{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T09:43:16Z","timestamp":1794562996937,"version":"4.9.1"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,3]],"date-time":"2024-11-03T00:00:00Z","timestamp":1730592000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,3]],"date-time":"2024-11-03T00:00:00Z","timestamp":1730592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81971526 and 82370629"],"award-info":[{"award-number":["81971526 and 82370629"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Natural Science Foundation of Guangdong Province","award":["2022A1515012223"],"award-info":[{"award-number":["2022A1515012223"]}]},{"name":"the Science and Technology Program of Guangzhou","award":["202201020398, 202201020430"],"award-info":[{"award-number":["202201020398, 202201020430"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"DOI":"10.1186\/s13287-024-03995-8","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:58:01Z","timestamp":1730681881000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Mesenchymal stromal cells alleviate APAP-induced liver injury via extracellular vesicle-mediated regulation of the miR-186-5p\/CXCL1 axis"],"prefix":"10.1186","volume":"15","author":[{"given":"Erming","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rukang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panlong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weikeng","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yana","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingcai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8090-8718","authenticated-orcid":false,"given":"Qiuli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,3]]},"reference":[{"key":"3995_CR1","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1002\/hep.21926","volume":"46","author":"WM Lee","year":"2007","unstructured":"Lee WM. Acetaminophen toxicity: changing perceptions on a social\/medical issue. Hepatology. 2007;46:966\u201370.","journal-title":"Hepatology"},{"key":"3995_CR2","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.cld.2019.09.005","volume":"24","author":"M Chayanupatkul","year":"2020","unstructured":"Chayanupatkul M, Schiano TD. Acute Liver failure secondary to Drug-Induced Liver Injury. Clin Liver Dis. 2020;24:75\u201387.","journal-title":"Clin Liver Dis"},{"key":"3995_CR3","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1053\/j.gastro.2015.02.050","volume":"148","author":"DS Goldberg","year":"2015","unstructured":"Goldberg DS, Forde KA, Carbonari DM, Lewis JD, Leidl KB, Reddy KR, et al. Population-representative incidence of drug-induced acute liver failure based on an analysis of an integrated health care system. Gastroenterology. 2015;148:1353\u201361.","journal-title":"Gastroenterology"},{"key":"3995_CR4","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1124\/jpet.123.001772","volume":"388","author":"A Bryan","year":"2024","unstructured":"Bryan A, Pingali P, Faber A, Landry J, Akakpo JY, Jaeschke H, et al. High-dose acetaminophen with concurrent CYP2E1 inhibition has profound anticancer activity without liver toxicity. J Pharmacol Exp Ther. 2024;388:209\u201317.","journal-title":"J Pharmacol Exp Ther"},{"key":"3995_CR5","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1016\/j.jhep.2017.07.005","volume":"67","author":"WM Lee","year":"2017","unstructured":"Lee WM. Acetaminophen (APAP) hepatotoxicity-Isn\u2019t it time for APAP to go away? J Hepatol. 2017;67:1324\u201331.","journal-title":"J Hepatol"},{"key":"3995_CR6","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1097\/HEP.0000000000000458","volume":"78","author":"RT Stravitz","year":"2023","unstructured":"Stravitz RT, Fontana RJ, Karvellas C, Durkalski V, McGuire B, Rule JA, et al. Future directions in acute liver failure. Hepatology. 2023;78:1266\u201389.","journal-title":"Hepatology"},{"key":"3995_CR7","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1002\/hep.20312","volume":"40","author":"N Kaplowitz","year":"2004","unstructured":"Kaplowitz N. Acetaminophen hepatoxicity: what do we know, what don\u2019t we know, and what do we do next? Hepatology. 2004;40:23\u20136.","journal-title":"Hepatology"},{"key":"3995_CR8","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1631\/jzus.B2100977","volume":"23","author":"X Cai","year":"2022","unstructured":"Cai X, Cai H, Wang J, Yang Q, Guan J, Deng J, et al. Molecular pathogenesis of acetaminophen-induced liver injury and its treatment options. J Zhejiang Univ-Sc B. 2022;23:265\u201385.","journal-title":"J Zhejiang Univ-Sc B"},{"key":"3995_CR9","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/s41423-020-00560-0","volume":"18","author":"K Liu","year":"2021","unstructured":"Liu K, Wang FS, Xu R. Neutrophils in liver diseases: pathogenesis and therapeutic targets. Cell Mol Immunol. 2021;18:38\u201344.","journal-title":"Cell Mol Immunol"},{"key":"3995_CR10","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1093\/toxsci\/54.2.509","volume":"54","author":"JA Lawson","year":"2000","unstructured":"Lawson JA, Farhood A, Hopper RD, Bajt ML, Jaeschke H. The hepatic inflammatory response after acetaminophen overdose: role of neutrophils. Toxicol Sci. 2000;54:509\u201316.","journal-title":"Toxicol Sci"},{"key":"3995_CR11","doi-asserted-by":"publisher","first-page":"620365","DOI":"10.3389\/fimmu.2021.620365","volume":"12","author":"W Wu","year":"2021","unstructured":"Wu W, Sun S, Wang Y, Zhao R, Ren H, Li Z, et al. Circulating Neutrophil Dysfunction in HBV-Related Acute-on-chronic liver failure. Front Immunol. 2021;12:620365.","journal-title":"Front Immunol"},{"key":"3995_CR12","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1002\/hep.26102","volume":"57","author":"NJ Taylor","year":"2013","unstructured":"Taylor NJ, Nishtala A, Manakkat VG, Abeles RD, Auzinger G, Bernal W, et al. Circulating neutrophil dysfunction in acute liver failure. Hepatology. 2013;57:1142\u201352.","journal-title":"Hepatology"},{"key":"3995_CR13","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1002\/sctm.19-0385","volume":"10","author":"S Midha","year":"2021","unstructured":"Midha S, Jain KG, Bhaskar N, Kaur A, Rawat S, Giri S, et al. Tissue-specific mesenchymal stem cell-dependent osteogenesis in highly porous chitosan-based bone analogs. Stem Cell Transl Med. 2021;10:303\u201319.","journal-title":"Stem Cell Transl Med"},{"key":"3995_CR14","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1080\/07853890500371957","volume":"37","author":"HK V\u00e4\u00e4n\u00e4nen","year":"2005","unstructured":"V\u00e4\u00e4n\u00e4nen HK. Mesenchymal stem cells. Ann Med. 2005;37:469\u201379.","journal-title":"Ann Med"},{"key":"3995_CR15","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1186\/s13287-020-01855-9","volume":"11","author":"X Wu","year":"2020","unstructured":"Wu X, Jiang J, Gu Z, Zhang J, Chen Y, Liu X. Mesenchymal stromal cell therapies: immunomodulatory properties and clinical progress. Stem Cell Res Ther. 2020;11:345.","journal-title":"Stem Cell Res Ther"},{"key":"3995_CR16","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1002\/stem.3016","volume":"37","author":"A Andrzejewska","year":"2019","unstructured":"Andrzejewska A, Lukomska B, Janowski M. Concise Review: mesenchymal stem cells: from roots to Boost. Stem Cells. 2019;37:855\u201364.","journal-title":"Stem Cells"},{"key":"3995_CR17","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1111\/jgh.16247","volume":"38","author":"P Liu","year":"2023","unstructured":"Liu P, Yao L, Hu X, Wang Z, Xiong Z, Jiang Y. Recent advances in the immunomodulation mechanism of mesenchymal stem cell therapy in liver diseases. J Gastroen Hepatol. 2023;38:1099\u2013106.","journal-title":"J Gastroen Hepatol"},{"key":"3995_CR18","doi-asserted-by":"publisher","first-page":"106229","DOI":"10.1016\/j.phrs.2022.106229","volume":"179","author":"J Zhou","year":"2022","unstructured":"Zhou J, Feng X, Zhu J, Feng B, Yao Q, Pan Q, et al. Mesenchymal stem cell treatment restores liver macrophages homeostasis to alleviate mouse acute liver injury revealed by single-cell analysis. Pharmacol Res. 2022;179:106229.","journal-title":"Pharmacol Res"},{"key":"3995_CR19","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1186\/s13287-022-02999-6","volume":"13","author":"M Yu","year":"2022","unstructured":"Yu M, Zhou M, Li J, Zong R, Yan Y, Kong L, et al. Notch-activated mesenchymal stromal\/stem cells enhance the protective effect against acetaminophen-induced acute liver injury by activating AMPK\/SIRT1 pathway. Stem Cell Res Ther. 2022;13:318.","journal-title":"Stem Cell Res Ther"},{"key":"3995_CR20","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/s13287-022-02754-x","volume":"13","author":"P Wang","year":"2022","unstructured":"Wang P, Cui Y, Wang J, Liu D, Tian Y, Liu K, et al. Mesenchymal stem cells protect against acetaminophen hepatotoxicity by secreting regenerative cytokine hepatocyte growth factor. Stem Cell Res Ther. 2022;13:94.","journal-title":"Stem Cell Res Ther"},{"key":"3995_CR21","doi-asserted-by":"crossref","unstructured":"Cen Y, Lou G, Qi J, Li M, Zheng M, Liu Y. Adipose-Derived Mesenchymal Stem Cells Inhibit JNK-Mediated Mitochondrial Retrograde Pathway to Alleviate Acetaminophen-Induced Liver Injury. Antioxidants-Basel. 2023;12.","DOI":"10.3390\/antiox12010158"},{"key":"3995_CR22","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1016\/j.jcyt.2014.05.018","volume":"16","author":"Z Liu","year":"2014","unstructured":"Liu Z, Meng F, Li C, Zhou X, Zeng X, He Y, et al. Human umbilical cord mesenchymal stromal cells rescue mice from acetaminophen-induced acute liver failure. Cytotherapy. 2014;16:1207\u201319.","journal-title":"Cytotherapy"},{"key":"3995_CR23","doi-asserted-by":"publisher","first-page":"690","DOI":"10.23736\/S0375-9393.23.17265-8","volume":"89","author":"A Sitbon","year":"2023","unstructured":"Sitbon A, Delmotte PR, Goumard C, Turco C, Gautheron J, Conti F, et al. Therapeutic potentials of mesenchymal stromal cells-derived extracellular vesicles in liver failure and marginal liver graft rehabilitation: a scoping review. Minerva Anestesiol. 2023;89:690\u2013706.","journal-title":"Minerva Anestesiol"},{"key":"3995_CR24","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1007\/s12015-021-10313-9","volume":"18","author":"S Gupta","year":"2022","unstructured":"Gupta S, Pinky, Vishal, Sharma H, Soni N, Rao EP, et al. Comparative evaluation of Anti-fibrotic Effect of tissue specific mesenchymal stem cells derived Extracellular vesicles for the amelioration of CCl4 Induced Chronic Liver Injury. Stem Cell Rev Rep. 2022;18:1097\u2013112.","journal-title":"Stem Cell Rev Rep"},{"key":"3995_CR25","doi-asserted-by":"publisher","first-page":"37421","DOI":"10.1021\/acsami.9b10126","volume":"11","author":"S Mardpour","year":"2019","unstructured":"Mardpour S, Ghanian MH, Sadeghi-Abandansari H, Mardpour S, Nazari A, Shekari F, et al. Hydrogel-mediated sustained systemic delivery of mesenchymal stem cell-derived extracellular vesicles improves hepatic regeneration in Chronic Liver failure. Acs Appl Mater Inter. 2019;11:37421\u201333.","journal-title":"Acs Appl Mater Inter"},{"key":"3995_CR26","doi-asserted-by":"publisher","first-page":"5979","DOI":"10.7150\/thno.40122","volume":"10","author":"S Varderidou-Minasian","year":"2020","unstructured":"Varderidou-Minasian S, Lorenowicz MJ. Mesenchymal stromal\/stem cell-derived extracellular vesicles in tissue repair: challenges and opportunities. Theranostics. 2020;10:5979\u201397.","journal-title":"Theranostics"},{"key":"3995_CR27","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1038\/s41536-022-00206-x","volume":"7","author":"S Gonther","year":"2022","unstructured":"Gonther S, Bachmann M, Goren I, Huard A, Weigert A, K\u00f6hl J, et al. 3\u2019mRNA sequencing reveals pro-regenerative properties of c5ar1 during resolution of murine acetaminophen-induced liver injury. Npj Regen Med. 2022;7:10.","journal-title":"Npj Regen Med"},{"key":"3995_CR28","first-page":"e2079307176","volume":"120","author":"M Yang","year":"2023","unstructured":"Yang M, Du B, Xu L, Wang H, Wang Y, Lin K, et al. Glutamate-GABA imbalance mediated by mir-8-5p and its STTM regulates phase-related behavior of locusts. P Natl Acad Sci Usa. 2023;120:e2079307176.","journal-title":"P Natl Acad Sci Usa"},{"key":"3995_CR29","doi-asserted-by":"publisher","first-page":"e1004206","DOI":"10.1371\/journal.pgen.1004206","volume":"10","author":"M Yang","year":"2014","unstructured":"Yang M, Wei Y, Jiang F, Wang Y, Guo X, He J, et al. MicroRNA-133 inhibits behavioral aggregation by controlling dopamine synthesis in locusts. Plos Genet. 2014;10:e1004206.","journal-title":"Plos Genet"},{"key":"3995_CR30","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.devcel.2010.11.004","volume":"19","author":"L Liu","year":"2010","unstructured":"Liu L, Das S, Losert W, Parent CA. mTORC2 regulates neutrophil chemotaxis in a cAMP- and RhoA-dependent fashion. Dev Cell. 2010;19:845\u201357.","journal-title":"Dev Cell"},{"key":"3995_CR31","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1038\/s41467-023-37227-z","volume":"14","author":"T Wang","year":"2023","unstructured":"Wang T, Zhou Y, Zhou Z, Zhang P, Yan R, Sun L, et al. Secreted protease PRSS35 suppresses hepatocellular carcinoma by disabling CXCL2-mediated neutrophil extracellular traps. Nat Commun. 2023;14:1513.","journal-title":"Nat Commun"},{"key":"3995_CR32","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1186\/s13287-021-02560-x","volume":"12","author":"L Pan","year":"2021","unstructured":"Pan L, Liu C, Liu Q, Li Y, Du C, Kang X, et al. Human Wharton\u2019s jelly-derived mesenchymal stem cells alleviate concanavalin A-induced fulminant hepatitis by repressing NF-\u03baB signaling and glycolysis. Stem Cell Res Ther. 2021;12:496.","journal-title":"Stem Cell Res Ther"},{"key":"3995_CR33","first-page":"241","volume":"4","author":"Z Dong","year":"2007","unstructured":"Dong Z, Wei H, Sun R, Tian Z. The roles of innate immune cells in liver injury and regeneration. Cell Mol Immunol. 2007;4:241\u201352.","journal-title":"Cell Mol Immunol"},{"key":"3995_CR34","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1089\/ars.2014.6108","volume":"23","author":"B Pulli","year":"2015","unstructured":"Pulli B, Ali M, Iwamoto Y, Zeller MW, Schob S, Linnoila JJ, et al. Myeloperoxidase-hepatocyte-stellate Cell Cross Talk promotes hepatocyte Injury and Fibrosis in Experimental Nonalcoholic Steatohepatitis. Antioxid Redox Sign. 2015;23:1255\u201369.","journal-title":"Antioxid Redox Sign"},{"key":"3995_CR35","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.2353\/ajpath.2009.080999","volume":"175","author":"SS Rensen","year":"2009","unstructured":"Rensen SS, Slaats Y, Nijhuis J, Jans A, Bieghs V, Driessen A, et al. Increased hepatic myeloperoxidase activity in obese subjects with nonalcoholic steatohepatitis. Am J Pathol. 2009;175:1473\u201382.","journal-title":"Am J Pathol"},{"key":"3995_CR36","doi-asserted-by":"publisher","first-page":"6495","DOI":"10.1038\/s41467-021-26834-3","volume":"12","author":"S Pang","year":"2021","unstructured":"Pang S, D\u2019Rozario J, Mendonca S, Bhuvan T, Payne NL, Zheng D, et al. Mesenchymal stromal cell apoptosis is required for their therapeutic function. Nat Commun. 2021;12:6495.","journal-title":"Nat Commun"},{"key":"3995_CR37","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s40364-019-0156-0","volume":"7","author":"P Lai","year":"2019","unstructured":"Lai P, Weng J, Guo L, Chen X, Du X. Novel insights into MSC-EVs therapy for immune diseases. Biomark Res. 2019;7:6.","journal-title":"Biomark Res"},{"key":"3995_CR38","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1002\/hep.27921","volume":"62","author":"B Chang","year":"2015","unstructured":"Chang B, Xu MJ, Zhou Z, Cai Y, Li M, Wang W, et al. Short- or long-term high-fat diet feeding plus acute ethanol binge synergistically induce acute liver injury in mice: an important role for CXCL1. Hepatology. 2015;62:1070\u201385.","journal-title":"Hepatology"},{"key":"3995_CR39","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1186\/s12967-016-0893-x","volume":"14","author":"LF Gulyaeva","year":"2016","unstructured":"Gulyaeva LF, Kushlinskiy NE. Regulatory mechanisms of microRNA expression. J Transl Med. 2016;14:143.","journal-title":"J Transl Med"},{"key":"3995_CR40","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1186\/s12964-020-00650-6","volume":"18","author":"K Asgarpour","year":"2020","unstructured":"Asgarpour K, Shojaei Z, Amiri F, Ai J, Mahjoubin-Tehran M, Ghasemi F, et al. Exosomal microRNAs derived from mesenchymal stem cells: cell-to-cell messages. Cell Commun Signal. 2020;18:149.","journal-title":"Cell Commun Signal"},{"key":"3995_CR41","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1002\/hep.21175","volume":"43","author":"ZX Liu","year":"2006","unstructured":"Liu ZX, Han D, Gunawan B, Kaplowitz N. Neutrophil depletion protects against murine acetaminophen hepatotoxicity. Hepatology. 2006;43:1220\u201330.","journal-title":"Hepatology"},{"key":"3995_CR42","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1002\/hep.21549","volume":"45","author":"H Jaeschke","year":"2007","unstructured":"Jaeschke H, Liu J. Neutrophil depletion protects against murine acetaminophen hepatotoxicity: another perspective. Hepatology. 2007;45:1588\u20139.","journal-title":"Hepatology"},{"key":"3995_CR43","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1002\/hep.25801","volume":"56","author":"PE Marques","year":"2012","unstructured":"Marques PE, Amaral SS, Pires DA, Nogueira LL, Soriani FM, Lima BH, et al. Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure. Hepatology. 2012;56:1971\u201382.","journal-title":"Hepatology"},{"key":"3995_CR44","doi-asserted-by":"crossref","unstructured":"Korbecki J, Barczak K, Gutowska I, Chlubek D, Baranowska-Bosiacka I. CXCL1: Gene, promoter, regulation of expression, mRNA Stability, Regulation of activity in the Intercellular Space. Int J Mol Sci. 2022;23.","DOI":"10.3390\/ijms23020792"},{"key":"3995_CR45","doi-asserted-by":"publisher","first-page":"e2400486","DOI":"10.1002\/advs.202400486","volume":"11","author":"MM Wu","year":"2024","unstructured":"Wu MM, Yang YC, Cai YX, Jiang S, Xiao H, Miao C, et al. Anti-CTLA-4 m2a antibody exacerbates Cardiac Injury in experimental autoimmune myocarditis mice by promoting Ccl5-Neutrophil infiltration. Adv Sci. 2024;11:e2400486.","journal-title":"Adv Sci"},{"key":"3995_CR46","doi-asserted-by":"publisher","first-page":"657076","DOI":"10.3389\/fmed.2021.657076","volume":"8","author":"L Xiao","year":"2021","unstructured":"Xiao L, Tang S, Zhang L, Ma S, Zhao Y, Zhang F, et al. Serum CXCL1 is a prognostic factor for patients with Hepatitis B Virus-related Acute-On-Chronic Liver failure. Front Med-Lausanne. 2021;8:657076.","journal-title":"Front Med-Lausanne"},{"key":"3995_CR47","doi-asserted-by":"publisher","first-page":"954","DOI":"10.4049\/jimmunol.2200705","volume":"211","author":"S Matsuo","year":"2023","unstructured":"Matsuo S, Nabekura T, Matsuda K, Shibuya K, Shibuya A. DNAM-1 Immunoreceptor protects mice from Concanavalin A-Induced Acute Liver Injury by reducing Neutrophil Infiltration. J Immunol. 2023;211:954\u201363.","journal-title":"J Immunol"},{"key":"3995_CR48","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/s41423-023-01034-9","volume":"20","author":"J Zhou","year":"2023","unstructured":"Zhou J, Shi Y. Mesenchymal stem\/stromal cells (MSCs): origin, immune regulation, and clinical applications. Cell Mol Immunol. 2023;20:555\u20137.","journal-title":"Cell Mol Immunol"},{"key":"3995_CR49","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1038\/cr.2010.44","volume":"20","author":"Y Shi","year":"2010","unstructured":"Shi Y, Hu G, Su J, Li W, Chen Q, Shou P, et al. Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair. Cell Res. 2010;20:510\u20138.","journal-title":"Cell Res"},{"key":"3995_CR50","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/s41392-022-00932-0","volume":"7","author":"Y Han","year":"2022","unstructured":"Han Y, Yang J, Fang J, Zhou Y, Candi E, Wang J, et al. The secretion profile of mesenchymal stem cells and potential applications in treating human diseases. Signal Transduct Tar. 2022;7:92.","journal-title":"Signal Transduct Tar"},{"key":"3995_CR51","doi-asserted-by":"crossref","unstructured":"Fu X, Liu G, Halim A, Ju Y, Luo Q, Song AG. Mesenchymal Stem Cell Migration and Tissue Repair. Cells-Basel. 2019;8.","DOI":"10.3390\/cells8080784"},{"key":"3995_CR52","doi-asserted-by":"crossref","unstructured":"Huang YL, De Gregorio C, Silva V, Elorza \u00c1A, L\u00e9niz P, Aliaga-Tobar V et al. Administration of Secretome Derived from Human mesenchymal stem cells induces Hepatoprotective effects in models of Idiosyncratic Drug-Induced Liver Injury caused by amiodarone or tamoxifen. Cells-Basel. 2023;12.","DOI":"10.3390\/cells12040636"},{"key":"3995_CR53","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.1038\/ncomms3427","volume":"4","author":"CV Pecot","year":"2013","unstructured":"Pecot CV, Rupaimoole R, Yang D, Akbani R, Ivan C, Lu C, et al. Tumour angiogenesis regulation by the miR-200 family. Nat Commun. 2013;4:2427.","journal-title":"Nat Commun"},{"key":"3995_CR54","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1111\/jcmm.16119","volume":"25","author":"Z Du","year":"2021","unstructured":"Du Z, Wu T, Liu L, Luo B, Wei C. Extracellular vesicles-derived mir-150-5p secreted by adipose-derived mesenchymal stem cells inhibits CXCL1 expression to attenuate hepatic fibrosis. J Cell Mol Med. 2021;25:701\u201315.","journal-title":"J Cell Mol Med"},{"key":"3995_CR55","doi-asserted-by":"crossref","unstructured":"Shrestha S, Yang CD, Hong HC, Chou CH, Tai CS, Chiew MY et al. Integrated MicroRNA-mRNA analysis reveals miR-204 inhibits cell proliferation in gastric Cancer by targeting CKS1B, CXCL1 and GPRC5A. Int J Mol Sci. 2017;19.","DOI":"10.3390\/ijms19010087"},{"key":"3995_CR56","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s13048-020-00697-6","volume":"13","author":"CH Liu","year":"2020","unstructured":"Liu CH, Jing XN, Liu XL, Qin SY, Liu MW, Hou CH. Tumor-suppressor miRNA-27b-5p regulates the growth and metastatic behaviors of ovarian carcinoma cells by targeting CXCL1. J Ovarian Res. 2020;13:92.","journal-title":"J Ovarian Res"},{"key":"3995_CR57","doi-asserted-by":"publisher","first-page":"106795","DOI":"10.1016\/j.phrs.2023.106795","volume":"193","author":"S Yin","year":"2023","unstructured":"Yin S, Zhou Z, Fu P, Jin C, Wu P, Ji C, et al. Roles of extracellular vesicles in ageing-related chronic kidney disease: demon or angel. Pharmacol Res. 2023;193:106795.","journal-title":"Pharmacol Res"},{"key":"3995_CR58","doi-asserted-by":"publisher","first-page":"134669","DOI":"10.1016\/j.neulet.2019.134669","volume":"718","author":"F Chen","year":"2020","unstructured":"Chen F, Li X, Li Z, Qiang Z, Ma H. Altered expression of MiR-186-5p and its target genes after spinal cord ischemia-reperfusion injury in rats. Neurosci Lett. 2020;718:134669.","journal-title":"Neurosci Lett"},{"key":"3995_CR59","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.yexmp.2019.04.007","volume":"108","author":"H Feng","year":"2019","unstructured":"Feng H, Zhang Z, Qing X, French SW, Liu D. Mir-186-5p promotes cell growth, migration and invasion of lung adenocarcinoma by targeting PTEN. Exp Mol Pathol. 2019;108:105\u201313.","journal-title":"Exp Mol Pathol"},{"key":"3995_CR60","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s13577-021-00617-w","volume":"35","author":"Y Yang","year":"2022","unstructured":"Yang Y, Wang J, Zhang Y, Hu X, Li L, Chen P. Exosomes derived from mesenchymal stem cells ameliorate renal fibrosis via delivery of miR-186-5p. Hum Cell. 2022;35:83\u201397.","journal-title":"Hum Cell"},{"key":"3995_CR61","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1038\/s41420-021-00645-3","volume":"7","author":"L Si","year":"2021","unstructured":"Si L, Bai J, Fu H, Qiu H, Guo R. The functions and potential roles of extracellular vesicle noncoding RNAs in gynecological malignancies. Cell Death Discov. 2021;7:258.","journal-title":"Cell Death Discov"},{"key":"3995_CR62","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1146\/annurev-cellbio-101512-122326","volume":"30","author":"M Colombo","year":"2014","unstructured":"Colombo M, Raposo G, Th\u00e9ry C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Bi. 2014;30:255\u201389.","journal-title":"Annu Rev Cell Dev Bi"},{"key":"3995_CR63","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1186\/s13287-022-02825-z","volume":"13","author":"S Shokravi","year":"2022","unstructured":"Shokravi S, Borisov V, Zaman BA, Niazvand F, Hazrati R, Khah MM, et al. Mesenchymal stromal cells (MSCs) and their exosome in acute liver failure (ALF): a comprehensive review. Stem Cell Res Ther. 2022;13:192.","journal-title":"Stem Cell Res Ther"},{"key":"3995_CR64","doi-asserted-by":"publisher","first-page":"100746","DOI":"10.1016\/j.jhepr.2023.100746","volume":"5","author":"F Yang","year":"2023","unstructured":"Yang F, Wu Y, Chen Y, Xi J, Chu Y, Jin J, et al. Human umbilical cord mesenchymal stem cell-derived exosomes ameliorate liver steatosis by promoting fatty acid oxidation and reducing fatty acid synthesis. Jhep Rep. 2023;5:100746.","journal-title":"Jhep Rep"},{"key":"3995_CR65","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.semcancer.2020.08.007","volume":"80","author":"M Pirisinu","year":"2022","unstructured":"Pirisinu M, Pham TC, Zhang DX, Hong TN, Nguyen LT, Le MT. Extracellular vesicles as natural therapeutic agents and innate drug delivery systems for cancer treatment: recent advances, current obstacles, and challenges for clinical translation. Semin Cancer Biol. 2022;80:340\u201355.","journal-title":"Semin Cancer Biol"},{"key":"3995_CR66","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.addr.2012.08.008","volume":"65","author":"AS El","year":"2013","unstructured":"El AS, Lakhal S, M\u00e4ger I, Wood MJ. Exosomes for targeted siRNA delivery across biological barriers. Adv Drug Deliver Rev. 2013;65:391\u20137.","journal-title":"Adv Drug Deliver Rev"},{"key":"3995_CR67","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/nrm.2017.125","volume":"19","author":"G van Niel","year":"2018","unstructured":"van Niel G, D\u2019Angelo G, Raposo G. Shedding light on the cell biology of extracellular vesicles. Nat Rev Mol Cell Bio. 2018;19:213\u201328.","journal-title":"Nat Rev Mol Cell Bio"}],"container-title":["Stem Cell Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-024-03995-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13287-024-03995-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-024-03995-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T12:06:02Z","timestamp":1730721962000},"score":1,"resource":{"primary":{"URL":"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/s13287-024-03995-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,3]]},"references-count":67,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3995"],"URL":"https:\/\/doi.org\/10.1186\/s13287-024-03995-8","relation":{},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,3]]},"assertion":[{"value":"18 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The animal protocol was reviewed and approved by the Institutional Animal Care and Use Committee (IACUC), Sun Yat-Sen University (Title: Mesenchymal stem cells alleviate acute liver injury in a mouse model induced by acetaminophen; Approval number: SYSU-IACUC-2023-000849; Date: May 25, 2023). For the patients\u2019 samples, the patients or their guardians provided written informed consent for participation in the study and the use of samples. All the human tissue experiments were approved by the Ethics Committee of the Third Affiliated Hospital of Sun Yat-sen University (Title: Role of the RNA-Editing Enzyme ADAR1 in Regulating the Immunosuppressive Function of Mesenchymal Stem Cells in the Treatment of Acute Liver Failure; Approval number: RG2023-301-02; Date: January 5, 2024).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The materials used in this study are available in the supplementary material.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Material availability"}},{"value":"The authors declare that they have no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"392"}}