{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:39:31Z","timestamp":1784295571001,"version":"3.55.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"DOI":"10.1186\/s13287-024-03946-3","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T16:24:51Z","timestamp":1727454291000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Human uncultured adipose-derived stromal vascular fraction shows therapeutic potential against osteoarthritis in immunodeficient rats via direct effects of transplanted M2 macrophages"],"prefix":"10.1186","volume":"15","author":[{"given":"Yuma","family":"Onoi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4587-0029","authenticated-orcid":false,"given":"Tomoyuki","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Anjiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Tsubosaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Kamenaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kemmei","family":"Ikuta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shotaro","family":"Tachibana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihito","family":"Suda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Wada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuma","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Saitoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Hiranaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Sobajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Iwaguro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiko","family":"Matsushita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,27]]},"reference":[{"issue":"6","key":"3946_CR1","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.3390\/cells10061365","volume":"10","author":"N Agarwal","year":"2021","unstructured":"Agarwal N, Mak C, Bojanic C, To K, Khan W. Meta-analysis of adipose tissue derived cell-based therapy for the treatment of knee osteoarthritis. Cells. 2021;10(6):1365.","journal-title":"Cells"},{"issue":"2","key":"3946_CR2","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1089\/107632701300062859","volume":"7","author":"PA Zuk","year":"2001","unstructured":"Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, Katz AJ, et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng. 2001;7(2):211\u201328.","journal-title":"Tissue Eng"},{"issue":"12","key":"3946_CR3","doi-asserted-by":"publisher","first-page":"3874","DOI":"10.1093\/ndt\/gfq603","volume":"25","author":"Z Feng","year":"2010","unstructured":"Feng Z, Ting J, Alfonso Z, Strem BM, Fraser JK, Rutenberg J, et al. Fresh and cryopreserved, uncultured adipose tissue-derived stem and regenerative cells ameliorate ischemia\u2013reperfusion-induced acute kidney injury. Nephrol Dial Transplant. 2010;25(12):3874\u201384.","journal-title":"Nephrol Dial Transplant"},{"issue":"6","key":"3946_CR4","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1111\/andr.12519","volume":"6","author":"M Li","year":"2018","unstructured":"Li M, Lei H, Xu Y, Li H, Yang B, Yu C, et al. Exosomes derived from mesenchymal stem cells exert therapeutic effect in a rat model of cavernous nerves injury. Andrology. 2018;6(6):927\u201335.","journal-title":"Andrology"},{"issue":"8","key":"3946_CR5","doi-asserted-by":"publisher","first-page":"3851","DOI":"10.3390\/ijms22083851","volume":"22","author":"M Pomatto","year":"2021","unstructured":"Pomatto M, Gai C, Negro F, Cedrino M, Grange C, Ceccotti E, et al. Differential therapeutic effect of extracellular vesicles derived by bone marrow and adipose mesenchymal stem cells on wound healing of diabetic ulcers and correlation to their cargoes. Int J Mol Sci. 2021;22(8):3851.","journal-title":"Int J Mol Sci"},{"issue":"3","key":"3946_CR6","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.scr.2011.06.003","volume":"7","author":"A van Dijk","year":"2011","unstructured":"van Dijk A, Naaijkens BA, Jurgens WJFM, Nalliah K, Sairras S, van der Pijl RJ, et al. Reduction of infarct size by intravenous injection of uncultured adipose derived stromal cells in a rat model is dependent on the time point of application. Stem Cell Res. 2011;7(3):219\u201329.","journal-title":"Stem Cell Res"},{"issue":"4","key":"3946_CR7","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1016\/j.biocel.2003.10.018","volume":"36","author":"JK Fraser","year":"2004","unstructured":"Fraser JK, Schreiber RE, Zuk PA, Hedrick MH. Adult stem cell therapy for the heart. Int J Biochem Cell Biol. 2004;36(4):658\u201366.","journal-title":"Int J Biochem Cell Biol"},{"issue":"1","key":"3946_CR8","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.jss.2013.05.024","volume":"185","author":"G Marino","year":"2013","unstructured":"Marino G, Moraci M, Armenia E, Orabona C, Sergio R, De Sena G, et al. Therapy with autologous adipose-derived regenerative cells for the care of chronic ulcer of lower limbs in patients with peripheral arterial disease. J Surg Res. 2013;185(1):36\u201344.","journal-title":"J Surg Res"},{"issue":"1","key":"3946_CR9","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.ahj.2014.03.022","volume":"168","author":"EC Perin","year":"2014","unstructured":"Perin EC, Sanz-Ruiz R, S\u00e1nchez PL, Lasso J, P\u00e9rez-Cano R, Alonso-Farto JC, et al. Adipose-derived regenerative cells in patients with ischemic cardiomyopathy: the PRECISE Trial. Am Heart J. 2014;168(1):88-95.e2.","journal-title":"Am Heart J"},{"issue":"12","key":"3946_CR10","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1007\/s00595-017-1544-4","volume":"47","author":"S Ito","year":"2017","unstructured":"Ito S, Kai Y, Masuda T, Tanaka F, Matsumoto T, Kamohara Y, et al. Long-term outcome of adipose-derived regenerative cell-enriched autologous fat transplantation for reconstruction after breast-conserving surgery for Japanese women with breast cancer. Surg Today. 2017;47(12):1500\u201311.","journal-title":"Surg Today"},{"issue":"1","key":"3946_CR11","doi-asserted-by":"publisher","first-page":"16045","DOI":"10.1038\/s41598-020-73096-y","volume":"10","author":"T Katagiri","year":"2020","unstructured":"Katagiri T, Kondo K, Shibata R, Hayashida R, Shintani S, Yamaguchi S, et al. Therapeutic angiogenesis using autologous adipose-derived regenerative cells in patients with critical limb ischaemia in Japan: a clinical pilot study. Sci Rep. 2020;10(1):16045.","journal-title":"Sci Rep"},{"key":"3946_CR12","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.reth.2017.04.002","volume":"6","author":"N Yokota","year":"2017","unstructured":"Yokota N, Yamakawa M, Shirata T, Kimura T, Kaneshima H. Clinical results following intra-articular injection of adipose-derived stromal vascular fraction cells in patients with osteoarthritis of the knee. Regen Ther. 2017;6:108\u201312.","journal-title":"Regen Ther"},{"issue":"5","key":"3946_CR13","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1007\/s00264-018-4099-0","volume":"43","author":"Z Hong","year":"2019","unstructured":"Hong Z, Chen J, Zhang S, Zhao C, Bi M, Chen X, et al. Intra-articular injection of autologous adipose-derived stromal vascular fractions for knee osteoarthritis: a double-blind randomized self-controlled trial. Int Orthop. 2019;43(5):1123\u201334.","journal-title":"Int Orthop"},{"issue":"1","key":"3946_CR14","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1186\/s12891-020-03231-3","volume":"21","author":"M Tsubosaka","year":"2020","unstructured":"Tsubosaka M, Matsumoto T, Sobajima S, Matsushita T, Iwaguro H, Kuroda R. The influence of adipose-derived stromal vascular fraction cells on the treatment of knee osteoarthritis. BMC Musculoskelet Disord. 2020;21(1):207.","journal-title":"BMC Musculoskelet Disord"},{"key":"3946_CR15","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.reth.2023.06.006","volume":"24","author":"Y Onoi","year":"2023","unstructured":"Onoi Y, Matsumoto T, Sobajima S, Tsubosaka M, Hayashi S, Matsushita T, et al. Clinical use of autologous adipose-derived stromal vascular fraction cell injections for hip osteoarthritis. Regen Ther. 2023;24:94\u2013102.","journal-title":"Regen Ther"},{"issue":"1","key":"3946_CR16","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1186\/s40064-015-1509-2","volume":"4","author":"JA Aronowitz","year":"2015","unstructured":"Aronowitz JA, Lockhart RA, Hakakian CS. Mechanical versus enzymatic isolation of stromal vascular fraction cells from adipose tissue. Springerplus. 2015;4(1):713.","journal-title":"Springerplus"},{"key":"3946_CR17","doi-asserted-by":"crossref","unstructured":"Fernandes TL, Gomoll AH, Lattermann C, Hernandez AJ, Bueno DF, Amano MT. Macrophage: a potential target on cartilage regeneration. Front Immunol. 2020;11.","DOI":"10.3389\/fimmu.2020.00111"},{"issue":"2","key":"3946_CR18","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1002\/jcp.20228","volume":"203","author":"HY Qureshi","year":"2005","unstructured":"Qureshi HY, Sylvester J, El MM, Zafarullah M. TGF-\u03b2-induced expression of tissue inhibitor of metalloproteinases-3 gene in chondrocytes is mediated by extracellular signal-regulated kinase pathway and Sp1 transcription factor. J Cell Physiol. 2005;203(2):345\u201352.","journal-title":"J Cell Physiol"},{"issue":"9","key":"3946_CR19","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1016\/j.bbamcr.2008.04.005","volume":"1783","author":"HY Qureshi","year":"2008","unstructured":"Qureshi HY, Ricci G, Zafarullah M. Smad signaling pathway is a pivotal component of tissue inhibitor of metalloproteinases-3 regulation by transforming growth factor beta in human chondrocytes. Biochim Biophys Acta (BBA) Mol Cell Res. 2008;1783(9):1605\u201312.","journal-title":"Biochim Biophys Acta (BBA) Mol Cell Res"},{"issue":"7","key":"3946_CR20","first-page":"723","volume":"114","author":"Y Wang","year":"2001","unstructured":"Wang Y, Lou S. Direct protective effect of interleukin-10 on articular chondrocytes in vitro. Chin Med J (Engl). 2001;114(7):723\u20135.","journal-title":"Chin Med J (Engl)"},{"key":"3946_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/561459","volume":"2014","author":"P Wojdasiewicz","year":"2014","unstructured":"Wojdasiewicz P, Poniatowski \u0141A, Szukiewicz D. The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis. Mediat Inflamm. 2014;2014:1\u201319.","journal-title":"Mediat Inflamm"},{"issue":"12","key":"3946_CR22","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1093\/rheumatology\/41.12.1413","volume":"41","author":"F Iannone","year":"2002","unstructured":"Iannone F. Increased expression of nerve growth factor (NGF) and high affinity NGF receptor (p140 TrkA) in human osteoarthritic chondrocytes. Rheumatology. 2002;41(12):1413\u20138.","journal-title":"Rheumatology"},{"issue":"4","key":"3946_CR23","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.joca.2006.10.006","volume":"15","author":"WL Parker","year":"2007","unstructured":"Parker WL, Finnson KW, Soe-Lin H, Knaus P, Philip A. Expression and function of T\u03b2RII-B, a variant of the type II TGF-\u03b2 receptor, in human chondrocytes. Osteoarthr Cartil. 2007;15(4):442\u201353.","journal-title":"Osteoarthr Cartil"},{"issue":"4","key":"3946_CR24","doi-asserted-by":"publisher","first-page":"369","DOI":"10.5966\/sctm.2014-0252","volume":"4","author":"ME Morris","year":"2015","unstructured":"Morris ME, Beare JE, Reed RM, Dale JR, LeBlanc AJ, Kaufman CL, et al. Systemically delivered adipose stromal vascular fraction cells disseminate to peripheral artery walls and reduce vasomotor tone through a CD11b+ cell-dependent mechanism. Stem Cells Transl Med. 2015;4(4):369\u201380.","journal-title":"Stem Cells Transl Med"},{"issue":"12","key":"3946_CR25","doi-asserted-by":"publisher","first-page":"3239","DOI":"10.2337\/db08-0872","volume":"57","author":"CN Lumeng","year":"2008","unstructured":"Lumeng CN, DelProposto JB, Westcott DJ, Saltiel AR. Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes. Diabetes. 2008;57(12):3239\u201346.","journal-title":"Diabetes"},{"issue":"6","key":"3946_CR26","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/j.cell.2011.08.039","volume":"146","author":"M Potente","year":"2011","unstructured":"Potente M, Gerhardt H, Carmeliet P. Basic and therapeutic aspects of angiogenesis. Cell. 2011;146(6):873\u201387.","journal-title":"Cell"},{"issue":"5","key":"3946_CR27","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1002\/art.37908","volume":"65","author":"C Manferdini","year":"2013","unstructured":"Manferdini C, Maumus M, Gabusi E, Piacentini A, Filardo G, Peyrafitte J, et al. Adipose-derived mesenchymal stem cells exert antiinflammatory effects on chondrocytes and synoviocytes from osteoarthritis patients through prostaglandin E2. Arthritis Rheum. 2013;65(5):1271\u201381.","journal-title":"Arthritis Rheum"},{"issue":"7","key":"3946_CR28","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1016\/j.joca.2017.01.011","volume":"25","author":"C Manferdini","year":"2017","unstructured":"Manferdini C, Paolella F, Gabusi E, Gambari L, Piacentini A, Filardo G, et al. Adipose stromal cells mediated switching of the pro-inflammatory profile of M1-like macrophages is facilitated by PGE2: in vitro evaluation. Osteoarthr Cartil. 2017;25(7):1161\u201371.","journal-title":"Osteoarthr Cartil"},{"issue":"19","key":"3946_CR29","doi-asserted-by":"publisher","first-page":"4309","DOI":"10.3390\/jcm10194309","volume":"10","author":"K Kamada","year":"2021","unstructured":"Kamada K, Matsushita T, Yamashita T, Matsumoto T, Iwaguro H, Sobajima S, et al. Attenuation of knee osteoarthritis progression in mice through polarization of M2 macrophages by intra-articular transplantation of non-cultured human adipose-derived regenerative cells. J Clin Med. 2021;10(19):4309.","journal-title":"J Clin Med"},{"issue":"7","key":"3946_CR30","doi-asserted-by":"publisher","first-page":"2407","DOI":"10.1007\/s12015-023-10589-z","volume":"19","author":"K Anjiki","year":"2023","unstructured":"Anjiki K, Matsumoto T, Kuroda Y, Fujita M, Hayashi S, Nakano N, et al. Heterogeneous cells as well as adipose-derived stromal cells in stromal vascular fraction contribute to enhance anabolic and inhibit catabolic factors in osteoarthritis. Stem Cell Rev Rep. 2023;19(7):2407\u201319.","journal-title":"Stem Cell Rev Rep"},{"key":"3946_CR31","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.reth.2019.07.010","volume":"11","author":"Y Onoi","year":"2019","unstructured":"Onoi Y, Hiranaka T, Nishida R, Takase K, Fujita M, Hida Y, et al. Second-look arthroscopic findings of cartilage and meniscus repair after injection of adipose-derived regenerative cells in knee osteoarthrits: report of two cases. Regen Ther. 2019;11:212\u20136.","journal-title":"Regen Ther"},{"issue":"9","key":"3946_CR32","doi-asserted-by":"publisher","first-page":"3627","DOI":"10.1002\/jcp.30823","volume":"237","author":"M Fujita","year":"2022","unstructured":"Fujita M, Matsumoto T, Hayashi S, Hashimoto S, Nakano N, Maeda T, et al. Paracrine effect of the stromal vascular fraction containing M2 macrophages on human chondrocytes through the Smad2\/3 signaling pathway. J Cell Physiol. 2022;237(9):3627\u201339.","journal-title":"J Cell Physiol"},{"issue":"9","key":"3946_CR33","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1016\/j.joca.2007.03.006","volume":"15","author":"SS Glasson","year":"2007","unstructured":"Glasson SS, Blanchet TJ, Morris EA. The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129\/SvEv mouse. Osteoarthr Cartil. 2007;15(9):1061\u20139.","journal-title":"Osteoarthr Cartil"},{"issue":"7","key":"3946_CR34","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1016\/j.joca.2014.05.009","volume":"22","author":"H Iijima","year":"2014","unstructured":"Iijima H, Aoyama T, Ito A, Tajino J, Nagai M, Zhang X, et al. Destabilization of the medial meniscus leads to subchondral bone defects and site-specific cartilage degeneration in an experimental rat model. Osteoarthr Cartil. 2014;22(7):1036\u201343.","journal-title":"Osteoarthr Cartil"},{"issue":"5","key":"3946_CR35","doi-asserted-by":"publisher","first-page":"R118","DOI":"10.1186\/ar2521","volume":"10","author":"M Hayashi","year":"2008","unstructured":"Hayashi M, Muneta T, Ju YJ, Mochizuki T, Sekiya I. Weekly intra-articular injections of bone morphogenetic protein-7 inhibits osteoarthritis progression. Arthritis Res Ther. 2008;10(5):R118.","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"3946_CR36","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.joca.2005.07.014","volume":"14","author":"KPH Pritzker","year":"2006","unstructured":"Pritzker KPH, Gay S, Jimenez SA, Ostergaard K, Pelletier JP, Revell PA, et al. Osteoarthritis cartilage histopathology: grading and staging. Osteoarthr Cartil. 2006;14(1):13\u201329.","journal-title":"Osteoarthr Cartil"},{"key":"3946_CR37","doi-asserted-by":"publisher","first-page":"S35","DOI":"10.1016\/j.joca.2010.04.015","volume":"18","author":"VB Kraus","year":"2010","unstructured":"Kraus VB, Huebner JL, DeGroot J, Bendele A. The OARSI histopathology initiative\u2014recommendations for histological assessments of osteoarthritis in the guinea pig. Osteoarthr Cartil. 2010;18:S35-52.","journal-title":"Osteoarthr Cartil"},{"key":"3946_CR38","first-page":"1","volume":"2014","author":"J Yamada","year":"2014","unstructured":"Yamada J, Tsuji K, Miyatake K, Matsukura Y, Abula K, Inoue M, et al. Follistatin alleviates synovitis and articular cartilage degeneration induced by carrageenan. Int J Inflamm. 2014;2014:1\u20139.","journal-title":"Int J Inflamm"},{"issue":"6","key":"3946_CR39","doi-asserted-by":"publisher","first-page":"2818","DOI":"10.4049\/jimmunol.1500325","volume":"195","author":"I Mattiola","year":"2015","unstructured":"Mattiola I, Pesant M, Tentorio PF, Molgora M, Marcenaro E, Lugli E, et al. Priming of human resting NK cells by autologous M1 macrophages via the engagement of IL-1\u03b2, IFN-\u03b2, and IL-15 pathways. J Immunol. 2015;195(6):2818\u201328.","journal-title":"J Immunol"},{"issue":"7","key":"3946_CR40","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s11095-019-2634-3","volume":"36","author":"A Crowe","year":"2019","unstructured":"Crowe A, Zheng W, Miller J, Pahwa S, Alam K, Fung KM, et al. Characterization of plasma membrane localization and phosphorylation status of organic anion transporting polypeptide (OATP) 1B1 c.521 T>C nonsynonymous single-nucleotide polymorphism. Pharm Res. 2019;36(7):101.","journal-title":"Pharm Res"},{"issue":"7","key":"3946_CR41","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1002\/jcb.25099","volume":"116","author":"S Shi","year":"2015","unstructured":"Shi S, Wang C, Acton AJ, Eckert GJ, Trippel SB. Role of Sox9 in growth factor regulation of articular chondrocytes. J Cell Biochem. 2015;116(7):1391\u2013400.","journal-title":"J Cell Biochem"},{"issue":"1","key":"3946_CR42","doi-asserted-by":"publisher","first-page":"54","DOI":"10.4103\/2277-9175.125799","volume":"3","author":"S Zamani","year":"2014","unstructured":"Zamani S, Hashemibeni B, Esfandiari E, Kabiri A, Rabbani H, Abutorabi R. Assessment of TGF-\u03b23 on production of aggrecan by human articular chondrocytes in pellet culture system. Adv Biomed Res. 2014;3(1):54.","journal-title":"Adv Biomed Res"},{"issue":"10","key":"3946_CR43","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1002\/jor.21394","volume":"29","author":"T Shirai","year":"2011","unstructured":"Shirai T, Kobayashi M, Nishitani K, Satake T, Kuroki H, Nakagawa Y, et al. Chondroprotective effect of alendronate in a rabbit model of osteoarthritis. J Orthop Res. 2011;29(10):1572\u20137.","journal-title":"J Orthop Res"},{"issue":"12","key":"3946_CR44","doi-asserted-by":"publisher","first-page":"3507","DOI":"10.1002\/jcb.23298","volume":"112","author":"P Verma","year":"2011","unstructured":"Verma P, Dalal K. ADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis. J Cell Biochem. 2011;112(12):3507\u201314.","journal-title":"J Cell Biochem"},{"issue":"10","key":"3946_CR45","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1136\/annrheumdis-2018-213450","volume":"77","author":"H Zhang","year":"2018","unstructured":"Zhang H, Lin C, Zeng C, Wang Z, Wang H, Lu J, et al. Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2. Ann Rheum Dis. 2018;77(10):1524\u201334.","journal-title":"Ann Rheum Dis"},{"issue":"22","key":"3946_CR46","doi-asserted-by":"publisher","first-page":"8513","DOI":"10.3390\/ijms21228513","volume":"21","author":"Y Sun","year":"2020","unstructured":"Sun Y, Zuo Z, Kuang Y. An emerging target in the battle against osteoarthritis: macrophage polarization. Int J Mol Sci. 2020;21(22):8513.","journal-title":"Int J Mol Sci"},{"issue":"10","key":"3946_CR47","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.1002\/jor.24958","volume":"39","author":"L Utomo","year":"2021","unstructured":"Utomo L, Fahy N, Kops N, van Tiel ST, Waarsing J, Verhaar JAN, et al. Macrophage phenotypes and monocyte subsets after destabilization of the medial meniscus in mice. J Orthop Res. 2021;39(10):2270\u201380.","journal-title":"J Orthop Res"},{"issue":"4","key":"3946_CR48","doi-asserted-by":"publisher","first-page":"774","DOI":"10.3390\/ijms18040774","volume":"18","author":"K O\u2019Brien","year":"2017","unstructured":"O\u2019Brien K, Tailor P, Leonard C, DiFrancesco L, Hart D, Matyas J, et al. Enumeration and localization of mesenchymal progenitor cells and macrophages in synovium from normal individuals and patients with pre-osteoarthritis or clinically diagnosed osteoarthritis. Int J Mol Sci. 2017;18(4):774.","journal-title":"Int J Mol Sci"},{"issue":"5","key":"3946_CR49","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.joca.2020.01.007","volume":"28","author":"H Zhang","year":"2020","unstructured":"Zhang H, Cai D, Bai X. Macrophages regulate the progression of osteoarthritis. Osteoarthr Cartil. 2020;28(5):555\u201361.","journal-title":"Osteoarthr Cartil"},{"key":"3946_CR50","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.biomaterials.2018.07.011","volume":"180","author":"M Dai","year":"2018","unstructured":"Dai M, Sui B, Xue Y, Liu X, Sun J. Cartilage repair in degenerative osteoarthritis mediated by squid type II collagen via immunomodulating activation of M2 macrophages, inhibiting apoptosis and hypertrophy of chondrocytes. Biomaterials. 2018;180:91\u2013103.","journal-title":"Biomaterials"},{"issue":"6","key":"3946_CR51","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1177\/0363546517689871","volume":"45","author":"T Inokuchi","year":"2017","unstructured":"Inokuchi T, Matsumoto T, Takayama K, Nakano N, Zhang S, Araki D, et al. Influence of the injury-to-surgery interval on the healing potential of human anterior cruciate ligament-derived cells. Am J Sports Med. 2017;45(6):1359\u201369.","journal-title":"Am J Sports Med"},{"issue":"1","key":"3946_CR52","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/s13287-021-02182-3","volume":"12","author":"T Kamenaga","year":"2021","unstructured":"Kamenaga T, Kuroda Y, Nagai K, Tsubosaka M, Takashima Y, Kikuchi K, et al. Cryopreserved human adipose-derived stromal vascular fraction maintains fracture healing potential via angiogenesis and osteogenesis in an immunodeficient rat model. Stem Cell Res Ther. 2021;12(1):110.","journal-title":"Stem Cell Res Ther"},{"issue":"6","key":"3946_CR53","doi-asserted-by":"publisher","first-page":"2838","DOI":"10.3390\/ijms22062838","volume":"22","author":"I Sekiya","year":"2021","unstructured":"Sekiya I, Katano H, Ozeki N. Characteristics of MSCs in synovial fluid and mode of action of intra-articular injections of synovial MSCs in knee osteoarthritis. Int J Mol Sci. 2021;22(6):2838.","journal-title":"Int J Mol Sci"},{"issue":"3","key":"3946_CR54","doi-asserted-by":"publisher","first-page":"363","DOI":"10.3899\/jrheum.140382","volume":"42","author":"EW Orlowsky","year":"2015","unstructured":"Orlowsky EW, Kraus VB. The role of innate immunity in osteoarthritis: when our first line of defense goes on the offensive. J Rheumatol. 2015;42(3):363\u201371.","journal-title":"J Rheumatol"},{"key":"3946_CR55","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.2147\/JIR.S413578","volume":"16","author":"P Luo","year":"2023","unstructured":"Luo P, Yuan Q, Wan X, Yang M, Xu P. Effects of immune cells and cytokines on different cells in OA. J Inflamm Res. 2023;16:2329\u201343.","journal-title":"J Inflamm Res"},{"key":"3946_CR56","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.pharmthera.2016.08.003","volume":"171","author":"AW James","year":"2017","unstructured":"James AW, Hindle P, Murray IR, West CC, Tawonsawatruk T, Shen J, et al. Pericytes for the treatment of orthopedic conditions. Pharmacol Ther. 2017;171:93\u2013103.","journal-title":"Pharmacol Ther"},{"issue":"1","key":"3946_CR57","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1111\/imr.12971","volume":"302","author":"R Schuster","year":"2021","unstructured":"Schuster R, Rockel JS, Kapoor M, Hinz B. The inflammatory speech of fibroblasts. Immunol Rev. 2021;302(1):126\u201346.","journal-title":"Immunol Rev"},{"issue":"7","key":"3946_CR58","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.1002\/art.20506","volume":"50","author":"B R\u00fcger","year":"2004","unstructured":"R\u00fcger B, Giurea A, Wanivenhaus AH, Zehetgruber H, Hollemann D, Yanagida G, et al. Endothelial precursor cells in the synovial tissue of patients with rheumatoid arthritis and osteoarthritis. Arthritis Rheum. 2004;50(7):2157\u201366.","journal-title":"Arthritis Rheum"}],"container-title":["Stem Cell Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-024-03946-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13287-024-03946-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-024-03946-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T16:29:02Z","timestamp":1727454542000},"score":1,"resource":{"primary":{"URL":"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/s13287-024-03946-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,27]]},"references-count":58,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3946"],"URL":"https:\/\/doi.org\/10.1186\/s13287-024-03946-3","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4185894\/v1","asserted-by":"object"}]},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,27]]},"assertion":[{"value":"30 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the ethical committee of the Kobe University. All cells donors signed informed consent documents. All procedures involving animals were approved by the Institutional Animal Care and Use committee at Kobe University and conducted in accordance with the national guidelines on animal care (Study of adipose-derived stromal cells for their effects in osteoarthritis of the knee; The Ethical Committee of Kobe University; Approval number, P210509; Date of approval, May 21, 2021).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have no competing interests to declare.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"325"}}