{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:19:37Z","timestamp":1791227977955,"version":"4.1.0"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470772"],"award-info":[{"award-number":["81470772"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chongqing Talent Program: Innovative leading talents","award":["CQYC20210303384"],"award-info":[{"award-number":["CQYC20210303384"]}]},{"name":"Chongqing Medical Scientific Research Project","award":["cstc2020jcyj-msxmX0307"],"award-info":[{"award-number":["cstc2020jcyj-msxmX0307"]}]},{"name":"Chongqing Medical Scientific Research Project","award":["CSTB2023NSCQ-MSX0233"],"award-info":[{"award-number":["CSTB2023NSCQ-MSX0233"]}]},{"name":"Program for Youth Innovation in Future Medicine, Chongqing Medical University","award":["W0033"],"award-info":[{"award-number":["W0033"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"DOI":"10.1186\/s13287-024-03884-0","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T15:02:52Z","timestamp":1725634972000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The cytoskeleton dynamics-dependent LINC complex in periodontal ligament stem cells transmits mechanical stress to the nuclear envelope and promotes YAP nuclear translocation"],"prefix":"10.1186","volume":"15","author":[{"given":"Xuehuan","family":"Meng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baraa","family":"Daraqel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Ming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3483-0638","authenticated-orcid":false,"given":"Leilei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,6]]},"reference":[{"issue":"15","key":"3884_CR1","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1089\/scd.2019.0031","volume":"28","author":"A Tomokiyo","year":"2019","unstructured":"Tomokiyo A, Wada N, Maeda H. Periodontal Ligament Stem cells: regenerative potency in Periodontium. Stem Cells Dev. 2019;28(15):974\u201385.","journal-title":"Stem Cells Dev"},{"key":"3884_CR2","doi-asserted-by":"crossref","unstructured":"Wang L, Liang H, Sun B, Mi J, Tong X, Wang Y et al. Role of TRPC6 in periodontal tissue reconstruction mediated by appropriate stress. Stem Cell Res Ther. 2022;13(1).","DOI":"10.1186\/s13287-022-03055-z"},{"issue":"1","key":"3884_CR3","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s11658-023-00420-5","volume":"28","author":"J Wang","year":"2023","unstructured":"Wang J, Yang H, Ma X, Liu J, Li L, Chen L, et al. LRP6\/filamentous-actin signaling facilitates osteogenic commitment in mechanically induced periodontal ligament stem cells. Cell Mol Biol Lett. 2023;28(1):7.","journal-title":"Cell Mol Biol Lett"},{"key":"3884_CR4","doi-asserted-by":"crossref","unstructured":"Zhang D, Lin W, Jiang S, Deng P, Liu L, Wang Q et al. Lepr-expressing PDLSCs contribute to Periodontal Homeostasis and respond to Mechanical Force by Piezo1. Adv Sci. 2023;10(29).","DOI":"10.1002\/advs.202303291"},{"key":"3884_CR5","doi-asserted-by":"crossref","unstructured":"Shi Q, Zheng L, Na J, Li X, Yang Z, Chen X et al. Fluid shear stress promotes periodontal ligament cells proliferation via p38-AMOT-YAP. Cell Mol Life Sci. 2022;79(11).","DOI":"10.1007\/s00018-022-04591-w"},{"issue":"7","key":"3884_CR6","doi-asserted-by":"publisher","first-page":"932","DOI":"10.3390\/biom11070932","volume":"11","author":"J Brockhaus","year":"2021","unstructured":"Brockhaus J, Craveiro RB, Azraq I, Niederau C, Schr\u00f6der SK, Weiskirchen R, et al. In Vitro Compression Model for Orthodontic Tooth Movement Modulates Human Periodontal Ligament Fibroblast Proliferation, apoptosis and cell cycle. Biomolecules. 2021;11(7):932.","journal-title":"Biomolecules"},{"key":"3884_CR7","doi-asserted-by":"crossref","unstructured":"Li Y, Zhan Q, Bao M, Yi J, Li Y. Biomechanical and biological responses of periodontium in orthodontic tooth movement: up-date in a new decade. Int J Oral Sci. 2021;13(1).","DOI":"10.1038\/s41368-021-00125-5"},{"issue":"12","key":"3884_CR8","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1038\/nrm3903","volume":"15","author":"T Iskratsch","year":"2014","unstructured":"Iskratsch T, Wolfenson H, Sheetz MP. Appreciating force and shape \u2014 the rise of mechanotransduction in cell biology. Nat Rev Mol Cell Biol. 2014;15(12):825\u201333.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"12","key":"3884_CR9","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1111\/j.1600-051X.2010.01597.x","volume":"37","author":"T Iwata","year":"2010","unstructured":"Iwata T, Yamato M, Zhang Z, Mukobata S, Washio K, Ando T, et al. Validation of human periodontal ligament-derived cells as a reliable source for cytotherapeutic use. J Clin Periodontol. 2010;37(12):1088\u201399.","journal-title":"J Clin Periodontol"},{"key":"3884_CR10","doi-asserted-by":"crossref","unstructured":"Mohebichamkhorami F, Fattahi R, Niknam Z, Aliashrafi M, Khakpour Naeimi S, Gilanchi S et al. Periodontal ligament stem cells as a promising therapeutic target for neural damage. Stem Cell Res Ther. 2022;13(1).","DOI":"10.1186\/s13287-022-02942-9"},{"key":"3884_CR11","doi-asserted-by":"crossref","unstructured":"Shao X, Hu Z, Su H, Wang Y, Lin Y. Effects of tension on mitochondrial autophagy and osteogenic differentiation of periodontal ligament stem cells. Cell Prolif. 2023.","DOI":"10.1111\/cpr.13561"},{"issue":"6","key":"3884_CR12","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1016\/j.ajodo.2018.01.023","volume":"154","author":"T Sugimori","year":"2018","unstructured":"Sugimori T, Yamaguchi M, Shimizu M, Kikuta J, Hikida T, Hikida M, et al. Micro-osteoperforations accelerate orthodontic tooth movement by stimulating periodontal ligament cell cycles. Am J Orthod Dentofac Orthop. 2018;154(6):788\u201396.","journal-title":"Am J Orthod Dentofac Orthop"},{"issue":"4","key":"3884_CR13","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1152\/physrev.00005.2014","volume":"94","author":"S Piccolo","year":"2014","unstructured":"Piccolo S, Dupont S, Cordenonsi M. The Biology of YAP\/TAZ: Hippo Signaling and Beyond. Physiol Rev. 2014;94(4):1287\u2013312.","journal-title":"Physiol Rev"},{"issue":"7350","key":"3884_CR14","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nature10137","volume":"474","author":"S Dupont","year":"2011","unstructured":"Dupont S, Morsut L, Aragona M, Enzo E, Giulitti S, Cordenonsi M, et al. Role of YAP\/TAZ in mechanotransduction. Nature. 2011;474(7350):179\u201383.","journal-title":"Nature"},{"issue":"1","key":"3884_CR15","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.cell.2014.06.013","volume":"158","author":"L Azzolin","year":"2014","unstructured":"Azzolin L, Panciera T, Soligo S, Enzo E, Bicciato S, Dupont S, et al. YAP\/TAZ incorporation in the beta-catenin destruction complex orchestrates the wnt response. Cell. 2014;158(1):157\u201370.","journal-title":"Cell"},{"issue":"1","key":"3884_CR16","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/s41580-020-00306-w","volume":"22","author":"P Romani","year":"2020","unstructured":"Romani P, Valcarcel-Jimenez L, Frezza C, Dupont S. Crosstalk between mechanotransduction and metabolism. Nat Rev Mol Cell Biol. 2020;22(1):22\u201338.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5","key":"3884_CR17","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/j.cell.2013.07.042","volume":"154","author":"M Aragona","year":"2013","unstructured":"Aragona M, Panciera T, Manfrin A, Giulitti S, Michielin F, Elvassore N, et al. A mechanical checkpoint controls multicellular growth through YAP\/TAZ regulation by actin-processing factors. Cell. 2013;154(5):1047\u201359.","journal-title":"Cell"},{"issue":"12","key":"3884_CR18","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1038\/emboj.2011.157","volume":"30","author":"L Sansores-Garcia","year":"2011","unstructured":"Sansores-Garcia L, Bossuyt W, Wada K, Yonemura S, Tao C, Sasaki H, et al. Modulating F-actin organization induces organ growth by affecting the Hippo pathway. EMBO J. 2011;30(12):2325\u201335.","journal-title":"EMBO J"},{"issue":"1","key":"3884_CR19","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1083\/jcb.200509124","volume":"172","author":"M Crisp","year":"2006","unstructured":"Crisp M, Liu Q, Roux K, Rattner JB, Shanahan C, Burke B, et al. Coupling of the nucleus and cytoplasm: role of the LINC complex. J Cell Biol. 2006;172(1):41\u201353.","journal-title":"J Cell Biol"},{"issue":"11","key":"3884_CR20","doi-asserted-by":"publisher","first-page":"R414","DOI":"10.1016\/j.cub.2011.04.022","volume":"21","author":"DA Starr","year":"2011","unstructured":"Starr DA. KASH and SUN proteins. Curr Biol. 2011;21(11):R414\u20135.","journal-title":"Curr Biol"},{"issue":"4","key":"3884_CR21","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1083\/jcb.200906068","volume":"186","author":"D Razafsky","year":"2009","unstructured":"Razafsky D, Hodzic D. Bringing KASH under the SUN: the many faces of nucleo-cytoskeletal connections. J Cell Biol. 2009;186(4):461\u201372.","journal-title":"J Cell Biol"},{"issue":"2","key":"3884_CR22","doi-asserted-by":"publisher","first-page":"0210061","DOI":"10.1115\/1.4035350","volume":"139","author":"SE Szczesny","year":"2017","unstructured":"Szczesny SE, Mauck RL. The Nuclear option: evidence implicating the cell nucleus in Mechanotransduction. J Biomech Eng. 2017;139(2):0210061\u201302100616.","journal-title":"J Biomech Eng"},{"issue":"30","key":"3884_CR23","doi-asserted-by":"publisher","first-page":"26743","DOI":"10.1074\/jbc.M111.233700","volume":"286","author":"ML Lombardi","year":"2011","unstructured":"Lombardi ML, Jaalouk DE, Shanahan CM, Burke B, Roux KJ, Lammerding J. The interaction between nesprins and sun proteins at the nuclear envelope is critical for force transmission between the nucleus and cytoskeleton. J Biol Chem. 2011;286(30):26743\u201353.","journal-title":"J Biol Chem"},{"issue":"12","key":"3884_CR24","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1038\/nmat4729","volume":"15","author":"A Tajik","year":"2016","unstructured":"Tajik A, Zhang Y, Wei F, Sun J, Jia Q, Zhou W, et al. Transcription upregulation via force-induced direct stretching of chromatin. Nat Mater. 2016;15(12):1287\u201396.","journal-title":"Nat Mater"},{"issue":"6","key":"3884_CR25","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1016\/j.cell.2017.10.008","volume":"171","author":"A Elosegui-Artola","year":"2017","unstructured":"Elosegui-Artola A, Andreu I, Beedle AEM, Lezamiz A, Uroz M, Kosmalska AJ, et al. Force triggers YAP Nuclear Entry by regulating transport across Nuclear pores. Cell. 2017;171(6):1397\u2013e41014.","journal-title":"Cell"},{"issue":"18","key":"3884_CR26","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1091\/mbc.E20-11-0698","volume":"32","author":"KB Denis","year":"2021","unstructured":"Denis KB, Cabe JI, Danielsson BE, Tieu KV, Mayer CR, Conway DE. The LINC complex is required for endothelial cell adhesion and adaptation to shear stress and cyclic stretch. Mol Biol Cell. 2021;32(18):1654\u201363.","journal-title":"Mol Biol Cell"},{"key":"3884_CR27","doi-asserted-by":"crossref","unstructured":"Carley E, Stewart RM, Zieman A, Jalilian I, King DE, Zubek A et al. The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiation. Elife. 2021;10.","DOI":"10.7554\/eLife.58541"},{"issue":"8","key":"3884_CR28","doi-asserted-by":"publisher","first-page":"3969","DOI":"10.1007\/s00018-021-03762-5","volume":"78","author":"M Shah","year":"2021","unstructured":"Shah M, Chacko LA, Joseph JP, Ananthanarayanan V. Mitochondrial dynamics, positioning and function mediated by cytoskeletal interactions. Cell Mol Life Sci. 2021;78(8):3969\u201386.","journal-title":"Cell Mol Life Sci"},{"key":"3884_CR29","doi-asserted-by":"publisher","first-page":"6531216","DOI":"10.1155\/2018\/6531216","volume":"2018","author":"H Huang","year":"2018","unstructured":"Huang H, Yang R, Zhou YH. Mechanobiology of Periodontal Ligament Stem Cells in Orthodontic Tooth Movement. Stem Cells Int. 2018;2018:6531216.","journal-title":"Stem Cells Int"},{"issue":"9","key":"3884_CR30","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.1089\/ten.tea.2008.0562","volume":"15","author":"W Zheng","year":"2009","unstructured":"Zheng W, Wang S, Ma D, Tang L, Duan Y, Jin Y. Loss of proliferation and differentiation capacity of aged human periodontal ligament stem cells and rejuvenation by exposure to the young extrinsic environment. Tissue Eng Part A. 2009;15(9):2363\u201371.","journal-title":"Tissue Eng Part A"},{"issue":"17","key":"3884_CR31","doi-asserted-by":"publisher","first-page":"2826","DOI":"10.1016\/j.cub.2019.07.021","volume":"29","author":"Q Zhang","year":"2019","unstructured":"Zhang Q, Narayanan V, Mui KL, O\u2019Bryan CS, Anderson RH, Kc B, et al. Mechanical stabilization of the glandular acinus by Linker of Nucleoskeleton and Cytoskeleton Complex. Curr Biol. 2019;29(17):2826\u2013e394.","journal-title":"Curr Biol"},{"key":"3884_CR32","doi-asserted-by":"crossref","unstructured":"Li H, Deng Y, Tan M, Feng G, Kuang Y, Li J et al. Low-intensity pulsed ultrasound upregulates osteogenesis under inflammatory conditions in periodontal ligament stem cells through unfolded protein response. Stem Cell Res Ther. 2020;11(1).","DOI":"10.1186\/s13287-020-01732-5"},{"issue":"1","key":"3884_CR33","doi-asserted-by":"publisher","first-page":"5925","DOI":"10.1038\/s41467-022-33492-6","volume":"13","author":"H Huang","year":"2022","unstructured":"Huang H, Pan W, Wang Y, Kim HS, Shao D, Huang B, et al. Nanoparticulate cell-free DNA scavenger for treating inflammatory bone loss in periodontitis. Nat Commun. 2022;13(1):5925.","journal-title":"Nat Commun"},{"issue":"5","key":"3884_CR34","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1093\/ndt\/gfh042","volume":"19","author":"MD Martin-Martinez","year":"2004","unstructured":"Martin-Martinez MD, Stoenoiu M, Verkaeren C, Devuyst O, Delporte C. Recombinant adenovirus administration in rat peritoneum: endothelial expression and safety concerns. Nephrol Dial Transpl. 2004;19(5):1293\u20137.","journal-title":"Nephrol Dial Transpl"},{"issue":"9429","key":"3884_CR35","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0140-6736(04)16627-0","volume":"364","author":"B-M Seo","year":"2004","unstructured":"Seo B-M, Miura M, Gronthos S, Mark Bartold P, Batouli S, Brahim J, et al. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet. 2004;364(9429):149\u201355.","journal-title":"Lancet"},{"issue":"1","key":"3884_CR36","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1146\/annurev-biochem-013118-111829","volume":"88","author":"S Ma","year":"2019","unstructured":"Ma S, Meng Z, Chen R, Guan K-L. The Hippo Pathway: Biology and Pathophysiology. Annu Rev Biochem. 2019;88(1):577\u2013604.","journal-title":"Annu Rev Biochem"},{"issue":"12","key":"3884_CR37","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1038\/s41580-023-00644-5","volume":"24","author":"JH Driskill","year":"2023","unstructured":"Driskill JH, Pan D. Control of stem cell renewal and fate by YAP and TAZ. Nat Rev Mol Cell Biol. 2023;24(12):895\u2013911.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"7280","key":"3884_CR38","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/nature08908","volume":"463","author":"DA Fletcher","year":"2010","unstructured":"Fletcher DA, Mullins RD. Cell mechanics and the cytoskeleton. Nature. 2010;463(7280):485\u201392.","journal-title":"Nature"},{"key":"3884_CR39","doi-asserted-by":"crossref","unstructured":"Svitkina T. The actin cytoskeleton and actin-based motility. Cold Spring Harb Perspect Biol. 2018;10(1).","DOI":"10.1101\/cshperspect.a018267"},{"issue":"6","key":"3884_CR40","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1038\/s41569-019-0155-8","volume":"16","author":"JJ Saucerman","year":"2019","unstructured":"Saucerman JJ, Tan PM, Buchholz KS, McCulloch AD, Omens JH. Mechanical regulation of gene expression in cardiac myocytes and fibroblasts. Nat Rev Cardiol. 2019;16(6):361\u201378.","journal-title":"Nat Rev Cardiol"},{"key":"3884_CR41","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.biomaterials.2019.03.009","volume":"205","author":"J Oliver-De La Cruz","year":"2019","unstructured":"Oliver-De La Cruz J, Nardone G, Vrbsky J, Pompeiano A, Perestrelo AR, Capradossi F, et al. Substrate mechanics controls adipogenesis through YAP phosphorylation by dictating cell spreading. Biomaterials. 2019;205:64\u201380.","journal-title":"Biomaterials"},{"issue":"29","key":"3884_CR42","doi-asserted-by":"publisher","first-page":"11930","DOI":"10.1073\/pnas.1103345108","volume":"108","author":"N-G Kim","year":"2011","unstructured":"Kim N-G, Koh E, Chen X, Gumbiner BM. E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components. Proc Natl Acad Sci U S A. 2011;108(29):11930\u20135.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3884_CR43","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.biomaterials.2017.04.039","volume":"134","author":"X Xue","year":"2017","unstructured":"Xue X, Hong X, Li Z, Deng CX, Fu J. Acoustic tweezing cytometry enhances osteogenesis of human mesenchymal stem cells through cytoskeletal contractility and YAP activation. Biomaterials. 2017;134:22\u201330.","journal-title":"Biomaterials"},{"issue":"1","key":"3884_CR44","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.stem.2017.03.023","volume":"21","author":"JK Hu","year":"2017","unstructured":"Hu JK, Du W, Shelton SJ, Oldham MC, DiPersio CM, Klein OD. An FAK-YAP-mTOR signaling Axis regulates stem cell-based tissue Renewal in mice. Cell Stem Cell. 2017;21(1):91\u2013106. e6.","journal-title":"Cell Stem Cell"},{"issue":"1","key":"3884_CR45","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1002\/path.5553","volume":"253","author":"K Hasegawa","year":"2021","unstructured":"Hasegawa K, Fujii S, Matsumoto S, Tajiri Y, Kikuchi A, Kiyoshima T. YAP signaling induces PIEZO1 to promote oral squamous cell carcinoma cell proliferation. J Pathol. 2021;253(1):80\u201393.","journal-title":"J Pathol"},{"issue":"1","key":"3884_CR46","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1002\/hep.32105","volume":"75","author":"S Fan","year":"2022","unstructured":"Fan S, Gao Y, Qu A, Jiang Y, Li H, Xie G, et al. YAP-TEAD mediates PPAR alpha-induced hepatomegaly and liver regeneration in mice. Hepatology. 2022;75(1):74\u201388.","journal-title":"Hepatology"},{"issue":"1","key":"3884_CR47","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1186\/s13287-022-02897-x","volume":"13","author":"C Wang","year":"2022","unstructured":"Wang C, Yang Q, Han Y, Liu H, Wang Y, Huang Y, et al. A reduced level of the long non-coding RNA SNHG8 activates the NF-kappaB pathway by releasing functional HIF-1alpha in a hypoxic inflammatory microenvironment. Stem Cell Res Ther. 2022;13(1):229.","journal-title":"Stem Cell Res Ther"},{"key":"3884_CR48","doi-asserted-by":"crossref","unstructured":"Zhang Z, Cui S, Fu Y, Wang J, Liu J, Wei F. Mechanical force induces mitophagy-mediated anaerobic oxidation in periodontal ligament stem cells. Cell Mol Biol Lett. 2023;28(1).","DOI":"10.1186\/s11658-023-00453-w"},{"issue":"4","key":"3884_CR49","doi-asserted-by":"publisher","first-page":"2703","DOI":"10.1039\/C9NR09452K","volume":"12","author":"J Gao","year":"2020","unstructured":"Gao J, He L, Zhou L, Jing Y, Wang F, Shi Y, et al. Mechanical force regulation of YAP by F-actin and GPCR revealed by super-resolution imaging. Nanoscale. 2020;12(4):2703\u201314.","journal-title":"Nanoscale"},{"issue":"17","key":"3884_CR50","doi-asserted-by":"publisher","first-page":"4993","DOI":"10.7150\/thno.35665","volume":"9","author":"S Li","year":"2019","unstructured":"Li S, Li C, Zhang Y, He X, Chen X, Zeng X, et al. Targeting mechanics-Induced Fibroblast activation through CD44-RhoA-YAP pathway ameliorates crystalline silica-Induced Silicosis. Theranostics. 2019;9(17):4993\u20135008.","journal-title":"Theranostics"},{"issue":"18","key":"3884_CR51","doi-asserted-by":"publisher","first-page":"11209","DOI":"10.1074\/jbc.M114.627166","volume":"290","author":"M Plessner","year":"2015","unstructured":"Plessner M, Melak M, Chinchilla P, Baarlink C, Grosse R. Nuclear F-actin formation and reorganization upon cell spreading. J Biol Chem. 2015;290(18):11209\u201316.","journal-title":"J Biol Chem"},{"key":"3884_CR52","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.actbio.2022.08.079","volume":"152","author":"SM Wen","year":"2022","unstructured":"Wen SM, Wen WC, Chao PG. Zyxin and actin structure confer anisotropic YAP mechanotransduction. Acta Biomater. 2022;152:313\u201320.","journal-title":"Acta Biomater"},{"issue":"20","key":"3884_CR53","doi-asserted-by":"publisher","first-page":"3097","DOI":"10.1016\/j.cub.2017.08.073","volume":"27","author":"R Zhu","year":"2017","unstructured":"Zhu R, Antoku S, Gundersen GG. Centrifugal displacement of nuclei reveals multiple LINC complex mechanisms for Homeostatic Nuclear Positioning. Curr Biol. 2017;27(20):3097\u2013110. e5.","journal-title":"Curr Biol"},{"issue":"3","key":"3884_CR54","doi-asserted-by":"publisher","first-page":"e10","DOI":"10.1161\/CIRCRESAHA.119.315582","volume":"126","author":"J Heffler","year":"2020","unstructured":"Heffler J, Shah PP, Robison P, Phyo S, Veliz K, Uchida K, et al. A Balance between Intermediate filaments and microtubules maintains Nuclear Architecture in the cardiomyocyte. Circ Res. 2020;126(3):e10\u201326.","journal-title":"Circ Res"},{"issue":"5994","key":"3884_CR55","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1126\/science.1189072","volume":"329","author":"GW Luxton","year":"2010","unstructured":"Luxton GW, Gomes ER, Folker ES, Vintinner E, Gundersen GG. Linear arrays of nuclear envelope proteins harness retrograde actin flow for nuclear movement. Science. 2010;329(5994):956\u20139.","journal-title":"Science"},{"issue":"3","key":"3884_CR56","doi-asserted-by":"publisher","first-page":"173","DOI":"10.4161\/nucl.2.3.16243","volume":"2","author":"GWG Luxton","year":"2014","unstructured":"Luxton GWG, Gomes ER, Folker ES, Worman H, Gundersen GG. TAN Lines Nucleus. 2014;2(3):173\u201381.","journal-title":"TAN Lines Nucleus"},{"key":"3884_CR57","doi-asserted-by":"publisher","first-page":"38063","DOI":"10.1038\/srep38063","volume":"6","author":"SG Alam","year":"2016","unstructured":"Alam SG, Zhang Q, Prasad N, Li Y, Chamala S, Kuchibhotla R, et al. The mammalian LINC complex regulates genome transcriptional responses to substrate rigidity. Sci Rep. 2016;6:38063.","journal-title":"Sci Rep"},{"issue":"1","key":"3884_CR58","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/nrm2594","volume":"10","author":"N Wang","year":"2009","unstructured":"Wang N, Tytell JD, Ingber DE. Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus. Nat Rev Mol Cell Biol. 2009;10(1):75\u201382.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"3884_CR59","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/s12195-019-00579-y","volume":"12","author":"CR Mayer","year":"2019","unstructured":"Mayer CR, Arsenovic PT, Bathula K, Denis KB, Conway DE. Characterization of 3D printed stretching devices for Imaging Force transmission in live-cells. Cell Mol Bioeng. 2019;12(4):289\u2013300.","journal-title":"Cell Mol Bioeng"},{"key":"3884_CR60","doi-asserted-by":"publisher","first-page":"100335","DOI":"10.1016\/j.mtbio.2022.100335","volume":"15","author":"S Saporito","year":"2022","unstructured":"Saporito S, Natale CF, Menna C, Netti PA, Ventre M. A role for nuclear stretching and NPCs changes in the cytoplasmic-nuclear trafficking of YAP: an experimental and numerical modelling approach. Mater Today Bio. 2022;15:100335.","journal-title":"Mater Today Bio"},{"key":"3884_CR61","doi-asserted-by":"crossref","unstructured":"Matsuda A, Mofrad MRK. On the nuclear pore complex and its emerging role in cellular mechanotransduction. APL Bioeng. 2022;6(1).","DOI":"10.1063\/5.0080480"},{"key":"3884_CR62","doi-asserted-by":"crossref","unstructured":"Bartolak-Suki E, Imsirovic J, Nishibori Y, Krishnan R, Suki B. Regulation of mitochondrial structure and Dynamics by the Cytoskeleton and mechanical factors. Int J Mol Sci. 2017;18(8).","DOI":"10.3390\/ijms18081812"},{"issue":"5","key":"3884_CR63","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/s41556-019-0313-6","volume":"21","author":"C Yang","year":"2019","unstructured":"Yang C, Svitkina TM. Ultrastructure and dynamics of the actin-myosin II cytoskeleton during mitochondrial fission. Nat Cell Biol. 2019;21(5):603\u201313.","journal-title":"Nat Cell Biol"},{"issue":"16","key":"3884_CR64","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1091\/mbc.e16-10-0741","volume":"28","author":"M-H Schuler","year":"2017","unstructured":"Schuler M-H, Lewandowska A, Caprio GD, Skillern W, Upadhyayula S, Kirchhausen T, et al. Miro1-mediated mitochondrial positioning shapes intracellular energy gradients required for cell migration. Mol Biol Cell. 2017;28(16):2159\u201369.","journal-title":"Mol Biol Cell"}],"container-title":["Stem Cell Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-024-03884-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13287-024-03884-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-024-03884-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T16:05:50Z","timestamp":1725638750000},"score":1,"resource":{"primary":{"URL":"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/s13287-024-03884-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,6]]},"references-count":64,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3884"],"URL":"https:\/\/doi.org\/10.1186\/s13287-024-03884-0","relation":{},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,6]]},"assertion":[{"value":"7 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Supplementary Information"}},{"value":"The extraction procedures of human PDLSCs were conducted in accordance with the Declaration of Helsinki, and informed consent was obtained from the donors and\/or their guardians before the tooth collection. The animal experiments were conducted following the ARRIVE guidelines 2.0 (Animal Research: Reporting of In Vivo Experiments). The extraction procedures of human PDLSCs and all animal experiments in this study were approved by the Ethics Committee of Stomatological Hospital of Chongqing Medical University in the same project (Project title: Research on cytoskeleton mediated YAP nuclear translocation regulating the mechanical response mechanism of periodontal ligament stem cells; Approval No: 2023151; Date of approval: 2023-10-10).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"284"}}