{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T08:42:28Z","timestamp":1783759348992,"version":"3.55.0"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:00:00Z","timestamp":1690761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:00:00Z","timestamp":1690761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100008307","name":"Beckman Research Institute, City of Hope","doi-asserted-by":"publisher","award":["Arthur Riggs Diabetes"],"award-info":[{"award-number":["Arthur Riggs Diabetes"]}],"id":[{"id":"10.13039\/100008307","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008307","name":"Beckman Research Institute, City of Hope","doi-asserted-by":"publisher","award":["Metabolism Research Institute Pilot Project"],"award-info":[{"award-number":["Metabolism Research Institute Pilot Project"]}],"id":[{"id":"10.13039\/100008307","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK112794"],"award-info":[{"award-number":["R01DK112794"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The circadian clock is an evolutionarily conserved mechanism that exerts pervasive temporal control in stem cell behavior. This time-keeping machinery is required for orchestrating myogenic progenitor properties in regenerative myogenesis that ameliorates muscular dystrophy. Here we report a screening platform to discover circadian clock modulators that promote myogenesis and identify chlorhexidine (CHX) as a clock-activating molecule with pro-myogenic activities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A high-throughput molecular docking pipeline was applied to identify compounds with a structural fit for a hydrophobic pocket within the key circadian transcription factor protein, Circadian Locomotor Output Cycles Kaput (CLOCK). These identified molecules were further screened for clock-modulatory activities and functional validations for pro-myogenic properties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CHX was identified as a clock activator that promotes distinct aspects of myogenesis. CHX activated circadian clock that reduced cycling period length and augmented amplitude. This action was mediated by the targeted CLOCK structure via augmented interaction with heterodimer partner Bmal1, leading to enhanced CLOCK\/Bmal1-controlled transcription with upregulation of core clock genes. Consistent with its clock-activating function, CHX displayed robust effects on stimulating myogenic differentiation in a clock-dependent manner. In addition, CHX augmented the proliferative and migratory activities of myoblasts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings demonstrate the feasibility of a screening platform to discover clock modulators with myogenic regulatory activities. Discovery of CHX as a pro-myogenic molecule could be applicable to promote regenerative capacities in ameliorating dystrophic or degenerative muscle diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13287-023-03424-2","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T18:35:39Z","timestamp":1690828539000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Targeted screening and identification of chlorhexidine as a pro-myogenic circadian clock activator"],"prefix":"10.1186","volume":"14","author":[{"given":"Tali","family":"Kiperman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weini","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuekai","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Horne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5206-1038","authenticated-orcid":false,"given":"Ke","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,31]]},"reference":[{"issue":"2","key":"3424_CR1","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.tcb.2013.07.002","volume":"24","author":"CL Partch","year":"2014","unstructured":"Partch CL, Green CB, Takahashi JS. Molecular architecture of the mammalian circadian clock. Trends Cell Biol. 2014;24(2):90\u20139.","journal-title":"Trends Cell Biol"},{"issue":"3","key":"3424_CR2","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1038\/nrg.2016.150","volume":"18","author":"JS Takahashi","year":"2017","unstructured":"Takahashi JS. Transcriptional architecture of the mammalian circadian clock. Nat Rev Genet. 2017;18(3):164\u201379.","journal-title":"Nat Rev Genet"},{"key":"3424_CR3","doi-asserted-by":"publisher","first-page":"1910","DOI":"10.12688\/f1000research.11770.1","volume":"6","author":"KA Lamia","year":"2017","unstructured":"Lamia KA. Ticking time bombs: connections between circadian clocks and cancer. F1000Research. 2017;6:1910.","journal-title":"F1000Research"},{"issue":"6315","key":"3424_CR4","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1126\/science.aah4967","volume":"354","author":"S Panda","year":"2016","unstructured":"Panda S. Circadian physiology of metabolism. Science. 2016;354(6315):1008\u201315.","journal-title":"Science"},{"issue":"3","key":"3424_CR5","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/S0092-8674(02)00722-5","volume":"109","author":"S Panda","year":"2002","unstructured":"Panda S, Antoch MP, Miller BH, Su AI, Schook AB, Straume M, et al. Coordinated transcription of key pathways in the mouse by the circadian clock. Cell. 2002;109(3):307\u201320.","journal-title":"Cell"},{"key":"3424_CR6","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.12688\/f1000research.9076.1","volume":"5","author":"S Chatterjee","year":"2016","unstructured":"Chatterjee S, Ma K. Circadian clock regulation of skeletal muscle growth and repair. F1000Research. 2016;5:1549.","journal-title":"F1000Research"},{"issue":"6","key":"3424_CR7","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/j.stem.2020.05.002","volume":"26","author":"SA Benitah","year":"2020","unstructured":"Benitah SA, Welz PS. Circadian regulation of adult stem cell homeostasis and aging. Cell Stem Cell. 2020;26(6):817\u201331.","journal-title":"Cell Stem Cell"},{"issue":"7376","key":"3424_CR8","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/nature10649","volume":"480","author":"P Janich","year":"2011","unstructured":"Janich P, Pascual G, Merlos-Suarez A, Batlle E, Ripperger J, Albrecht U, et al. The circadian molecular clock creates epidermal stem cell heterogeneity. Nature. 2011;480(7376):209\u201314.","journal-title":"Nature"},{"issue":"2","key":"3424_CR9","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/s41574-018-0122-1","volume":"15","author":"DJ Stenvers","year":"2019","unstructured":"Stenvers DJ, Scheer F, Schrauwen P, la Fleur SE, Kalsbeek A. Circadian clocks and insulin resistance. Nat Rev Endocrinol. 2019;15(2):75\u201389.","journal-title":"Nat Rev Endocrinol"},{"issue":"6009","key":"3424_CR10","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1126\/science.1195027","volume":"330","author":"J Bass","year":"2010","unstructured":"Bass J, Takahashi JS. Circadian integration of metabolism and energetics. Science. 2010;330(6009):1349\u201354.","journal-title":"Science"},{"issue":"8","key":"3424_CR11","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.trecan.2019.07.002","volume":"5","author":"G Sulli","year":"2019","unstructured":"Sulli G, Lam MTY, Panda S. Interplay between circadian clock and cancer: new frontiers for cancer treatment. Trends Cancer. 2019;5(8):475\u201394.","journal-title":"Trends Cancer"},{"issue":"5","key":"3424_CR12","doi-asserted-by":"publisher","first-page":"503","DOI":"10.2174\/1389200217666160111124439","volume":"17","author":"B He","year":"2016","unstructured":"He B, Chen Z. Molecular targets for small-molecule modulators of circadian clocks. Curr Drug Metab. 2016;17(5):503\u201312.","journal-title":"Curr Drug Metab"},{"issue":"11","key":"3424_CR13","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1158\/2159-8290.CD-19-0215","volume":"9","author":"Z Dong","year":"2019","unstructured":"Dong Z, Zhang G, Qu M, Gimple RC, Wu Q, Qiu Z, et al. Targeting glioblastoma stem cells through disruption of the circadian clock. Cancer Discov. 2019;9(11):1556\u201373.","journal-title":"Cancer Discov"},{"issue":"9","key":"3424_CR14","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1002\/cmdc.201500260","volume":"10","author":"JW Lee","year":"2015","unstructured":"Lee JW, Hirota T, Kumar A, Kim NJ, Irle S, Kay SA. Development of small-molecule cryptochrome stabilizer derivatives as modulators of the circadian clock. ChemMedChem. 2015;10(9):1489\u201397.","journal-title":"ChemMedChem"},{"issue":"1","key":"3424_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2020.112348","volume":"397","author":"H Gao","year":"2020","unstructured":"Gao H, Xiong X, Lin Y, Chatterjee S, Ma K. The clock regulator Bmal1 protects against muscular dystrophy. Exp Cell Res. 2020;397(1): 112348.","journal-title":"Exp Cell Res"},{"issue":"2","key":"3424_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2021.112766","volume":"406","author":"X Xiong","year":"2021","unstructured":"Xiong X, Gao H, Lin Y, Yechoor V, Ma K. Inhibition of Rev-erbalpha ameliorates muscular dystrophy. Exp Cell Res. 2021;406(2): 112766.","journal-title":"Exp Cell Res"},{"key":"3424_CR17","doi-asserted-by":"publisher","first-page":"100","DOI":"10.3389\/fneur.2017.00100","volume":"8","author":"GF Gloston","year":"2017","unstructured":"Gloston GF, Yoo SH, Chen ZJ. Clock-enhancing small molecules and potential applications in chronic diseases and aging. Front Neurol. 2017;8:100.","journal-title":"Front Neurol"},{"issue":"9","key":"3424_CR18","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1016\/j.tips.2018.07.003","volume":"39","author":"G Sulli","year":"2018","unstructured":"Sulli G, Manoogian ENC, Taub PR, Panda S. Training the circadian clock, clocking the drugs, and drugging the clock to prevent, manage, and treat chronic diseases. Trends Pharmacol Sci. 2018;39(9):812\u201327.","journal-title":"Trends Pharmacol Sci"},{"issue":"18","key":"3424_CR19","doi-asserted-by":"publisher","first-page":"3187","DOI":"10.1038\/s41388-021-01778-6","volume":"40","author":"F Battaglin","year":"2021","unstructured":"Battaglin F, Chan P, Pan Y, Soni S, Qu M, Spiller ER, et al. Clocking cancer: the circadian clock as a target in cancer therapy. Oncogene. 2021;40(18):3187\u2013200.","journal-title":"Oncogene"},{"issue":"6091","key":"3424_CR20","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1126\/science.1222804","volume":"337","author":"N Huang","year":"2012","unstructured":"Huang N, Chelliah Y, Shan Y, Taylor CA, Yoo SH, Partch C, et al. Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex. Science. 2012;337(6091):189\u201394.","journal-title":"Science"},{"issue":"2","key":"3424_CR21","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/S0092-8674(02)00825-5","volume":"110","author":"N Preitner","year":"2002","unstructured":"Preitner N, Damiola F, Lopez-Molina L, Zakany J, Duboule D, Albrecht U, et al. The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell. 2002;110(2):251\u201360.","journal-title":"Cell"},{"issue":"6","key":"3424_CR22","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/j.cmet.2012.05.006","volume":"15","author":"M Stratmann","year":"2012","unstructured":"Stratmann M, Schibler U. REV-ERBs: more than the sum of the individual parts. Cell Metab. 2012;15(6):791\u20133.","journal-title":"Cell Metab"},{"issue":"7688","key":"3424_CR23","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1038\/nature25170","volume":"553","author":"G Sulli","year":"2018","unstructured":"Sulli G, Rommel A, Wang X, Kolar MJ, Puca F, Saghatelian A, et al. Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence. Nature. 2018;553(7688):351\u20135.","journal-title":"Nature"},{"issue":"7396","key":"3424_CR24","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/nature11030","volume":"485","author":"LA Solt","year":"2012","unstructured":"Solt LA, Wang Y, Banerjee S, Hughes T, Kojetin DJ, Lundasen T, et al. Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature. 2012;485(7396):62\u20138.","journal-title":"Nature"},{"issue":"6098","key":"3424_CR25","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1126\/science.1223710","volume":"337","author":"T Hirota","year":"2012","unstructured":"Hirota T, Lee JW, St John PC, Sawa M, Iwaisako K, Noguchi T, et al. Identification of small molecule activators of cryptochrome. Science. 2012;337(6098):1094\u20137.","journal-title":"Science"},{"issue":"6","key":"3424_CR26","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.stem.2013.09.004","volume":"13","author":"P Janich","year":"2013","unstructured":"Janich P, Toufighi K, Solanas G, Luis NM, Minkwitz S, Serrano L, et al. Human epidermal stem cell function is regulated by circadian oscillations. Cell Stem Cell. 2013;13(6):745\u201353.","journal-title":"Cell Stem Cell"},{"issue":"4","key":"3424_CR27","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/j.cell.2017.07.035","volume":"170","author":"G Solanas","year":"2017","unstructured":"Solanas G, Peixoto FO, Perdiguero E, Jardi M, Ruiz-Bonilla V, Datta D, et al. Aged stem cells reprogram their daily rhythmic functions to adapt to stress. Cell. 2017;170(4):678\u201392.","journal-title":"Cell"},{"issue":"44","key":"3424_CR28","doi-asserted-by":"publisher","first-page":"19090","DOI":"10.1073\/pnas.1014523107","volume":"107","author":"JL Andrews","year":"2010","unstructured":"Andrews JL, Zhang X, McCarthy JJ, McDearmon EL, Hornberger TA, Russell B, et al. CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function. Proc Natl Acad Sci USA. 2010;107(44):19090\u20135.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3424_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2022.101504","volume":"61","author":"N Casanova-Vallve","year":"2022","unstructured":"Casanova-Vallve N, Duglan D, Vaughan ME, Pariollaud M, Handzlik MK, Fan W, et al. Daily running enhances molecular and physiological circadian rhythms in skeletal muscle. Mol Metab. 2022;61: 101504.","journal-title":"Mol Metab"},{"issue":"5","key":"3424_CR30","doi-asserted-by":"publisher","first-page":"6613","DOI":"10.1096\/fj.201903226RR","volume":"34","author":"H Yin","year":"2020","unstructured":"Yin H, Li W, Chatterjee S, Xiong X, Saha P, Yechoor V, et al. Metabolic-sensing of the skeletal muscle clock coordinates fuel oxidation. FASEB J. 2020;34(5):6613\u201327.","journal-title":"FASEB J"},{"issue":"1","key":"3424_CR31","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.cmet.2019.03.013","volume":"30","author":"S Sato","year":"2019","unstructured":"Sato S, Basse AL, Schonke M, Chen S, Samad M, Altintas A, et al. Time of exercise specifies the impact on muscle metabolic pathways and systemic energy homeostasis. Cell Metab. 2019;30(1):92\u2013110.","journal-title":"Cell Metab"},{"issue":"Pt 10","key":"3424_CR32","first-page":"2213","volume":"126","author":"S Chatterjee","year":"2013","unstructured":"Chatterjee S, Nam D, Guo B, Kim JM, Winnier GE, Lee J, et al. Brain and muscle Arnt-like 1 is a key regulator of myogenesis. J Cell Sci. 2013;126(Pt 10):2213\u201324.","journal-title":"J Cell Sci"},{"issue":"1","key":"3424_CR33","doi-asserted-by":"publisher","first-page":"4585","DOI":"10.1038\/s41598-019-41059-7","volume":"9","author":"S Chatterjee","year":"2019","unstructured":"Chatterjee S, Yin H, Li W, Lee J, Yechoor VK, Ma K. The nuclear receptor and clock repressor Rev-erbalpha suppresses myogenesis. Sci Rep. 2019;9(1):4585.","journal-title":"Sci Rep"},{"issue":"7","key":"3424_CR34","doi-asserted-by":"publisher","first-page":"e202101057","DOI":"10.1083\/jcb.202101057","volume":"220","author":"N Katoku-Kikyo","year":"2021","unstructured":"Katoku-Kikyo N, Paatela E, Houtz DL, Lee B, Munson D, Wang X, et al. Per1\/Per2-Igf2 axis-mediated circadian regulation of myogenic differentiation. J Cell Biol. 2021;220(7):e202101057.","journal-title":"J Cell Biol"},{"issue":"8","key":"3424_CR35","doi-asserted-by":"publisher","first-page":"2118","DOI":"10.1016\/j.celrep.2018.01.077","volume":"22","author":"M Lowe","year":"2018","unstructured":"Lowe M, Lage J, Paatela E, Munson D, Hostager R, Yuan C, et al. Cry2 is critical for circadian regulation of myogenic differentiation by Bclaf1-mediated mRNA stabilization of cyclin D1 and Tmem176b. Cell Rep. 2018;22(8):2118\u201332.","journal-title":"Cell Rep"},{"issue":"1","key":"3424_CR36","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.yexcr.2014.08.041","volume":"331","author":"S Chatterjee","year":"2015","unstructured":"Chatterjee S, Yin H, Nam D, Li Y, Ma K. Brain and muscle Arnt-like 1 promotes skeletal muscle regeneration through satellite cell expansion. Exp Cell Res. 2015;331(1):200\u201310.","journal-title":"Exp Cell Res."},{"issue":"8","key":"3424_CR37","doi-asserted-by":"publisher","first-page":"3453","DOI":"10.1096\/fj.12-205781","volume":"26","author":"B Guo","year":"2012","unstructured":"Guo B, Chatterjee S, Li L, Kim JM, Lee J, Yechoor VK, et al. The clock gene, brain and muscle Arnt-like 1, regulates adipogenesis via Wnt signaling pathway. FASEB J. 2012;26(8):3453\u201363.","journal-title":"FASEB J"},{"issue":"3","key":"3424_CR38","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/nrd4100","volume":"13","author":"DJ Kojetin","year":"2014","unstructured":"Kojetin DJ, Burris TP. REV-ERB and ROR nuclear receptors as drug targets. Nat Rev Drug Discov. 2014;13(3):197\u2013216.","journal-title":"Nat Rev Drug Discov"},{"issue":"4","key":"3424_CR39","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.cmet.2016.03.007","volume":"23","author":"B He","year":"2016","unstructured":"He B, Nohara K, Park N, Park YS, Guillory B, Zhao Z, et al. The small molecule nobiletin targets the molecular oscillator to enhance circadian rhythms and protect against metabolic syndrome. Cell Metab. 2016;23(4):610\u201321.","journal-title":"Cell Metab"},{"issue":"1","key":"3424_CR40","doi-asserted-by":"publisher","first-page":"3923","DOI":"10.1038\/s41467-019-11926-y","volume":"10","author":"K Nohara","year":"2019","unstructured":"Nohara K, Mallampalli V, Nemkov T, Wirianto M, Yang J, Ye Y, et al. Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge. Nat Commun. 2019;10(1):3923.","journal-title":"Nat Commun"},{"key":"3424_CR41","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.ebiom.2016.02.043","volume":"6","author":"W Liu","year":"2016","unstructured":"Liu W, Zhou M, Li Z, Li H, Polaczek P, Dai H, et al. A selective small molecule DNA2 inhibitor for sensitization of human cancer cells to chemotherapy. EBioMedicine. 2016;6:73\u201386.","journal-title":"EBioMedicine"},{"issue":"1","key":"3424_CR42","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.ccell.2020.04.017","volume":"38","author":"R Su","year":"2020","unstructured":"Su R, Dong L, Li Y, Gao M, Han L, Wunderlich M, et al. Targeting FTO suppresses cancer stem cell maintenance and immune evasion. Cancer Cell. 2020;38(1):79\u201396.","journal-title":"Cancer Cell"},{"issue":"7","key":"3424_CR43","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1021\/jm030644s","volume":"47","author":"TA Halgren","year":"2004","unstructured":"Halgren TA, Murphy RB, Friesner RA, Beard HS, Frye LL, Pollard WT, et al. Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening. J Med Chem. 2004;47(7):1750\u20139.","journal-title":"J Med Chem"},{"issue":"4","key":"3424_CR44","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.ddtec.2004.11.007","volume":"1","author":"CA Lipinski","year":"2004","unstructured":"Lipinski CA. Lead- and drug-like compounds: the rule-of-five revolution. Drug Discov Today Technol. 2004;1(4):337\u201341.","journal-title":"Drug Discov Today Technol"},{"issue":"7","key":"3424_CR45","doi-asserted-by":"publisher","first-page":"2719","DOI":"10.1021\/jm901137j","volume":"53","author":"JB Baell","year":"2010","unstructured":"Baell JB, Holloway GA. New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. J Med Chem. 2010;53(7):2719\u201340.","journal-title":"J Med Chem"},{"issue":"1","key":"3424_CR46","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1021\/ja0455547","volume":"127","author":"JR Huth","year":"2005","unstructured":"Huth JR, Mendoza R, Olejniczak ET, Johnson RW, Cothron DA, Liu Y, et al. ALARM NMR: a rapid and robust experimental method to detect reactive false positives in biochemical screens. J Am Chem Soc. 2005;127(1):217\u201324.","journal-title":"J Am Chem Soc"},{"issue":"2","key":"3424_CR47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000023","volume":"4","author":"AC Liu","year":"2008","unstructured":"Liu AC, Tran HG, Zhang EE, Priest AA, Welsh DK, Kay SA. Redundant function of REV-ERBalpha and beta and non-essential role for Bmal1 cycling in transcriptional regulation of intracellular circadian rhythms. PLoS Genet. 2008;4(2): e1000023.","journal-title":"PLoS Genet"},{"issue":"15","key":"3424_CR48","doi-asserted-by":"publisher","first-page":"5339","DOI":"10.1073\/pnas.0308709101","volume":"101","author":"SH Yoo","year":"2004","unstructured":"Yoo SH, Yamazaki S, Lowrey PL, Shimomura K, Ko CH, Buhr ED, et al. PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues. Proc Natl Acad Sci USA. 2004;101(15):5339\u201346.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"3424_CR49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007369","volume":"14","author":"C Ramanathan","year":"2018","unstructured":"Ramanathan C, Kathale ND, Liu D, Lee C, Freeman DA, Hogenesch JB, et al. mTOR signaling regulates central and peripheral circadian clock function. PLoS Genet. 2018;14(5): e1007369.","journal-title":"PLoS Genet"},{"issue":"1","key":"3424_CR50","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1073\/pnas.1118034108","volume":"109","author":"Z Chen","year":"2012","unstructured":"Chen Z, Yoo SH, Park YS, Kim KH, Wei S, Buhr E, et al. Identification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening. Proc Natl Acad Sci USA. 2012;109(1):101\u20136.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8","key":"3424_CR51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006843","volume":"4","author":"K Ma","year":"2009","unstructured":"Ma K, Xiao R, Tseng HT, Shan L, Fu L, Moore DD. Circadian dysregulation disrupts bile acid homeostasis. PLoS ONE. 2009;4(8): e6843.","journal-title":"PLoS ONE"},{"issue":"7","key":"3424_CR52","doi-asserted-by":"publisher","first-page":"2608","DOI":"10.1073\/pnas.0409763102","volume":"102","author":"SH Yoo","year":"2005","unstructured":"Yoo SH, Ko CH, Lowrey PL, Buhr ED, Song EJ, Chang S, et al. A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo. Proc Natl Acad Sci USA. 2005;102(7):2608\u201313.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"3424_CR53","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1152\/physrev.00019.2003","volume":"84","author":"SB Charge","year":"2004","unstructured":"Charge SB, Rudnicki MA. Cellular and molecular regulation of muscle regeneration. Physiol Rev. 2004;84(1):209\u201338.","journal-title":"Physiol Rev"},{"issue":"2","key":"3424_CR54","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.molmed.2007.12.004","volume":"14","author":"S Kuang","year":"2008","unstructured":"Kuang S, Rudnicki MA. The emerging biology of satellite cells and their therapeutic potential. Trends Mol Med. 2008;14(2):82\u201391.","journal-title":"Trends Mol Med"},{"key":"3424_CR55","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1101\/sqb.2008.73.064","volume":"73","author":"MA Rudnicki","year":"2008","unstructured":"Rudnicki MA, Le Grand F, McKinnell I, Kuang S. The molecular regulation of muscle stem cell function. Cold Spring Harb Symp Quant Biol. 2008;73:323\u201331.","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"3424_CR56","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/B978-0-12-396971-2.00009-9","volume":"119","author":"L Fu","year":"2013","unstructured":"Fu L, Kettner NM. The circadian clock in cancer development and therapy. Prog Mol Biol Transl Sci. 2013;119:221\u201382.","journal-title":"Prog Mol Biol Transl Sci"},{"issue":"6524","key":"3424_CR57","doi-asserted-by":"publisher","first-page":"eabb0738","DOI":"10.1126\/science.abb0738","volume":"371","author":"A Sancar","year":"2021","unstructured":"Sancar A, Van Gelder RN. Clocks, cancer, and chronochemotherapy. Science. 2021;371(6524):eabb0738.","journal-title":"Science"},{"issue":"2","key":"3424_CR58","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1021\/cb1002575","volume":"6","author":"D Kojetin","year":"2011","unstructured":"Kojetin D, Wang Y, Kamenecka TM, Burris TP. Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB. ACS Chem Biol. 2011;6(2):131\u20134.","journal-title":"ACS Chem Biol"},{"issue":"7344","key":"3424_CR59","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/nature10075","volume":"472","author":"LA Solt","year":"2011","unstructured":"Solt LA, Kumar N, Nuhant P, Wang Y, Lauer JL, Liu J, et al. Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand. Nature. 2011;472(7344):491\u20134.","journal-title":"Nature"},{"issue":"6","key":"3424_CR60","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/s41589-020-0505-1","volume":"16","author":"S Miller","year":"2020","unstructured":"Miller S, Son YL, Aikawa Y, Makino E, Nagai Y, Srivastava A, et al. Isoform-selective regulation of mammalian cryptochromes. Nat Chem Biol. 2020;16(6):676\u201385.","journal-title":"Nat Chem Biol"},{"issue":"4","key":"3424_CR61","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1177\/0310057X0803600404","volume":"36","author":"KS Lim","year":"2008","unstructured":"Lim KS, Kam PC. Chlorhexidine\u2013pharmacology and clinical applications. Anaesth Intensive Care. 2008;36(4):502\u201312.","journal-title":"Anaesth Intensive Care"},{"issue":"2","key":"3424_CR62","doi-asserted-by":"publisher","first-page":"202","DOI":"10.2334\/josnusd.19-0225","volume":"62","author":"PG Arduino","year":"2020","unstructured":"Arduino PG, Gambino A, Cabras M, Sciannameo V, Nimot Y, Karimi D, et al. Effect of two different alcohol-free chlorhexidine formulations in mouthrinses on the immediate postoperative period for oral mucosal biopsies. J Oral Sci. 2020;62(2):202\u20135.","journal-title":"J Oral Sci"},{"issue":"5","key":"3424_CR63","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.jdent.2007.01.007","volume":"35","author":"LG Ribeiro","year":"2007","unstructured":"Ribeiro LG, Hashizume LN, Maltz M. The effect of different formulations of chlorhexidine in reducing levels of mutans streptococci in the oral cavity: a systematic review of the literature. J Dent. 2007;35(5):359\u201370.","journal-title":"J Dent"},{"issue":"5","key":"3424_CR64","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1111\/joim.12347","volume":"277","author":"C Dibner","year":"2015","unstructured":"Dibner C, Schibler U. Circadian timing of metabolism in animal models and humans. J Intern Med. 2015;277(5):513\u201327.","journal-title":"J Intern Med"},{"key":"3424_CR65","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2020.111110","volume":"521","author":"X Xiong","year":"2021","unstructured":"Xiong X, Lin Y, Lee J, Paul A, Yechoor V, Figueiro M, et al. Chronic circadian shift leads to adipose tissue inflammation and fibrosis. Mol Cell Endocrinol. 2021;521: 111110.","journal-title":"Mol Cell Endocrinol"},{"issue":"1","key":"3424_CR66","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.yexcr.2014.08.041","volume":"331","author":"S Chatterjee","year":"2015","unstructured":"Chatterjee S, Yin H, Nam D, Li Y, Ma K. Brain and muscle Arnt-like 1 promotes skeletal muscle regeneration through satellite cell expansion. Exp Cell Res. 2015;331(1):200\u201310.","journal-title":"Exp Cell Res"},{"issue":"1","key":"3424_CR67","doi-asserted-by":"publisher","first-page":"17142","DOI":"10.1038\/s41598-017-17496-7","volume":"7","author":"RD Welch","year":"2017","unstructured":"Welch RD, Billon C, Valfort AC, Burris TP, Flaveny CA. Pharmacological inhibition of REV-ERB stimulates differentiation, inhibits turnover and reduces fibrosis in dystrophic muscle. Sci Rep. 2017;7(1):17142.","journal-title":"Sci Rep"}],"container-title":["Stem Cell Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-023-03424-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13287-023-03424-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-023-03424-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T19:04:25Z","timestamp":1690830265000},"score":1,"resource":{"primary":{"URL":"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/s13287-023-03424-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,31]]},"references-count":67,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["3424"],"URL":"https:\/\/doi.org\/10.1186\/s13287-023-03424-2","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.01.18.524648","asserted-by":"object"}]},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,31]]},"assertion":[{"value":"28 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that no competing interests exist that is relevant to the subject matter or materials included in this work.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"190"}}