{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T18:59:06Z","timestamp":1789239546685,"version":"build-2803163510"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T00:00:00Z","timestamp":1635552000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T00:00:00Z","timestamp":1635552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"national natural science foundation of china","doi-asserted-by":"publisher","award":["31971365"],"award-info":[{"award-number":["31971365"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"national key r&d program of china","award":["2017YFA0102801"],"award-info":[{"award-number":["2017YFA0102801"]}]},{"name":"national key r&d program of china","award":["2017YFC1001901"],"award-info":[{"award-number":["2017YFC1001901"]}]},{"DOI":"10.13039\/501100021171","name":"guangdong basic and applied basic research foundation","doi-asserted-by":"crossref","award":["2020B1515120090"],"award-info":[{"award-number":["2020B1515120090"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"crossref"}]},{"name":"guangdong special support program","award":["2019BT02Y276"],"award-info":[{"award-number":["2019BT02Y276"]}]},{"name":"guangzhou science and technology project","award":["201803010020"],"award-info":[{"award-number":["201803010020"]}]},{"name":"guangzhou science and technology project","award":["201803010032"],"award-info":[{"award-number":["201803010032"]}]},{"DOI":"10.13039\/501100012226","name":"fundamental research funds for the central universities","doi-asserted-by":"publisher","award":["19lgpy190"],"award-info":[{"award-number":["19lgpy190"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Diabetic cutaneous ulcers (DCU) are a complication of diabetes with diabetic foot ulcers being the most common, and the wounds are difficult to heal, increasing the risk of bacterial infection. Cell-based therapy utilizing mesenchymal stem cells (MSCs) is currently being investigated as a therapeutic avenue for both chronic diabetic ulcers and severe burns. Wharton\u2019s jelly mesenchymal stem cell (WJMSC) with PF-127 hydrogel and sodium ascorbyl phosphate (SAP) improved skin wound healing in mice. Whether this combination strategy is helpful to diabetic ulcers wound healing remains to be explored.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Firstly, the WJMSCs embedded in PF-127 and SAP combination were transplanted onto excisional cutaneous wound bed in type 2 diabetic Sprague Dawley (SD) rats. Two weeks after transplantation, the skin tissue was collected for histological and immunohistochemical analysis. Further, overexpressing-EGFP WJMSCs were performed to investigate cell engraftment in the diabetic cutaneous ulcer. The apoptosis of WJMSCs which encapsulated with combination of PF-127 and SAP was detected by TUNEL fluorescence assay and RT-PCR in vitro. And the mitochondrial damage induced by oxidative stress assessed by MitoTracker and CMH2DCFDA fluorescence assay.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In diabetic cutaneous wound rat model, PF-127 plus SAP-encapsulated WJMSCs transplantation promoted diabetic wound healing, indicating improving dermis regeneration and collagen deposition. In diabetic wound healing, less pro-inflammatory M1 macrophages, more anti-inflammatory M2 tissue-healing macrophages, and neovascularization were observed in PF-127\u2009+\u2009SAP\u2009+\u2009WJMSCs group compared with other groups. SAP supplementation alleviated the apoptosis ratio of WJMSCs embedded in the PF-127 in vitro and promoted cell survival in vivo.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>PF-127 plus SAP combination facilitates WJMSCs-mediated diabetic wound healing in rat through promoting cell survival, the macrophage transformation, and angiogenesis. Our findings may potentially provide a helpful therapeutic strategy for patients with diabetic cutaneous ulcer.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13287-021-02626-w","type":"journal-article","created":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T16:02:38Z","timestamp":1635609758000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Wharton\u2019s jelly mesenchymal stem cells embedded in PF-127 hydrogel plus sodium ascorbyl phosphate combination promote diabetic wound healing in type 2 diabetic rat"],"prefix":"10.1186","volume":"12","author":[{"given":"Yiren","family":"Jiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxia","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunxing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxun","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3417-1196","authenticated-orcid":false,"given":"Junjiu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,30]]},"reference":[{"key":"2626_CR1","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.diabres.2018.02.023","volume":"138","author":"NH Cho","year":"2018","unstructured":"Cho NH, Shaw JE, Karuranga S, et al. IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract. 2018;138:271\u201381.","journal-title":"Diabetes Res Clin Pract"},{"key":"2626_CR2","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1016\/S0140-6736(05)67698-2","volume":"366","author":"AJ Boulton","year":"2005","unstructured":"Boulton AJ, Vileikyte L, Ragnarson-Tennvall G, et al. The global burden of diabetic foot disease. Lancet (London, England). 2005;366:1719\u201324.","journal-title":"Lancet (London, England)"},{"key":"2626_CR3","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1080\/14712598.2017.1333596","volume":"17","author":"J Adeghate","year":"2017","unstructured":"Adeghate J, Nurulain S, Tekes K, et al. Novel biological therapies for the treatment of diabetic foot ulcers. Expert Opin Biol Ther. 2017;17:979\u201387.","journal-title":"Expert Opin Biol Ther"},{"key":"2626_CR4","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s13287-016-0303-6","volume":"7","author":"DE Lee","year":"2016","unstructured":"Lee DE, Ayoub N, Agrawal DK. Mesenchymal stem cells and cutaneous wound healing: novel methods to increase cell delivery and therapeutic efficacy. Stem Cell Res Ther. 2016;7:37.","journal-title":"Stem Cell Res Ther"},{"key":"2626_CR5","first-page":"23","volume":"5","author":"BC Dash","year":"2018","unstructured":"Dash BC, Xu Z, Lin L, et al. Stem cells and engineered scaffolds for regenerative wound healing. Bioengineering (Basel, Switzerland). 2018;5:23.","journal-title":"Bioengineering (Basel, Switzerland)."},{"key":"2626_CR6","doi-asserted-by":"publisher","first-page":"2588","DOI":"10.2337\/db12-1822","volume":"62","author":"A O'Loughlin","year":"2013","unstructured":"O\u2019Loughlin A, Kulkarni M, Creane M, et al. Topical administration of allogeneic mesenchymal stromal cells seeded in a collagen scaffold augments wound healing and increases angiogenesis in the diabetic rabbit ulcer. Diabetes. 2013;62:2588\u201394.","journal-title":"Diabetes"},{"key":"2626_CR7","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.ymthe.2017.09.023","volume":"26","author":"SR Park","year":"2018","unstructured":"Park SR, Kim JW, Jun HS, et al. Stem cell secretome and its effect on cellular mechanisms relevant to wound healing. Mol Ther J Am Soc Gene Ther. 2018;26:606\u201317.","journal-title":"Mol Ther J Am Soc Gene Ther"},{"key":"2626_CR8","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.retram.2019.09.001","volume":"68","author":"LL Liau","year":"2020","unstructured":"Liau LL, Ruszymah BHI, Ng MH, et al. Characteristics and clinical applications of Wharton\u2019s jelly-derived mesenchymal stromal cells. Curr Res Transl Med. 2020;68:5\u201316.","journal-title":"Curr Res Transl Med"},{"key":"2626_CR9","doi-asserted-by":"publisher","first-page":"80","DOI":"10.7150\/ijbs.7237","volume":"10","author":"QS Zhao","year":"2013","unstructured":"Zhao QS, Xia N, Zhao N, et al. Localization of human mesenchymal stem cells from umbilical cord blood and their role in repair of diabetic foot ulcers in rats. Int J Biol Sci. 2013;10:80\u20139.","journal-title":"Int J Biol Sci"},{"key":"2626_CR10","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1055\/s-0042-103684","volume":"124","author":"HL Qin","year":"2016","unstructured":"Qin HL, Zhu XH, Zhang B, et al. Clinical evaluation of human umbilical cord mesenchymal stem cell transplantation after angioplasty for diabetic foot. Exp Clin Endocrinol Diabetes. 2016;124:497\u2013503.","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"2626_CR11","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1089\/scd.2009.0397","volume":"20","author":"M Khan","year":"2011","unstructured":"Khan M, Akhtar S, Mohsin S, et al. Growth factor preconditioning increases the function of diabetes-impaired mesenchymal stem cells. Stem Cells Dev. 2011;20:67\u201375.","journal-title":"Stem Cells Dev"},{"key":"2626_CR12","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1007\/s00774-015-0662-6","volume":"34","author":"B Zhang","year":"2016","unstructured":"Zhang B, Liu N, Shi H, et al. High glucose microenvironments inhibit the proliferation and migration of bone mesenchymal stem cells by activating GSK3\u03b2. J Bone Miner Metab. 2016;34:140\u201350.","journal-title":"J Bone Miner Metab"},{"key":"2626_CR13","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1159\/000381877","volume":"62","author":"D Duscher","year":"2016","unstructured":"Duscher D, Barrera J, Wong VW, et al. Stem cells in wound healing: the future of regenerative medicine? A mini-review. Gerontology. 2016;62:216\u201325.","journal-title":"Gerontology"},{"key":"2626_CR14","doi-asserted-by":"crossref","unstructured":"Hashemi SS, Mohammadi AA, Moshirabadi K, et al. The effect of dermal fibroblasts and mesenchymal stem cells seeded on an amniotic membrane scaffold in skin regeneration: a case series. J Cosmet Dermatol. 2021.","DOI":"10.1111\/jocd.14043"},{"key":"2626_CR15","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.jconrel.2015.04.032","volume":"209","author":"MS Akash","year":"2015","unstructured":"Akash MS, Rehman K. Recent progress in biomedical applications of Pluronic (PF127): pharmaceutical perspectives. J Control Rel. 2015;209:120\u201338.","journal-title":"J Control Rel"},{"key":"2626_CR16","doi-asserted-by":"publisher","first-page":"e00390","DOI":"10.1016\/j.heliyon.2017.e00390","volume":"3","author":"A Fakhari","year":"2017","unstructured":"Fakhari A, Corcoran M, Schwarz A. Thermogelling properties of purified poloxamer 407. Heliyon. 2017;3:e00390.","journal-title":"Heliyon."},{"key":"2626_CR17","doi-asserted-by":"publisher","first-page":"5911","DOI":"10.2147\/IJN.S249129","volume":"15","author":"J Yang","year":"2020","unstructured":"Yang J, Chen Z, Pan D, et al. Umbilical cord-derived mesenchymal stem cell-derived exosomes combined pluronic F127 hydrogel promote chronic diabetic wound healing and complete skin regeneration. Int J Nanomed. 2020;15:5911\u201326.","journal-title":"Int J Nanomed"},{"key":"2626_CR18","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1177\/0192623318810199","volume":"47","author":"S Yogev","year":"2019","unstructured":"Yogev S, Shabtay-Orbach A, Nyska A, et al. Local toxicity of topically administrated thermoresponsive systems: in vitro studies with in vivo correlation. Toxicol Pathol. 2019;47:426\u201332.","journal-title":"Toxicol Pathol"},{"key":"2626_CR19","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1089\/ten.2005.11.974","volume":"11","author":"SF Khattak","year":"2005","unstructured":"Khattak SF, Bhatia SR, Roberts SC. Pluronic F127 as a cell encapsulation material: utilization of membrane-stabilizing agents. Tissue Eng. 2005;11:974\u201383.","journal-title":"Tissue Eng"},{"key":"2626_CR20","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1177\/0885328208096534","volume":"24","author":"JM Brunet-Maheu","year":"2009","unstructured":"Brunet-Maheu JM, Fernandes JC, de Lacerda CA, et al. Pluronic F-127 as a cell carrier for bone tissue engineering. J Biomater Appl. 2009;24:275\u201387.","journal-title":"J Biomater Appl"},{"key":"2626_CR21","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1186\/s13287-020-01638-2","volume":"11","author":"Q Deng","year":"2020","unstructured":"Deng Q, Huang S, Wen J, et al. PF-127 hydrogel plus sodium ascorbyl phosphate improves Wharton\u2019s jelly mesenchymal stem cell-mediated skin wound healing in mice. Stem Cell Res Ther. 2020;11:143.","journal-title":"Stem Cell Res Ther"},{"key":"2626_CR22","first-page":"1339","volume":"73","author":"H Khan","year":"2016","unstructured":"Khan H, Akhtar N, Ali A, et al. Physical and chemical stability analysis of cosmetic multiple emulsions loaded with ascorbyl palmitate and sodium ascorbyl phosphate salts. Acta Pol Pharm. 2016;73:1339\u201349.","journal-title":"Acta Pol Pharm"},{"key":"2626_CR23","doi-asserted-by":"publisher","first-page":"644160","DOI":"10.3389\/fcell.2021.644160","volume":"9","author":"K Meng","year":"2021","unstructured":"Meng K, Cai H, Cai S, et al. Adiponectin modified BMSCs alleviate heart fibrosis via inhibition TGF-beta1\/smad in diabetic rats. Front Cell Dev Biol. 2021;9:644160.","journal-title":"Front Cell Dev Biol"},{"key":"2626_CR24","doi-asserted-by":"publisher","first-page":"327","DOI":"10.3390\/ijms19020327","volume":"19","author":"Y Jiao","year":"2018","unstructured":"Jiao Y, Huang B, Chen Y, et al. Integrated analyses reveal overexpressed Notch1 promoting porcine satellite cells\u2019 proliferation through regulating the cell cycle. Int J Mol Sci. 2018;19:327.","journal-title":"Int J Mol Sci"},{"key":"2626_CR25","doi-asserted-by":"publisher","first-page":"605875","DOI":"10.3389\/fcell.2021.605875","volume":"9","author":"B Huang","year":"2021","unstructured":"Huang B, Jiao Y, Zhu Y, et al. Mdfi promotes C2C12 cell differentiation and positively modulates fast-to-slow-twitch muscle fiber transformation. Front Cell Dev Biol. 2021;9:605875.","journal-title":"Front Cell Dev Biol"},{"key":"2626_CR26","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1089\/wound.2014.0561","volume":"5","author":"LE Tracy","year":"2016","unstructured":"Tracy LE, Minasian RA, Caterson EJ. Extracellular matrix and dermal fibroblast function in the healing wound. Adv Wound Care. 2016;5:119\u201336.","journal-title":"Adv Wound Care"},{"key":"2626_CR27","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1038\/nrm3904","volume":"15","author":"C Bonnans","year":"2014","unstructured":"Bonnans C, Chou J, Werb Z. Remodelling the extracellular matrix in development and disease. Nat Rev Mol Cell Biol. 2014;15:786\u2013801.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2626_CR28","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1126\/science.1253836","volume":"346","author":"BK Sun","year":"2014","unstructured":"Sun BK, Siprashvili Z, Khavari PA. Advances in skin grafting and treatment of cutaneous wounds. Science (New York, NY). 2014;346:941\u20135.","journal-title":"Science (New York, NY)"},{"key":"2626_CR29","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s00383-017-4179-z","volume":"34","author":"AS Klar","year":"2018","unstructured":"Klar AS, Michalak-Micka K, Biedermann T, et al. Characterization of M1 and M2 polarization of macrophages in vascularized human dermo-epidermal skin substitutes in vivo. Pediatr Surg Int. 2018;34:129\u201335.","journal-title":"Pediatr Surg Int"},{"key":"2626_CR30","doi-asserted-by":"publisher","first-page":"2596","DOI":"10.1016\/j.ajpath.2015.06.001","volume":"185","author":"A Das","year":"2015","unstructured":"Das A, Sinha M, Datta S, et al. Monocyte and macrophage plasticity in tissue repair and regeneration. Am J Pathol. 2015;185:2596\u2013606.","journal-title":"Am J Pathol"},{"key":"2626_CR31","doi-asserted-by":"publisher","first-page":"146293","DOI":"10.1016\/j.brainres.2019.06.012","volume":"1720","author":"Y Yu","year":"2019","unstructured":"Yu Y, Wang D, Li H, et al. Mesenchymal stem cells derived from induced pluripotent stem cells play a key role in immunomodulation during cardiopulmonary resuscitation. Brain Res. 2019;1720:146293.","journal-title":"Brain Res"},{"key":"2626_CR32","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1038\/nm.3887","volume":"21","author":"SL Wong","year":"2015","unstructured":"Wong SL, Demers M, Martinod K, et al. Diabetes primes neutrophils to undergo NETosis, which impairs wound healing. Nat Med. 2015;21:815\u20139.","journal-title":"Nat Med"},{"key":"2626_CR33","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1126\/science.aam7928","volume":"356","author":"SA Eming","year":"2017","unstructured":"Eming SA, Wynn TA, Martin P. Inflammation and metabolism in tissue repair and regeneration. Science (New York, NY). 2017;356:1026\u201330.","journal-title":"Science (New York, NY)"},{"key":"2626_CR34","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/1523-1747.ep12471216","volume":"89","author":"JN Mansbridge","year":"1987","unstructured":"Mansbridge JN, Knapp AM. Changes in keratinocyte maturation during wound healing. J Investig Dermatol. 1987;89:253\u201363.","journal-title":"J Investig Dermatol"},{"key":"2626_CR35","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1083\/jcb.49.2.247","volume":"49","author":"WS Krawczyk","year":"1971","unstructured":"Krawczyk WS. A pattern of epidermal cell migration during wound healing. J Cell Biol. 1971;49:247\u201363.","journal-title":"J Cell Biol"},{"key":"2626_CR36","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.addr.2018.06.019","volume":"146","author":"P Rousselle","year":"2019","unstructured":"Rousselle P, Braye F, Dayan G. Re-epithelialization of adult skin wounds: cellular mechanisms and therapeutic strategies. Adv Drug Deliv Rev. 2019;146:344\u201365.","journal-title":"Adv Drug Deliv Rev"},{"key":"2626_CR37","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.tibs.2018.08.004","volume":"43","author":"R Sales Gil","year":"2018","unstructured":"Sales Gil R, Vagnarelli P. Ki-67: more hidden behind a \u201cclassic proliferation marker.\u201d Trends Biochem Sci. 2018;43:747\u20138.","journal-title":"Trends Biochem Sci"},{"key":"2626_CR38","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1097\/BOR.0b013e32835b13b6","volume":"25","author":"LA DiPietro","year":"2013","unstructured":"DiPietro LA. Angiogenesis and scar formation in healing wounds. Curr Opin Rheumatol. 2013;25:87\u201391.","journal-title":"Curr Opin Rheumatol"},{"key":"2626_CR39","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1172\/JCI32169","volume":"117","author":"H Brem","year":"2007","unstructured":"Brem H, Tomic-Canic M. Cellular and molecular basis of wound healing in diabetes. J Clin Investig. 2007;117:1219\u201322.","journal-title":"J Clin Investig"},{"key":"2626_CR40","doi-asserted-by":"publisher","first-page":"2514","DOI":"10.1161\/ATVBAHA.107.151456","volume":"27","author":"A Woodfin","year":"2007","unstructured":"Woodfin A, Voisin MB, Nourshargh S. PECAM-1: a multi-functional molecule in inflammation and vascular biology. Arterioscler Thromb Vasc Biol. 2007;27:2514\u201323.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2626_CR41","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.phrs.2016.12.035","volume":"117","author":"S Zhang","year":"2017","unstructured":"Zhang S, Chen S, Li Y, et al. Melatonin as a promising agent of regulating stem cell biology and its application in disease therapy. Pharmacol Res. 2017;117:252\u201360.","journal-title":"Pharmacol Res"},{"key":"2626_CR42","doi-asserted-by":"publisher","first-page":"e109090","DOI":"10.1371\/journal.pone.0109090","volume":"9","author":"SG Choi","year":"2014","unstructured":"Choi SG, Lee SE, Kang BS, et al. Thermosensitive and mucoadhesive sol-gel composites of paclitaxel\/dimethyl-\u03b2-cyclodextrin for buccal delivery. PLoS ONE. 2014;9:e109090.","journal-title":"PLoS ONE"},{"key":"2626_CR43","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1186\/s13287-017-0718-8","volume":"8","author":"H Yang","year":"2017","unstructured":"Yang H, Wu S, Feng R, et al. Vitamin C plus hydrogel facilitates bone marrow stromal cell-mediated endometrium regeneration in rats. Stem Cell Res Ther. 2017;8:267.","journal-title":"Stem Cell Res Ther"},{"key":"2626_CR44","doi-asserted-by":"publisher","first-page":"108823","DOI":"10.1016\/j.abb.2021.108823","volume":"701","author":"M Fiocchetti","year":"2021","unstructured":"Fiocchetti M, Cracco P, Montalesi E, et al. Neuroglobin and mitochondria: the impact on neurodegenerative diseases. Arch Biochem Biophys. 2021;701:108823.","journal-title":"Arch Biochem Biophys"},{"key":"2626_CR45","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s10495-021-01661-5","volume":"26","author":"J Jia","year":"2021","unstructured":"Jia J, Jin H, Nan D, et al. New insights into targeting mitochondria in ischemic injury. Apoptosis Int J Program Cell Death. 2021;26:163\u201383.","journal-title":"Apoptosis Int J Program Cell Death"},{"key":"2626_CR46","doi-asserted-by":"publisher","first-page":"2897","DOI":"10.7150\/thno.40495","volume":"10","author":"Y Li","year":"2020","unstructured":"Li Y, He Y, Miao K, et al. Imaging of macrophage mitochondria dynamics in vivo reveals cellular activation phenotype for diagnosis. Theranostics. 2020;10:2897\u2013917.","journal-title":"Theranostics"},{"key":"2626_CR47","first-page":"999","volume":"9","author":"Y Zhao","year":"2019","unstructured":"Zhao Y, Liu S, Zhou L, et al. Aberrant shuttling of long noncoding RNAs during the mitochondria-nuclear crosstalk in hepatocellular carcinoma cells. Am J Cancer Res. 2019;9:999\u20131008.","journal-title":"Am J Cancer Res"},{"key":"2626_CR48","first-page":"228080001983035","volume":"17","author":"P Varela","year":"2019","unstructured":"Varela P, Sartori S, Viebahn R, et al. Macrophage immunomodulation: an indispensable tool to evaluate the performance of wound dressing biomaterials. J Appl Biomater Funct Mater. 2019;17:2280800019830355.","journal-title":"J Appl Biomater Funct Mater"},{"key":"2626_CR49","doi-asserted-by":"publisher","first-page":"4678","DOI":"10.1038\/s41467-020-18276-0","volume":"11","author":"AP Sawaya","year":"2020","unstructured":"Sawaya AP, Stone RC, Brooks SR, et al. Deregulated immune cell recruitment orchestrated by FOXM1 impairs human diabetic wound healing. Nat Commun. 2020;11:4678.","journal-title":"Nat Commun"},{"key":"2626_CR50","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.3390\/ijms18071545","volume":"18","author":"M Hesketh","year":"2017","unstructured":"Hesketh M, Sahin KB, West ZE, et al. Macrophage phenotypes regulate scar formation and chronic wound healing. Int J Mol Sci. 2017;18:1545.","journal-title":"Int J Mol Sci"},{"key":"2626_CR51","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1159\/000339613","volume":"49","author":"JM Reinke","year":"2012","unstructured":"Reinke JM, Sorg H. Wound repair and regeneration. European surgical research Europaische chirurgische Forschung Recherches chirurgicales europeennes. 2012;49:35\u201343.","journal-title":"European surgical research Europaische chirurgische Forschung Recherches chirurgicales europeennes"},{"key":"2626_CR52","doi-asserted-by":"publisher","first-page":"3706315","DOI":"10.1155\/2019\/3706315","volume":"2019","author":"L Ca\u00f1edo-Dorantes","year":"2019","unstructured":"Ca\u00f1edo-Dorantes L, Ca\u00f1edo-Ayala M. Skin acute wound healing: a comprehensive review. Int J Inflamm. 2019;2019:3706315.","journal-title":"Int J Inflamm"},{"key":"2626_CR53","doi-asserted-by":"publisher","first-page":"256043","DOI":"10.1155\/2013\/256043","volume":"2013","author":"J Berlanga-Acosta","year":"2013","unstructured":"Berlanga-Acosta J, Schultz GS, L\u00f3pez-Mola E, et al. Glucose toxic effects on granulation tissue productive cells: the diabetics\u2019 impaired healing. BioMed Res Int. 2013;2013:256043.","journal-title":"BioMed Res Int"},{"key":"2626_CR54","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1159\/000492413","volume":"59","author":"FS Frueh","year":"2018","unstructured":"Frueh FS, Sanchez-Macedo N, Calcagni M, et al. The crucial role of vascularization and lymphangiogenesis in skin reconstruction. European surgical research Europaische chirurgische Forschung Recherches chirurgicales europeennes. 2018;59:242\u201354.","journal-title":"European surgical research Europaische chirurgische Forschung Recherches chirurgicales europeennes"},{"key":"2626_CR55","doi-asserted-by":"publisher","first-page":"3606","DOI":"10.1172\/JCI81423","volume":"125","author":"NA Manieri","year":"2015","unstructured":"Manieri NA, Mack MR, Himmelrich MD, et al. Mucosally transplanted mesenchymal stem cells stimulate intestinal healing by promoting angiogenesis. J Clin Investig. 2015;125:3606\u201318.","journal-title":"J Clin Investig"},{"key":"2626_CR56","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/j.biopha.2018.08.013","volume":"107","author":"M Gadelkarim","year":"2018","unstructured":"Gadelkarim M, Abushouk AI, Ghanem E, et al. Adipose-derived stem cells: effectiveness and advances in delivery in diabetic wound healing. Biomed Pharmacother. 2018;107:625\u201333.","journal-title":"Biomed Pharmacother"},{"key":"2626_CR57","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.3390\/ijms20082019","volume":"20","author":"A Musia\u0142-Wysocka","year":"2019","unstructured":"Musia\u0142-Wysocka A, Kot M, Su\u0142kowski M, et al. Regenerative potential of the product \u201cCARDIOCELL\u201d derived from the Wharton\u2019s jelly mesenchymal stem cells for treating hindlimb ischemia. Int J Mol Sci. 2019;20:2019.","journal-title":"Int J Mol Sci"}],"container-title":["Stem Cell Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-021-02626-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13287-021-02626-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-021-02626-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T17:07:18Z","timestamp":1635613638000},"score":1,"resource":{"primary":{"URL":"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/s13287-021-02626-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,30]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2626"],"URL":"https:\/\/doi.org\/10.1186\/s13287-021-02626-w","relation":{},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,30]]},"assertion":[{"value":"24 June 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experiments involving animals were performed in accordance with guidelines approved by the Institutional Animal Care and Use Committee of Sun Yat-Sen University, P.R. China.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"559"}}