{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:30:59Z","timestamp":1792801859353,"version":"4.5.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82151312"],"award-info":[{"award-number":["82151312"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272493"],"award-info":[{"award-number":["82272493"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204820"],"award-info":[{"award-number":["82204820"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Haidian Frontier Project of Beijing Natural Science Foundation","award":["L212066"],"award-info":[{"award-number":["L212066"]}]},{"name":"The Beijing Science Nova Program","award":["20220484155"],"award-info":[{"award-number":["20220484155"]}]},{"name":"the Teaching Reform Research Project of Dalian Medical University","award":["DYLX22025"],"award-info":[{"award-number":["DYLX22025"]}],"id":[{"id":"https:\/\/ror.org\/04c8eg608","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"DOI":"10.1186\/s13287-024-03999-4","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T11:02:26Z","timestamp":1729681346000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Promotion of nerve regeneration and motor function recovery in SCI rats using LOCAS-iPSCs-NSCs"],"prefix":"10.1186","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3550-2882","authenticated-orcid":false,"given":"Gang","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziteng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanhao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WenJie","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yantao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxun","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,23]]},"reference":[{"key":"3999_CR1","doi-asserted-by":"publisher","first-page":"17018","DOI":"10.1038\/nrdp.2017.18","volume":"3","author":"CS Ahuja","year":"2017","unstructured":"Ahuja CS, Wilson JR, Nori S, Kotter MRN, Druschel C, Curt A, Fehlings MG. Traumatic spinal cord injury. Nat Rev Dis Primers. 2017;3:17018.","journal-title":"Nat Rev Dis Primers"},{"key":"3999_CR2","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.actbio.2017.01.009","volume":"51","author":"C Fan","year":"2017","unstructured":"Fan C, Li X, Xiao Z, Zhao Y, Liang H, Wang B, Han S, Li X, Xu B, Wang N, Liu S, Xue W, Dai J. A modified collagen scaffold facilitates endogenous neurogenesis for acute spinal cord injury repair. Acta Biomater. 2017;51:304\u201316.","journal-title":"Acta Biomater"},{"key":"3999_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.119941","volume":"243","author":"W Liu","year":"2020","unstructured":"Liu W, Xu B, Xue W, Yang B, Fan Y, Chen B, Xiao Z, Xue X, Sun Z, Shu M, Zhang Q, Shi Y, Zhao Y, Dai J. A functional scaffold to promote the migration and neuronal differentiation of neural stem\/progenitor cells for spinal cord injury repair. Biomaterials. 2020;243: 119941.","journal-title":"Biomaterials"},{"key":"3999_CR4","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1007\/s11427-021-1985-5","volume":"65","author":"F Tang","year":"2022","unstructured":"Tang F, Tang J, Zhao Y, Zhang J, Xiao Z, Chen B, Han G, Yin N, Jiang X, Zhao C, Cheng S, Wang Z, Chen Y, Chen Q, Song K, Zhang Z, Niu J, Wang L, Shi Q, Chen L, Yang H, Hou S, Zhang S, Dai J. Long-term clinical observation of patients with acute and chronic complete spinal cord injury after transplantation of NeuroRegen scaffold. Sci China Life Sci. 2022;65:909\u201326.","journal-title":"Sci China Life Sci"},{"key":"3999_CR5","doi-asserted-by":"publisher","first-page":"3358","DOI":"10.1016\/j.biomaterials.2010.11.011","volume":"32","author":"Y Tanaka","year":"2011","unstructured":"Tanaka Y, Baba K, Duncan TJ, Kubota A, Asahi T, Quantock AJ, Yamato M, Okano T, Nishida K. Transparent, tough collagen laminates prepared by oriented flow casting, multi-cyclic vitrification and chemical cross-linking. Biomaterials. 2011;32:3358\u201366.","journal-title":"Biomaterials"},{"key":"3999_CR6","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1080\/09205063.2016.1160561","volume":"27","author":"Y Liu","year":"2016","unstructured":"Liu Y, Lv H, Ren L, Xue G, Wang Y. Improving the moisturizing properties of collagen film by surface grafting of chondroitin sulfate for corneal tissue engineering. J Biomater Sci Polym Ed. 2016;27:758\u201372.","journal-title":"J Biomater Sci Polym Ed"},{"key":"3999_CR7","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1002\/jbm.a.36011","volume":"105","author":"C Chen","year":"2017","unstructured":"Chen C, Zhao ML, Zhang RK, Lu G, Zhao CY, Fu F, Sun HT, Zhang S, Tu Y, Li XH. Collagen\/heparin sulfate scaffolds fabricated by a 3D bioprinter improved mechanical properties and neurological function after spinal cord injury in rats. J Biomed Mater Res A. 2017;105:1324\u201332.","journal-title":"J Biomed Mater Res A"},{"key":"3999_CR8","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.ijbiomac.2019.05.182","volume":"135","author":"X Chen","year":"2019","unstructured":"Chen X, Zhou L, Xu H, Yamamoto M, Shinoda M, Tada I, Minami S, Urayama K, Yamane H. The structure and properties of natural sheep casing and artificial films prepared from natural collagen with various crosslinking treatments. Int J Biol Macromol. 2019;135:959\u201368.","journal-title":"Int J Biol Macromol"},{"key":"3999_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2022.100376","volume":"16","author":"X He","year":"2022","unstructured":"He X, Li W, Liu S, Li Y, Chen Y, Dan N, Dan W, Zhu M. Fabrication of high-strength, flexible, porous collagen-based scaffolds to promote tissue regeneration. Mater Today Bio. 2022;16: 100376.","journal-title":"Mater Today Bio"},{"key":"3999_CR10","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.4103\/1673-5374.300458","volume":"16","author":"J Zhang","year":"2021","unstructured":"Zhang J, Wang RJ, Chen M, Liu XY, Ma K, Xu HY, Deng WS, Ye YC, Li WX, Chen XY, Sun HT. Collagen\/heparan sulfate porous scaffolds loaded with neural stem cells improve neurological function in a rat model of traumatic brain injury. Neural Regen Res. 2021;16:1068\u201377.","journal-title":"Neural Regen Res"},{"key":"3999_CR11","doi-asserted-by":"publisher","first-page":"6362","DOI":"10.1039\/D0BM01116A","volume":"8","author":"J Jiang","year":"2020","unstructured":"Jiang J, Liu X, Chen H, Dai C, Niu X, Dai L, Chen X, Zhang S. 3D printing collagen\/heparin sulfate scaffolds boost neural network reconstruction and motor function recovery after traumatic brain injury in canine. Biomater Sci. 2020;8:6362\u201374.","journal-title":"Biomater Sci"},{"key":"3999_CR12","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1038\/nn.4541","volume":"20","author":"P Assinck","year":"2017","unstructured":"Assinck P, Duncan GJ, Hilton BJ, Plemel JR, Tetzlaff W. Cell transplantation therapy for spinal cord injury. Nat Neurosci. 2017;20:637\u201347.","journal-title":"Nat Neurosci"},{"key":"3999_CR13","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.stem.2018.05.014","volume":"22","author":"E Curtis","year":"2018","unstructured":"Curtis E, Martin JR, Gabel B, Sidhu N, Rzesiewicz TK, Mandeville R, Van Gorp S, Leerink M, Tadokoro T, Marsala S, Jamieson C, Marsala M, Ciacci JD, First-in-Human A. Phase I study of neural stem cell transplantation for chronic spinal cord injury. Cell Stem Cell. 2018;22:941\u201350.","journal-title":"Cell Stem Cell"},{"key":"3999_CR14","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1038\/nmeth.1591","volume":"8","author":"K Okita","year":"2011","unstructured":"Okita K, Matsumura Y, Sato Y, Okada A, Morizane A, Okamoto S, Hong H, Nakagawa M, Tanabe K, Tezuka K, Shibata T, Kunisada T, Takahashi M, Takahashi J, Saji H, Yamanaka S. A more efficient method to generate integration-free human iPS cells. Nat Methods. 2011;8:409\u201312.","journal-title":"Nat Methods"},{"key":"3999_CR15","doi-asserted-by":"publisher","first-page":"2853650","DOI":"10.1155\/2020\/2853650","volume":"2020","author":"L Gao","year":"2020","unstructured":"Gao L, Peng Y, Xu W, He P, Li T, Lu X, Chen G. Progress in stem cell therapy for spinal cord injury. Stem Cells Int. 2020;2020:2853650.","journal-title":"Stem Cells Int"},{"key":"3999_CR16","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1002\/stem.1293","volume":"31","author":"K Okita","year":"2013","unstructured":"Okita K, Yamakawa T, Matsumura Y, Sato Y, Amano N, Watanabe A, Goshima N, Yamanaka S. An efficient nonviral method to generate integration-free human-induced pluripotent stem cells from cord blood and peripheral blood cells. Stem Cells. 2013;31:458\u201366.","journal-title":"Stem Cells"},{"key":"3999_CR17","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1111\/bjh.17297","volume":"194","author":"A Scaradavou","year":"2021","unstructured":"Scaradavou A. Cord blood beyond transplantation: Can we use the experience to advance all cell therapies? Br J Haematol. 2021;194:14\u201327.","journal-title":"Br J Haematol"},{"key":"3999_CR18","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.ijbiomac.2016.03.066","volume":"88","author":"X Liu","year":"2016","unstructured":"Liu X, Dan N, Dan W. Preparation and characterization of an advanced collagen aggregate from porcine acellular dermal matrix. Int J Biol Macromol. 2016;88:179\u201388.","journal-title":"Int J Biol Macromol"},{"key":"3999_CR19","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.3390\/nu14102051","volume":"14","author":"R Fan","year":"2022","unstructured":"Fan R, Hao Y, Du Q, Kang J, Xu M, Li Y. Beneficial effects of walnut oligopeptides on muscle loss in senescence-accelerated mouse prone-8 (SAMP8) mice: focusing on mitochondrial function. Nutrients. 2022;14:2051.","journal-title":"Nutrients"},{"key":"3999_CR20","doi-asserted-by":"publisher","first-page":"62","DOI":"10.3171\/2016.6.SPINE16343","volume":"26","author":"D Jalan","year":"2017","unstructured":"Jalan D, Saini N, Zaidi M, Pallottie A, Elkabes S, Heary RF. Effects of early surgical decompression on functional and histological outcomes after severe experimental thoracic spinal cord injury. J Neurosurg Spine. 2017;26:62\u201375.","journal-title":"J Neurosurg Spine"},{"key":"3999_CR21","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.jneumeth.2008.08.026","volume":"176","author":"M Neumann","year":"2009","unstructured":"Neumann M, Wang Y, Kim S, Hong SM, Jeng L, Bilgen M, Liu J. Assessing gait impairment following experimental traumatic brain injury in mice. J Neurosci Methods. 2009;176:34\u201344.","journal-title":"J Neurosci Methods"},{"key":"3999_CR22","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1002\/hep.27987","volume":"62","author":"HR Siddique","year":"2015","unstructured":"Siddique HR, Feldman DE, Chen CL, Punj V, Tokumitsu H, Machida K. NUMB phosphorylation destabilizes p53 and promotes self-renewal of tumor-initiating cells by a NANOG-dependent mechanism in liver cancer. Hepatology. 2015;62:1466\u201379.","journal-title":"Hepatology"},{"key":"3999_CR23","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202104424","volume":"9","author":"Z Guo","year":"2022","unstructured":"Guo Z, Sun C, Yang H, Gao H, Liang N, Wang J, Hu S, Ren N, Pang J, Wang J, Meng N, Han L, Liu H. Regulation of neural differentiation of ADMSCs using graphene-mediated wireless-localized electrical signals driven by electromagnetic induction. Adv Sci (Weinh). 2022;9: e2104424.","journal-title":"Adv Sci (Weinh)"},{"key":"3999_CR24","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s11910-019-0984-1","volume":"19","author":"M Karsy","year":"2019","unstructured":"Karsy M, Hawryluk G. Modern medical management of spinal cord injury. Curr Neurol Neurosci Rep. 2019;19:65.","journal-title":"Curr Neurol Neurosci Rep"},{"key":"3999_CR25","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.biomaterials.2017.01.024","volume":"123","author":"JR Slotkin","year":"2017","unstructured":"Slotkin JR, Pritchard CD, Luque B, Ye J, Layer RT, Lawrence MS, O\u2019Shea TM, Roy RR, Zhong H, Vollenweider I, Edgerton VR, Courtine G, Woodard EJ, Langer R. Biodegradable scaffolds promote tissue remodeling and functional improvement in non-human primates with acute spinal cord injury. Biomaterials. 2017;123:63\u201376.","journal-title":"Biomaterials"},{"key":"3999_CR26","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.3390\/ijms23031035","volume":"23","author":"JH Lee","year":"2022","unstructured":"Lee JH, Kim KH, Kwon OH, Kwon OK, Uyama H, Kim Y-J. Photodynamic activity of protoporphyrin IX-immobilized cellulose monolith for nerve tissue regeneration. Int J Mol Sci. 2022;23:1035.","journal-title":"Int J Mol Sci"},{"key":"3999_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120769","volume":"272","author":"WB Swanson","year":"2021","unstructured":"Swanson WB, Omi M, Zhang Z, Nam HK, Jung Y, Wang G, Ma PX, Hatch NE, Mishina Y. Macropore design of tissue engineering scaffolds regulates mesenchymal stem cell differentiation fate. Biomaterials. 2021;272: 120769.","journal-title":"Biomaterials"},{"key":"3999_CR28","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1038\/nrn1964","volume":"7","author":"EJ Bradbury","year":"2006","unstructured":"Bradbury EJ, McMahon SB. Spinal cord repair strategies: Why do they work? Nat Rev Neurosci. 2006;7:644\u201353.","journal-title":"Nat Rev Neurosci"},{"key":"3999_CR29","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1038\/nrn1955","volume":"7","author":"S Thuret","year":"2006","unstructured":"Thuret S, Moon LD, Gage FH. Therapeutic interventions after spinal cord injury. Nat Rev Neurosci. 2006;7:628\u201343.","journal-title":"Nat Rev Neurosci"},{"key":"3999_CR30","doi-asserted-by":"publisher","first-page":"3838","DOI":"10.3390\/ijms20153838","volume":"20","author":"M Csobonyeiova","year":"2019","unstructured":"Csobonyeiova M, Polak S, Zamborsky R, Danisovic L. Recent progress in the regeneration of spinal cord injuries by induced pluripotent stem cells. Int J Mol Sci. 2019;20:3838.","journal-title":"Int J Mol Sci"},{"key":"3999_CR31","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.conb.2014.03.010","volume":"27","author":"P Lu","year":"2014","unstructured":"Lu P, Kadoya K, Tuszynski MH. Axonal growth and connectivity from neural stem cell grafts in models of spinal cord injury. Curr Opin Neurobiol. 2014;27:103\u20139.","journal-title":"Curr Opin Neurobiol"},{"key":"3999_CR32","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1016\/j.cell.2012.08.020","volume":"150","author":"P Lu","year":"2012","unstructured":"Lu P, Wang Y, Graham L, McHale K, Gao M, Wu D, Brock J, Blesch A, Rosenzweig ES, Havton LA, Zheng B, Conner JM, Marsala M, Tuszynski MH. Long-distance growth and connectivity of neural stem cells after severe spinal cord injury. Cell. 2012;150:1264\u201373.","journal-title":"Cell"},{"key":"3999_CR33","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s13287-020-02090-y","volume":"12","author":"B Lv","year":"2021","unstructured":"Lv B, Zhang X, Yuan J, Chen Y, Ding H, Cao X, Huang A. Biomaterial-supported MSC transplantation enhances cell-cell communication for spinal cord injury. Stem Cell Res Ther. 2021;12:36.","journal-title":"Stem Cell Res Ther"},{"key":"3999_CR34","first-page":"1","volume":"50","author":"JE Shin","year":"2018","unstructured":"Shin JE, Jung K, Kim M, Hwang K, Lee H, Kim IS, Lee BH, Lee IS, Park KI. Brain and spinal cord injury repair by implantation of human neural progenitor cells seeded onto polymer scaffolds. Exp Mol Med. 2018;50:1\u201318.","journal-title":"Exp Mol Med"},{"key":"3999_CR35","doi-asserted-by":"publisher","first-page":"1700499","DOI":"10.1002\/advs.201700499","volume":"5","author":"Y Qian","year":"2018","unstructured":"Qian Y, Song J, Zhao X, Chen W, Ouyang Y, Yuan W, Fan C. 3D fabrication with integration molding of a graphene oxide\/polycaprolactone nanoscaffold for neurite regeneration and angiogenesis. Adv Sci (Weinh). 2018;5:1700499.","journal-title":"Adv Sci (Weinh)"},{"key":"3999_CR36","doi-asserted-by":"publisher","first-page":"1958631","DOI":"10.1155\/2019\/1958631","volume":"2019","author":"S Liu","year":"2019","unstructured":"Liu S, Chen Z. Employing endogenous NSCs to promote recovery of spinal cord injury. Stem Cells Int. 2019;2019:1958631.","journal-title":"Stem Cells Int"},{"key":"3999_CR37","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1186\/s13287-021-02217-9","volume":"12","author":"D Kong","year":"2021","unstructured":"Kong D, Feng B, Amponsah AE, He J, Guo R, Liu B, Du X, Liu X, Zhang S, Lv F, Ma J, Cui H. hiPSC-derived NSCs effectively promote the functional recovery of acute spinal cord injury in mice. Stem Cell Res Ther. 2021;12:172.","journal-title":"Stem Cell Res Ther"},{"key":"3999_CR38","doi-asserted-by":"publisher","first-page":"6265","DOI":"10.2147\/IJN.S175914","volume":"13","author":"X Zhou","year":"2018","unstructured":"Zhou X, Shi G, Fan B, Cheng X, Zhang X, Wang X, Liu S, Hao Y, Wei Z, Wang L, Feng S. Polycaprolactone electrospun fiber scaffold loaded with iPSCs-NSCs and ASCs as a novel tissue engineering scaffold for the treatment of spinal cord injury. Int J Nanomed. 2018;13:6265\u201377.","journal-title":"Int J Nanomed"},{"key":"3999_CR39","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1038\/s41592-018-0074-3","volume":"15","author":"H Kumamaru","year":"2018","unstructured":"Kumamaru H, Kadoya K, Adler AF, Takashima Y, Graham L, Coppola G, Tuszynski MH. Generation and post-injury integration of human spinal cord neural stem cells. Nat Methods. 2018;15:723\u201331.","journal-title":"Nat Methods"},{"key":"3999_CR40","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202001896","volume":"10","author":"L Zhang","year":"2021","unstructured":"Zhang L, Fan C, Hao W, Zhuang Y, Liu X, Zhao Y, Chen B, Xiao Z, Chen Y, Dai J. NSCs migration promoted and drug delivered exosomes-collagen scaffold via a bio-specific peptide for one-step spinal cord injury repair. Adv Healthc Mater. 2021;10: e2001896.","journal-title":"Adv Healthc Mater"},{"key":"3999_CR41","doi-asserted-by":"publisher","first-page":"8583","DOI":"10.3390\/ijms23158583","volume":"23","author":"SV Demyanenko","year":"2022","unstructured":"Demyanenko SV, Pitinova MA, Kalyuzhnaya YN, Khaitin AM, Batalshchikova SA, Dobaeva NM, Shevtsova YA, Goryunov KV, Plotnikov EY, Pashkevich SG, Sukhikh GT, Silachev DN. Human multipotent mesenchymal stromal cell-derived extracellular vesicles enhance neuroregeneration in a rat model of sciatic nerve crush injury. Int J Mol Sci. 2022;23:8583.","journal-title":"Int J Mol Sci"},{"key":"3999_CR42","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.biomaterials.2015.08.054","volume":"72","author":"JL Roam","year":"2015","unstructured":"Roam JL, Yan Y, Nguyen PK, Kinstlinger IS, Leuchter MK, Hunter DA, Wood MD, Elbert DL. A modular, plasmin-sensitive, clickable poly(ethylene glycol)-heparin-laminin microsphere system for establishing growth factor gradients in nerve guidance conduits. Biomaterials. 2015;72:112\u201324.","journal-title":"Biomaterials"},{"key":"3999_CR43","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.813169","volume":"9","author":"B Lv","year":"2021","unstructured":"Lv B, Shen N, Cheng Z, Chen Y, Ding H, Yuan J, Zhao K, Zhang Y. Strategies for biomaterial-based spinal cord injury repair via the TLR4-NF-kappaB signaling pathway. Front Bioeng Biotechnol. 2021;9: 813169.","journal-title":"Front Bioeng Biotechnol"},{"key":"3999_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2020.111532","volume":"199","author":"XQ Zheng","year":"2021","unstructured":"Zheng XQ, Huang JF, Lin JL, Zhu YX, Wang MQ, Guo ML, Zan XJ, Wu AM. Controlled release of baricitinib from a thermos-responsive hydrogel system inhibits inflammation by suppressing JAK2\/STAT3 pathway in acute spinal cord injury. Colloids Surf B Biointerfaces. 2021;199: 111532.","journal-title":"Colloids Surf B Biointerfaces"},{"key":"3999_CR45","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.neuroscience.2022.06.007","volume":"498","author":"X Guo","year":"2022","unstructured":"Guo X, Kang J, Wang Z, Wang Y, Liu M, Zhu D, Yang F, Kang X. Nrf2 signaling in the oxidative stress response after spinal cord injury. Neuroscience. 2022;498:311\u201324.","journal-title":"Neuroscience"},{"key":"3999_CR46","doi-asserted-by":"publisher","first-page":"11573","DOI":"10.3390\/ijms222111573","volume":"22","author":"T Kimura","year":"2021","unstructured":"Kimura T, Horikoshi Y, Kuriyagawa C, Niiyama Y. Rho\/ROCK pathway and noncoding RNAs: implications in ischemic stroke and spinal cord injury. Int J Mol Sci. 2021;22:11573.","journal-title":"Int J Mol Sci"},{"key":"3999_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113881","volume":"156","author":"CL Xiao","year":"2022","unstructured":"Xiao CL, Yin WC, Zhong YC, Luo JQ, Liu LL, Liu WY, Zhao K. The role of PI3K\/Akt signalling pathway in spinal cord injury. Biomed Pharmacother. 2022;156: 113881.","journal-title":"Biomed Pharmacother"},{"key":"3999_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112430","volume":"145","author":"Y Ding","year":"2022","unstructured":"Ding Y, Chen Q. mTOR pathway: a potential therapeutic target for spinal cord injury. Biomed Pharmacother. 2022;145: 112430.","journal-title":"Biomed Pharmacother"}],"container-title":["Stem Cell Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-024-03999-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13287-024-03999-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-024-03999-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T11:07:46Z","timestamp":1729681666000},"score":1,"resource":{"primary":{"URL":"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/s13287-024-03999-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,23]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3999"],"URL":"https:\/\/doi.org\/10.1186\/s13287-024-03999-4","relation":{},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,23]]},"assertion":[{"value":"1 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the animal experiments were conducted in conformity to the Guide for the Care and Use of Laboratory Animals (National Institutes of Health Publication no. 80-23, revised 1996) and the project \u201cSCI repaired by modified collagen scaffolds\u201d was approved by the Animal Care and Use Committee of Chinese PLA General Hospital, Beijing, China (2019-X13-67, in September 2019). Performing experiments using human cells was also approved by Chinese PLA General Hospital. The patients or their guardians\/legally authorized representatives\/next of kin have provided written informed consent for participation in the study and\/or the use of samples.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"All authors confirm their consent for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"376"}}