{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:41:27Z","timestamp":1789400487941,"version":"build-2803163510"},"reference-count":85,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004515","name":"Universiti Kebangsaan Malaysia","doi-asserted-by":"publisher","award":["FF-2020-469\/1"],"award-info":[{"award-number":["FF-2020-469\/1"]}],"id":[{"id":"10.13039\/501100004515","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004515","name":"Universiti Kebangsaan Malaysia","doi-asserted-by":"publisher","award":["DPK-2021-006"],"award-info":[{"award-number":["DPK-2021-006"]}],"id":[{"id":"10.13039\/501100004515","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ming Medical Sdn. Bhd.","award":["FF-2020-469"],"award-info":[{"award-number":["FF-2020-469"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Metabolic syndrome (MetS) is a significant epidemiological problem worldwide. It is a pre-morbid, chronic and low-grade inflammatory disorder that precedes many chronic diseases. Wharton\u2019s jelly-derived mesenchymal stem cells (WJ-MSCs) could be used to treat MetS because they express high regenerative capacity, strong immunomodulatory properties and allogeneic biocompatibility. This study aims to investigate WJ-MSCs as a therapy against MetS in a rat model.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Twenty-four animals were fed with high-fat high-fructose (HFHF) diet ad libitum. After 16\u00a0weeks, the animals were randomised into treatment groups (n\u2009=\u20098\/group) and received a single intravenous administration of vehicle, that is, 3\u2009\u00d7\u200910<jats:sup>6<\/jats:sup> cells\/kg or 10\u2009\u00d7\u200910<jats:sup>6<\/jats:sup> cells\/kg of WJ-MSCs. A healthy animal group (n\u2009=\u20096) fed with a normal diet received the same vehicle as the control (CTRL). All animals were periodically assessed (every 4\u00a0weeks) for physical measurements, serum biochemistry, glucose tolerance test, cardiovascular function test and whole-body composition. Post-euthanasia, organs were weighed and processed for histopathology. Serum was collected for C-reactive protein and inflammatory cytokine assay.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The results between HFHF-treated groups and healthy or HFHF-CTRL did not achieve statistical significance (\u03b1\u2009=\u20090.05). The effects of WJ-MSCs were masked by the manifestation of different disease subclusters and continuous supplementation of HFHF diet. Based on secondary analysis, WJ-MSCs had major implications in improving cardiopulmonary morbidities. The lungs, liver and heart show significantly better histopathology in the WJ-MSC-treated groups than in the untreated CTRL group. The cells produced a dose-dependent effect (high dose lasted until week 8) in preventing further metabolic decay in MetS animals.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The establishment of safety and therapeutic proof-of-concept encourages further studies by improving the current therapeutic model.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13287-024-03769-2","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:01:32Z","timestamp":1717545692000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Single high-dose intravenous injection of Wharton\u2019s jelly-derived mesenchymal stem cell exerts protective effects in a rat model of metabolic syndrome"],"prefix":"10.1186","volume":"15","author":[{"given":"Alvin Man Lung","family":"Chan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela Min Hwei","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Heikal Mohd","family":"Yunus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruszymah Hj","family":"Idrus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia Xian","family":"Law","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Dain","family":"Yazid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kok-Yong","family":"Chin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Rafizul Mohd","family":"Yusof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"See Nguan","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benson","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9548-6490","authenticated-orcid":false,"given":"Yogeswaran","family":"Lokanathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,5]]},"reference":[{"issue":"9","key":"3769_CR1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105056","volume":"9","author":"GC Moreira","year":"2014","unstructured":"Moreira GC, Cipullo JP, Ciorlia LA, Cesarino CB, Vilela-Martin JF. Prevalence of metabolic syndrome: association with risk factors and cardiovascular complications in an urban population. PLoS ONE. 2014;9(9): e105056. https:\/\/doi.org\/10.1371\/journal.pone.0105056.","journal-title":"PLoS ONE"},{"issue":"3","key":"3769_CR2","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1159\/000443743","volume":"68","author":"M Uzunlulu","year":"2016","unstructured":"Uzunlulu M, Telci Caklili O, Oguz A. Association between metabolic syndrome and cancer. Ann Nutr Metab. 2016;68(3):173\u20139. https:\/\/doi.org\/10.1159\/000443743.","journal-title":"Ann Nutr Metab"},{"key":"3769_CR3","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.trsl.2017.01.001","volume":"183","author":"JD Tune","year":"2017","unstructured":"Tune JD, Goodwill AG, Sassoon DJ, Mather KJ. Cardiovascular consequences of metabolic syndrome. Transl Res. 2017;183:57\u201370. https:\/\/doi.org\/10.1016\/j.trsl.2017.01.001.","journal-title":"Transl Res"},{"issue":"13","key":"3769_CR4","doi-asserted-by":"publisher","first-page":"3667","DOI":"10.2147\/DMSO.S275560","volume":"13","author":"KY Chin","year":"2020","unstructured":"Chin KY, Wong SK, Ekeuku SO, Pang KL. Relationship between metabolic syndrome and bone health - an evaluation of epidemiological studies and mechanisms involved. Diabetes Metab Syndr Obes. 2020;13(13):3667\u201390. https:\/\/doi.org\/10.2147\/DMSO.S275560.","journal-title":"Diabetes Metab Syndr Obes"},{"issue":"6","key":"3769_CR5","doi-asserted-by":"publisher","first-page":"e101","DOI":"10.1097\/j.pbj.0000000000000101","volume":"5","author":"VMG Regufe","year":"2020","unstructured":"Regufe VMG, Pinto CMCB, Perez PMVHC. Metabolic syndrome in type 2 diabetic patients: a review of current evidence. Porto Biomed J. 2020;5(6):e101. https:\/\/doi.org\/10.1097\/j.pbj.0000000000000101.","journal-title":"Porto Biomed J."},{"key":"3769_CR6","doi-asserted-by":"publisher","unstructured":"Pammer LM, Lamina C, Schultheiss UT, Kotsis F, Kollerits B, Stockmann H, Lipovsek J, Meiselbach H, Busch M, Eckardt KU, Kronenberg F; GCKD Investigators (2021) Association of the metabolic syndrome with mortality and major adverse cardiac events: a large chronic kidney disease cohort. J Intern Med. 290(6):1219\u20131232. https:\/\/doi.org\/10.1111\/joim.13355.","DOI":"10.1111\/joim.13355"},{"key":"3769_CR7","doi-asserted-by":"publisher","unstructured":"Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC Jr; International Diabetes Federation Task Force on Epidemiology and Prevention; Hational Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; International Association for the Study of Obesity (2009) Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120(16):1640\u20131645. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.109.192644.","DOI":"10.1161\/CIRCULATIONAHA.109.192644"},{"issue":"9","key":"3769_CR8","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13817","volume":"52","author":"X Tang","year":"2022","unstructured":"Tang X, Wu M, Wu S, Tian Y. Continuous metabolic syndrome severity score and the risk of CVD and all-cause mortality. Eur J Clin Invest. 2022;52(9): e13817. https:\/\/doi.org\/10.1111\/eci.13817.","journal-title":"Eur J Clin Invest"},{"issue":"17","key":"3769_CR9","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.9734\/BJPR\/2014\/8382","volume":"4","author":"PO Osadebe","year":"2014","unstructured":"Osadebe PO, Odoh EU, Uzor PF. Natural products as potential sources of antidiabetic drugs. JPRI. 2014;4(17):2075\u20139. https:\/\/doi.org\/10.9734\/BJPR\/2014\/8382.","journal-title":"JPRI"},{"issue":"1","key":"3769_CR10","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1001\/jama.2013.281361","volume":"311","author":"SZ Yanovski","year":"2014","unstructured":"Yanovski SZ, Yanovski JA. Long-term drug treatment for obesity: a systematic and clinical review. JAMA. 2014;311(1):74\u201386. https:\/\/doi.org\/10.1001\/jama.2013.281361.","journal-title":"JAMA"},{"issue":"2","key":"3769_CR11","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s11906-019-0915-1","volume":"21","author":"JB Cohen","year":"2019","unstructured":"Cohen JB, Gadde KM. Weight Loss Medications in the Treatment of Obesity and Hypertension. Curr Hypertens Rep. 2019;21(2):16. https:\/\/doi.org\/10.1007\/s11906-019-0915-1.","journal-title":"Curr Hypertens Rep"},{"issue":"2","key":"3769_CR12","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1001\/jama.2021.9486","volume":"326","author":"SZ Yanovski","year":"2021","unstructured":"Yanovski SZ, Yanovski JA. Progress in pharmacotherapy for obesity. JAMA. 2021;326(2):129\u201330. https:\/\/doi.org\/10.1001\/jama.2021.9486.","journal-title":"JAMA"},{"issue":"4","key":"3769_CR13","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1124\/pr.117.014803","volume":"70","author":"TD M\u00fcller","year":"2018","unstructured":"M\u00fcller TD, Clemmensen C, Finan B, DiMarchi RD, Tsch\u00f6p MH. Anti-obesity therapy: from rainbow pills to polyagonists. Pharmacol Rev. 2018;70(4):712\u201346. https:\/\/doi.org\/10.1124\/pr.117.014803.","journal-title":"Pharmacol Rev"},{"issue":"3","key":"3769_CR14","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/s41573-021-00337-8","volume":"21","author":"TD M\u00fcller","year":"2022","unstructured":"M\u00fcller TD, Bl\u00fcher M, Tsch\u00f6p MH, DiMarchi RD. Anti-obesity drug discovery: advances and challenges. Nat Rev Drug Discov. 2022;21(3):201\u201323. https:\/\/doi.org\/10.1038\/s41573-021-00337-8.","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"3769_CR15","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1002\/sctm.19-0202","volume":"9","author":"M Kabat","year":"2020","unstructured":"Kabat M, Bobkov I, Kumar S, Grumet M. Trends in mesenchymal stem cell clinical trials 2004\u20132018: Is efficacy optimal in a narrow dose range? Stem Cells Transl Med. 2020;9(1):17\u201327. https:\/\/doi.org\/10.1002\/sctm.19-0202.","journal-title":"Stem Cells Transl Med"},{"issue":"12","key":"3769_CR16","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.626755","volume":"30","author":"V Planat-Benard","year":"2021","unstructured":"Planat-Benard V, Varin A, Casteilla L. MSCs and inflammatory cells crosstalk in regenerative medicine: concerted actions for optimized resolution driven by energy metabolism. Front Immunol. 2021;30(12): 626755. https:\/\/doi.org\/10.3389\/fimmu.2021.626755.","journal-title":"Front Immunol"},{"issue":"1","key":"3769_CR17","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.arcmed.2020.08.006","volume":"52","author":"DE Rodr\u00edguez-Fuentes","year":"2021","unstructured":"Rodr\u00edguez-Fuentes DE, Fern\u00e1ndez-Garza LE, Samia-Meza JA, Barrera-Barrera SA, Caplan AI, Barrera-Salda\u00f1a HA. Mesenchymal stem cells current clinical applications: a systematic review. Arch Med Res. 2021;52(1):93\u2013101. https:\/\/doi.org\/10.1016\/j.arcmed.2020.08.006.","journal-title":"Arch Med Res"},{"issue":"10","key":"3769_CR18","doi-asserted-by":"publisher","first-page":"549","DOI":"10.3923\/ajava.2015.549.555","volume":"10","author":"L Santra","year":"2015","unstructured":"Santra L, Gupta S, Singh AK, Sahu AR, Gandham RK, Naskar S, Maity SK, Ghosh J, Dhara SK. A comparative analysis of invasive and non-invasive method of bone marrow stromal cell isolation. AJAVA. 2015;10(10):549\u201355. https:\/\/doi.org\/10.3923\/ajava.2015.549.555.","journal-title":"AJAVA"},{"issue":"2","key":"3769_CR19","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s12015-006-0022-y","volume":"2","author":"ML Weiss","year":"2006","unstructured":"Weiss ML, Troyer DL. Stem cells in the umbilical cord. Stem Cell Rev. 2006;2(2):155\u201362. https:\/\/doi.org\/10.1007\/s12015-006-0022-y.","journal-title":"Stem Cell Rev"},{"issue":"9","key":"3769_CR20","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1016\/j.arthro.2015.03.014","volume":"31","author":"CT Vangsness Jr","year":"2015","unstructured":"Vangsness CT Jr, Sternberg H, Harris L. Umbilical cord tissue offers the greatest number of harvestable mesenchymal stem cells for research and clinical application: a literature review of different harvest sites. Arthroscopy. 2015;31(9):1836\u201343. https:\/\/doi.org\/10.1016\/j.arthro.2015.03.014.","journal-title":"Arthroscopy"},{"issue":"4","key":"3769_CR21","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/s41536-019-0083-6","volume":"2","author":"MF Pittenger","year":"2019","unstructured":"Pittenger MF, Discher DE, P\u00e9ault BM, Phinney DG, Hare JM, Caplan AI. Mesenchymal stem cell perspective: cell biology to clinical progress. NPJ Regen Med. 2019;2(4):22. https:\/\/doi.org\/10.1038\/s41536-019-0083-6.","journal-title":"NPJ Regen Med"},{"issue":"7","key":"3769_CR22","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1177\/0963689719837897","volume":"28","author":"A Musia\u0142-Wysocka","year":"2019","unstructured":"Musia\u0142-Wysocka A, Kot M, Majka M. The pros and cons of mesenchymal stem cell-based therapies. Cell Transplant. 2019;28(7):801\u201312. https:\/\/doi.org\/10.1177\/0963689719837897.","journal-title":"Cell Transplant"},{"issue":"1","key":"3769_CR23","doi-asserted-by":"publisher","first-page":"3403","DOI":"10.1038\/s41598-021-83088-1","volume":"11","author":"S Bhat","year":"2021","unstructured":"Bhat S, Viswanathan P, Chandanala S, Prasanna SJ, Seetharam RN. Expansion and characterization of bone marrow derived human mesenchymal stromal cells in serum-free conditions. Sci Rep. 2021;11(1):3403. https:\/\/doi.org\/10.1038\/s41598-021-83088-1.","journal-title":"Sci Rep"},{"issue":"8","key":"3769_CR24","doi-asserted-by":"publisher","first-page":"7","DOI":"10.21037\/sci-2020-037","volume":"2","author":"S Muthu","year":"2021","unstructured":"Muthu S, Bapat A, Jain R, Jeyaraman N, Jeyaraman M. Exosomal therapy-a new frontier in regenerative medicine. Stem Cell Investig. 2021;2(8):7. https:\/\/doi.org\/10.21037\/sci-2020-037.","journal-title":"Stem Cell Investig"},{"issue":"3","key":"3769_CR25","doi-asserted-by":"publisher","first-page":"73","DOI":"10.4252\/wjsc.v8.i3.73","volume":"8","author":"A De Becker","year":"2016","unstructured":"De Becker A, Riet IV. Homing and migration of mesenchymal stromal cells: How to improve the efficacy of cell therapy? World J Stem Cells. 2016;8(3):73\u201387. https:\/\/doi.org\/10.4252\/wjsc.v8.i3.73.","journal-title":"World J Stem Cells"},{"key":"3769_CR26","doi-asserted-by":"publisher","unstructured":"Galleu A, Riffo-Vasquez Y, Trento C, Lomas C, Dolcetti L, Cheung TS, von Bonin M, Barbieri L, Halai K, Ward S, Weng L, Chakraverty R, Lombardi G, Watt FM, Orchard K, Marks DI, Apperley J, Bornhauser M, Walczak H, Bennett C, Dazzi F (2017) Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation. Science Transl Med 9(416):eaam7828. https:\/\/doi.org\/10.1126\/scitranslmed.aam7828","DOI":"10.1126\/scitranslmed.aam7828"},{"issue":"10","key":"3769_CR27","doi-asserted-by":"publisher","first-page":"e438","DOI":"10.3324\/haematol.2018.214767","volume":"104","author":"TS Cheung","year":"2019","unstructured":"Cheung TS, Galleu A, von Bonin M, Bornh\u00e4user M, Dazzi F. Apoptotic mesenchymal stromal cells induce prostaglandin E2 in monocytes: implications for the monitoring of mesenchymal stromal cell activity. Haematologica. 2019;104(10):e438\u201341. https:\/\/doi.org\/10.3324\/haematol.2018.214767.","journal-title":"Haematologica"},{"issue":"19","key":"3769_CR28","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.reth.2022.01.008","volume":"17","author":"AML Chan","year":"2022","unstructured":"Chan AML, Ng AMH, Mohd Yunus MH, Hj Idrus RB, Law JX, Yazid MD, Chin KY, Shamsuddin SA, Mohd Yusof MR, Razali RA, Mat Afandi MA, Hassan MNF, Ng SN, Koh B, Lokanathan Y. Safety study of allogeneic mesenchymal stem cell therapy in animal model. Regen Ther. 2022;17(19):158\u201365. https:\/\/doi.org\/10.1016\/j.reth.2022.01.008.","journal-title":"Regen Ther"},{"issue":"9","key":"3769_CR29","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.3389\/fphar.2018.01395","volume":"6","author":"AKN Alencar","year":"2018","unstructured":"Alencar AKN, Pimentel-Coelho PM, Montes GC, da Silva MMC, Mendes LVP, Montagnoli TL, Silva AMS, Vasques JF, Rosado-de-Castro PH, Gutfilen B, Cunha VDMN, Fraga AGM, Silva PMRE, Martins MA, Ferreira TPT, Mendes-Otero R, Trachez MM, Sudo RT, Zapata-Sudo G. Human mesenchymal stem cell therapy reverses Su5416\/hypoxia-induced pulmonary arterial hypertension in mice. Front Pharmacol. 2018;6(9):1395. https:\/\/doi.org\/10.3389\/fphar.2018.01395.","journal-title":"Front Pharmacol"},{"issue":"4","key":"3769_CR30","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1002\/cld.742","volume":"12","author":"Z Lominadze","year":"2018","unstructured":"Lominadze Z, Kallwitz ER. Misconception: you can\u2019t have liver disease with normal liver chemistries. Clin Liver Dis (Hoboken). 2018;12(4):96\u20139. https:\/\/doi.org\/10.1002\/cld.742.","journal-title":"Clin Liver Dis (Hoboken)"},{"key":"3769_CR31","first-page":"135","volume":"28","author":"M Zafar","year":"2010","unstructured":"Zafar M, Naqvi SN. Effects of STZ-induced diabetes on the relative weights of kidney, liver and pancreas in albino rats: a comparative study. J Morphol. 2010;28:135\u201342.","journal-title":"J Morphol"},{"key":"3769_CR32","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/592915","volume":"2015","author":"S Fujimaki","year":"2015","unstructured":"Fujimaki S, Wakabayashi T, Takemasa T, Asashima M, Kuwabara T. Diabetes and stem cell function. Biomed Res Int. 2015;2015: 592915. https:\/\/doi.org\/10.1155\/2015\/592915.","journal-title":"Biomed Res Int"},{"issue":"10","key":"3769_CR33","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3389\/fphys.2019.00107","volume":"13","author":"A Elksnis","year":"2019","unstructured":"Elksnis A, Martinell M, Eriksson O, Espes D. Heterogeneity of metabolic defects in type 2 diabetes and its relation to reactive oxygen species and alterations in beta-cell mass. Front Physiol. 2019;13(10):107. https:\/\/doi.org\/10.3389\/fphys.2019.00107.","journal-title":"Front Physiol"},{"issue":"1","key":"3769_CR34","doi-asserted-by":"publisher","first-page":"124","DOI":"10.5603\/FM.a2018.0063","volume":"78","author":"SM Zaki","year":"2019","unstructured":"Zaki SM, Fattah SA, Hassan DS. The differential effects of high-fat and high- -fructose diets on the liver of male albino rat and the proposed underlying mechanisms. Folia Morphol (Warsz). 2019;78(1):124\u201336. https:\/\/doi.org\/10.5603\/FM.a2018.0063.","journal-title":"Folia Morphol (Warsz)"},{"issue":"9","key":"3769_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022","volume":"39","author":"L Han","year":"2022","unstructured":"Han L, Wang G, Zhou S, Situ C, He Z, Li Y, Qiu Y, Huang Y, Xu A, Ong MTY, Wang H, Zhang J, Wu Z. Muscle satellite cells are impaired in type 2 diabetic mice by elevated extracellular adenosine. Cell Rep. 2022;39(9): 110884. https:\/\/doi.org\/10.1016\/j.celrep.2022.","journal-title":"Cell Rep"},{"key":"3769_CR36","doi-asserted-by":"publisher","unstructured":"Lee CM, Huxley RR, Woodward M, Zimmet P, Shaw J, Cho NH, Kim HR, Viali S, Tominaga M, Vistisen D, Borch-Johnsen K, Colagiuri S, DETECT-2 Collaboration (2008) The metabolic syndrome identifies a heterogeneous group of metabolic component combinations in the Asia-Pacific region. Diabetes Res Clin Pract 81(3):377\u2013380. https:\/\/doi.org\/10.1016\/j.diabres.2008.05.011.","DOI":"10.1016\/j.diabres.2008.05.011"},{"issue":"13","key":"3769_CR37","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1161\/CIRCULATIONAHA.117.029617","volume":"137","author":"IJ Neeland","year":"2018","unstructured":"Neeland IJ, Poirier P, Despr\u00e9s JP. Cardiovascular and metabolic heterogeneity of obesity: clinical challenges and implications for management. Circulation. 2018;137(13):1391\u2013406. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.117.029617.","journal-title":"Circulation"},{"issue":"8","key":"3769_CR38","doi-asserted-by":"publisher","first-page":"2497","DOI":"10.3390\/nu13082497","volume":"13","author":"AML Chan","year":"2021","unstructured":"Chan AML, Ng AMH, Mohd Yunus MH, Idrus RBH, Law JX, Yazid MD, Chin KY, Shamsuddin SA, Lokanathan Y. Recent developments in rodent models of high-fructose diet-induced metabolic syndrome: a systematic review. Nutrients. 2021;13(8):2497. https:\/\/doi.org\/10.3390\/nu13082497.","journal-title":"Nutrients"},{"key":"3769_CR39","doi-asserted-by":"publisher","unstructured":"Rozendaal YJW, Wang Y, Paalvast Y, Tambyrajah LL, Li Z, Willems van Dijk K, Rensen PCN, Kuivenhoven JA, Groen AK, Hilbers PAJ, van Riel NAW (2018) In vivo and in silico dynamics of the development of Metabolic Syndrome. PLoS Comput Biol 14(6):e1006145. https:\/\/doi.org\/10.1371\/journal.pcbi.1006145.","DOI":"10.1371\/journal.pcbi.1006145"},{"key":"3769_CR40","doi-asserted-by":"publisher","unstructured":"Fassio A, Idolazzi L, Rossini M, Gatti D, Adami G, Giollo A, Viapiana O (2018) The obesity paradox and osteoporosis. Eat Weight Disord 23(3):293\u2013302. https:\/\/doi.org\/10.1007\/s40519-018-0505-2. Epub 2018 Apr 11. Erratum in: Eat Weight Disord. 2018 May 2","DOI":"10.1007\/s40519-018-0505-2"},{"issue":"6","key":"3769_CR41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0252487","volume":"16","author":"AF Turcotte","year":"2021","unstructured":"Turcotte AF, O\u2019Connor S, Morin SN, Gibbs JC, Willie BM, Jean S, Gagnon C. Association between obesity and risk of fracture, bone mineral density and bone quality in adults: a systematic review and meta-analysis. PLoS ONE. 2021;16(6): e0252487. https:\/\/doi.org\/10.1371\/journal.pone.0252487.","journal-title":"PLoS ONE"},{"issue":"11","key":"3769_CR42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078464","volume":"8","author":"EB Oliveira-Sales","year":"2013","unstructured":"Oliveira-Sales EB, Maquigussa E, Semedo P, Pereira LG, Ferreira VM, C\u00e2mara NO, Bergamaschi CT, Campos RR, Boim MA. Mesenchymal stem cells (MSC) prevented the progression of renovascular hypertension, improved renal function and architecture. PLoS ONE. 2013;8(11): e78464. https:\/\/doi.org\/10.1371\/journal.pone.0078464.","journal-title":"PLoS ONE"},{"issue":"5","key":"3769_CR43","doi-asserted-by":"publisher","first-page":"576","DOI":"10.3346\/jkms.2015.30.5.576","volume":"30","author":"H Lee","year":"2015","unstructured":"Lee H, Lee JC, Kwon JH, Kim KC, Cho MS, Yang YS, Oh W, Choi SJ, Seo ES, Lee SJ, Wang TJ, Hong YM. The effect of umbilical cord blood derived mesenchymal stem cells in monocrotaline-induced pulmonary artery hypertension rats. J Kor Med Sci. 2015;30(5):576\u201385. https:\/\/doi.org\/10.3346\/jkms.2015.30.5.576.","journal-title":"J Kor Med Sci"},{"issue":"3","key":"3769_CR44","doi-asserted-by":"publisher","first-page":"570","DOI":"10.3349\/ymj.2017.58.3.570","volume":"58","author":"H Lee","year":"2017","unstructured":"Lee H, Kim KC, Choi SJ, Hong YM. Optimal dose and timing of umbilical stem cells treatment in pulmonary arterial hypertensive rats. Yonsei Med J. 2017;58(3):570\u201380. https:\/\/doi.org\/10.3349\/ymj.2017.58.3.570.","journal-title":"Yonsei Med J"},{"issue":"12","key":"3769_CR45","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1002\/sctm.17-0130","volume":"6","author":"S Van Linthout","year":"2017","unstructured":"Van Linthout S, Hamdani N, Miteva K, Koschel A, M\u00fcller I, Pinzur L, Aberman Z, Pappritz K, Linke WA, Tsch\u00f6pe C. Placenta-derived adherent stromal cells improve diabetes mellitus-associated left ventricular diastolic performance. Stem Cells Transl Med. 2017;6(12):2135\u201345. https:\/\/doi.org\/10.1002\/sctm.17-0130.","journal-title":"Stem Cells Transl Med"},{"issue":"1","key":"3769_CR46","doi-asserted-by":"publisher","first-page":"19","DOI":"10.5334\/gh.1098","volume":"17","author":"MS Poomani","year":"2022","unstructured":"Poomani MS, Mariappan I, Perumal R, Regurajan R, Muthan K, Subramanian V. Mesenchymal stem cell (MSCs) therapy for ischemic heart disease: a promising frontier. Glob Heart. 2022;17(1):19. https:\/\/doi.org\/10.5334\/gh.1098.","journal-title":"Glob Heart"},{"key":"3769_CR47","doi-asserted-by":"publisher","unstructured":"Chin KY (2020) Calculating in-vivo short-term precision error of dual-energy X-ray absorptiometry in human and animal: a technical report. Med Health 15(1): 70\u201377. https:\/\/doi.org\/10.17576\/MH.2020.1501.06","DOI":"10.17576\/MH.2020.1501.06"},{"key":"3769_CR48","doi-asserted-by":"publisher","unstructured":"Zhu H, Xiong Y, Xia Y, et al. (2017) Therapeutic Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Acute Lung Injury Mice. Sci Rep 7:39889. https:\/\/doi.org\/10.1038\/srep39889","DOI":"10.1038\/srep39889"},{"issue":"46","key":"3769_CR49","doi-asserted-by":"publisher","first-page":"8152","DOI":"10.3748\/wjg.v23.i46.8152","volume":"23","author":"GZ Zhang","year":"2017","unstructured":"Zhang GZ, Sun HC, Zheng LB, Guo JB, Zhang XL. In vivo hepatic differentiation potential of human umbilical cord-derived mesenchymal stem cells: therapeutic effect on liver fibrosis\/cirrhosis. World J Gastroenterol. 2017;23(46):8152\u201368. https:\/\/doi.org\/10.3748\/wjg.v23.i46.8152.","journal-title":"World J Gastroenterol"},{"issue":"1","key":"3769_CR50","doi-asserted-by":"publisher","first-page":"3123","DOI":"10.1038\/s41467-019-11091-2","volume":"10","author":"SJ Park","year":"2019","unstructured":"Park SJ, Kim RY, Park BW, et al. Dual stem cell therapy synergistically improves cardiac function and vascular regeneration following myocardial infarction. Nat Commun. 2019;10(1):3123. https:\/\/doi.org\/10.1038\/s41467-019-11091-2.","journal-title":"Nat Commun"},{"issue":"5","key":"3769_CR51","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/s0939-4753(04)80048-6","volume":"14","author":"K Esposito","year":"2004","unstructured":"Esposito K, Giugliano D. The metabolic syndrome and inflammation: association or causation? Nutr Metab Cardiovasc Dis. 2004;14(5):228\u201332. https:\/\/doi.org\/10.1016\/s0939-4753(04)80048-6.","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"4","key":"3769_CR52","volume":"3","author":"A Lopez-Candales","year":"2017","unstructured":"Lopez-Candales A, Hern\u00e1ndez Burgos PM, Hernandez-Suarez DF, Harris D. Linking chronic inflammation with cardiovascular disease: from normal aging to the metabolic syndrome. J Nat Sci. 2017;3(4): e341.","journal-title":"J Nat Sci"},{"issue":"12","key":"3769_CR53","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1172\/JCI18921.Erratum.In:JClinInvest.2003Jul;112(2):299","volume":"111","author":"MB Pepys","year":"2003","unstructured":"Pepys MB, Hirschfield GM. C-reactive protein: a critical update. J Clin Invest. 2003;111(12):1805\u201312. https:\/\/doi.org\/10.1172\/JCI18921.Erratum.In:JClinInvest.2003Jul;112(2):299.","journal-title":"J Clin Invest"},{"issue":"9","key":"3769_CR54","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1177\/014107680409700903","volume":"97","author":"E Suresh","year":"2004","unstructured":"Suresh E. Diagnosis of early rheumatoid arthritis: what the non-specialist needs to know. J R Soc Med. 2004;97(9):421\u20134. https:\/\/doi.org\/10.1177\/014107680409700903.","journal-title":"J R Soc Med"},{"issue":"11","key":"3769_CR55","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.622326","volume":"28","author":"H Enocsson","year":"2021","unstructured":"Enocsson H, Gullstrand B, Eloranta ML, Wetter\u00f6 J, Leonard D, R\u00f6nnblom L, Bengtsson AA, Sj\u00f6wall C. C-reactive protein levels in systemic lupus erythematosus are modulated by the interferon gene signature and CRP gene polymorphism rs1205. Front Immunol. 2021;28(11): 622326. https:\/\/doi.org\/10.3389\/fimmu.2020.622326.","journal-title":"Front Immunol"},{"issue":"12","key":"3769_CR56","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1186\/1471-2105-12-413","volume":"25","author":"J Ambroise","year":"2011","unstructured":"Ambroise J, Bearzatto B, Robert A, Govaerts B, Macq B, Gala JL. Impact of the spotted microarray preprocessing method on fold-change compression and variance stability. BMC Bioinf. 2011;25(12):413. https:\/\/doi.org\/10.1186\/1471-2105-12-413.","journal-title":"BMC Bioinf"},{"key":"3769_CR57","doi-asserted-by":"crossref","unstructured":"Weingand K, Brown G, Hall R, Davies D, Gossett K, Neptun D, Waner T, Matsuzawa T, Salemink P, Froelke W, Provost JP, Dal Negro G, Batchelor J, Nomura M, Groetsch H, Boink A, Kimball J, Woodman D, York M, Fabianson-Johnson E, Lupart M, Melloni E (1996) Harmonization of animal clinical pathology testing in toxicity and safety studies. The Joint Scientific Committee for International Harmonization of Clinical Pathology Testing. Fundam Appl Toxicol 29(2):198\u2013201","DOI":"10.1093\/toxsci\/29.2.198"},{"issue":"1","key":"3769_CR58","doi-asserted-by":"publisher","first-page":"79","DOI":"10.11613\/bm.2011.015","volume":"21","author":"M Koseoglu","year":"2011","unstructured":"Koseoglu M, Hur A, Atay A, Cuhadar S. Effects of hemolysis interferences on routine biochemistry parameters. Biochem Med (Zagreb). 2011;21(1):79\u201385. https:\/\/doi.org\/10.11613\/bm.2011.015.","journal-title":"Biochem Med (Zagreb)"},{"key":"3769_CR59","doi-asserted-by":"publisher","unstructured":"Ali D, Sacchetto E, Dumontet E, Le Carrer D, Orsonneau JL, Delaroche O, Bigot-Corbel E (2014) Interf\u00e9rence de l\u2019h\u00e9molyse sur le dosage de vingt-deux param\u00e8tres biochimiques [Hemolysis influence on twenty-two biochemical parameters measurement]. Ann Biol Clin (Paris). 72(3):297\u2013311. https:\/\/doi.org\/10.1684\/abc.2014.0952","DOI":"10.1684\/abc.2014.0952"},{"key":"3769_CR60","doi-asserted-by":"publisher","first-page":"1987960","DOI":"10.1155\/2016\/1987960","volume":"2016","author":"V Nunes-Souza","year":"2016","unstructured":"Nunes-Souza V, C\u00e9sar-Gomes CJ, Da Fonseca LJ, Guedes Gda S, Smaniotto S, Rabelo LA. Aging increases susceptibility to high fat diet-induced metabolic syndrome in C57BL\/6 mice: improvement in glycemic and lipid profile after antioxidant therapy. Oxid Med Cell Longev. 2016;2016:1987960. https:\/\/doi.org\/10.1155\/2016\/1987960.","journal-title":"Oxid Med Cell Longev"},{"issue":"6","key":"3769_CR61","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001312","volume":"3","author":"T Hattori","year":"2014","unstructured":"Hattori T, Murase T, Takatsu M, Nagasawa K, Matsuura N, Watanabe S, Murohara T, Nagata K. Dietary salt restriction improves cardiac and adipose tissue pathology independently of obesity in a rat model of metabolic syndrome. J Am Heart Assoc. 2014;3(6): e001312. https:\/\/doi.org\/10.1161\/JAHA.114.001312.","journal-title":"J Am Heart Assoc"},{"issue":"6","key":"3769_CR62","doi-asserted-by":"publisher","first-page":"30817","DOI":"10.1038\/srep30817","volume":"28","author":"N Li","year":"2016","unstructured":"Li N, Guenancia C, Rigal E, Hachet O, Chollet P, Desmoulins L, Leloup C, Rochette L, Vergely C. Short-term moderate diet restriction in adulthood can reverse oxidative, cardiovascular and metabolic alterations induced by postnatal overfeeding in mice. Sci Rep. 2016;28(6):30817. https:\/\/doi.org\/10.1038\/srep30817.","journal-title":"Sci Rep"},{"issue":"12","key":"3769_CR63","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.128308","volume":"4","author":"PN Hyde","year":"2019","unstructured":"Hyde PN, Sapper TN, Crabtree CD, LaFountain RA, Bowling ML, Buga A, Fell B, McSwiney FT, Dickerson RM, Miller VJ, Scandling D, Simonetti OP, Phinney SD, Kraemer WJ, King SA, Krauss RM, Volek JS. Dietary carbohydrate restriction improves metabolic syndrome independent of weight loss. JCI Insight. 2019;4(12): e128308. https:\/\/doi.org\/10.1172\/jci.insight.128308.","journal-title":"JCI Insight"},{"issue":"8","key":"3769_CR64","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.3390\/nu12082185","volume":"12","author":"S Aouichat","year":"2020","unstructured":"Aouichat S, Chayah M, Bouguerra-Aouichat S, Agil A. Time-Restricted Feeding Improves Body Weight Gain, Lipid Profiles, and Atherogenic Indices in Cafeteria-Diet-Fed Rats: Role of Browning of Inguinal White Adipose Tissue. Nutrients. 2020;12(8):2185. https:\/\/doi.org\/10.3390\/nu12082185.","journal-title":"Nutrients"},{"issue":"3","key":"3769_CR65","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1136\/bjsm.2007.043208","volume":"43","author":"A Schmidt","year":"2009","unstructured":"Schmidt A, Bierwirth S, Weber S, Platen P, Schink\u00f6the T, Bloch W. Short intensive exercise increases the migratory activity of mesenchymal stem cells. Br J Sports Med. 2009;43(3):195\u20138. https:\/\/doi.org\/10.1136\/bjsm.2007.043208.","journal-title":"Br J Sports Med"},{"issue":"4","key":"3769_CR66","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.amepre.2011.06.042","volume":"41","author":"C Mason","year":"2011","unstructured":"Mason C, Foster-Schubert KE, Imayama I, Kong A, Xiao L, Bain C, Campbell KL, Wang CY, Duggan CR, Ulrich CM, Alfano CM, Blackburn GL, McTiernan A. Dietary weight loss and exercise effects on insulin resistance in postmenopausal women. Am J Prev Med. 2011;41(4):366\u201375. https:\/\/doi.org\/10.1016\/j.amepre.2011.06.042.","journal-title":"Am J Prev Med"},{"issue":"23","key":"3769_CR67","doi-asserted-by":"publisher","first-page":"3074","DOI":"10.1089\/scd.2013.0142","volume":"22","author":"L Zhang","year":"2013","unstructured":"Zhang L, Li K, Liu X, Li D, Luo C, Fu B, Cui S, Zhu F, Zhao RC, Chen X. Repeated systemic administration of human adipose-derived stem cells attenuates overt diabetic nephropathy in rats. Stem Cells Dev. 2013;22(23):3074\u201386. https:\/\/doi.org\/10.1089\/scd.2013.0142.","journal-title":"Stem Cells Dev"},{"issue":"4","key":"3769_CR68","doi-asserted-by":"publisher","first-page":"C642","DOI":"10.1152\/ajpcell.00530.2018","volume":"317","author":"C Bourzac","year":"2019","unstructured":"Bourzac C, Bensidhoum M, Pallu S, Portier H. Use of adult mesenchymal stromal cells in tissue repair: impact of physical exercise. Am J Physiol Cell Physiol. 2019;317(4):C642\u201354. https:\/\/doi.org\/10.1152\/ajpcell.00530.2018.","journal-title":"Am J Physiol Cell Physiol"},{"issue":"4","key":"3769_CR69","doi-asserted-by":"publisher","first-page":"368","DOI":"10.3390\/cells8040368","volume":"8","author":"Y Lee","year":"2019","unstructured":"Lee Y, Shin SH, Cho KA, Kim YH, Woo SY, Kim HS, Jung SC, Jo I, Jun HS, Park WJ, Park JW, Ryu KH. Administration of Tonsil-derived mesenchymal stem cells improves glucose tolerance in high fat diet-induced diabetic mice via insulin-like growth factor-binding protein 5-mediated endoplasmic reticulum stress modulation. Cells. 2019;8(4):368. https:\/\/doi.org\/10.3390\/cells8040368.","journal-title":"Cells"},{"issue":"11","key":"3769_CR70","first-page":"12217","volume":"13","author":"SA Shamsuddin","year":"2021","unstructured":"Shamsuddin SA, Chan AML, Ng MH, Yazid MD, Law JX, Hj Idrus RB, Fauzi MB, Mohd Yunus MH, Lokanathan Y. Stem cells as a potential therapy in managing various disorders of metabolic syndrome: a systematic review. Am J Transl Res. 2021;13(11):12217\u201327.","journal-title":"Am J Transl Res"},{"issue":"4","key":"3769_CR71","first-page":"2147","volume":"14","author":"AML Chan","year":"2022","unstructured":"Chan AML, Sampasivam Y, Lokanathan Y. Biodistribution of mesenchymal stem cells (MSCs) in animal models and implied role of exosomes following systemic delivery of MSCs: a systematic review. Am J Transl Res. 2022;14(4):2147\u201361.","journal-title":"Am J Transl Res"},{"issue":"5","key":"3769_CR72","doi-asserted-by":"publisher","first-page":"148","DOI":"10.3389\/fimmu.2014.00148","volume":"19","author":"E Eggenhofer","year":"2014","unstructured":"Eggenhofer E, Luk F, Dahlke MH, Hoogduijn MJ. The life and fate of mesenchymal stem cells. Front Immunol. 2014;19(5):148. https:\/\/doi.org\/10.3389\/fimmu.2014.00148.","journal-title":"Front Immunol"},{"key":"3769_CR73","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/652034","volume":"2012","author":"Y Wang","year":"2012","unstructured":"Wang Y, Han ZB, Song YP, Han ZC. Safety of mesenchymal stem cells for clinical application. Stem Cells Int. 2012;2012: 652034. https:\/\/doi.org\/10.1155\/2012\/652034.","journal-title":"Stem Cells Int"},{"key":"3769_CR74","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1021\/acs.chemmater.6b04096","volume":"29","author":"D Choi","year":"2017","unstructured":"Choi D, Lee H, Kim H, Yang M, Heo J, Won Y, Jang S, Park JK, Son Y, Oh T, Lee E, Hong J. Cytoprotective self-assembled RGD peptide nanofilms for surface modification of viable mesenchymal stem cells. Chem Mater. 2017;29:2055\u201365. https:\/\/doi.org\/10.1021\/acs.chemmater.6b04096.","journal-title":"Chem Mater"},{"issue":"9","key":"3769_CR75","doi-asserted-by":"publisher","first-page":"923","DOI":"10.2147\/PPA.S87271","volume":"2","author":"JF Jin","year":"2015","unstructured":"Jin JF, Zhu LL, Chen M, Xu HM, Wang HF, Feng XQ, Zhu XP, Zhou Q. The optimal choice of medication administration route regarding intravenous, intramuscular, and subcutaneous injection. Patient Prefer Adherence. 2015;2(9):923\u201342. https:\/\/doi.org\/10.2147\/PPA.S87271.","journal-title":"Patient Prefer Adherence"},{"issue":"6","key":"3769_CR76","doi-asserted-by":"publisher","first-page":"823","DOI":"10.3727\/096368910X508942","volume":"19","author":"H Yagi","year":"2010","unstructured":"Yagi H, Soto-Gutierrez A, Kitagawa Y, Tilles AW, Tompkins RG, Yarmush ML. Bone marrow mesenchymal stromal cells attenuate organ injury induced by LPS and burn. Cell Transpl. 2010;19(6):823\u201330. https:\/\/doi.org\/10.3727\/096368910X508942.","journal-title":"Cell Transpl"},{"issue":"3","key":"3769_CR77","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1177\/1534734613502041","volume":"12","author":"G Lu","year":"2013","unstructured":"Lu G, Huang S, Chen Y, Ma K. Umbilical cord mesenchymal stem cell transplantation ameliorates burn-induced acute kidney injury in rats. Int J Low Extrem Wounds. 2013;12(3):205\u201311. https:\/\/doi.org\/10.1177\/1534734613502041.","journal-title":"Int J Low Extrem Wounds"},{"key":"3769_CR78","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.ebiom.2016.04.030","volume":"8","author":"X Li","year":"2016","unstructured":"Li X, Liu L, Yang J, et al. Exosome derived from human umbilical cord mesenchymal stem cell mediates MiR-181c attenuating burn-induced excessive inflammation. EBioMedicine. 2016;8:72\u201382. https:\/\/doi.org\/10.1016\/j.ebiom.2016.04.030.","journal-title":"EBioMedicine"},{"key":"3769_CR79","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.omtn.2021.08.013","volume":"26","author":"S Wang","year":"2021","unstructured":"Wang S, Wang Z, Su H, et al. Effects of long-term culture on the biological characteristics and RNA profiles of human bone-marrow-derived mesenchymal stem cells. Mol Ther Nucleic Acids. 2021;26:557\u201374. https:\/\/doi.org\/10.1016\/j.omtn.2021.08.013.","journal-title":"Mol Ther Nucleic Acids"},{"issue":"4","key":"3769_CR80","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1747-5341-4-2","volume":"15","author":"N Shanks","year":"2009","unstructured":"Shanks N, Greek R, Greek J. Are animal models predictive for humans? Philos Ethics Humanit Med. 2009;15(4):2. https:\/\/doi.org\/10.1186\/1747-5341-4-2.","journal-title":"Philos Ethics Humanit Med"},{"issue":"9","key":"3769_CR81","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1007\/s00259-012-2175-z","volume":"39","author":"MI Marti\u0107-Kehl","year":"2012","unstructured":"Marti\u0107-Kehl MI, Schibli R, Schubiger PA. Can animal data predict human outcome? Problems and pitfalls of translational animal research. Eur J Nucl Med Mol Imaging. 2012;39(9):1492\u20136. https:\/\/doi.org\/10.1007\/s00259-012-2175-z.","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"2","key":"3769_CR82","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1093\/jmp\/jht004","volume":"38","author":"C Degeling","year":"2013","unstructured":"Degeling C, Johnson J. Evaluating animal models: some taxonomic worries. J Med Philos. 2013;38(2):91\u2013106. https:\/\/doi.org\/10.1093\/jmp\/jht004.","journal-title":"J Med Philos"},{"issue":"1","key":"3769_CR83","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1186\/s12967-018-1678-1","volume":"16","author":"P Pound","year":"2018","unstructured":"Pound P, Ritskes-Hoitinga M. Is it possible to overcome issues of external validity in preclinical animal research? Why most animal models are bound to fail. J Transl Med. 2018;16(1):304. https:\/\/doi.org\/10.1186\/s12967-018-1678-1.","journal-title":"J Transl Med"},{"issue":"1","key":"3769_CR84","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1186\/s12967-019-1976-2","volume":"17","author":"CHC Leenaars","year":"2019","unstructured":"Leenaars CHC, Kouwenaar C, Stafleu FR, Bleich A, Ritskes-Hoitinga M, De Vries RBM, Meijboom FLB. Animal to human translation: a systematic scoping review of reported concordance rates. J Transl Med. 2019;17(1):223. https:\/\/doi.org\/10.1186\/s12967-019-1976-2.","journal-title":"J Transl Med"},{"issue":"2","key":"3769_CR85","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1080\/09637486.2019.1646714","volume":"71","author":"C Ricci","year":"2020","unstructured":"Ricci C, Baumgartner J, Malan L, Smuts CM. Determining sample size adequacy for animal model studies in nutrition research: limits and ethical challenges of ordinary power calculation procedures. Int J Food Sci Nutr. 2020;71(2):256\u201364. https:\/\/doi.org\/10.1080\/09637486.2019.1646714.","journal-title":"Int J Food Sci Nutr"}],"container-title":["Stem Cell Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-024-03769-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13287-024-03769-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-024-03769-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:02:45Z","timestamp":1717545765000},"score":1,"resource":{"primary":{"URL":"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/s13287-024-03769-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,5]]},"references-count":85,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3769"],"URL":"https:\/\/doi.org\/10.1186\/s13287-024-03769-2","relation":{},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,5]]},"assertion":[{"value":"2 March 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The animal study protocol was approved by the UKMREC (JEP-2020\u2013790) and UKMAEC (TEC\/FP\/2020\/YOGESWARAN\/23-SEPT.\/1124-OCT.-2020-SEPT-2023) with adherence to Declaration of Helsinki, for project title \u201cSafety and efficacy study of allogeneic mesenchymal stem cell therapy for treatment for Metabolic Syndrome in Sprague Dawley rat\u201d from September 2020 to September 2023. Likewise, use of human WJ-MSC cells was acquired through approved Human Primary Cell Banking (UKM 1.5.3.5\/244\/FF-2015\u2013376). The umbilical cord tissues were obtained with consent from maternal volunteers who were undergoing scheduled Caesarean sections.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors have declared no conflict of interest to report.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"160"}}