{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T17:23:43Z","timestamp":1740158623030,"version":"3.37.3"},"reference-count":6,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Department of Pathology and Microbiology, UNMC","award":["Department of Pathology and Microbiology, UNMC"],"award-info":[{"award-number":["Department of Pathology and Microbiology, UNMC"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Collection of hematopoietic progenitor cell products [HPC(A)] is deferred if the donor is symptomatic and tests positive for Covid-19. However, donor questionnaires are subjective and may miss minimally symptomatic donors. Alternatively, myalgia associated with Covid-19 infection can be falsely dismissed as an adverse effect of granulocyte stimulating factor (Filgrastim) administered prior to product collection. The likelihood of donors with an underlying acute but minimally symptomatic infection undergoing successful product collection is significant. In these circumstances, it is less known whether Covid-19 infection results in product viremia or alters the clinical outcome of transplant. We aimed to evaluate the above question by studying a donor whose product was collected during acute Covid-19 infection. Aliquots of the product tested negative for SARS-CoV-2 RNA by reverse-transcriptase polymerase chain reaction assay (RT-PCR). Importantly, the donor received an autologous stem cell transplant using the product collected at the time of infection, and their case will be described in this report. We describe one of the very few reports of successful transplant of HPC(A) product collected during acute Covid-19 infection.<\/jats:p>","DOI":"10.1186\/s13287-024-03872-4","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T01:02:11Z","timestamp":1723510931000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characteristics of HPC(A) product obtained from a donor with SARS-CoV-2 infection and outcome of autologous transplant"],"prefix":"10.1186","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4226-2633","authenticated-orcid":false,"given":"Pranav S.","family":"Renavikar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phyllis I.","family":"Warkentin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelly M.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishna","family":"Gundabolu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Branson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott A.","family":"Koepsell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,8,13]]},"reference":[{"key":"3872_CR1","doi-asserted-by":"publisher","first-page":"e13408","DOI":"10.1111\/tid.13408","volume":"22","author":"K Gajurel","year":"2020","unstructured":"Gajurel K. Persistently positive severe acute respiratory syndrome coronavirus 2 (SARS-COV2) nasopharyngeal PCR in a kidney transplant recipient. Transpl Infect Dis. 2020;22:e13408.","journal-title":"Transpl Infect Dis"},{"key":"3872_CR2","doi-asserted-by":"publisher","first-page":"5917","DOI":"10.1038\/s41467-020-19802-w","volume":"11","author":"S Cao","year":"2020","unstructured":"Cao S, Gan Y, Wang C, et al. Post-lockdown SARS-CoV-2 nucleic acid screening in nearly ten million residents of Wuhan, China. Nat Commun. 2020;11:5917.","journal-title":"Nat Commun"},{"issue":"6","key":"3872_CR3","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1111\/trf.15831","volume":"60","author":"LM Katz","year":"2020","unstructured":"Katz LM. Is SARS-CoV-2 transfusion transmitted? Transfusion. 2020;60(6):1111\u20134. https:\/\/doi.org\/10.1111\/trf.15831.","journal-title":"Transfusion"},{"key":"3872_CR4","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1111\/trf.16155","volume":"61","author":"L Loubaki","year":"2020","unstructured":"Loubaki L, Ganter P, Pagliuzza A, et al. Testing for the presence of SARS-CoV-2 RNA in presymptomatic blood donors. Transfusion. 2020;61:649\u201351.","journal-title":"Transfusion"},{"issue":"6","key":"3872_CR5","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1111\/trf.15841","volume":"60","author":"VM Corman","year":"2020","unstructured":"Corman VM, Rabenau HF, Adams O, Oberle D, Funk MB, Keller-Stanislawski B, Timm J, Drosten C, Ciesek S. SARS-CoV-2 asymptomatic and symptomatic patients and risk for transfusion transmission. Transfusion. 2020;60(6):1119\u201322. https:\/\/doi.org\/10.1111\/trf.15841.","journal-title":"Transfusion"},{"issue":"3","key":"3872_CR6","doi-asserted-by":"publisher","first-page":"e2701","DOI":"10.1016\/j.jtct.2020.11.019","volume":"27","author":"N Worel","year":"2021","unstructured":"Worel N, Shaw BE, Aljurf M, Koh M, Seber A, Weisdorf D, Schwartz J, Galeano S, Kodera Y, Eldridge PW, Hashmi S, Atsuta Y, Szer J, Saber W, Niederwieser D, Greinix HT, Worldwide Network for Blood & Marrow Transplantation. Changes in hematopoietic cell transplantation practices in response to COVID-19: a Survey from the Worldwide Network for Blood & Marrow Transplantation. Transplantation Cell Therapy. 2021;27(3):e2701\u20136. https:\/\/doi.org\/10.1016\/j.jtct.2020.11.019.","journal-title":"Transplantation Cell Therapy"}],"container-title":["Stem Cell Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-024-03872-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13287-024-03872-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-024-03872-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T13:13:45Z","timestamp":1723554825000},"score":1,"resource":{"primary":{"URL":"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/s13287-024-03872-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,13]]},"references-count":6,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3872"],"URL":"https:\/\/doi.org\/10.1186\/s13287-024-03872-4","relation":{},"ISSN":["1757-6512"],"issn-type":[{"type":"electronic","value":"1757-6512"}],"subject":[],"published":{"date-parts":[[2024,8,13]]},"assertion":[{"value":"30 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable - the study is waived from review as determined by the University of Nebraska Medical Center Institutional Review Board.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from the patient for the publication of this case report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no potential conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"251"}}