{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:40:34Z","timestamp":1790347234648,"version":"4.1.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071071"],"award-info":[{"award-number":["82071071"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82130028"],"award-info":[{"award-number":["82130028"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2022YFA1104401"],"award-info":[{"award-number":["2022YFA1104401"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine","doi-asserted-by":"publisher","award":["2019-I2M-5-031"],"award-info":[{"award-number":["2019-I2M-5-031"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"DOI":"10.1186\/s13287-024-03929-4","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T19:03:06Z","timestamp":1726513386000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["NQO1 promotes osteogenesis and suppresses angiogenesis in DPSCs via MAPK pathway modulation"],"prefix":"10.1186","volume":"15","author":[{"given":"Wanqing","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoqing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1662-9420","authenticated-orcid":false,"given":"Zhipeng","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruitang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,16]]},"reference":[{"issue":"12","key":"3929_CR1","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1038\/s41569-022-00718-5","volume":"19","author":"I Akoumianakis","year":"2022","unstructured":"Akoumianakis I, Polkinghorne M, Antoniades C. Non-canonical WNT signalling in cardiovascular disease: mechanisms and therapeutic implications. Nat Rev Cardiol. 2022;19(12):783\u201397. https:\/\/doi.org\/10.1038\/s41569-022-00718-5.","journal-title":"Nat Rev Cardiol"},{"issue":"9","key":"3929_CR2","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1111\/eci.12493","volume":"45","author":"M T\u00f6lle","year":"2015","unstructured":"T\u00f6lle M, Reshetnik A, Schuchardt M, H\u00f6hne M, van der Giet M. Arteriosclerosis and vascular calcification: causes, clinical assessment and therapy. Eur J Clin Invest. 2015;45(9):976\u201385. https:\/\/doi.org\/10.1111\/eci.12493.","journal-title":"Eur J Clin Invest"},{"issue":"6","key":"3929_CR3","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1093\/ije\/dyv347","volume":"44","author":"EC Andrus","year":"2015","unstructured":"Andrus EC, Allen EV, Merritt HH, Duff GL, Moore RA, Kendall FE, et al. The pathogenesis of arteriosclerosis. Int J Epidemiol. 2015;44(6):1791\u20133. https:\/\/doi.org\/10.1093\/ije\/dyv347.","journal-title":"Int J Epidemiol"},{"issue":"1","key":"3929_CR4","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1186\/s13287-022-03143-0","volume":"13","author":"C Zhang","year":"2022","unstructured":"Zhang C, Huang L, Wang X, Zhou X, Zhang X, Li L, et al. Topical and intravenous administration of human umbilical cord mesenchymal stem cells in patients with diabetic foot ulcer and peripheral arterial disease: a phase I pilot study with a 3-year follow-up. Stem Cell Res Ther. 2022;13(1):451. https:\/\/doi.org\/10.1186\/s13287-022-03143-0.","journal-title":"Stem Cell Res Ther"},{"key":"3929_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115551","volume":"167","author":"H Zhang","year":"2023","unstructured":"Zhang H, Wan X, Tian J, An Z, Liu L, Zhao X, et al. The therapeutic efficacy and clinical translation of mesenchymal stem cell-derived exosomes in cardiovascular diseases. Biomed Pharmacother. 2023;167: 115551. https:\/\/doi.org\/10.1016\/j.biopha.2023.115551.","journal-title":"Biomed Pharmacother"},{"issue":"3","key":"3929_CR6","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1634\/stemcells.2007-0484","volume":"26","author":"C Gandia","year":"2008","unstructured":"Gandia C, Armi\u00f1an A, Garc\u00eda-Verdugo JM, Lled\u00f3 E, Ruiz A, Mi\u00f1ana MD, et al. Human dental pulp stem cells improve left ventricular function, induce angiogenesis, and reduce infarct size in rats with acute myocardial infarction. Stem Cells. 2008;26(3):638\u201345. https:\/\/doi.org\/10.1634\/stemcells.2007-0484.","journal-title":"Stem Cells"},{"issue":"8","key":"3929_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2023.107202","volume":"32","author":"N Jashire Nezhad","year":"2023","unstructured":"Jashire Nezhad N, Safari A, Namavar MR, Nami M, Karimi-Haghighi S, Pandamooz S, et al. Short-term beneficial effects of human dental pulp stem cells and their secretome in a rat model of mild ischemic stroke. J Stroke Cerebrovasc Dis. 2023;32(8): 107202. https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2023.107202.","journal-title":"J Stroke Cerebrovasc Dis"},{"issue":"2","key":"3929_CR8","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.thromres.2013.11.017","volume":"133","author":"X Yu","year":"2014","unstructured":"Yu X, Liu J, Zhu H, Xia Y, Gao L, Dong Y, et al. Synergistic association of DNA repair relevant gene polymorphisms with the risk of coronary artery disease in northeastern Han Chinese. Thromb Res. 2014;133(2):229\u201334. https:\/\/doi.org\/10.1016\/j.thromres.2013.11.017.","journal-title":"Thromb Res"},{"issue":"2","key":"3929_CR9","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/jes.2014.84","volume":"26","author":"S Wittkopp","year":"2016","unstructured":"Wittkopp S, Staimer N, Tjoa T, Stinchcombe T, Daher N, Schauer JJ, et al. Nrf2-related gene expression and exposure to traffic-related air pollution in elderly subjects with cardiovascular disease: An exploratory panel study. J Expo Sci Environ Epidemiol. 2016;26(2):141\u20139. https:\/\/doi.org\/10.1038\/jes.2014.84.","journal-title":"J Expo Sci Environ Epidemiol"},{"key":"3929_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.101950","volume":"41","author":"D Ross","year":"2021","unstructured":"Ross D, Siegel D. The diverse functionality of NQO1 and its roles in redox control. Redox Biol. 2021;41: 101950. https:\/\/doi.org\/10.1016\/j.redox.2021.101950.","journal-title":"Redox Biol"},{"issue":"1","key":"3929_CR11","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/s12933-024-02238-7","volume":"23","author":"X Zhang","year":"2024","unstructured":"Zhang X, Leng S, Liu X, Hu X, Liu Y, Li X, et al. Ion channel Piezo1 activation aggravates the endothelial dysfunction under a high glucose environment. Cardiovasc Diabetol. 2024;23(1):150. https:\/\/doi.org\/10.1186\/s12933-024-02238-7.","journal-title":"Cardiovasc Diabetol"},{"issue":"2","key":"3929_CR12","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.yexcr.2016.02.017","volume":"342","author":"R Pantan","year":"2016","unstructured":"Pantan R, Tocharus J, Suksamrarn A, Tocharus C. Synergistic effect of atorvastatin and Cyanidin-3-glucoside on angiotensin II-induced inflammation in vascular smooth muscle cells. Exp Cell Res. 2016;342(2):104\u201312. https:\/\/doi.org\/10.1016\/j.yexcr.2016.02.017.","journal-title":"Exp Cell Res"},{"issue":"12","key":"3929_CR13","doi-asserted-by":"publisher","first-page":"2256","DOI":"10.1016\/j.freeradbiomed.2012.10.001","volume":"53","author":"N Harada","year":"2012","unstructured":"Harada N, Ito K, Hosoya T, Mimura J, Maruyama A, Noguchi N, et al. Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation. Free Radic Biol Med. 2012;53(12):2256\u201362. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2012.10.001.","journal-title":"Free Radic Biol Med"},{"key":"3929_CR14","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.2147\/IJN.S452045","volume":"19","author":"M Zhang","year":"2024","unstructured":"Zhang M, Huang SS, He WY, Cao WJ, Sun MY, Zhu NW. Nasal administration of bFGF-loaded nanoliposomes attenuates neuronal injury and cognitive deficits in mice with vascular dementia induced by repeated cerebral ischemia-reperfusion. Int J Nanomed. 2024;19:1431\u201350. https:\/\/doi.org\/10.2147\/IJN.S452045.","journal-title":"Int J Nanomed"},{"issue":"1","key":"3929_CR15","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1186\/s13287-022-03125-2","volume":"13","author":"K Wang","year":"2022","unstructured":"Wang K, Zhou C, Li L, Dai C, Wang Z, Zhang W, et al. Aucubin promotes bone-fracture healing via the dual effects of anti-oxidative damage and enhancing osteoblastogenesis of hBM-MSCs. Stem Cell Res Ther. 2022;13(1):424. https:\/\/doi.org\/10.1186\/s13287-022-03125-2.","journal-title":"Stem Cell Res Ther"},{"key":"3929_CR16","doi-asserted-by":"publisher","first-page":"6666836","DOI":"10.1155\/2021\/6666836","volume":"2021","author":"J Gao","year":"2021","unstructured":"Gao J, Xiang S, Wei X, Yadav RI, Han M, Zheng W, et al. Icariin promotes the osteogenesis of bone marrow mesenchymal stem cells through regulating sclerostin and activating the Wnt\/\u03b2-catenin signaling pathway. Biomed Res Int. 2021;2021:6666836. https:\/\/doi.org\/10.1155\/2021\/6666836.","journal-title":"Biomed Res Int"},{"issue":"1\u20132","key":"3929_CR17","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.cbi.2010.10.008","volume":"192","author":"D Ross","year":"2011","unstructured":"Ross D, Zhou H, Siegel D. Benzene toxicity: the role of the susceptibility factor NQO1 in bone marrow endothelial cell signaling and function. Chem Biol Interact. 2011;192(1\u20132):145\u20139. https:\/\/doi.org\/10.1016\/j.cbi.2010.10.008.","journal-title":"Chem Biol Interact"},{"key":"3929_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154255","volume":"104","author":"PY Wu","year":"2022","unstructured":"Wu PY, Lai SY, Su YT, Yang KC, Chau YP, Don MJ, et al. \u03b2-Lapachone, an NQO1 activator, alleviates diabetic cardiomyopathy by regulating antioxidant ability and mitochondrial function. Phytomedicine. 2022;104: 154255. https:\/\/doi.org\/10.1016\/j.phymed.2022.154255.","journal-title":"Phytomedicine"},{"issue":"2","key":"3929_CR19","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.cmet.2023.01.003","volume":"35","author":"J Suh","year":"2023","unstructured":"Suh J, Kim NK, Shim W, Lee SH, Kim HJ, Moon E, et al. Mitochondrial fragmentation and donut formation enhance mitochondrial secretion to promote osteogenesis. Cell Metab. 2023;35(2):345-360.e7. https:\/\/doi.org\/10.1016\/j.cmet.2023.01.003.","journal-title":"Cell Metab"},{"issue":"4","key":"3929_CR20","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202204871","volume":"10","author":"W Cai","year":"2023","unstructured":"Cai W, Zhang J, Yu Y, Ni Y, Wei Y, Cheng Y, et al. Mitochondrial transfer regulates cell fate through metabolic remodeling in osteoporosis. Adv Sci (Weinh). 2023;10(4): e2204871. https:\/\/doi.org\/10.1002\/advs.202204871.","journal-title":"Adv Sci (Weinh)"},{"issue":"1","key":"3929_CR21","doi-asserted-by":"publisher","first-page":"2616","DOI":"10.1038\/s41467-021-22771-3","volume":"12","author":"C Wang","year":"2021","unstructured":"Wang C, Dai X, Wu S, Xu W, Song P, Huang K. FUNDC1-dependent mitochondria-associated endoplasmic reticulum membranes are involved in angiogenesis and neoangiogenesis. Nat Commun. 2021;12(1):2616. https:\/\/doi.org\/10.1038\/s41467-021-22771-3.","journal-title":"Nat Commun"},{"issue":"2","key":"3929_CR22","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1111\/jipb.13215","volume":"64","author":"M Zhang","year":"2022","unstructured":"Zhang M, Zhang S. Mitogen-activated protein kinase cascades in plant signaling. J Integr Plant Biol. 2022;64(2):301\u201341. https:\/\/doi.org\/10.1111\/jipb.13215.","journal-title":"J Integr Plant Biol"},{"issue":"1","key":"3929_CR23","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s12951-023-01789-3","volume":"21","author":"T Wang","year":"2023","unstructured":"Wang T, Zhao H, Jing S, Fan Y, Sheng G, Ding Q, et al. Magnetofection of miR-21 promoted by electromagnetic field and iron oxide nanoparticles via the p38 MAPK pathway contributes to osteogenesis and angiogenesis for intervertebral fusion. J Nanobiotechnology. 2023;21(1):27. https:\/\/doi.org\/10.1186\/s12951-023-01789-3.","journal-title":"J Nanobiotechnology"},{"issue":"8","key":"3929_CR24","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1007\/s00125-006-0278-4","volume":"49","author":"JH Lim","year":"2006","unstructured":"Lim JH, Lee JI, Suh YH, Kim W, Song JH, Jung MH. Mitochondrial dysfunction induces aberrant insulin signalling and glucose utilisation in murine C2C12 myotube cells. Diabetologia. 2006;49(8):1924\u201336. https:\/\/doi.org\/10.1007\/s00125-006-0278-4.","journal-title":"Diabetologia"},{"issue":"1","key":"3929_CR25","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/s41368-021-00148-y","volume":"13","author":"H Zheng","year":"2021","unstructured":"Zheng H, Wang N, Li L, Ge L, Jia H, Fan Z. miR-140-3p enhanced the osteo\/odontogenic differentiation of DPSCs via inhibiting KMT5B under hypoxia condition. Int J Oral Sci. 2021;13(1):41. https:\/\/doi.org\/10.1038\/s41368-021-00148-y.","journal-title":"Int J Oral Sci"},{"issue":"11","key":"3929_CR26","doi-asserted-by":"publisher","first-page":"8432","DOI":"10.1002\/jcp.29687","volume":"235","author":"H Yang","year":"2020","unstructured":"Yang H, Liang Y, Cao Y, Cao Y, Fan Z. Homeobox C8 inhibited the osteo-\/dentinogenic differentiation and migration ability of stem cells of the apical papilla via activating KDM1A. J Cell Physiol. 2020;235(11):8432\u201345. https:\/\/doi.org\/10.1002\/jcp.29687.","journal-title":"J Cell Physiol"},{"key":"3929_CR27","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202400042","author":"W Wang","year":"2024","unstructured":"Wang W, Yang H, Fan Z, Shi R. STL inhibited angiogenesis of DPSCs through depressing mitochondrial respiration by enhancing RNF217. Adv Biol (Weinh). 2024. https:\/\/doi.org\/10.1002\/adbi.202400042.","journal-title":"Adv Biol (Weinh)"},{"issue":"Suppl 1","key":"3929_CR28","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/joor.12859","volume":"47","author":"S Diao","year":"2020","unstructured":"Diao S, Yang H, Cao Y, Yang D, Fan Z. IGF2 enhanced the osteo-\/dentinogenic and neurogenic differentiation potentials of stem cells from apical papilla. J Oral Rehabil. 2020;47(Suppl 1):55\u201365. https:\/\/doi.org\/10.1111\/joor.12859.","journal-title":"J Oral Rehabil"},{"issue":"12","key":"3929_CR29","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.14670\/HH-11-642","volume":"30","author":"J Garc\u00eda-L\u00f3pez","year":"2015","unstructured":"Garc\u00eda-L\u00f3pez J, Garciadiego-C\u00e1zares D, Melgarejo-Ram\u00edrez Y, S\u00e1nchez-S\u00e1nchez R, Sol\u00eds-Arrieta L, Garc\u00eda-Carvajal Z, et al. Chondrocyte differentiation for auricular cartilage reconstruction using a chitosan based hydrogel. Histol Histopathol. 2015;30(12):1477\u201385. https:\/\/doi.org\/10.14670\/HH-11-642.","journal-title":"Histol Histopathol"},{"key":"3929_CR30","doi-asserted-by":"publisher","first-page":"5595580","DOI":"10.1155\/2021\/5595580","volume":"2021","author":"Q Qin","year":"2021","unstructured":"Qin Q, Yang H, Zhang C, Han X, Guo J, Fan Z, et al. lncRNA HHIP-AS1 promotes the osteogenic differentiation potential and inhibits the migration ability of periodontal ligament stem cells. Stem Cells Int. 2021;2021:5595580. https:\/\/doi.org\/10.1155\/2021\/5595580.","journal-title":"Stem Cells Int"},{"issue":"1","key":"3929_CR31","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s13287-022-02702-9","volume":"13","author":"W Yan","year":"2022","unstructured":"Yan W, Li L, Ge L, Zhang F, Fan Z, Hu L. The cannabinoid receptor I (CB1) enhanced the osteogenic differentiation of BMSCs by rescue impaired mitochondrial metabolism function under inflammatory condition. Stem Cell Res Ther. 2022;13(1):22. https:\/\/doi.org\/10.1186\/s13287-022-02702-9.","journal-title":"Stem Cell Res Ther"},{"issue":"35","key":"3929_CR32","doi-asserted-by":"publisher","first-page":"eadh8939","DOI":"10.1126\/sciadv.adh8939","volume":"9","author":"Y Lu","year":"2023","unstructured":"Lu Y, Leng Y, Li Y, Wang J, Wang W, Wang R, et al. Endothelial RIPK1 protects artery bypass graft against arteriosclerosis by regulating SMC growth. Sci Adv. 2023;9(35):eadh8939. https:\/\/doi.org\/10.1126\/sciadv.adh8939.","journal-title":"Sci Adv"},{"issue":"1","key":"3929_CR33","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.canlet.2011.12.005","volume":"318","author":"X Zhang","year":"2012","unstructured":"Zhang X, Su Y, Zhang M, Sun Z. Opposite effects of arsenic trioxide on the Nrf2 pathway in oral squamous cell carcinoma in vitro and in vivo. Cancer Lett. 2012;318(1):93\u20138. https:\/\/doi.org\/10.1016\/j.canlet.2011.12.005.","journal-title":"Cancer Lett"},{"issue":"5","key":"3929_CR34","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1261","volume":"13","author":"J Liu","year":"2023","unstructured":"Liu J, Long X, Li H, Yan Q, Wang L, Qin Z, et al. C1q\/TNF-related protein 4 mediates proliferation and migration of vascular smooth muscle cells during vascular remodelling. Clin Transl Med. 2023;13(5): e1261. https:\/\/doi.org\/10.1002\/ctm2.1261.","journal-title":"Clin Transl Med"},{"issue":"11","key":"3929_CR35","doi-asserted-by":"publisher","first-page":"2649","DOI":"10.1161\/ATVBAHA.120.315146","volume":"40","author":"X He","year":"2020","unstructured":"He X, Deng J, Yu XJ, Yang S, Yang Y, Zang WJ. Activation of M3AChR (type 3 muscarinic acetylcholine receptor) and nrf2 (nuclear factor erythroid 2-related factor 2) signaling by choline alleviates vascular smooth muscle cell phenotypic switching and vascular remodeling. Arterioscler Thromb Vasc Biol. 2020;40(11):2649\u201364. https:\/\/doi.org\/10.1161\/ATVBAHA.120.315146.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"2","key":"3929_CR36","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.atherosclerosis.2012.07.023","volume":"224","author":"JS Lee","year":"2012","unstructured":"Lee JS, Morrisett JD, Tung CH. Detection of hydroxyapatite in calcified cardiovascular tissues. Atherosclerosis. 2012;224(2):340\u20137. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2012.07.023.","journal-title":"Atherosclerosis"},{"key":"3929_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.176244","volume":"965","author":"S Xiang","year":"2024","unstructured":"Xiang S, Zhao L, Tang C, Ling L, Xie C, Shi Y, et al. Icariin inhibits osteoblast ferroptosis via Nrf2\/HO-1 signaling and enhances healing of osteoporotic fractures. Eur J Pharmacol. 2024;965: 176244. https:\/\/doi.org\/10.1016\/j.ejphar.2023.176244.","journal-title":"Eur J Pharmacol"},{"key":"3929_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111382","volume":"137","author":"X Su","year":"2021","unstructured":"Su X, Guo W, Yuan B, Wang D, Liu L, Wu X, et al. Artesunate attenuates bone erosion in rheumatoid arthritis by suppressing reactive oxygen species via activating p62\/Nrf2 signaling. Biomed Pharmacother. 2021;137: 111382. https:\/\/doi.org\/10.1016\/j.biopha.2021.111382.","journal-title":"Biomed Pharmacother"},{"issue":"32","key":"3929_CR39","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202303584","volume":"10","author":"N Sheng","year":"2023","unstructured":"Sheng N, Zhang Z, Zheng H, Ma C, Li M, Wang Z, et al. Scutellarin rescued mitochondrial damage through ameliorating mitochondrial glucose oxidation via the Pdk-Pdc axis. Adv Sci (Weinh). 2023;10(32): e2303584. https:\/\/doi.org\/10.1002\/advs.202303584.","journal-title":"Adv Sci (Weinh)"},{"issue":"4","key":"3929_CR40","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/j.cmet.2020.03.005","volume":"31","author":"J G\u04e7bel","year":"2020","unstructured":"G\u04e7bel J, Engelhardt E, Pelzer P, Sakthivelu V, Jahn HM, Jevtic M, et al. Mitochondria-endoplasmic reticulum contacts in reactive astrocytes promote vascular remodeling. Cell Metab. 2020;31(4):791-808.e8. https:\/\/doi.org\/10.1016\/j.cmet.2020.03.005.","journal-title":"Cell Metab"},{"issue":"2","key":"3929_CR41","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.cmet.2020.12.006","volume":"33","author":"J Levoux","year":"2021","unstructured":"Levoux J, Prola A, Lafuste P, Gervais M, Chevallier N, Koumaiha Z, et al. Platelets facilitate the wound-healing capability of mesenchymal stem cells by mitochondrial transfer and metabolic reprogramming. Cell Metab. 2021;33(2):283-299.e9. https:\/\/doi.org\/10.1016\/j.cmet.2020.12.006.","journal-title":"Cell Metab"},{"key":"3929_CR42","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.ebiom.2019.03.038","volume":"43","author":"W Xu","year":"2019","unstructured":"Xu W, Liang M, Zhang Y, Huang K, Wang C. Endothelial FAM3A positively regulates post-ischaemic angiogenesis. EBioMedicine. 2019;43:32\u201342. https:\/\/doi.org\/10.1016\/j.ebiom.2019.03.038.","journal-title":"EBioMedicine"},{"issue":"6","key":"3929_CR43","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1007\/s13238-017-0385-7","volume":"8","author":"Q Li","year":"2017","unstructured":"Li Q, Gao Z, Chen Y, Guan MX. The role of mitochondria in osteogenic, adipogenic and chondrogenic differentiation of mesenchymal stem cells. Protein Cell. 2017;8(6):439\u201345. https:\/\/doi.org\/10.1007\/s13238-017-0385-7.","journal-title":"Protein Cell"},{"issue":"2","key":"3929_CR44","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/cdd.2017.144","volume":"25","author":"J Gao","year":"2018","unstructured":"Gao J, Feng Z, Wang X, Zeng M, Liu J, Han S, et al. SIRT3\/SOD2 maintains osteoblast differentiation and bone formation by regulating mitochondrial stress. Cell Death Differ. 2018;25(2):229\u201340. https:\/\/doi.org\/10.1038\/cdd.2017.144.","journal-title":"Cell Death Differ"},{"issue":"1","key":"3929_CR45","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s12989-018-0253-5","volume":"15","author":"Y Shen","year":"2018","unstructured":"Shen Y, Wu L, Qin D, Xia Y, Zhou Z, Zhang X, et al. Carbon black suppresses the osteogenesis of mesenchymal stem cells: the role of mitochondria. Part Fibre Toxicol. 2018;15(1):16. https:\/\/doi.org\/10.1186\/s12989-018-0253-5.","journal-title":"Part Fibre Toxicol"},{"issue":"8","key":"3929_CR46","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1161\/01.RES.0000163633.10240.3b","volume":"96","author":"N Ouchi","year":"2005","unstructured":"Ouchi N, Shibata R, Walsh K. AMP-activated protein kinase signaling stimulates VEGF expression and angiogenesis in skeletal muscle. Circ Res. 2005;96(8):838\u201346. https:\/\/doi.org\/10.1161\/01.RES.0000163633.10240.3b.","journal-title":"Circ Res"},{"issue":"10","key":"3929_CR47","doi-asserted-by":"publisher","first-page":"3960","DOI":"10.1182\/blood-2002-04-1237","volume":"101","author":"P Kumar","year":"2003","unstructured":"Kumar P, Amin MA, Harlow LA, Polverini PJ, Koch AE. Src and phosphatidylinositol 3-kinase mediate soluble E-selectin-induced angiogenesis. Blood. 2003;101(10):3960\u20138. https:\/\/doi.org\/10.1182\/blood-2002-04-1237.","journal-title":"Blood"},{"issue":"4","key":"3929_CR48","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1161\/01.RES.0000087641.56024.DA","volume":"93","author":"MA Amin","year":"2003","unstructured":"Amin MA, Volpert OV, Woods JM, Kumar P, Harlow LA, Koch AE. Migration inhibitory factor mediates angiogenesis via mitogen-activated protein kinase and phosphatidylinositol kinase. Circ Res. 2003;93(4):321\u20139. https:\/\/doi.org\/10.1161\/01.RES.0000087641.56024.DA.","journal-title":"Circ Res"},{"issue":"2","key":"3929_CR49","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/j.cardiores.2005.09.019","volume":"69","author":"G Wu","year":"2006","unstructured":"Wu G, Luo J, Rana JS, Laham R, Sellke FW, Li J. Involvement of COX-2 in VEGF-induced angiogenesis via P38 and JNK pathways in vascular endothelial cells. Cardiovasc Res. 2006;69(2):512\u20139. https:\/\/doi.org\/10.1016\/j.cardiores.2005.09.019.","journal-title":"Cardiovasc Res"},{"issue":"1","key":"3929_CR50","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/1423-0127-20-71","volume":"20","author":"H Sonowal","year":"2013","unstructured":"Sonowal H, Kumar A, Bhattacharyya J, Gogoi PK, Jaganathan BG. Inhibition of actin polymerization decreases osteogeneic differentiation of mesenchymal stem cells through p38 MAPK pathway. J Biomed Sci. 2013;20(1):71. https:\/\/doi.org\/10.1186\/1423-0127-20-71.","journal-title":"J Biomed Sci"},{"issue":"6","key":"3929_CR51","doi-asserted-by":"publisher","first-page":"2392","DOI":"10.7150\/ijbs.70620","volume":"18","author":"CY Tang","year":"2022","unstructured":"Tang CY, Wang H, Zhang Y, Wang Z, Zhu G, McVicar A, et al. GPR125 positively regulates osteoclastogenesis potentially through AKT-NF-\u03baB and MAPK signaling pathways. Int J Biol Sci. 2022;18(6):2392\u2013405. https:\/\/doi.org\/10.7150\/ijbs.70620.","journal-title":"Int J Biol Sci"},{"issue":"6","key":"3929_CR52","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12485","volume":"51","author":"Y Wang","year":"2018","unstructured":"Wang Y, Lu Y, Li Z, Zhou Y, Gu Y, Pang X, et al. Oestrogen receptor \u03b1 regulates the odonto\/osteogenic differentiation of stem cells from apical papilla via ERK and JNK MAPK pathways. Cell Prolif. 2018;51(6): e12485. https:\/\/doi.org\/10.1111\/cpr.12485.","journal-title":"Cell Prolif"}],"container-title":["Stem Cell Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-024-03929-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13287-024-03929-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-024-03929-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T19:07:24Z","timestamp":1726513644000},"score":1,"resource":{"primary":{"URL":"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/s13287-024-03929-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,16]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3929"],"URL":"https:\/\/doi.org\/10.1186\/s13287-024-03929-4","relation":{},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,16]]},"assertion":[{"value":"4 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The experiments involving human DPSCs in this study have been approved by the Ethical Committee of Beijing Stomatological Hospital, Capital Medical University (Title: Effect and mechanism of the STL-NQO1 signaling pathway on the function of dental pulp stem cells and dentin regeneration under hypoxic conditions; Ethical Review No. CMUSH-IRB-KJ-PJ-2022-22; Date of approval: 2022-7-15). This study was adhered to the tenants of the Declaration of Helsinki. Human third molars or premolars were obtained with informed patient consent. DPSCs were cultured and used from passages 3\u20135 in our experiments. The patients provided written informed consent for the use of the samples. The animal experiment was approved by the Animal Ethics Committee of the Beijing Stomatological Hospital of the Capital Medical University (Title: Effect and mechanism of NQO1 on osteogenic and angiogenic differentiation of dental pulp stem cells; Approval number: KQYY-202309-007; Date of approval: 2023-10-18). In animal experiments, we euthanized experimental animals with cervical dislocation.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"306"}}