year":"2018","unstructured":"Ji C, Zhao Y, Kou YW, Shao H, Guo L, Bao CH, et al. Cathepsin F Knockdown Induces Proliferation and Inhibits Apoptosis in Gastric Cancer Cells. Oncol Res. 2018;26(1):83\u201393. https:\/\/doi.org\/10.3727\/096504017X14928634401204.","journal-title":"Oncol Res"},{"issue":"7","key":"2516_CR15","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1038\/s41591-018-0043-5","volume":"24","author":"A Janic","year":"2018","unstructured":"Janic A, Valente LJ, Wakefield MJ, di Stefano L, Milla L, Wilcox S, et al. DNA repair processes are critical mediators of p53-dependent tumor suppression. Nat Med. 2018;24(7):947\u201353. https:\/\/doi.org\/10.1038\/s41591-018-0043-5.","journal-title":"Nat Med"},{"issue":"2","key":"2516_CR16","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1089\/107632701300062859","volume":"7","author":"PA Zuk","year":"2001","unstructured":"Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, Katz AJ, et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng. 2001;7(2):211\u201328. https:\/\/doi.org\/10.1089\/107632701300062859.","journal-title":"Tissue Eng"},{"key":"2516_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fsurg.2015.00001","volume":"2","author":"L Shukla","year":"2015","unstructured":"Shukla L, Morrison WA, Shayan R. Adipose-derived stem cells in radiotherapy injury: a new frontier. Front Surg. 2015;2:1.","journal-title":"Front Surg"},{"key":"2516_CR18","first-page":"87","volume":"2018","author":"M Lee","year":"1691","unstructured":"Lee M, Ban JJ, Yang S, et al. The exosome of adipose-derived stem cells reduces beta-amyloid pathology and apoptosis of neuronal cells derived from the transgenic mouse model of Alzheimer's disease. Brain Res. 1691;2018:87\u201393.","journal-title":"Brain Res"},{"issue":"1","key":"2516_CR19","doi-asserted-by":"publisher","first-page":"14608","DOI":"10.1038\/s41598-017-15022-3","volume":"7","author":"T Kotani","year":"2017","unstructured":"Kotani T, Masutani R, Suzuka T, Oda K, Makino S, Ii M. Anti-inflammatory and anti-fibrotic effects of intravenous adipose-derived stem cell transplantation in a mouse model of bleomycin-induced interstitial pneumonia. Sci Rep. 2017;7(1):14608. https:\/\/doi.org\/10.1038\/s41598-017-15022-3.","journal-title":"Sci Rep"},{"issue":"1","key":"2516_CR20","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/s13287-018-0846-9","volume":"9","author":"S Chen","year":"2018","unstructured":"Chen S, Cui G, Peng C, Lavin MF, Sun X, Zhang E, et al. Transplantation of adipose-derived mesenchymal stem cells attenuates pulmonary fibrosis of silicosis via anti-inflammatory and anti-apoptosis effects in rats. Stem Cell Res Ther. 2018;9(1):110. https:\/\/doi.org\/10.1186\/s13287-018-0846-9.","journal-title":"Stem Cell Res Ther"},{"issue":"2","key":"2516_CR21","doi-asserted-by":"publisher","first-page":"150","DOI":"10.11817\/j.issn.1672-7347.2019.02.006","volume":"44","author":"Z Liu","year":"2019","unstructured":"Liu Z, Rao Z, Sheng X, Long Y, Zhou X. Effect of adipose-derived stem cells on radiation-induced acute skin injury in rats. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2019;44(2):150\u20137. https:\/\/doi.org\/10.11817\/j.issn.1672-7347.2019.02.006.","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban"},{"issue":"6","key":"2516_CR22","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1080\/09553007614551411","volume":"30","author":"SB Field","year":"1976","unstructured":"Field SB, Law MP. The relationship between early and late radiation damage in rodents' skin. Int J Radiat Biol Relat Stud Phys Chem Med. 1976;30(6):557\u201364. https:\/\/doi.org\/10.1080\/09553007614551411.","journal-title":"Int J Radiat Biol Relat Stud Phys Chem Med"},{"issue":"1","key":"2516_CR23","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/1748-717X-3-40","volume":"3","author":"S Kumar","year":"2008","unstructured":"Kumar S, Kolozsvary A, Kohl R, Lu M, Brown S, Kim JH. Radiation-induced skin injury in the animal model of scleroderma: implications for post-radiotherapy fibrosis. Radiat Oncol. 2008;3(1):40. https:\/\/doi.org\/10.1186\/1748-717X-3-40.","journal-title":"Radiat Oncol"},{"issue":"5","key":"2516_CR24","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1097\/01.prs.0000256047.47909.71","volume":"119","author":"G Rigotti","year":"2007","unstructured":"Rigotti G, Marchi A, Galie M, et al. Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant: a healing process mediated by adipose-derived adult stem cells. Plast Reconstr Surg. 2007;119(5):1409\u201322; discussion 1423-1404. https:\/\/doi.org\/10.1097\/01.prs.0000256047.47909.71.","journal-title":"Plast Reconstr Surg"},{"issue":"2","key":"2516_CR25","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1097\/PRS.0b013e31821e6e90","volume":"128","author":"SM Sultan","year":"2011","unstructured":"Sultan SM, Stern CS, Allen RJ Jr, Thanik VD, Chang CC, Nguyen PD, et al. Human fat grafting alleviates radiation skin damage in a murine model. Plast Reconstr Surg. 2011;128(2):363\u201372. https:\/\/doi.org\/10.1097\/PRS.0b013e31821e6e90.","journal-title":"Plast Reconstr Surg"},{"issue":"1","key":"2516_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00277-006-0166-5","volume":"86","author":"S Francois","year":"2007","unstructured":"Francois S, Mouiseddine M, Mathieu N, et al. Human mesenchymal stem cells favour healing of the cutaneous radiation syndrome in a xenogenic transplant model. Ann Hematol. 2007;86(1):1\u20138. https:\/\/doi.org\/10.1007\/s00277-006-0166-5.","journal-title":"Ann Hematol"},{"issue":"1","key":"2516_CR27","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/1423-0127-20-51","volume":"20","author":"SP Huang","year":"2013","unstructured":"Huang SP, Huang CH, Shyu JF, Lee HS, Chen SG, Chan JYH, et al. Promotion of wound healing using adipose-derived stem cells in radiation ulcer of a rat model. J Biomed Sci. 2013;20(1):51. https:\/\/doi.org\/10.1186\/1423-0127-20-51.","journal-title":"J Biomed Sci"},{"key":"2516_CR28","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/j.biopha.2018.02.093","volume":"101","author":"Z Liu","year":"2018","unstructured":"Liu Z, Yu D, Xu J, Li X, Wang X, He Z, et al. Human umbilical cord mesenchymal stem cells improve irradiation-induced skin ulcers healing of rat models. Biomed Pharmacother. 2018;101:729\u201336. https:\/\/doi.org\/10.1016\/j.biopha.2018.02.093.","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"2516_CR29","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1186\/s13287-019-1456-x","volume":"10","author":"X Rong","year":"2019","unstructured":"Rong X, Li J, Yang Y, Shi L, Jiang T. Human fetal skin-derived stem cell secretome enhances radiation-induced skin injury therapeutic effects by promoting angiogenesis. Stem Cell Res Ther. 2019;10(1):383. https:\/\/doi.org\/10.1186\/s13287-019-1456-x.","journal-title":"Stem Cell Res Ther"},{"issue":"2","key":"2516_CR30","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.jdermsci.2007.08.004","volume":"49","author":"WS Kim","year":"2008","unstructured":"Kim WS, Park BS, Kim HK, Park JS, Kim KJ, Choi JS, et al. Evidence supporting antioxidant action of adipose-derived stem cells: protection of human dermal fibroblasts from oxidative stress. J Dermatol Sci. 2008;49(2):133\u201342. https:\/\/doi.org\/10.1016\/j.jdermsci.2007.08.004.","journal-title":"J Dermatol Sci"},{"issue":"11","key":"2516_CR31","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1002\/sctm.19-0317","volume":"9","author":"MR Borrelli","year":"2020","unstructured":"Borrelli MR, Patel RA, Adem S, Diaz Deleon NM, Shen AH, Sokol J, et al. The antifibrotic adipose-derived stromal cell: Grafted fat enriched with CD74+ adipose-derived stromal cells reduces chronic radiation-induced skin fibrosis. Stem Cells Transl Med. 2020;9(11):1401\u201313. https:\/\/doi.org\/10.1002\/sctm.19-0317.","journal-title":"Stem Cells Transl Med"},{"issue":"10","key":"2516_CR32","doi-asserted-by":"publisher","first-page":"e77895","DOI":"10.1371\/journal.pone.0077895","volume":"8","author":"S Neri","year":"2013","unstructured":"Neri S, Bourin P, Peyrafitte JA, Cattini L, Facchini A, Mariani E. Human adipose stromal cells (ASC) for the regeneration of injured cartilage display genetic stability after in vitro culture expansion. PLoS One. 2013;8(10):e77895. https:\/\/doi.org\/10.1371\/journal.pone.0077895.","journal-title":"PLoS One"},{"issue":"10","key":"2516_CR33","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1111\/exd.13451","volume":"27","author":"EW Choi","year":"2018","unstructured":"Choi EW, Seo MK, Woo EY, Kim SH, Park EJ, Kim S. Exosomes from human adipose-derived stem cells promote proliferation and migration of skin fibroblasts. Exp Dermatol. 2018;27(10):1170\u20132. https:\/\/doi.org\/10.1111\/exd.13451.","journal-title":"Exp Dermatol"},{"issue":"8","key":"2516_CR34","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1080\/15384101.2018.1480207","volume":"17","author":"Z Zheng","year":"2018","unstructured":"Zheng Z, Liu L, Zhan Y, Yu S, Kang T. Adipose-derived stem cell-derived microvesicle-released miR-210 promoted proliferation, migration and invasion of endothelial cells by regulating RUNX3. Cell Cycle. 2018;17(8):1026\u201333. https:\/\/doi.org\/10.1080\/15384101.2018.1480207.","journal-title":"Cell Cycle"},{"issue":"7","key":"2516_CR35","doi-asserted-by":"publisher","first-page":"535","DOI":"10.2174\/1574888X12666170829161058","volume":"12","author":"CH Won","year":"2017","unstructured":"Won CH, Park GH, Wu X, Tran TN, Park KY, Park BS, et al. The Basic Mechanism of Hair Growth Stimulation by Adipose-derived Stem Cells and Their Secretory Factors. Curr Stem Cell Res Ther. 2017;12(7):535\u201343. https:\/\/doi.org\/10.2174\/1574888X12666170829161058.","journal-title":"Curr Stem Cell Res Ther"},{"issue":"1","key":"2516_CR36","doi-asserted-by":"publisher","first-page":"512","DOI":"10.18632\/oncotarget.13473","volume":"8","author":"TH Shin","year":"2017","unstructured":"Shin TH, Lee BC, Choi SW, Shin JH, Kang I, Lee JY, et al. Human adipose tissue-derived mesenchymal stem cells alleviate atopic dermatitis via regulation of B lymphocyte maturation. Oncotarget. 2017;8(1):512\u201322. https:\/\/doi.org\/10.18632\/oncotarget.13473.","journal-title":"Oncotarget"},{"issue":"10","key":"2516_CR37","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1161\/01.CIR.0000121425.42966.F1","volume":"109","author":"J Rehman","year":"2004","unstructured":"Rehman J, Traktuev D, Li J, Merfeld-Clauss S, Temm-Grove CJ, Bovenkerk JE, et al. Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation. 2004;109(10):1292\u20138. https:\/\/doi.org\/10.1161\/01.CIR.0000121425.42966.F1.","journal-title":"Circulation"},{"issue":"1","key":"2516_CR38","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1186\/s13287-019-1289-7","volume":"10","author":"X Li","year":"2019","unstructured":"Li X, Ma T, Sun J, Shen M, Xue X, Chen Y, et al. Harnessing the secretome of adipose-derived stem cells in the treatment of ischemic heart diseases. Stem Cell Res Ther. 2019;10(1):196. https:\/\/doi.org\/10.1186\/s13287-019-1289-7.","journal-title":"Stem Cell Res Ther"}],"container-title":["Stem Cell Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-021-02516-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13287-021-02516-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-021-02516-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T04:34:38Z","timestamp":1628483678000},"score":1,"resource":{"primary":{"URL":"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/s13287-021-02516-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,9]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2516"],"URL":"https:\/\/doi.org\/10.1186\/s13287-021-02516-1","relation":{},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,9]]},"assertion":[{"value":"21 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethics approval was obtained from the Animal Ethics Committee of Hunan Cancer Hospital, the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"447"}}