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The protocols for animal experiments adhere to the ARRIVE (Animal Research: Reporting of in Vivo Experiments) guidelines. (1) Fresh BM of human was obtained from donors for effectiveness of stem cell therapy (2) The Institutional Review Board of Kyung Hee University hospital (3) 2020-09-036 (4) 2020.10.23 Patient provided written informed consent for the use of samples. Human BM-MNCs, frozen manufactured by Lonza were isolated from donated human tissue after obtaining permission for their use in research applications by informed consent or legal authorization. Human BM-MNCs frozen manufactured by STEMCELL Technologies were obtained using Institutional Review Board (IRB) approved consent forms and protocols.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors confirm their consent for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All authors declare that they have no conflicts of interes.t","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"388"}}