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Recent studies have reported that adipose tissue-derived stem cell conditioned media (ADSC-CM) could induce hair growth and regeneration.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>To investigate the efficacy of ADSC-CM combined with minoxidil for hair regeneration therapy in male AGA.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This study lasted for 6\u00a0weeks. Subjects were divided into two groups: concentrated and non-concentrated ADSC-CM. Scalp was divided vertically in half before intradermal injection was administered from the frontal region of the scalp toward the vertex with a 30G needle, spaced about 1\u00a0cm apart. Treatment side received 2\u00a0ml of ADSC-CM; the other side was given 2\u00a0ml of NaCl 0.9% as placebo. Patients applied 5% minoxidil twice daily post-injection. Improvements were assessed using photographs and trichoscan every 2\u00a0weeks.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Hair count, hair density, and mean thickness increased significantly on both sides after 6\u00a0weeks, while vellus rate decreased proportionally with the increase of terminal rate. No statistically significant differences between treatment groups were found. Minimum side effects were reported, and subjects were satisfied with the results.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Combination of ADSC-CM and minoxidil could be a potential agent for hair regrowth. Follow-up research with extensive populations, longer duration, and different study design may be required to confirm the exact mechanisms of ADSC-CM on hair growth.<\/jats:p>\n                <jats:p><jats:italic>Trial registration<\/jats:italic>: Clinicaltrials.gov, NCT05296863. Registered 25 March 2022\u2014Retrospectively registered, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05296863\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05296863<\/jats:ext-link>.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13287-023-03440-2","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T15:02:54Z","timestamp":1692630174000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Combination of adipose-derived stem cell conditioned media and minoxidil for hair regrowth in male androgenetic alopecia: a randomized, double-blind clinical trial"],"prefix":"10.1186","volume":"14","clinical-trial-number":[{"clinical-trial-number":"nct05296863","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5793-2525","authenticated-orcid":false,"given":"Lili","family":"Legiawati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lis Surachmiati","family":"Suseno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irma Bernadette S.","family":"Sitohang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannaz Nadia","family":"Yusharyahya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne Adiwinata","family":"Pawitan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella Kurnia","family":"Liem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trie","family":"Kurniawati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athaya","family":"Ardelia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanya","family":"Paramastri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,8,21]]},"reference":[{"key":"3440_CR1","unstructured":"Soepardiman L, Legiawati L. 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As a result of the COVID-19 pandemic, ethical approval was extended until February 23, 2022 with decision number of ND-369\/UN2.F1\/ETIK\/PPM.00.02\/2021 on May 24, 2021. The Innovation and Intellectual Property Management Unit of Dr. Cipto Mangunkusumo Hospital issued the location permit to conduct the research on July 5, 2021, with decision number LB.02.01\/2.6.1\/0862\/2021. Prior to the study, we provided a thorough explanation about the research protocol and asked the participants to sign a consent form before enrolling in the study. All participants consented for images or other clinical information relating to their case to be reported in a medical publication. The writers will make substantial efforts to conceal their identities.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All participants consented for images or other clinical information relating to their case to be reported in a medical publication. The writers will make substantial efforts to conceal their identities.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"210"}}