{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T01:26:52Z","timestamp":1792891612912,"version":"4.5.0"},"reference-count":88,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T00:00:00Z","timestamp":1641945600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T00:00:00Z","timestamp":1641945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100012459","name":"Chongqing Graduate Student Research Innovation Project","doi-asserted-by":"publisher","award":["CYS20223"],"award-info":[{"award-number":["CYS20223"]}],"id":[{"id":"10.13039\/501100012459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012457","name":"Chongqing Basic and Frontier Research Project","doi-asserted-by":"publisher","award":["20190122"],"award-info":[{"award-number":["20190122"]}],"id":[{"id":"10.13039\/501100012457","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012669","name":"Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission","doi-asserted-by":"publisher","award":["cstc2020jcyj-msxmX0206"],"award-info":[{"award-number":["cstc2020jcyj-msxmX0206"]}],"id":[{"id":"10.13039\/501100012669","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and technology research project of Chongqing Municipal Education Commission","award":["KJQN20190432"],"award-info":[{"award-number":["KJQN20190432"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Caused by the injury to the endometrial basal layer, intrauterine adhesions (IUA) are characterized by uterine cavity obliteration, leading to impaired fertility. Human amniotic mesenchymal stem cells (hAMSCs) have the potential to promote endometrial regeneration mainly through paracrine ability. PPCNg is a thermoresponsive biomaterial consisted of Poly (polyethylene glycol citrate-co-<jats:italic>N<\/jats:italic>-isopropylacrylamide) (PPCN) mixed with gelatin, which has been reported as a scaffold for stem cell transplantation. This study aims to investigate the therapeutic effect of hAMSCs combined with PPCNg transplantation in promoting the regeneration of injured endometrium.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>hAMSCs were cultured in different concentrates of PPCNg in vitro, and their proliferation, apoptosis and cell cycle were examined by CCK-8 assay and flow cytometry. Immunofluorescence was used to determine the MSCs specific surface markers. The expression of pluripotent genes was analyzed by qRT-PCR. The multiple-lineage differentiation potential was further evaluated by detecting the differentiation-related genes using qRT-PCR and specific staining. The Sprague\u2013Dawley (SD) rat IUA model was established with 95% ethanol. hAMSCs combined with PPCNg were transplanted through intrauterine injection. The retention of DiR-labeled hAMSCs was observed by vivo fluorescence imaging. The endometrium morphology was assessed using hematoxylin and eosin (H&amp;E) and Masson staining. Immunohistochemistry staining was performed to detect biomarkers related to endometrial proliferation, re-epithelialization, angiogenesis and endometrial receptivity. The function of regenerated endometrium was evaluated by pregnancy tests.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>hAMSCs maintained normal cell proliferation, apoptosis and cell cycle in PPCNg. Immunofluorescence and qRT-PCR showed that hAMSCs cultured in PPCNg and hAMSCs cultured alone expressed the same surface markers and pluripotent genes. hAMSCs exhibited normal multilineage differentiation potential in PPCNg. Vivo fluorescence imaging results revealed that the fluorescence intensity of hAMSCs combined with PPCNg intrauterine transplantation was stronger than that of direct hAMSCs intrauterine transplantation. Histological assays showed the increase in the thickness of endometrial and the number of endometrial glands, and the remarkably decrease in the fibrosis area in the PPCNg\/hAMSCs group. The expressions of Ki-67, CK7, CK19, VEGF, ER and PR were significantly increased in the PPCNg\/hAMSCs group. Moreover, the number of implanted embryos and pregnancy rate were significantly higher in the PPCNg\/hAMSCs group than in the hAMSCs group.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>PPCNg is suitable for growth, phenotype maintenance and multilineage differentiation of hAMSCs. hAMSCs combined with PPCNg intrauterine transplantation can facilitate the regeneration of injured endometrium by improving utilization rates of hAMSCs, and eventually restore reproductive capacity.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13287-021-02682-2","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T18:02:46Z","timestamp":1642010566000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Human amniotic mesenchymal stem cells combined with PPCNg facilitate injured endometrial regeneration"],"prefix":"10.1186","volume":"13","author":[{"given":"Jiayue","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Gou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nizhou","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congcong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benyuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinpei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhua","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingfeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6709-728X","authenticated-orcid":false,"given":"Jia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,12]]},"reference":[{"issue":"2","key":"2682_CR1","first-page":"137","volume":"11","author":"LA Torres-De La Roche","year":"2019","unstructured":"Torres-De La Roche LA, Campo R, Devassy R, Dei S, Sardo A, Hooker A, Koninckx P, et al. Adhesions and anti-adhesion systems highlights. Facts Views Vis Obgyn. 2019;11(2):137\u201349.","journal-title":"Facts Views Vis Obgyn"},{"issue":"2","key":"2682_CR2","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1093\/humupd\/dmt045","volume":"20","author":"AB Hooker","year":"2014","unstructured":"Hooker AB, Lemmers M, Thurkow AL, Heymans MW, Opmeer BC, Brolmann HA, et al. Systematic review and meta-analysis of intrauterine adhesions after miscarriage: prevalence, risk factors and long-term reproductive outcome. Hum Reprod Update. 2014;20(2):262\u201378. https:\/\/doi.org\/10.1093\/humupd\/dmt045.","journal-title":"Hum Reprod Update"},{"key":"2682_CR3","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.ejogrb.2016.05.050","volume":"203","author":"A Di Spiezio Sardo","year":"2016","unstructured":"Di Spiezio Sardo A, Calagna G, Scognamiglio M, Oonovan P, Campo R, De Wilde RL. Prevention of intrauterine post-surgical adhesions in hysteroscopy. A systematic review. Eur J Obstet Gynecol Reprod Biol. 2016;203:182\u201392. https:\/\/doi.org\/10.1016\/j.ejogrb.2016.05.050.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"4","key":"2682_CR4","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/j.fertnstert.2008.02.09","volume":"89","author":"D Yu","year":"2008","unstructured":"Yu D, Wong YM, Cheong Y, Xia E, Li TC. Asherman syndrome\u2013one century later. Fertil Steril. 2008;89(4):759\u201379. https:\/\/doi.org\/10.1016\/j.fertnstert.2008.02.09.","journal-title":"Fertil Steril"},{"issue":"5","key":"2682_CR5","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1590\/s1516-31802007000500002","volume":"125","author":"A Salzani","year":"2007","unstructured":"Salzani A, Yela DA, Gabiatti JR, Bedone AJ, Monteiro IM. Prevalence of uterine synechia after abortion evacuation curettage. Sao Paulo Med J. 2007;125(5):261\u20134. https:\/\/doi.org\/10.1590\/s1516-31802007000500002.","journal-title":"Sao Paulo Med J"},{"issue":"7","key":"2682_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2020.101797","volume":"49","author":"P Capmas","year":"2020","unstructured":"Capmas P, Mihalache A, Duminil L, Hor LS, Pourcelot AG, Fernandez H. Intrauterine adhesions: what is the pregnancy rate after hysteroscopic management? J Gynecol Obstet Hum Reprod. 2020;49(7): 101797. https:\/\/doi.org\/10.1016\/j.jogoh.2020.101797.","journal-title":"J Gynecol Obstet Hum Reprod"},{"issue":"3","key":"2682_CR7","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1080\/14647273.2018.1444798","volume":"22","author":"L Liu","year":"2019","unstructured":"Liu L, Huang X, Xia E, Zhang X, Li TC, Liu Y. A cohort study comparing 4 mg and 10 mg daily doses of postoperative oestradiol therapy to prevent adhesion reformation after hysteroscopic adhesiolysis. Hum Fertil (Camb). 2019;22(3):191\u20137. https:\/\/doi.org\/10.1080\/14647273.2018.1444798.","journal-title":"Hum Fertil (Camb)"},{"issue":"6","key":"2682_CR8","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.tjog.2019.09.002","volume":"58","author":"Z Fei","year":"2019","unstructured":"Fei Z, Bin Z, Xin X, Fei H, Yuechong C. Meta-analysis on the use of hyaluronic acid gel to prevent recurrence of intrauterine adhesion after hysteroscopic adhesiolysis. Taiwan J Obstet Gynecol. 2019;58(6):731\u20136. https:\/\/doi.org\/10.1016\/j.tjog.2019.09.002.","journal-title":"Taiwan J Obstet Gynecol"},{"issue":"7","key":"2682_CR9","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/j.jmig.2017.08.005","volume":"24","author":"X Peng","year":"2017","unstructured":"Peng X, Li T, Zhao Y, Guo Y, Xia E. Safety and efficacy of amnion graft in preventing reformation of intrauterine adhesions. J Minim Invasive Gynecol. 2017;24(7):1204\u201310. https:\/\/doi.org\/10.1016\/j.jmig.2017.08.005.","journal-title":"J Minim Invasive Gynecol"},{"issue":"8","key":"2682_CR10","doi-asserted-by":"publisher","first-page":"784","DOI":"10.3390\/cells8080784","volume":"8","author":"X Fu","year":"2019","unstructured":"Fu X, Liu G, Halim A, Ju Y, Luo Q, Song AG. Mesenchymal stem cell migration and tissue repair. Cells. 2019;8(8):784. https:\/\/doi.org\/10.3390\/cells8080784.","journal-title":"Cells"},{"key":"2682_CR11","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.pharmthera.2019.04.005","volume":"200","author":"P Li","year":"2019","unstructured":"Li P, Gong Z, Shultz LD, Ren G. Mesenchymal stem cells: from regeneration to cancer. Pharmacol Ther. 2019;200:42\u201354. https:\/\/doi.org\/10.1016\/j.pharmthera.2019.04.005.","journal-title":"Pharmacol Ther"},{"key":"2682_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biologicals.2020.08.003","volume":"67","author":"A Liubaviciute","year":"2020","unstructured":"Liubaviciute A, Ivaskiene T, Biziuleviciene G. Modulated mesenchymal stromal cells improve skin wound healing. Biologicals. 2020;67:1\u20138. https:\/\/doi.org\/10.1016\/j.biologicals.2020.08.003.","journal-title":"Biologicals"},{"issue":"7","key":"2682_CR13","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1080\/14712598.2019.1607836","volume":"19","author":"O Al-Jaibaji","year":"2019","unstructured":"Al-Jaibaji O, Swioklo S, Connon CJ. Mesenchymal stromal cells for ocular surface repair. Expert Opin Biol Ther. 2019;19(7):643\u201353. https:\/\/doi.org\/10.1080\/14712598.2019.1607836.","journal-title":"Expert Opin Biol Ther"},{"key":"2682_CR14","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-021-10243-6","author":"D Bhartiya","year":"2021","unstructured":"Bhartiya D, Singh P, Sharma D, Kaushik A. Very small embryonic-like stem cells (VSELs) regenerate whereas mesenchymal stromal cells (MSCs) rejuvenate diseased reproductive tissues. Stem Cell Rev Rep. 2021. https:\/\/doi.org\/10.1007\/s12015-021-10243-6.","journal-title":"Stem Cell Rev Rep"},{"issue":"1","key":"2682_CR15","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s13287-019-1136-x","volume":"10","author":"L Ling","year":"2019","unstructured":"Ling L, Feng X, Wei T, Wang Y, Wang Y, Wang Z, et al. Human amnion-derived mesenchymal stem cell (hAD-MSC) transplantation improves ovarian function in rats with premature ovarian insufficiency (POI) at least partly through a paracrine mechanism. Stem Cell Res Ther. 2019;10(1):46. https:\/\/doi.org\/10.1186\/s13287-019-1136-x.","journal-title":"Stem Cell Res Ther"},{"issue":"12","key":"2682_CR16","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1002\/sctm.17-0129","volume":"6","author":"RM Samsonraj","year":"2017","unstructured":"Samsonraj RM, Raghunath M, Nurcombe V, Hui JH, van Wijnen AJ, Cool SM. Concise review: multifaceted characterization of human mesenchymal stem cells for use in regenerative medicine. Stem Cells Transl Med. 2017;6(12):2173\u201385. https:\/\/doi.org\/10.1002\/sctm.17-0129.","journal-title":"Stem Cells Transl Med"},{"issue":"6","key":"2682_CR17","doi-asserted-by":"publisher","first-page":"4541","DOI":"10.1007\/s11033-020-05505-4","volume":"47","author":"N Cil","year":"2020","unstructured":"Cil N, Yaka M, Unal MS, Dodurga Y, Tan S, Secme M, et al. Adipose derived mesenchymal stem cell treatment in experimental asherman syndrome induced rats. Mol Biol Rep. 2020;47(6):4541\u201352. https:\/\/doi.org\/10.1007\/s11033-020-05505-4.","journal-title":"Mol Biol Rep"},{"issue":"4","key":"2682_CR18","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.3390\/cells1041061","volume":"1","author":"A Lindenmair","year":"2012","unstructured":"Lindenmair A, Hatlapatka T, Kollwig G, Hennerbichler S, Gabriel C, Wolbank S, et al. Mesenchymal stem or stromal cells from amnion and umbilical cord tissue and their potential for clinical applications. Cells. 2012;1(4):1061\u201388. https:\/\/doi.org\/10.3390\/cells1041061.","journal-title":"Cells"},{"issue":"8","key":"2682_CR19","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1089\/scd.2012.0359","volume":"22","author":"M Leyva-Leyva","year":"2013","unstructured":"Leyva-Leyva M, Barrera L, Lopez-Camarillo C, Arriaga-Pizano L, Orozco-Hoyuela G, Carrillo-Casas EM, et al. Characterization of mesenchymal stem cell subpopulations from human amniotic membrane with dissimilar osteoblastic potential. Stem Cells Dev. 2013;22(8):1275\u201387. https:\/\/doi.org\/10.1089\/scd.2012.0359.","journal-title":"Stem Cells Dev"},{"issue":"6","key":"2682_CR20","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1093\/abbs\/gmaa042","volume":"52","author":"Y Li","year":"2020","unstructured":"Li Y, Liu Z, Tang Y, Fan Q, Feng W, Luo C, et al. Three-dimensional silk fibroin scaffolds enhance the bone formation and angiogenic differentiation of human amniotic mesenchymal stem cells: a biocompatibility analysis. Acta Biochim Biophys Sin (Shanghai). 2020;52(6):590\u2013602. https:\/\/doi.org\/10.1093\/abbs\/gmaa042.","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"issue":"1","key":"2682_CR21","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1186\/s13287-019-1366-y","volume":"10","author":"JY Li","year":"2019","unstructured":"Li JY, Ren KK, Zhang WJ, Xiao L, Wu HY, Liu QY, et al. Human amniotic mesenchymal stem cells and their paracrine factors promote wound healing by inhibiting heat stress-induced skin cell apoptosis and enhancing their proliferation through activating PI3K\/AKT signaling pathway. Stem Cell Res Ther. 2019;10(1):247. https:\/\/doi.org\/10.1186\/s13287-019-1366-y.","journal-title":"Stem Cell Res Ther"},{"key":"2682_CR22","doi-asserted-by":"publisher","first-page":"9845497","DOI":"10.1155\/2019\/9845497","volume":"2019","author":"L Yin","year":"2019","unstructured":"Yin L, Zhou ZX, Shen M, Chen N, Jiang F, Wang SL. The human amniotic mesenchymal stem cells (hAMSCs) improve the implant osseointegration and bone regeneration in maxillary sinus floor elevation in rabbits. Stem Cells Int. 2019;2019:9845497. https:\/\/doi.org\/10.1155\/2019\/9845497.","journal-title":"Stem Cells Int"},{"issue":"5","key":"2682_CR23","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.jcyt.2017.02.003","volume":"19","author":"L Gan","year":"2017","unstructured":"Gan L, Duan H, Xu Q, Tang YQ, Li JJ, Sun FQ, et al. Human amniotic mesenchymal stromal cell transplantation improves endometrial regeneration in rodent models of intrauterine adhesions. Cytotherapy. 2017;19(5):603\u201316. https:\/\/doi.org\/10.1016\/j.jcyt.2017.02.003.","journal-title":"Cytotherapy"},{"issue":"6","key":"2682_CR24","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1016\/j.fertnstert.2015.08.032","volume":"104","author":"I Cervello","year":"2015","unstructured":"Cervello I, Gil-Sanchis C, Santamaria X, Cabanillas S, Diaz A, Faus A, et al. Human CD133(+) bone marrow-derived stem cells promote endometrial proliferation in a murine model of Asherman syndrome. Fertil Steril. 2015;104(6):1552-60e1-3. https:\/\/doi.org\/10.1016\/j.fertnstert.2015.08.032.","journal-title":"Fertil Steril"},{"issue":"1","key":"2682_CR25","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/jcmm.13294","volume":"22","author":"Y Liu","year":"2018","unstructured":"Liu Y, Tal R, Pluchino N, Mamillapalli R, Taylor HS. Systemic administration of bone marrow-derived cells leads to better uterine engraftment than use of uterine-derived cells or local injection. J Cell Mol Med. 2018;22(1):67\u201376. https:\/\/doi.org\/10.1111\/jcmm.13294.","journal-title":"J Cell Mol Med"},{"key":"2682_CR26","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/j.colsurfb.2019.06.041","volume":"181","author":"JH Choi","year":"2019","unstructured":"Choi JH, Choi OK, Lee J, Noh J, Lee S, Park A, et al. Evaluation of double network hydrogel of poloxamer-heparin\/gellan gum for bone marrow stem cells delivery carrier. Colloids Surf B Biointerfaces. 2019;181:879\u201389. https:\/\/doi.org\/10.1016\/j.colsurfb.2019.06.041.","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"11","key":"2682_CR27","doi-asserted-by":"publisher","first-page":"3942","DOI":"10.1021\/bm5010004","volume":"15","author":"J Yang","year":"2014","unstructured":"Yang J, van Lith R, Baler K, Hoshi RA, Ameer GA. A thermoresponsive biodegradable polymer with intrinsic antioxidant properties. Biomacromol. 2014;15(11):3942\u201352. https:\/\/doi.org\/10.1021\/bm5010004.","journal-title":"Biomacromol"},{"key":"2682_CR28","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.jconrel.2016.07.043","volume":"238","author":"Y Zhu","year":"2016","unstructured":"Zhu Y, Hoshi R, Chen S, Yi J, Duan C, Galiano RD, et al. Sustained release of stromal cell derived factor-1 from an antioxidant thermoresponsive hydrogel enhances dermal wound healing in diabetes. J Control Release. 2016;238:114\u201322. https:\/\/doi.org\/10.1016\/j.jconrel.2016.07.043.","journal-title":"J Control Release"},{"issue":"2","key":"2682_CR29","doi-asserted-by":"publisher","DOI":"10.1088\/1748-6041\/11\/2\/025021","volume":"11","author":"J Ye","year":"2016","unstructured":"Ye J, Wang J, Zhu Y, Wei Q, Wang X, Yang J, et al. A thermoresponsive polydiolcitrate-gelatin scaffold and delivery system mediates effective bone formation from BMP9-transduced mesenchymal stem cells. Biomed Mater. 2016;11(2): 025021. https:\/\/doi.org\/10.1088\/1748-6041\/11\/2\/025021.","journal-title":"Biomed Mater"},{"issue":"9","key":"2682_CR30","first-page":"3710","volume":"8","author":"S Lu","year":"2016","unstructured":"Lu S, Wang J, Ye J, Zou Y, Zhu Y, Wei Q, et al. Bone morphogenetic protein 9 (BMP9) induces effective bone formation from reversibly immortalized multipotent adipose-derived (iMAD) mesenchymal stem cells. Am J Transl Res. 2016;8(9):3710\u201330.","journal-title":"Am J Transl Res"},{"issue":"3","key":"2682_CR31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0172327","volume":"12","author":"ZP Dumanian","year":"2017","unstructured":"Dumanian ZP, Tollemar V, Ye J, Lu M, Zhu Y, Liao J, et al. Repair of critical sized cranial defects with BMP9-transduced calvarial cells delivered in a thermoresponsive scaffold. PLoS ONE. 2017;12(3): e0172327. https:\/\/doi.org\/10.1371\/journal.pone.0172327.","journal-title":"PLoS ONE"},{"issue":"1","key":"2682_CR32","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1186\/s13287-021-02202-2","volume":"12","author":"P Xiao","year":"2021","unstructured":"Xiao P, Zhu Z, Du C, Zeng Y, Liao J, Cheng Q, et al. Silencing Smad7 potentiates BMP2-induced chondrogenic differentiation and inhibits endochondral ossification in human synovial-derived mesenchymal stromal cells. Stem Cell Res Ther. 2021;12(1):132. https:\/\/doi.org\/10.1186\/s13287-021-02202-2.","journal-title":"Stem Cell Res Ther"},{"key":"2682_CR33","doi-asserted-by":"publisher","first-page":"180","DOI":"10.3389\/fbioe.2020.00180","volume":"8","author":"SH Ghamari","year":"2020","unstructured":"Ghamari SH, Abbasi-Kangevari M, Tayebi T, Bahrami S, Niknejad H. The bottlenecks in translating placenta-derived amniotic epithelial and mesenchymal stromal cells into the clinic: current discrepancies in marker reports. Front Bioeng Biotechnol. 2020;8:180. https:\/\/doi.org\/10.3389\/fbioe.2020.00180.","journal-title":"Front Bioeng Biotechnol"},{"issue":"23","key":"2682_CR34","first-page":"4627","volume":"19","author":"SC Yu","year":"2015","unstructured":"Yu SC, Xu YY, Li Y, Xu B, Sun Q, Li F, et al. Construction of tissue engineered skin with human amniotic mesenchymal stem cells and human amniotic epithelial cells. Eur Rev Med Pharmacol Sci. 2015;19(23):4627\u201335.","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"1","key":"2682_CR35","first-page":"1","volume":"2","author":"JD Lamplot","year":"2013","unstructured":"Lamplot JD, Qin J, Nan G, Wang J, Liu X, Yin L, et al. BMP9 signaling in stem cell differentiation and osteogenesis. Am J Stem Cells. 2013;2(1):1\u201321.","journal-title":"Am J Stem Cells"},{"issue":"4","key":"2682_CR36","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1089\/scd.2008.0130","volume":"18","author":"Q Kang","year":"2009","unstructured":"Kang Q, Song WX, Luo Q, Tang N, Luo J, Luo X, et al. A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells. Stem Cells Dev. 2009;18(4):545\u201359. https:\/\/doi.org\/10.1089\/scd.2008.0130.","journal-title":"Stem Cells Dev"},{"issue":"12","key":"2682_CR37","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1089\/scd.2013.0580","volume":"23","author":"J Wang","year":"2014","unstructured":"Wang J, Zhang H, Zhang W, Huang E, Wang N, Wu N, et al. Bone morphogenetic protein-9 effectively induces osteo\/odontoblastic differentiation of the reversibly immortalized stem cells of dental apical papilla. Stem Cells Dev. 2014;23(12):1405\u201316. https:\/\/doi.org\/10.1089\/scd.2013.0580.","journal-title":"Stem Cells Dev"},{"issue":"1\u20132","key":"2682_CR38","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.mce.2008.02.026","volume":"288","author":"CE Gargett","year":"2008","unstructured":"Gargett CE, Chan RW, Schwab KE. Hormone and growth factor signaling in endometrial renewal: role of stem\/progenitor cells. Mol Cell Endocrinol. 2008;288(1\u20132):22\u20139. https:\/\/doi.org\/10.1016\/j.mce.2008.02.026.","journal-title":"Mol Cell Endocrinol"},{"issue":"1","key":"2682_CR39","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.fertnstert.2012.05.004","volume":"98","author":"CE Gargett","year":"2012","unstructured":"Gargett CE, Ye L. Endometrial reconstruction from stem cells. Fertil Steril. 2012;98(1):11\u201320. https:\/\/doi.org\/10.1016\/j.fertnstert.2012.05.004.","journal-title":"Fertil Steril"},{"issue":"3","key":"2682_CR40","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1093\/rb\/rbz021","volume":"6","author":"F Liu","year":"2019","unstructured":"Liu F, Hu S, Wang S, Cheng K. Cell and biomaterial-based approaches to uterus regeneration. Regen Biomater. 2019;6(3):141\u20138. https:\/\/doi.org\/10.1093\/rb\/rbz021.","journal-title":"Regen Biomater"},{"issue":"10","key":"2682_CR41","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.13345\/j.cjb.180018","volume":"34","author":"Y Yang","year":"2018","unstructured":"Yang Y, Mao Y, Wang J, Sun C, Zhang Y, Chen X. In vivo tracing of human amniotic mesenchymal stem cells labeled with PKH26 in rat intrauterine adhesions model. Chin J Biotechnol. 2018;34(10):1660\u20137. https:\/\/doi.org\/10.13345\/j.cjb.180018.","journal-title":"Chin J Biotechnol"},{"issue":"08","key":"2682_CR42","first-page":"1016","volume":"44","author":"X Chen","year":"2019","unstructured":"Chen X, Zhang W, Mao Y, Yang Y, Wu B, Li C, et al. A study of PPCNg-mediated effect of human amniotic mesenchymal stem cells in the treatment of intrauterine adhesion in rats. J Chongqing Med Univ. 2019;44(08):1016\u201323.","journal-title":"J Chongqing Med Univ"},{"issue":"11","key":"2682_CR43","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.16016\/j.1000-5404.202003065","volume":"42","author":"Y Gou","year":"2020","unstructured":"Gou Y, Zhang W, Li C, Yu J, Mao Y, Wu B, et al. Role of NF-\u03baB signaling pathway in treatment of intrauterine adhesions by human amniotic mesenchymal stem cells. Acta Acad Med Mil Tert. 2020;42(11):1101\u20138. https:\/\/doi.org\/10.16016\/j.1000-5404.202003065.","journal-title":"Acta Acad Med Mil Tert"},{"issue":"5","key":"2682_CR44","doi-asserted-by":"publisher","first-page":"1801455","DOI":"10.1002\/adhm.201801455","volume":"8","author":"B Xiao","year":"2019","unstructured":"Xiao B, Yang W, Lei D, Huang J, Yin Y, Zhu Y, et al. PGS scaffolds promote the in vivo survival and directional differentiation of bone marrow mesenchymal stem cells restoring the morphology and function of wounded rat uterus. Adv Healthc Mater. 2019;8(5):1801455. https:\/\/doi.org\/10.1002\/adhm.201801455.","journal-title":"Adv Healthc Mater"},{"key":"2682_CR45","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/547501","volume":"2013","author":"D Bhartiya","year":"2013","unstructured":"Bhartiya D. Are mesenchymal cells indeed pluripotent stem cells or just stromal cells? OCT-4 and VSELs biology has led to better understanding. Stem Cells Int. 2013;2013: 547501. https:\/\/doi.org\/10.1155\/2013\/547501.","journal-title":"Stem Cells Int"},{"issue":"1","key":"2682_CR46","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1007\/s43032-020-00250-2","volume":"28","author":"P Singh","year":"2021","unstructured":"Singh P, Bhartiya D. Pluripotent stem (VSELs) and progenitor (EnSCs) cells exist in adult mouse uterus and show cyclic changes across estrus cycle. Reprod Sci. 2021;28(1):278\u201390. https:\/\/doi.org\/10.1007\/s43032-020-00250-2.","journal-title":"Reprod Sci"},{"issue":"1","key":"2682_CR47","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1093\/humupd\/dmw030","volume":"23","author":"D Bhartiya","year":"2016","unstructured":"Bhartiya D, Shaikh A, Anand S, Patel H, Kapoor S, Sriraman K, Parte S, Unni S. Endogenous, very small embryonic-like stem cells: critical review, therapeutic potential and a look ahead. Hum Reprod Update. 2016;23(1):41\u201376. https:\/\/doi.org\/10.1093\/humupd\/dmw030.","journal-title":"Hum Reprod Update"},{"issue":"6","key":"2682_CR48","doi-asserted-by":"publisher","first-page":"6196","DOI":"10.3390\/molecules17066196","volume":"17","author":"W Zhao","year":"2012","unstructured":"Zhao W, Ji X, Zhang F, Li L, Ma L. Embryonic stem cell markers. Molecules. 2012;17(6):6196\u2013236. https:\/\/doi.org\/10.3390\/molecules17066196.","journal-title":"Molecules"},{"issue":"11","key":"2682_CR49","doi-asserted-by":"publisher","first-page":"2469","DOI":"10.14202\/vetworld.2020.2469-2476","volume":"13","author":"E Safitri","year":"2020","unstructured":"Safitri E. Effect of low oxygen tension on transcriptional factor OCT4 and SOX2 expression in New Zealand rabbit bone marrow-derived mesenchymal stem cells. Vet World. 2020;13(11):2469\u201376. https:\/\/doi.org\/10.14202\/vetworld.2020.2469-2476.","journal-title":"Vet World"},{"issue":"7","key":"2682_CR50","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.3390\/ijms20071694","volume":"20","author":"T Komori","year":"2019","unstructured":"Komori T. Regulation of proliferation, differentiation and functions of osteoblasts by Runx2. Int J Mol Sci. 2019;20(7):1694. https:\/\/doi.org\/10.3390\/ijms20071694.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"2682_CR51","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s12906-019-2435-6","volume":"19","author":"C Yu","year":"2019","unstructured":"Yu C, Dai L, Ma Z, Zhao H, Yuan Y, Zhang Y, et al. Effect of Osteoking on the osteogenic and adipogenic differentiation potential of rat bone marrow mesenchymal stem cells in vitro. BMC Complement Altern Med. 2019;19(1):36. https:\/\/doi.org\/10.1186\/s12906-019-2435-6.","journal-title":"BMC Complement Altern Med"},{"issue":"3","key":"2682_CR52","doi-asserted-by":"publisher","first-page":"913","DOI":"10.3892\/ijmm.2019.4269","volume":"44","author":"JH Kim","year":"2019","unstructured":"Kim JH, Kim M, Jung HS, Sohn Y. Leonurus sibiricus L. ethanol extract promotes osteoblast differentiation and inhibits osteoclast formation. Int J Mol Med. 2019;44(3):913\u201326. https:\/\/doi.org\/10.3892\/ijmm.2019.4269.","journal-title":"Int J Mol Med"},{"key":"2682_CR53","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.mcp.2019.01.005","volume":"44","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Wang Y, Wang H, Ma X, Zan L. MicroRNA-224 impairs adipogenic differentiation of bovine preadipocytes by targeting LPL. Mol Cell Probes. 2019;44:29\u201336. https:\/\/doi.org\/10.1016\/j.mcp.2019.01.005.","journal-title":"Mol Cell Probes"},{"issue":"11","key":"2682_CR54","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1016\/j.jcyt.2014.05.005","volume":"16","author":"E Martella","year":"2014","unstructured":"Martella E, Bellotti C, Dozza B, Perrone S, Donati D, Lucarelli E. Secreted adiponectin as a marker to evaluate in vitro the adipogenic differentiation of human mesenchymal stromal cells. Cytotherapy. 2014;16(11):1476\u201385. https:\/\/doi.org\/10.1016\/j.jcyt.2014.05.005.","journal-title":"Cytotherapy"},{"issue":"1","key":"2682_CR55","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1080\/03008207.2016.1183667","volume":"58","author":"V Lefebvre","year":"2017","unstructured":"Lefebvre V, Dvir-Ginzberg M. SOX9 and the many facets of its regulation in the chondrocyte lineage. Connect Tissue Res. 2017;58(1):2\u201314. https:\/\/doi.org\/10.1080\/03008207.2016.1183667.","journal-title":"Connect Tissue Res"},{"issue":"6","key":"2682_CR56","doi-asserted-by":"publisher","first-page":"2357","DOI":"10.3892\/mmr.2020.11044","volume":"21","author":"Y Xu","year":"2020","unstructured":"Xu Y, Wang YQ, Wang AT, Yu CY, Luo Y, Liu RM, et al. Effect of CD44 on differentiation of human amniotic mesenchymal stem cells into chondrocytes via Smad and ERK signaling pathways. Mol Med Rep. 2020;21(6):2357\u201366. https:\/\/doi.org\/10.3892\/mmr.2020.11044.","journal-title":"Mol Med Rep"},{"issue":"7","key":"2682_CR57","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.3390\/molecules25071539","volume":"25","author":"C Vasile","year":"2020","unstructured":"Vasile C, Pamfil D, Stoleru E, Baican M. New developments in medical applications of hybrid hydrogels containing natural polymers. Molecules. 2020;25(7):1539. https:\/\/doi.org\/10.3390\/molecules25071539.","journal-title":"Molecules"},{"issue":"13","key":"2682_CR58","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201902005","volume":"32","author":"AL Facklam","year":"2020","unstructured":"Facklam AL, Volpatti LR, Anderson DG. Biomaterials for personalized cell therapy. Adv Mater. 2020;32(13): e1902005. https:\/\/doi.org\/10.1002\/adma.201902005.","journal-title":"Adv Mater"},{"issue":"4","key":"2682_CR59","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.addr.2012.09.043","volume":"65","author":"B Kundu","year":"2013","unstructured":"Kundu B, Rajkhowa R, Kundu SC, Wang X. Silk fibroin biomaterials for tissue regenerations. Adv Drug Deliv Rev. 2013;65(4):457\u201370. https:\/\/doi.org\/10.1016\/j.addr.2012.09.043.","journal-title":"Adv Drug Deliv Rev"},{"issue":"1","key":"2682_CR60","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/j.1600-0897.1998.tb00384.x","volume":"40","author":"IO Song","year":"1998","unstructured":"Song IO, Hong SR, Huh Y, Yoo KJ, Koong MK, Jun JY, et al. Expression of vimentin and cytokeratin in eutopic and ectopic endometrium of women with adenomyosis and ovarian endometrioma. Am J Reprod Immunol. 1998;40(1):26\u201331. https:\/\/doi.org\/10.1111\/j.1600-0897.1998.tb00384.x.","journal-title":"Am J Reprod Immunol"},{"issue":"3","key":"2682_CR61","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.tjog.2012.07.013","volume":"51","author":"I Kahyaoglu","year":"2012","unstructured":"Kahyaoglu I, Kahyaoglu S, Moraloglu O, Zergeroglu S, Sut N, Batioglu S. Comparison of Ki-67 proliferative index between eutopic and ectopic endometrium: a case control study. Taiwan J Obstet Gynecol. 2012;51(3):393\u20136. https:\/\/doi.org\/10.1016\/j.tjog.2012.07.013.","journal-title":"Taiwan J Obstet Gynecol"},{"issue":"11","key":"2682_CR62","doi-asserted-by":"publisher","first-page":"1984","DOI":"10.1242\/dev.117952","volume":"142","author":"X Duan","year":"2015","unstructured":"Duan X, Murata Y, Liu Y, Nicolae C, Olsen BR, Berendsen AD. Vegfa regulates perichondrial vascularity and osteoblast differentiation in bone development. Development. 2015;142(11):1984\u201391. https:\/\/doi.org\/10.1242\/dev.117952.","journal-title":"Development"},{"issue":"1","key":"2682_CR63","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1096\/fj.201901603RR","volume":"34","author":"SS Zhang","year":"2020","unstructured":"Zhang SS, Xu XX, Xiang WW, Zhang HH, Lin HL, Shen LE, et al. Using 17beta-estradiol heparin-poloxamer thermosensitive hydrogel to enhance the endometrial regeneration and functional recovery of intrauterine adhesions in a rat model. FASEB J. 2020;34(1):446\u201357. https:\/\/doi.org\/10.1096\/fj.201901603RR.","journal-title":"FASEB J"},{"issue":"7","key":"2682_CR64","first-page":"1343","volume":"6","author":"Y Chen","year":"2013","unstructured":"Chen Y, Chang Y, Yao S. Role of angiogenesis in endometrial repair of patients with severe intrauterine adhesion. Int J Clin Exp Pathol. 2013;6(7):1343\u201350.","journal-title":"Int J Clin Exp Pathol"},{"issue":"2","key":"2682_CR65","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1093\/humupd\/dmy044","volume":"25","author":"L Craciunas","year":"2019","unstructured":"Craciunas L, Gallos I, Chu J, Bourne T, Quenby S, Brosens JJ, et al. Conventional and modern markers of endometrial receptivity: a systematic review and meta-analysis. Hum Reprod Update. 2019;25(2):202\u201323. https:\/\/doi.org\/10.1093\/humupd\/dmy044.","journal-title":"Hum Reprod Update"},{"key":"2682_CR66","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/1477-7827-11-118","volume":"11","author":"AAC Conforti","year":"2013","unstructured":"Conforti AAC, Mollo A, De Placido G, Magos A. The management of Asherman syndrome: a review of literature. Reprod Biol Endocrinol. 2013;11:118. https:\/\/doi.org\/10.1186\/1477-7827-11-118.","journal-title":"Reprod Biol Endocrinol"},{"issue":"4","key":"2682_CR67","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000009689","volume":"97","author":"T Zhang","year":"2018","unstructured":"Zhang T, Li Z, Ren X, Huang B, Zhu G, Yang W, et al. Endometrial thickness as a predictor of the reproductive outcomes in fresh and frozen embryo transfer cycles: a retrospective cohort study of 1512 IVF cycles with morphologically good-quality blastocyst. Medicine (Baltimore). 2018;97(4): e9689. https:\/\/doi.org\/10.1097\/MD.0000000000009689.","journal-title":"Medicine (Baltimore)"},{"issue":"9","key":"2682_CR68","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0239120","volume":"15","author":"Z Shaodi","year":"2020","unstructured":"Shaodi Z, Qiuyuan L, Yisha Y, Cuilian Z. The effect of endometrial thickness on pregnancy outcomes of frozen-thawed embryo transfer cycles which underwent hormone replacement therapy. PLoS ONE. 2020;15(9): e0239120. https:\/\/doi.org\/10.1371\/journal.pone.0239120.","journal-title":"PLoS ONE"},{"issue":"4","key":"2682_CR69","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.beem.2015.04.008","volume":"29","author":"M Jia","year":"2015","unstructured":"Jia M, Dahlman-Wright K, Gustafsson JA. Estrogen receptor alpha and beta in health and disease. Best Pract Res Clin Endocrinol Metab. 2015;29(4):557\u201368. https:\/\/doi.org\/10.1016\/j.beem.2015.04.008.","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"3","key":"2682_CR70","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.acthis.2009.04.004","volume":"112","author":"R Demir","year":"2010","unstructured":"Demir R, Yaba A, Huppertz B. Vasculogenesis and angiogenesis in the endometrium during menstrual cycle and implantation. Acta Histochem. 2010;112(3):203\u201314. https:\/\/doi.org\/10.1016\/j.acthis.2009.04.004.","journal-title":"Acta Histochem"},{"issue":"4","key":"2682_CR71","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.fertnstert.2019.02.009","volume":"111","author":"BA Lessey","year":"2019","unstructured":"Lessey BA, Young SL. What exactly is endometrial receptivity? Fertil Steril. 2019;111(4):611\u20137. https:\/\/doi.org\/10.1016\/j.fertnstert.2019.02.009.","journal-title":"Fertil Steril"},{"issue":"8","key":"2682_CR72","first-page":"4726","volume":"11","author":"LP Guo","year":"2019","unstructured":"Guo LP, Chen LM, Chen F, Jiang NH, Sui L. Smad signaling coincides with epithelial-mesenchymal transition in a rat model of intrauterine adhesion. Am J Transl Res. 2019;11(8):4726\u201337.","journal-title":"Am J Transl Res"},{"issue":"4","key":"2682_CR73","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1159\/000447857","volume":"39","author":"J Wang","year":"2016","unstructured":"Wang J, Ju B, Pan C, Gu Y, Zhang Y, Sun L, et al. Application of bone marrow-derived mesenchymal stem cells in the treatment of intrauterine adhesions in rats. Cell Physiol Biochem. 2016;39(4):1553\u201360. https:\/\/doi.org\/10.1159\/000447857.","journal-title":"Cell Physiol Biochem"},{"issue":"5","key":"2682_CR74","doi-asserted-by":"publisher","first-page":"6337","DOI":"10.3892\/mmr.2018.8685","volume":"17","author":"Y Chi","year":"2018","unstructured":"Chi Y, He P, Lei L, Lan Y, Hu J, Meng Y, et al. Transdermal estrogen gel and oral aspirin combination therapy improves fertility prognosis via the promotion of endometrial receptivity in moderate to severe intrauterine adhesion. Mol Med Rep. 2018;17(5):6337\u201344. https:\/\/doi.org\/10.3892\/mmr.2018.8685.","journal-title":"Mol Med Rep"},{"issue":"3","key":"2682_CR75","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1007\/s00404-018-4802-9","volume":"298","author":"Z Zhi","year":"2018","unstructured":"Zhi Z, Yang W, Liu L, Jiang X, Pang L. Early missed abortion is associated with villous angiogenesis via the HIF-1alpha\/VEGF signaling pathway. Arch Gynecol Obstet. 2018;298(3):537\u201343. https:\/\/doi.org\/10.1007\/s00404-018-4802-9.","journal-title":"Arch Gynecol Obstet"},{"issue":"5","key":"2682_CR76","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.3892\/ijmm.2020.4506","volume":"45","author":"Z Zhang","year":"2020","unstructured":"Zhang Z, Li S, Deng J, Yang S, Xiang Z, Guo H, et al. Aspirin inhibits endometrial fibrosis by suppressing the TGF-\u03b21-Smad2\/Smad3 pathway in intrauterine adhesions. Int J Mol Med. 2020;45(5):1351\u201360. https:\/\/doi.org\/10.3892\/ijmm.2020.4506.","journal-title":"Int J Mol Med"},{"key":"2682_CR77","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106703","volume":"86","author":"Y Ai","year":"2020","unstructured":"Ai Y, Chen M, Liu J, Ren L, Yan X, Feng Y. lncRNA TUG1 promotes endometrial fibrosis and inflammation by sponging miR-590-5p to regulate Fasl in intrauterine adhesions. Int Immunopharmacol. 2020;86: 106703. https:\/\/doi.org\/10.1016\/j.intimp.2020.106703.","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"2682_CR78","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1111\/j.1365-2133.2009.09215.x","volume":"161","author":"LR Luckett-Chastain","year":"2009","unstructured":"Luckett-Chastain LR, Gallucci RM. Interleukin (IL)-6 modulates transforming growth factor-beta expression in skin and dermal fibroblasts from IL-6-deficient mice. Br J Dermatol. 2009;161(2):237\u201348. https:\/\/doi.org\/10.1111\/j.1365-2133.2009.09215.x.","journal-title":"Br J Dermatol"},{"issue":"2","key":"2682_CR79","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1111\/resp.13928","volume":"26","author":"S Periera-Simon","year":"2021","unstructured":"Periera-Simon S, Xia X, Catanuto P, Coronado R, Kurtzberg J, Bellio M, et al. Anti-fibrotic effects of different sources of MSC in bleomycin-induced lung fibrosis in C57BL6 male mice. Respirology. 2021;26(2):161\u201370. https:\/\/doi.org\/10.1111\/resp.13928.","journal-title":"Respirology"},{"key":"2682_CR80","doi-asserted-by":"publisher","first-page":"4158287","DOI":"10.1155\/2016\/4158287","volume":"2016","author":"U Salma","year":"2016","unstructured":"Salma U, Xue M, Ali Sheikh MS, Guan X, Xu B, Zhang A, et al. Role of transforming growth factor-\u03b21 and smads signaling pathway in intrauterine adhesion. Mediators Inflamm. 2016;2016:4158287. https:\/\/doi.org\/10.1155\/2016\/4158287.","journal-title":"Mediators Inflamm"},{"issue":"1","key":"2682_CR81","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3892\/mmr.2020.11646","volume":"23","author":"J Li","year":"2021","unstructured":"Li J, Huang B, Dong L, Zhong Y, Huang Z. WJ-MSCs intervention may relieve intrauterine adhesions in female rats via TGF-\u03b21-mediated Rho\/ROCK signaling inhibition. Mol Med Rep. 2021;23(1):8. https:\/\/doi.org\/10.3892\/mmr.2020.11646.","journal-title":"Mol Med Rep"},{"issue":"3","key":"2682_CR82","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/scrt215","volume":"4","author":"T Du","year":"2013","unstructured":"Du T, Zou X, Cheng J, Wu S, Zhong L, Ju G, et al. Human Wharton\u2019s jelly-derived mesenchymal stromal cells reduce renal fibrosis through induction of native and foreign hepatocyte growth factor synthesis in injured tubular epithelial cells. Stem Cell Res Ther. 2013;4(3):59. https:\/\/doi.org\/10.1186\/scrt215.","journal-title":"Stem Cell Res Ther"},{"issue":"2","key":"2682_CR83","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.fertnstert.2013.10.053","volume":"101","author":"Z Jing","year":"2014","unstructured":"Jing Z, Qiong Z, Yonggang W, Yanping L. Rat bone marrow mesenchymal stem cells improve regeneration of thin endometrium in rat. Fertil Steril. 2014;101(2):587\u201394. https:\/\/doi.org\/10.1016\/j.fertnstert.2013.10.053.","journal-title":"Fertil Steril"},{"issue":"1","key":"2682_CR84","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/s13287-018-0846-9","volume":"9","author":"S Chen","year":"2018","unstructured":"Chen S, Cui G, Peng C, Lavin MF, Sun X, Zhang E, et al. Transplantation of adipose-derived mesenchymal stem cells attenuates pulmonary fibrosis of silicosis via anti-inflammatory and anti-apoptosis effects in rats. Stem Cell Res Ther. 2018;9(1):110. https:\/\/doi.org\/10.1186\/s13287-018-0846-9.","journal-title":"Stem Cell Res Ther"},{"issue":"6","key":"2682_CR85","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a001651","volume":"1","author":"T Lawrence","year":"2009","unstructured":"Lawrence T. The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol. 2009;1(6): a001651. https:\/\/doi.org\/10.1101\/cshperspect.a001651.","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"3","key":"2682_CR86","doi-asserted-by":"publisher","first-page":"208","DOI":"10.5603\/FHC.a2020.0024","volume":"58","author":"NM Salama","year":"2020","unstructured":"Salama NM, Zaghlol SS, Mohamed HH, Kamar SS. Suppression of the inflammation and fibrosis in Asherman syndrome rat model by mesenchymal stem cells: histological and immunohistochemical studies. Folia Histochem Cytobiol. 2020;58(3):208\u201318. https:\/\/doi.org\/10.5603\/FHC.a2020.0024.","journal-title":"Folia Histochem Cytobiol"},{"issue":"11","key":"2682_CR87","doi-asserted-by":"publisher","first-page":"2347","DOI":"10.1111\/jog.14449","volume":"46","author":"H Ma","year":"2020","unstructured":"Ma H, Liu M, Li Y, Wang W, Yang K, Lu L, et al. Intrauterine transplantation of autologous menstrual blood stem cells increases endometrial thickness and pregnancy potential in patients with refractory intrauterine adhesion. J Obstet Gynaecol Res. 2020;46(11):2347\u201355. https:\/\/doi.org\/10.1111\/jog.14449.","journal-title":"J Obstet Gynaecol Res"},{"issue":"1","key":"2682_CR88","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1186\/s13287-021-02499-z","volume":"12","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Shi L, Lin X, Zhou F, Xin L, Xu W, Yu H, Li J, Pan M, Pan Y, Dai Y, Zhang Y, Shen J, Zhao L, Lu M, Zhang S. Unresponsive thin endometrium caused by Asherman syndrome treated with umbilical cord mesenchymal stem cells on collagen scaffolds: a pilot study. Stem Cell Res Ther. 2021;12(1):420. https:\/\/doi.org\/10.1186\/s13287-021-02499-z.","journal-title":"Stem Cell Res Ther"}],"container-title":["Stem Cell Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-021-02682-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13287-021-02682-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-021-02682-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T18:14:14Z","timestamp":1642011254000},"score":1,"resource":{"primary":{"URL":"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/s13287-021-02682-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,12]]},"references-count":88,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["2682"],"URL":"https:\/\/doi.org\/10.1186\/s13287-021-02682-2","relation":{},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,12]]},"assertion":[{"value":"8 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Animal experiment protocols were approved by the Ethics Committee of Chongqing Medical University (2014050).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"There is no competing interests to declare.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"17"}}