{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T16:00:54Z","timestamp":1793635254120,"version":"4.5.1"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:00:00Z","timestamp":1722211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:00:00Z","timestamp":1722211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201789"],"award-info":[{"award-number":["82201789"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271662"],"award-info":[{"award-number":["82271662"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971337"],"award-info":[{"award-number":["81971337"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2022YFA1303900"],"award-info":[{"award-number":["2022YFA1303900"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Shanghai","award":["22ZR1477000"],"award-info":[{"award-number":["22ZR1477000"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ferroptosis is associated with the pathological progression of hemorrhagic injury and ischemia\u2013reperfusion injury. According to our previous study, exosomes formed through bone marrow mesenchymal stem cells modified with miR-340-3p (MB-exos) can restore damaged endometrium. However, the involvement of ferroptosis in endometrial injury and the effect of MB-exos on ferroptosis remain elusive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The endometrial injury rat model was developed. Exosomes were obtained from the supernatants of bone marrow mesenchymal stromal cells (BMSCs) and miR-340\/BMSCs through differential centrifugation. We conducted RNA-seq analysis on endometrial tissues obtained from the PBS and MB-exos groups. Ferroptosis was induced in endometrial stromal cells (ESCs) by treating them with erastin or RSL3, followed by treatment with B-exos or MB-exos. We assessed the endometrial total m\n                      <jats:sup>6<\/jats:sup>\n                      A modification level after injury and subsequent treatment with B-exos or MB-exos by methylation quantification assay. We performed meRIP-qPCR to analyze m\n                      <jats:sup>6<\/jats:sup>\n                      A modification-regulated endogenous mRNAs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We reveal that MB-exos facilitate the injured endometrium to recover by suppressing ferroptosis in endometrial stromal cells. The injured endometrium showed significantly upregulated\n                      <jats:italic>N<\/jats:italic>\n                      <jats:sup>6<\/jats:sup>\n                      -methyladenosine (m\n                      <jats:sup>6<\/jats:sup>\n                      A) modification levels; these levels were attenuated by MB-exos through downregulation of the methylase METTL3. Intriguingly, METTL3 downregulation appears to repress ferroptosis by stabilizing HMOX1 mRNA, thereby potentially elucidating the mechanism through which MB-exos inhibit ferroptosis in ESCs. We identified YTHDF2 as a critical m\n                      <jats:sup>6<\/jats:sup>\n                      A reader protein that contributes to HMOX1 mRNA degradation. YTHDF2 facilitates HMOX1 mRNA degradation by identifying the m\n                      <jats:sup>6<\/jats:sup>\n                      A binding site in the 3\u2032-untranslated regions of HMOX1. In a rat model, treatment with MB-exos ameliorated endometrial injury-induced fibrosis by inhibiting ferroptosis in ESCs. Moreover, METTL3 short hairpin RNA-mediated inhibition of m\n                      <jats:sup>6<\/jats:sup>\n                      A modification enhanced the inhibitory effect of MB-exos on ferroptosis in endometrial injury.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Thus, these observations provide new insights regarding the molecular mechanisms responsible for endometrial recovery promotion by MB-exos and highlight m\n                      <jats:sup>6<\/jats:sup>\n                      A modification-dependent ferroptosis inhibition as a prospective therapeutic target to attenuate endometrial injury.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13287-024-03846-6","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T10:29:59Z","timestamp":1722248999000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["miR-340-3p-modified bone marrow mesenchymal stem cell-derived exosomes inhibit ferroptosis through METTL3-mediated m6A modification of HMOX1 to promote recovery of injured rat uterus"],"prefix":"10.1186","volume":"15","author":[{"given":"Bang","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dabing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningxia","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2459-3923","authenticated-orcid":false,"given":"Fu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,29]]},"reference":[{"issue":"6","key":"3846_CR1","first-page":"311","volume":"116","author":"T Romer","year":"1994","unstructured":"Romer T. Intrauterine adhesions\u2013etiology, diagnosis, therapy and possibilities for prevention. Zentralbl Gynakol. 1994;116(6):311\u20137.","journal-title":"Zentralbl Gynakol"},{"issue":"2","key":"3846_CR2","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.jmig.2017.09.020","volume":"25","author":"Z Khan","year":"2018","unstructured":"Khan Z, Goldberg JM. Hysteroscopic management of Asherman\u2019s syndrome. J Minim Invasive Gynecol. 2018;25(2):218\u201328.","journal-title":"J Minim Invasive Gynecol"},{"issue":"1","key":"3846_CR3","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1186\/s13287-021-02620-2","volume":"12","author":"YT Song","year":"2021","unstructured":"Song YT, Liu PC, Tan J, Zou CY, Li QJ, Li-Ling J, et al. Stem cell-based therapy for ameliorating intrauterine adhesion and endometrium injury. Stem Cell Res Ther. 2021;12(1):556.","journal-title":"Stem Cell Res Ther"},{"issue":"21\u201322","key":"3846_CR4","first-page":"824","volume":"45","author":"P Kaminski","year":"1992","unstructured":"Kaminski P, Wieczorek K, Marianowski L. Usefulness of hysteroscopy in the diagnosis and treatment of intrauterine adhesions. Wiad Lek. 1992;45(21\u201322):824\u20136.","journal-title":"Wiad Lek"},{"issue":"5","key":"3846_CR5","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1016\/j.cell.2020.04.039","volume":"181","author":"K Hadian","year":"2020","unstructured":"Hadian K, Stockwell BR. SnapShot: ferroptosis. Cell. 2020;181(5):1188-e1.","journal-title":"Cell"},{"issue":"4","key":"3846_CR6","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","volume":"22","author":"X Jiang","year":"2021","unstructured":"Jiang X, Stockwell BR, Conrad M. Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol. 2021;22(4):266\u201382.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"3846_CR7","doi-asserted-by":"publisher","first-page":"661663","DOI":"10.3389\/fnins.2021.661663","volume":"15","author":"T Liu","year":"2021","unstructured":"Liu T, Li X, Cui Y, Meng P, Zeng G, Wang Y, et al. Bioinformatics analysis identifies potential ferroptosis key genes in the pathogenesis of intracerebral hemorrhage. Front Neurosci. 2021;15:661663.","journal-title":"Front Neurosci"},{"issue":"4","key":"3846_CR8","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1111\/cns.13069","volume":"25","author":"BS Xie","year":"2019","unstructured":"Xie BS, Wang YQ, Lin Y, Mao Q, Feng JF, Gao GY, et al. Inhibition of ferroptosis attenuates tissue damage and improves long-term outcomes after traumatic brain injury in mice. CNS Neurosci Ther. 2019;25(4):465\u201375.","journal-title":"CNS Neurosci Ther"},{"issue":"1","key":"3846_CR9","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s12958-022-00988-1","volume":"20","author":"L Yuan","year":"2022","unstructured":"Yuan L, Cao J, Hu M, Xu D, Li Y, Zhao S, et al. Bone marrow mesenchymal stem cells combined with estrogen synergistically promote endometrial regeneration and reverse EMT via Wnt\/beta-catenin signaling pathway. Reprod Biol Endocrinol. 2022;20(1):121.","journal-title":"Reprod Biol Endocrinol"},{"issue":"12","key":"3846_CR10","doi-asserted-by":"publisher","first-page":"3278","DOI":"10.3390\/cells10123278","volume":"10","author":"M Kulus","year":"2021","unstructured":"Kulus M, Sibiak R, Stefanska K, Zdun M, Wieczorkiewicz M, Piotrowska-Kempisty H, et al. Mesenchymal stem\/stromal cells derived from human and animal perinatal tissues-origins, characteristics, signaling pathways, and clinical trials. Cells. 2021;10(12):3278.","journal-title":"Cells"},{"issue":"1","key":"3846_CR11","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1186\/s13287-020-01781-w","volume":"11","author":"L He","year":"2020","unstructured":"He L, He T, Xing J, Zhou Q, Fan L, Liu C, et al. Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis. Stem Cell Res Ther. 2020;11(1):276.","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"3846_CR12","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1186\/s13287-019-1332-8","volume":"10","author":"Y Yao","year":"2019","unstructured":"Yao Y, Chen R, Wang G, Zhang Y, Liu F. Exosomes derived from mesenchymal stem cells reverse EMT via TGF-beta1\/Smad pathway and promote repair of damaged endometrium. Stem Cell Res Ther. 2019;10(1):225.","journal-title":"Stem Cell Res Ther"},{"key":"3846_CR13","doi-asserted-by":"publisher","first-page":"104836","DOI":"10.1016\/j.chemphyslip.2019.104836","volume":"226","author":"S Rahmati","year":"2020","unstructured":"Rahmati S, Shojaei F, Shojaeian A, Rezakhani L, Dehkordi MB. An overview of current knowledge in biological functions and potential theragnostic applications of exosomes. Chem Phys Lip. 2020;226:104836.","journal-title":"Chem Phys Lip"},{"key":"3846_CR14","doi-asserted-by":"publisher","first-page":"102102","DOI":"10.1016\/j.tice.2023.102102","volume":"82","author":"S Rahmati","year":"2023","unstructured":"Rahmati S, Khazaei M, Nadi A, Alizadeh M, Rezakhani L. Exosome-loaded scaffolds for regenerative medicine in hard tissues. Tissue Cell. 2023;82:102102.","journal-title":"Tissue Cell"},{"issue":"1","key":"3846_CR15","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1186\/s12967-020-02622-3","volume":"18","author":"S Nikfarjam","year":"2020","unstructured":"Nikfarjam S, Rezaie J, Zolbanin NM, Jafari R. Mesenchymal stem cell derived-exosomes: a modern approach in translational medicine. J Transl Med. 2020;18(1):449.","journal-title":"J Transl Med"},{"issue":"5","key":"3846_CR16","doi-asserted-by":"publisher","first-page":"bio039958","DOI":"10.1242\/bio.039958","volume":"8","author":"B Xiao","year":"2019","unstructured":"Xiao B, Zhu Y, Huang J, Wang T, Wang F, Sun S. Exosomal transfer of bone marrow mesenchymal stem cell-derived miR-340 attenuates endometrial fibrosis. Biol Open. 2019;8(5):bio039958.","journal-title":"Biol Open."},{"issue":"6292","key":"3846_CR17","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1126\/science.aad8711","volume":"352","author":"WV Gilbert","year":"2016","unstructured":"Gilbert WV, Bell TA, Schaening C. Messenger RNA modifications: form, distribution, and function. Science. 2016;352(6292):1408\u201312.","journal-title":"Science"},{"issue":"3","key":"3846_CR18","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.molcel.2023.01.006","volume":"83","author":"E Sendinc","year":"2023","unstructured":"Sendinc E, Shi Y. RNA m6A methylation across the transcriptome. Mol Cell. 2023;83(3):428\u201341.","journal-title":"Mol Cell"},{"key":"3846_CR19","doi-asserted-by":"publisher","first-page":"102151","DOI":"10.1016\/j.redox.2021.102151","volume":"47","author":"M Shen","year":"2021","unstructured":"Shen M, Li Y, Wang Y, Shao J, Zhang F, Yin G, et al. N(6)-methyladenosine modification regulates ferroptosis through autophagy signaling pathway in hepatic stellate cells. Redox Biol. 2021;47:102151.","journal-title":"Redox Biol"},{"key":"3846_CR20","first-page":"e3037","volume":"59","author":"C Lasser","year":"2012","unstructured":"Lasser C, Eldh M, Lotvall J. Isolation and characterization of RNA-containing exosomes. J Vis Exp. 2012;59:e3037.","journal-title":"J Vis Exp"},{"issue":"1","key":"3846_CR21","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1186\/s13287-017-0718-8","volume":"8","author":"H Yang","year":"2017","unstructured":"Yang H, Wu S, Feng R, Huang J, Liu L, Liu F, et al. Vitamin C plus hydrogel facilitates bone marrow stromal cell-mediated endometrium regeneration in rats. Stem Cell Res Ther. 2017;8(1):267.","journal-title":"Stem Cell Res Ther"},{"issue":"10","key":"3846_CR22","doi-asserted-by":"publisher","first-page":"2339","DOI":"10.1093\/humrep\/dew191","volume":"31","author":"X Zhang","year":"2016","unstructured":"Zhang X, Fu LJ, Liu XQ, Hu ZY, Jiang Y, Gao RF, et al. nm23 regulates decidualization through the PI3K-Akt-mTOR signaling pathways in mice and humans. Hum Reprod. 2016;31(10):2339\u201351.","journal-title":"Hum Reprod"},{"key":"3846_CR23","first-page":"283","volume":"556","author":"CA Opefi","year":"2015","unstructured":"Opefi CA, Tranter D, Smith SO, Reeves PJ. Construction of stable mammalian cell lines for inducible expression of G protein-coupled receptors. Membr Proteins Prod Funct Charact. 2015;556:283\u2013305.","journal-title":"Membr Proteins Prod Funct Charact"},{"issue":"8","key":"3846_CR24","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1080\/15548627.2019.1687985","volume":"16","author":"Z Zhang","year":"2020","unstructured":"Zhang Z, Guo M, Li Y, Shen M, Kong D, Shao J, et al. RNA-binding protein ZFP36\/TTP protects against ferroptosis by regulating autophagy signaling pathway in hepatic stellate cells. Autophagy. 2020;16(8):1482\u2013505.","journal-title":"Autophagy"},{"issue":"6","key":"3846_CR25","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1002\/hep.31222","volume":"72","author":"XM Liu","year":"2020","unstructured":"Liu XM, Liu JY, Xiao W, Zeng QH, Bo H, Zhu YX, et al. SIRT1 regulates N-methyladenosine RNA modification in hepatocarcinogenesis by inducing RANBP2-dependent FTO SUMOylation. Hepatology. 2020;72(6):2029\u201350.","journal-title":"Hepatology"},{"issue":"12","key":"3846_CR26","doi-asserted-by":"publisher","first-page":"6130","DOI":"10.1093\/nar\/gkz312","volume":"47","author":"T Song","year":"2019","unstructured":"Song T, Yang Y, Wei H, Xie X, Lu J, Zeng Q, et al. Zfp217 mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to promote adipogenic differentiation. Nucleic Acids Res. 2019;47(12):6130\u201344.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"3846_CR27","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1038\/s41467-019-09865-9","volume":"10","author":"X Lin","year":"2019","unstructured":"Lin X, Chai G, Wu Y, Li J, Chen F, Liu J, et al. RNA m(6)A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail. Nat Commun. 2019;10(1):2065.","journal-title":"Nat Commun"},{"issue":"12","key":"3846_CR28","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.1016\/j.molcel.2022.05.029","volume":"82","author":"S Murakami","year":"2022","unstructured":"Murakami S, Jaffrey SR. Hidden codes in mRNA: Control of gene expression by mA. Mol Cell. 2022;82(12):2236\u201351.","journal-title":"Mol Cell"},{"issue":"18","key":"3846_CR29","doi-asserted-by":"publisher","first-page":"1903746","DOI":"10.1002\/advs.201903746","volume":"7","author":"J Zheng","year":"2020","unstructured":"Zheng J, Lu T, Zhou C, Cai J, Zhang X, Liang J, et al. Extracellular vesicles derived from human umbilical cord mesenchymal stem cells protect liver ischemia\/reperfusion injury by reducing CD154 expression on CD4+ T cells via CCT2. Adv Sci (Weinh). 2020;7(18):1903746.","journal-title":"Adv Sci (Weinh)"},{"issue":"1","key":"3846_CR30","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1186\/s12951-021-01077-y","volume":"19","author":"H Zheng","year":"2021","unstructured":"Zheng H, Liang X, Han Q, Shao Z, Zhang Y, Shi L, et al. Hemin enhances the cardioprotective effects of mesenchymal stem cell-derived exosomes against infarction via amelioration of cardiomyocyte senescence. J Nanobiotechnol. 2021;19(1):332.","journal-title":"J Nanobiotechnol"},{"issue":"1","key":"3846_CR31","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1186\/s12951-024-02421-8","volume":"22","author":"HF Zheng","year":"2024","unstructured":"Zheng HF, Liang XT, Liu BJ, Huang XR, Shen Y, Lin F, et al. Exosomal miR-9\u20135p derived from iPSC-MSCs ameliorates doxorubicin-induced cardiomyopathy by inhibiting cardiomyocyte senescence. J Nanobiotechnol. 2024;22(1):195.","journal-title":"J Nanobiotechnol"},{"key":"3846_CR32","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmae013","author":"A Rodriguez-Eguren","year":"2024","unstructured":"Rodriguez-Eguren A, Bueno-Fernandez C, Gomez-Alvarez M, Frances-Herrero E, Pellicer A, Bellver J, et al. Evolution of biotechnological advances and regenerative therapies for endometrial disorders: a systematic review. Hum Reprod Update. 2024. https:\/\/doi.org\/10.1093\/humupd\/dmae013.","journal-title":"Hum Reprod Update"},{"issue":"5","key":"3846_CR33","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/s41571-020-00462-0","volume":"18","author":"X Chen","year":"2021","unstructured":"Chen X, Kang R, Kroemer G, Tang D. Broadening horizons: the role of ferroptosis in cancer. Nat Rev Clin Oncol. 2021;18(5):280\u201396.","journal-title":"Nat Rev Clin Oncol"},{"issue":"8","key":"3846_CR34","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.3390\/cells12081128","volume":"12","author":"H Akiyama","year":"2023","unstructured":"Akiyama H, Carter BZ, Andreeff M, Ishizawa J. Molecular mechanisms of ferroptosis and updates of ferroptosis studies in cancers and leukemia. Cells. 2023;12(8):1128.","journal-title":"Cells"},{"issue":"12","key":"3846_CR35","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1016\/j.molcel.2022.03.022","volume":"82","author":"D Liang","year":"2022","unstructured":"Liang D, Minikes AM, Jiang X. Ferroptosis at the intersection of lipid metabolism and cellular signaling. Mol Cell. 2022;82(12):2215\u201327.","journal-title":"Mol Cell"},{"issue":"11","key":"3846_CR36","doi-asserted-by":"publisher","first-page":"6251","DOI":"10.1093\/nar\/gkaa347","volume":"48","author":"H Zhang","year":"2020","unstructured":"Zhang H, Shi X, Huang T, Zhao X, Chen W, Gu N, et al. Dynamic landscape and evolution of m6A methylation in human. Nucleic Acids Res. 2020;48(11):6251\u201364.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"3846_CR37","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1038\/s41467-022-28547-7","volume":"13","author":"G Zhang","year":"2022","unstructured":"Zhang G, Xu Y, Wang X, Zhu Y, Wang L, Zhang W, et al. Dynamic FMR1 granule phase switch instructed by m6A modification contributes to maternal RNA decay. Nat Commun. 2022;13(1):859.","journal-title":"Nat Commun"},{"issue":"1","key":"3846_CR38","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/s13045-021-01129-8","volume":"14","author":"W Huang","year":"2021","unstructured":"Huang W, Chen TQ, Fang K, Zeng ZC, Ye H, Chen YQ. N6-methyladenosine methyltransferases: functions, regulation, and clinical potential. J Hematol Oncol. 2021;14(1):117.","journal-title":"J Hematol Oncol"},{"issue":"4","key":"3846_CR39","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.molcel.2020.10.026","volume":"80","author":"HL Sun","year":"2020","unstructured":"Sun HL, Zhu AC, Gao Y, Terajima H, Fei Q, Liu S, et al. Stabilization of ERK-phosphorylated METTL3 by USP5 increases m(6)A methylation. Mol Cell. 2020;80(4):633-47 e7.","journal-title":"Mol Cell"},{"issue":"7849","key":"3846_CR40","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1038\/s41586-020-03135-1","volume":"591","author":"T Chelmicki","year":"2021","unstructured":"Chelmicki T, Roger E, Teissandier A, Dura M, Bonneville L, Rucli S, et al. m(6)A RNA methylation regulates the fate of endogenous retroviruses. Nature. 2021;591(7849):312\u20136.","journal-title":"Nature"},{"issue":"7","key":"3846_CR41","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1080\/15548627.2019.1659617","volume":"16","author":"X Wang","year":"2020","unstructured":"Wang X, Wu R, Liu Y, Zhao Y, Bi Z, Yao Y, et al. m(6)A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7. Autophagy. 2020;16(7):1221\u201335.","journal-title":"Autophagy"},{"issue":"2","key":"3846_CR42","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1002\/hep.28885","volume":"65","author":"JZ Ma","year":"2017","unstructured":"Ma JZ, Yang F, Zhou CC, Liu F, Yuan JH, Wang F, et al. METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N(6)-methyladenosine-dependent primary MicroRNA processing. Hepatology. 2017;65(2):529\u201343.","journal-title":"Hepatology"},{"issue":"9","key":"3846_CR43","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1038\/s41589-020-0524-y","volume":"16","author":"Y Fu","year":"2020","unstructured":"Fu Y, Zhuang X. m(6)A-binding YTHDF proteins promote stress granule formation. Nat Chem Biol. 2020;16(9):955\u201363.","journal-title":"Nat Chem Biol"},{"issue":"7","key":"3846_CR44","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1016\/j.molcel.2023.03.010","volume":"83","author":"M Paget","year":"2023","unstructured":"Paget M, Cadena C, Ahmad S, Wang HT, Jordan TX, Kim E, et al. Stress granules are shock absorbers that prevent excessive innate immune responses to dsRNA. Mol Cell. 2023;83(7):1180-96 e8.","journal-title":"Mol Cell"},{"issue":"15","key":"3846_CR45","doi-asserted-by":"publisher","first-page":"3048","DOI":"10.1016\/j.molcel.2021.06.014","volume":"81","author":"JM Einstein","year":"2021","unstructured":"Einstein JM, Perelis M, Chaim IA, Meena JK, Nussbacher JK, Tankka AT, et al. Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer. Mol Cell. 2021;81(15):3048-64 e9.","journal-title":"Mol Cell"},{"issue":"2","key":"3846_CR46","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/s41590-022-01398-6","volume":"24","author":"S Ma","year":"2023","unstructured":"Ma S, Sun B, Duan S, Han J, Barr T, Zhang J, et al. YTHDF2 orchestrates tumor-associated macrophage reprogramming and controls antitumor immunity through CD8(+) T cells. Nat Immunol. 2023;24(2):255\u201366.","journal-title":"Nat Immunol"},{"issue":"1","key":"3846_CR47","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s13059-018-1436-y","volume":"19","author":"M Li","year":"2018","unstructured":"Li M, Zhao X, Wang W, Shi H, Pan Q, Lu Z, et al. Ythdf2-mediated m(6)A mRNA clearance modulates neural development in mice. Genome Biol. 2018;19(1):69.","journal-title":"Genome Biol"},{"issue":"1","key":"3846_CR48","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/s13045-021-01124-z","volume":"14","author":"RC Chai","year":"2021","unstructured":"Chai RC, Chang YZ, Chang X, Pang B, An SY, Zhang KN, et al. YTHDF2 facilitates UBXN1 mRNA decay by recognizing METTL3-mediated m(6)A modification to activate NF-kappaB and promote the malignant progression of glioma. J Hematol Oncol. 2021;14(1):109.","journal-title":"J Hematol Oncol"},{"issue":"1","key":"3846_CR49","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/s13059-021-02308-z","volume":"22","author":"J Yu","year":"2021","unstructured":"Yu J, Chai P, Xie M, Ge S, Ruan J, Fan X, et al. Histone lactylation drives oncogenesis by facilitating m(6)A reader protein YTHDF2 expression in ocular melanoma. Genome Biol. 2021;22(1):85.","journal-title":"Genome Biol"},{"issue":"23","key":"3846_CR50","doi-asserted-by":"publisher","first-page":"4507","DOI":"10.1038\/s41388-020-1303-7","volume":"39","author":"C Zhang","year":"2020","unstructured":"Zhang C, Huang S, Zhuang H, Ruan S, Zhou Z, Huang K, et al. YTHDF2 promotes the liver cancer stem cell phenotype and cancer metastasis by regulating OCT4 expression via m6A RNA methylation. Oncogene. 2020;39(23):4507\u201318.","journal-title":"Oncogene"},{"issue":"5","key":"3846_CR51","doi-asserted-by":"publisher","first-page":"2859","DOI":"10.1093\/nar\/gkab065","volume":"49","author":"G Hou","year":"2021","unstructured":"Hou G, Zhao X, Li L, Yang Q, Liu X, Huang C, et al. SUMOylation of YTHDF2 promotes mRNA degradation and cancer progression by increasing its binding affinity with m6A-modified mRNAs. Nucleic Acids Res. 2021;49(5):2859\u201377.","journal-title":"Nucleic Acids Res"}],"updated-by":[{"DOI":"10.1186\/s13287-024-03985-w","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000}}],"container-title":["Stem Cell Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-024-03846-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13287-024-03846-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-024-03846-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T19:06:33Z","timestamp":1728587193000},"score":1,"resource":{"primary":{"URL":"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/s13287-024-03846-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,29]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3846"],"URL":"https:\/\/doi.org\/10.1186\/s13287-024-03846-6","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4209230\/v1","asserted-by":"object"}]},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,29]]},"assertion":[{"value":"8 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2024","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1186\/s13287-024-03985-w","URL":"https:\/\/doi.org\/10.1186\/s13287-024-03985-w","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments in the project were granted approval by the Committee on Ethics of Medical Research, Naval Medical University (Research Proposal Title: study on the mechanism of MiR-340-3p promoting repair after endometrial injury by inhibiting ferroptosis of stromal cells; approval no. NMUMREC-2021-038) On March 10, 2021.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"224"}}