{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T03:08:19Z","timestamp":1793761699828,"version":"4.6.1"},"reference-count":152,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T00:00:00Z","timestamp":1731110400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T00:00:00Z","timestamp":1731110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100019014","name":"Chengdu Municipal Science and Technology Program","doi-asserted-by":"publisher","award":["No. 2024-YF05- 01140-SN"],"award-info":[{"award-number":["No. 2024-YF05- 01140-SN"]}],"id":[{"id":"10.13039\/501100019014","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019014","name":"Chengdu Municipal Science and Technology Program","doi-asserted-by":"publisher","award":["No. 2024-YF09-00026-SN"],"award-info":[{"award-number":["No. 2024-YF09-00026-SN"]}],"id":[{"id":"10.13039\/501100019014","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"DOI":"10.1186\/s13287-024-04024-4","type":"journal-article","created":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T12:59:39Z","timestamp":1731157179000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Exosomes to exosome-functionalized scaffolds: a novel approach to stimulate bone regeneration"],"prefix":"10.1186","volume":"15","author":[{"given":"Li","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yandong","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9720-535X","authenticated-orcid":false,"given":"Mingqing","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,9]]},"reference":[{"issue":"12","key":"4024_CR1","doi-asserted-by":"publisher","first-page":"6203","DOI":"10.3390\/ijms22126203","volume":"22","author":"E Pishavar","year":"2021","unstructured":"Pishavar E, Luo H, Naserifar M, et al. Advanced hydrogels as exosome delivery systems for osteogenic differentiation of MSCs: application in bone regeneration. Int J Mol Sci. 2021;22(12):6203.","journal-title":"Int J Mol Sci"},{"key":"4024_CR2","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1016\/S0140-6736(02)08657-9","volume":"359","author":"SR Cummings","year":"2002","unstructured":"Cummings SR, Melton LJ. Epidemiology and outcomes of osteoporotic fractures. Lancet (London, England). 2002;359:1761\u20137.","journal-title":"Lancet (London, England)"},{"issue":"10","key":"4024_CR3","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1007\/s00198-022-06454-3","volume":"33","author":"PL Xiao","year":"2022","unstructured":"Xiao PL, Cui AY, Hsu CJ, et al. Global, regional prevalence, and risk factors of osteoporosis according to the World Health Organization diagnostic criteria: a systematic review and meta-analysis. Osteoporos Int. 2022;33(10):2137\u201353.","journal-title":"Osteoporos Int"},{"key":"4024_CR4","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1007\/s00198-006-0172-4","volume":"17","author":"O Johnell","year":"2006","unstructured":"Johnell O, Kanis JA. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int. 2006;17:1726\u201333.","journal-title":"Osteoporos Int"},{"key":"4024_CR5","doi-asserted-by":"crossref","unstructured":"Hernlund E, Svedbom A, Iverg\u00e5rd M et\u00a0al. Osteoporosis in the European Union: medical management, epidemiology and economic burden. A report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA). 2013; Arch Osteopor 8:136;","DOI":"10.1007\/s11657-013-0136-1"},{"key":"4024_CR6","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1001\/archinte.164.6.603","volume":"164","author":"ML Gourlay","year":"2004","unstructured":"Gourlay ML, Brown SA. Clinical considerations in premenopausal osteoporosis. Arch Internal Med. 2004;164:603\u201314.","journal-title":"Arch Internal Med"},{"key":"4024_CR7","doi-asserted-by":"crossref","unstructured":"Yang P, Zhou J, Ai Q, et al. Comparison of Individual Tissue-Engineered Bones and Allogeneic Bone in Treating Bone Defects: A Long-Term Follow-Up Study. Cell Transplant. 2020 Jan-Dec;29:963689720940722;","DOI":"10.1177\/0963689720940722"},{"issue":"6","key":"4024_CR8","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s00264-006-0146-3","volume":"30","author":"F Malek","year":"2006","unstructured":"Malek F, Krueger P, Hatmi ZN, et al. Local control of long bone giant cell tumour using curettage, burring and bone grafting without adjuvant therapy. Int Orthop. 2006;30(6):495\u20138.","journal-title":"Int Orthop"},{"key":"4024_CR9","unstructured":"Roudbari S, Haji Aliloo Sami S, Roudbari M. The clinical results of benign bone tumor treatment with allograft or autograft. Arch Iran Med. 2015;18(2):109\u2013113"},{"key":"4024_CR10","doi-asserted-by":"crossref","unstructured":"Donos N, Akcali A, Padhye N, et al. Bone regeneration in implant dentistry: Which are the factors affecting the clinical outcome?. Periodontol 2000. 2023;93(1):26\u201355;","DOI":"10.1111\/prd.12518"},{"issue":"4","key":"4024_CR11","doi-asserted-by":"publisher","first-page":"2937","DOI":"10.1002\/jcp.26042","volume":"233","author":"M Majidinia","year":"2018","unstructured":"Majidinia M, Sadeghpour A, Yousefi B. The roles of signaling pathways in bone repair and regeneration. J Cell Physiol. 2018;233(4):2937\u201348.","journal-title":"J Cell Physiol"},{"issue":"11","key":"4024_CR12","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1038\/s41580-020-00279-w","volume":"21","author":"A Salhotra","year":"2020","unstructured":"Salhotra A, Shah HN, Levi B, et al. Mechanisms of bone development and repair. Nat Rev Mol Cell Biol. 2020;21(11):696\u2013711.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4024_CR13","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.actbio.2019.12.034","volume":"106","author":"D Xiao","year":"2020","unstructured":"Xiao D, Zhang J, Zhang C, et al. The role of calcium phosphate surface structure in osteogenesis and the mechanisms involved. Acta Biomater. 2020;106:22\u201333.","journal-title":"Acta Biomater"},{"key":"4024_CR14","doi-asserted-by":"crossref","unstructured":"Summers BN, Eisenstein SM. Donor site pain from the ilium. A complication of lumbar spine fusion. J Bone Joint Surg Br. 1989; 71:677\u2013680;","DOI":"10.1302\/0301-620X.71B4.2768321"},{"key":"4024_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5435\/00124635-199501000-00001","volume":"3","author":"AR Gazdag","year":"1995","unstructured":"Gazdag AR, Lane JM, Glaser D, Forster RA. Alternatives to autogenous bone graft: efficacy and indications. J Am Acad Orthop Surg. 1995;3:1\u20138.","journal-title":"J Am Acad Orthop Surg"},{"issue":"1","key":"4024_CR16","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/s13287-018-0847-8","volume":"9","author":"A Pirosa","year":"2018","unstructured":"Pirosa A, Gottardi R, Alexander PG, et al. Engineering in-vitro stem cell-based vascularized bone models for drug screening and predictive toxicology. Stem Cell Res Ther. 2018;9(1):112.","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"4024_CR17","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1186\/s13287-022-02852-w","volume":"13","author":"Y Zhao","year":"2022","unstructured":"Zhao Y, He J, Qiu T, et al. Epigenetic therapy targeting bone marrow mesenchymal stem cells for age-related bone diseases. Stem Cell Res Ther. 2022;13(1):201.","journal-title":"Stem Cell Res Ther"},{"key":"4024_CR18","doi-asserted-by":"publisher","first-page":"100067","DOI":"10.1016\/j.mtbio.2020.100067","volume":"7","author":"SHS Tan","year":"2020","unstructured":"Tan SHS, Wong JRY, Sim SJY, et al. Mesenchymal stem cell exosomes in bone regenerative strategies-a systematic review of preclinical studies. Mater Today Bio. 2020;7:100067.","journal-title":"Mater Today Bio"},{"issue":"1","key":"4024_CR19","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1089\/ten.teb.2020.0246","volume":"28","author":"J Huber","year":"2022","unstructured":"Huber J, Griffin MF, Longaker MT, Quarto N. Exosomes: a tool for bone tissue engineering. Tissue Eng Part B Rev. 2022;28(1):101\u201313.","journal-title":"Tissue Eng Part B Rev"},{"key":"4024_CR20","doi-asserted-by":"crossref","unstructured":"Kalluri, R., and LeBleu, V. S. (2020). The biology, function, and biomedical applications of exosomes. Science 367 (6478), eaau6977;","DOI":"10.1126\/science.aau6977"},{"issue":"1","key":"4024_CR21","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s13287-023-03287-7","volume":"14","author":"A Lotfy","year":"2023","unstructured":"Lotfy A, AboQuella NM, Wang H. Mesenchymal stromal\/stem cell (MSC)-derived exosomes in clinical trials. Stem Cell Res Ther. 2023;14(1):66.","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"4024_CR22","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1186\/s13287-023-03345-0","volume":"14","author":"C Zhou","year":"2023","unstructured":"Zhou C, Zhang B, Yang Y, et al. Stem cell-derived exosomes: emerging therapeutic opportunities for wound healing. Stem Cell Res Ther. 2023;14(1):107.","journal-title":"Stem Cell Res Ther"},{"issue":"11","key":"4024_CR23","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.3390\/biom10111525","volume":"10","author":"T Kobayashi","year":"2020","unstructured":"Kobayashi T, Chanmee T, Itano N. Hyaluronan: metabolism and function. Biomolecules. 2020;10(11):1525.","journal-title":"Biomolecules"},{"issue":"1","key":"4024_CR24","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1186\/s13287-020-01781-w","volume":"11","author":"L He","year":"2020","unstructured":"He L, He T, Xing J, et al. Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis. Stem Cell Res Ther. 2020;11(1):276.","journal-title":"Stem Cell Res Ther"},{"issue":"10","key":"4024_CR25","doi-asserted-by":"publisher","first-page":"1091360","DOI":"10.3389\/fbioe.2022.1091360","volume":"7","author":"S Ma","year":"2022","unstructured":"Ma S, Zhang Y, Li S, et al. Engineering exosomes for bone defect repair. Front Bioeng Biotechnol. 2022;7(10):1091360.","journal-title":"Front Bioeng Biotechnol"},{"issue":"13","key":"4024_CR26","doi-asserted-by":"publisher","first-page":"17190","DOI":"10.18632\/aging.203169","volume":"13","author":"Y Wei","year":"2021","unstructured":"Wei Y, Ma H, Zhou H, et al. miR-424-5p shuttled by bone marrow stem cells-derived exosomes attenuates osteogenesis via regulating WIF1-mediated Wnt\/\u03b2-catenin axis. Aging (Albany NY). 2021;13(13):17190\u2013201.","journal-title":"Aging (Albany NY)"},{"issue":"13","key":"4024_CR27","first-page":"300","volume":"3","author":"Z Lin","year":"2021","unstructured":"Lin Z, Xiong Y, Meng W, et al. Exosomal PD-L1 induces osteogenic differentiation and promotes fracture healing by acting as an immunosuppressant. Bioact Mater. 2021;3(13):300\u201311.","journal-title":"Bioact Mater"},{"issue":"8","key":"4024_CR28","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.3390\/cells10081959","volume":"10","author":"MD Hade","year":"2021","unstructured":"Hade MD, Suire CN, Suo Z. Mesenchymal stem cell-derived exosomes: applications in regenerative medicine. Cells. 2021;10(8):1959.","journal-title":"Cells"},{"issue":"8","key":"4024_CR29","doi-asserted-by":"publisher","first-page":"3684","DOI":"10.7150\/thno.41580","volume":"10","author":"D Yang","year":"2020","unstructured":"Yang D, Zhang W, Zhang H, et al. Progress, opportunity, and perspective on exosome isolation-efforts for efficient exosome-based theranostics. Theranostics. 2020;10(8):3684\u2013707.","journal-title":"Theranostics"},{"key":"4024_CR30","doi-asserted-by":"publisher","first-page":"307","DOI":"10.3390\/cells8040307","volume":"8","author":"S Gurunathan","year":"2019","unstructured":"Gurunathan S, Kang MH, Jeyaraj M, et al. Review of the isolation, characterization, biological function, and multifarious therapeutic approaches of exosomes. Cells. 2019;8:307.","journal-title":"Cells"},{"key":"4024_CR31","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1146\/annurev-cellbio-101512-122326","volume":"30","author":"M Colombo","year":"2014","unstructured":"Colombo M, Raposo G, Thery C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Biol. 2014;30:255.","journal-title":"Annu Rev Cell Dev Biol"},{"key":"4024_CR32","doi-asserted-by":"crossref","unstructured":"Poon IKH, Parkes MAF, Jiang L et al. Moving beyond size and phosphatidylserine exposure: evidence for a diversity of apoptotic cell-derived extracellular vesicles in vitro. J Extracell Vesicles 8, 2019;","DOI":"10.1080\/20013078.2019.1608786"},{"key":"4024_CR33","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.cell.2019.08.001","volume":"179","author":"Y Zhu","year":"2019","unstructured":"Zhu Y, Crowley SC, Latimer AJ, et al. Migratory neural crest cells phagocytose dead cells in the developing nervous system. Cell. 2019;179:74-89.e10.","journal-title":"Cell"},{"key":"4024_CR34","doi-asserted-by":"crossref","unstructured":"Brock CK, Wallin ST, Ruiz OE et al. Stem cell proliferation is induced by apoptotic bodies from dying cells during epithelial tissue maintenance. Nat Commun; 2019; 10:1044;","DOI":"10.1038\/s41467-019-09010-6"},{"key":"4024_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-017-14305-z","volume":"7","author":"L Jiang","year":"2017","unstructured":"Jiang L, Paone S, Caruso S, et al. Determining the contents and cell origins of apoptotic bodies by flow cytometry. Sci Rep. 2017;7:1\u201312.","journal-title":"Sci Rep"},{"issue":"4","key":"4024_CR36","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/nrm.2017.125","volume":"19","author":"G van Niel","year":"2018","unstructured":"van Niel G, D\u2019Angelo G, Raposo G. Shedding light on the cell biology of extracellular vesicles. Nat Rev Mol Cell Biol. 2018;19(4):213\u201328.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4024_CR37","doi-asserted-by":"crossref","unstructured":"Casado-D\u0131\u00b4az, A., Quesada-Go\u00b4mez, J.M., and Dorado, G. Extracellular vesicles derived from mesenchymal stem cells (MSC) in regenerative medicine: applications in skin wound healing. Front Bioeng Biotechnol 8, 146, 2020;","DOI":"10.3389\/fbioe.2020.00146"},{"key":"4024_CR38","doi-asserted-by":"publisher","first-page":"e0193059","DOI":"10.1371\/journal.pone.0193059","volume":"13","author":"X Wang","year":"2018","unstructured":"Wang X, Omar O, Vazirisani F, et al. Mesenchymal stem cell-derived exosomes have altered microRNA profiles and induce osteogenic differentiation depending on the stage of differentiation. PLoS ONE. 2018;13:e0193059.","journal-title":"PLoS ONE"},{"issue":"36","key":"4024_CR39","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1146\/annurev-immunol-041015-055700","volume":"26","author":"MFS Lindenbergh","year":"2018","unstructured":"Lindenbergh MFS, Stoorvogel W. Antigen presentation by extracellular vesicles from professional antigen-presenting cells. Annu Rev Immunol. 2018;26(36):435\u201359.","journal-title":"Annu Rev Immunol"},{"key":"4024_CR40","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/978-1-0716-2823-2_2","volume":"2595","author":"N Rahimian","year":"2023","unstructured":"Rahimian N, Nahand JS, Hamblin MR, Mirzaei H. Exosomal MicroRNA profiling. Methods Mol Biol. 2023;2595:13\u201347.","journal-title":"Methods Mol Biol"},{"key":"4024_CR41","doi-asserted-by":"publisher","first-page":"5136","DOI":"10.1021\/acsami.9b21333","volume":"12","author":"S Dong","year":"2020","unstructured":"Dong S, Wang Y, Liu Z, Zhang W, Yi K, Zhang X, et al. Beehive-inspired macroporous sers probe for cancer detection through capturing and analyzing exosomes in plasma. ACS Appl Mater Interfaces. 2020;12:5136\u201346.","journal-title":"ACS Appl Mater Interfaces"},{"key":"4024_CR42","doi-asserted-by":"crossref","unstructured":"Choi Y, Park U, Koo H-J, Park J-s, Lee DH, Kim K, et al. Exosome-mediated diagnosis of pancreatic cancer using lectin-conjugated nanoparticles bound to selective glycans. Biosens Bioelectron. 2021; 177: 112980;","DOI":"10.1016\/j.bios.2021.112980"},{"key":"4024_CR43","doi-asserted-by":"publisher","first-page":"1741176","DOI":"10.1080\/20013078.2020.1741176","volume":"9","author":"K Brinkman","year":"2020","unstructured":"Brinkman K, Meyer L, Bickel A, Enderle D, Berking C, Skog J, et al. Extracellular vesicles from plasma have higher tumour rna fraction than platelets. J Extracell Vesicles. 2020;9:1741176.","journal-title":"J Extracell Vesicles"},{"issue":"6","key":"4024_CR44","doi-asserted-by":"publisher","first-page":"5159","DOI":"10.3390\/ijms24065159","volume":"24","author":"C Agnoletto","year":"2023","unstructured":"Agnoletto C, Pignochino Y, Caruso C, et al. Exosome-based liquid biopsy approaches in bone and soft tissue sarcomas: review of the literature, prospectives, and hopes for clinical application. Int J Mol Sci. 2023;24(6):5159.","journal-title":"Int J Mol Sci"},{"key":"4024_CR45","doi-asserted-by":"crossref","unstructured":"Wan T, Zhong J, Pan Q, et al. Exosome-mediated delivery of Cas9 ribonucleoprotein complexes for tissue-specific gene therapy of liver diseases. Sci Adv. 2022;8(37):eabp9435;","DOI":"10.1126\/sciadv.abp9435"},{"issue":"33","key":"4024_CR46","doi-asserted-by":"publisher","first-page":"e2302622","DOI":"10.1002\/advs.202302622","volume":"10","author":"Y Ma","year":"2023","unstructured":"Ma Y, Sun L, Zhang J, et al. Exosomal mRNAs for angiogenic-osteogenic coupled bone repair. Adv Sci (Weinh). 2023;10(33):e2302622.","journal-title":"Adv Sci (Weinh)"},{"issue":"8","key":"4024_CR47","doi-asserted-by":"publisher","first-page":"3684","DOI":"10.7150\/thno.41580","volume":"1910","author":"D Yang","year":"2020","unstructured":"Yang D, Zhang W, Zhang H, et al. Progress, opportunity, and perspective on exosome isolation-efforts for efficient exosome-based theranostics. Theranostics. 2020;1910(8):3684\u2013707.","journal-title":"Theranostics"},{"issue":"7","key":"4024_CR48","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1161\/CIRCRESAHA.111.253286","volume":"109","author":"S Sahoo","year":"2011","unstructured":"Sahoo S, Klychko E, Thorne T, et al. Exosomes from human CD34(+) stem cells mediate their proangiogenic paracrine activity. Circ Res. 2011;109(7):724\u20138.","journal-title":"Circ Res"},{"issue":"1","key":"4024_CR49","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.tcb.2013.10.009","volume":"24","author":"C Bissig","year":"2014","unstructured":"Bissig C, Gruenberg J. ALIX and the multivesicular endosome: ALIX in Wonderland. Trends Cell Biol. 2014;24(1):19\u201325.","journal-title":"Trends Cell Biol"},{"issue":"19","key":"4024_CR50","doi-asserted-by":"publisher","first-page":"2421","DOI":"10.3390\/cells12192421","volume":"12","author":"Y Wang","year":"2023","unstructured":"Wang Y, Zou M, Zhao Y, Kabir MA, Peng X. Exosomal microRNA\/miRNA dysregulation in respiratory diseases: from mycoplasma-induced respiratory disease to COVID-19 and beyond. Cells. 2023;12(19):2421.","journal-title":"Cells"},{"issue":"10","key":"4024_CR51","doi-asserted-by":"publisher","first-page":"953916","DOI":"10.3389\/fbioe.2022.953916","volume":"22","author":"Z Wang","year":"2022","unstructured":"Wang Z, Zhao Z, Gao B, et al. Exosome mediated biological functions within skeletal microenvironment. Front Bioeng Biotechnol. 2022;22(10):953916.","journal-title":"Front Bioeng Biotechnol"},{"key":"4024_CR52","doi-asserted-by":"publisher","first-page":"119204","DOI":"10.1016\/j.lfs.2021.119204","volume":"272","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Cao X, Li P, et al. microRNA-935-modified bone marrow mesenchymal stem cells-derived exosomes enhance osteoblast proliferation and differentiation in osteoporotic rats. Life Sci. 2021;272:119204.","journal-title":"Life Sci"},{"issue":"5","key":"4024_CR53","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1002\/jcp.24250","volume":"228","author":"H Okamura","year":"2013","unstructured":"Okamura H, Yoshida K, Yang D, Haneji T. Protein phosphatase 2A C\u03b1 regulates osteoblast differentiation and the expressions of bone sialoprotein and osteocalcin via osterix transcription factor. J Cell Physiol. 2013;228(5):1031\u20137.","journal-title":"J Cell Physiol"},{"issue":"1","key":"4024_CR54","doi-asserted-by":"publisher","first-page":"159","DOI":"10.3390\/ijms18010159","volume":"18","author":"YT Tsao","year":"2017","unstructured":"Tsao YT, Huang YJ, Wu HH, Liu YA, Liu YS, Lee O. Osteocalcin mediates biomineralization during osteogenic maturation in human mesenchymal stromal cells. Int J Mol Sci. 2017;18(1):159.","journal-title":"Int J Mol Sci"},{"issue":"4","key":"4024_CR55","doi-asserted-by":"publisher","first-page":"e12794","DOI":"10.1111\/acel.12794","volume":"17","author":"R Xu","year":"2018","unstructured":"Xu R, Shen X, Si Y, Fu Y, Zhu W, Xiao T, et al. MicroRNA-31a-5p from aging BMSCs links bone formation and resorption in the aged bone marrow microenvironment. Aging Cell. 2018;17(4):e12794.","journal-title":"Aging Cell"},{"issue":"1","key":"4024_CR56","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1186\/s13287-020-01781-w","volume":"11","author":"L He","year":"2020","unstructured":"He L, He T, Xing J, et al. Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis. Stem Cell Res Ther. 2020;11(1):276.","journal-title":"Stem Cell Res Ther"},{"issue":"6","key":"4024_CR57","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1097\/SHK.0000000000001549","volume":"54","author":"H Deng","year":"2020","unstructured":"Deng H, Wu L, Liu M, et al. Bone marrow mesenchymal stem cell-derived exosomes attenuate LPS-induced ARDS by modulating macrophage polarization through inhibiting glycolysis in macrophages. Shock. 2020;54(6):828\u201343.","journal-title":"Shock"},{"issue":"1","key":"4024_CR58","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1186\/s13287-021-02591-4","volume":"12","author":"H Ning","year":"2021","unstructured":"Ning H, Chen H, Deng J, et al. Exosomes secreted by FNDC5-BMMSCs protect myocardial infarction by anti-infammation and macrophage polarization via NF-kappaB signaling pathway and Nrf2\/HO-1 axis. Stem Cell Res Ther. 2021;12(1):519.","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"4024_CR59","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1089\/jir.2021.0146","volume":"42","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Yan J, Li Z, et al. Exosomes derived from human umbilical cord mesenchymal stem cells alleviate psoriasis-like skin infammation. J Interferon Cytokine Res. 2022;42(1):8\u201318.","journal-title":"J Interferon Cytokine Res"},{"key":"4024_CR60","doi-asserted-by":"publisher","first-page":"3843","DOI":"10.1111\/jcmm.14228","volume":"23","author":"Y Cui","year":"2019","unstructured":"Cui Y, Fu S, Sun D, et al. EPC-derived exosomes promote osteoclastogenesis through LncRNA-MALAT1. J Cell Mol Med. 2019;23:3843\u201354.","journal-title":"J Cell Mol Med"},{"key":"4024_CR61","doi-asserted-by":"publisher","first-page":"3040","DOI":"10.1021\/acs.nanolett.9b00287","volume":"19","author":"H Song","year":"2019","unstructured":"Song H, Li X, Zhao Z, et al. Reversal of osteoporotic activity by endothelial cell-secreted bone targeting and biocompatible exosomes. Nano Lett. 2019;19:3040\u20138.","journal-title":"Nano Lett"},{"issue":"1","key":"4024_CR62","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s12951-020-00601-w","volume":"18","author":"T Xu","year":"2020","unstructured":"Xu T, Luo Y, Wang J, et al. Exosomal miRNA-128-3p from mesenchymal stem cells of aged rats regulates osteogenesis and bone fracture healing by targeting Smad5. J Nanobiotechnology. 2020;18(1):47.","journal-title":"J Nanobiotechnology"},{"issue":"5","key":"4024_CR63","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1038\/s12276-021-00631-w","volume":"53","author":"Y Huang","year":"2021","unstructured":"Huang Y, Xu Y, Feng S, et al. miR-19b enhances osteogenic differentiation of mesenchymal stem cells and promotes fracture healing through the WWP1\/Smurf2-mediated KLF5\/\u03b2-catenin signaling pathway. Exp Mol Med. 2021;53(5):973\u201385.","journal-title":"Exp Mol Med"},{"issue":"18","key":"4024_CR64","doi-asserted-by":"publisher","first-page":"9499","DOI":"10.18632\/aging.205031","volume":"15","author":"J Liu","year":"2023","unstructured":"Liu J, Sun Z, You Y, et al. M2 macrophage-derived exosomal miR-486-5p influences the differentiation potential of bone marrow mesenchymal stem cells and osteoporosis. Aging (Albany NY). 2023;15(18):9499\u2013520.","journal-title":"Aging (Albany NY)"},{"key":"4024_CR65","doi-asserted-by":"publisher","first-page":"115627","DOI":"10.1016\/j.bone.2020.115627","volume":"141","author":"M Kang","year":"2020","unstructured":"Kang M, Huang CC, Lu Y, et al. Bone regeneration is mediated by macrophage extracellular vesicles. Bone. 2020;141:115627.","journal-title":"Bone"},{"key":"4024_CR66","doi-asserted-by":"publisher","first-page":"115627","DOI":"10.1016\/j.bone.2020.115627","volume":"141","author":"M Kang","year":"2020","unstructured":"Kang M, Huang CC, Lu Y, Shirazi S, Gajendrareddy P, Ravindran S, Cooper LF. Bone regeneration is mediated by macrophage extracellular vesicles. Bone. 2020;141:115627.","journal-title":"Bone"},{"issue":"4","key":"4024_CR67","doi-asserted-by":"publisher","first-page":"e1708","DOI":"10.1002\/wrna.1708","volume":"13","author":"CJ Ross","year":"2022","unstructured":"Ross CJ, Ulitsky I. Discovering functional motifs in long noncoding RNAs. Wiley Interdiscip Rev RNA. 2022;13(4):e1708.","journal-title":"Wiley Interdiscip Rev RNA"},{"issue":"1","key":"4024_CR68","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1186\/s12951-022-01655-8","volume":"20","author":"Y Tang","year":"2022","unstructured":"Tang Y, Sun Y, Zeng J, et al. Exosomal miR-140-5p inhibits osteogenesis by targeting IGF1R and regulating the mTOR pathway in ossification of the posterior longitudinal ligament. J Nanobiotechnology. 2022;20(1):452.","journal-title":"J Nanobiotechnology"},{"issue":"3","key":"4024_CR69","doi-asserted-by":"publisher","first-page":"e12056","DOI":"10.1002\/jev2.12056","volume":"10","author":"L Yu","year":"2021","unstructured":"Yu L, Sui B, Fan W, et al. Exosomes derived from osteogenic tumor activate osteoclast differentiation and concurrently inhibit osteogenesis by transferring COL1A1-targeting miRNA-92a-1-5p. J Extracell Vesicles. 2021;10(3):e12056.","journal-title":"J Extracell Vesicles"},{"issue":"6","key":"4024_CR70","doi-asserted-by":"publisher","first-page":"e1545","DOI":"10.1002\/wrna.1545","volume":"10","author":"T Hirose","year":"2019","unstructured":"Hirose T, Yamazaki T, Nakagawa S. Molecular anatomy of the architectural NEAT1 noncoding RNA: the domains, interactors, and biogenesis pathway required to build phase-separated nuclear paraspeckles. Wiley Interdiscip Rev RNA. 2019;10(6):e1545.","journal-title":"Wiley Interdiscip Rev RNA"},{"issue":"1","key":"4024_CR71","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/s41572-021-00289-8","volume":"7","author":"B Wildemann","year":"2021","unstructured":"Wildemann B, Ignatius A, Leung F, et al. Non-union bone fractures. Nat Rev Dis Primers. 2021;7(1):57.","journal-title":"Nat Rev Dis Primers"},{"issue":"3","key":"4024_CR72","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1111\/jcmm.16273","volume":"25","author":"Y Wang","year":"2021","unstructured":"Wang Y, Chen W, Zhao L, et al. Obesity regulates miR-467\/HoxA10 axis on osteogenic differentiation and fracture healing by BMSC-derived exosome LncRNA H19. J Cell Mol Med. 2021;25(3):1712\u201324.","journal-title":"J Cell Mol Med"},{"issue":"1","key":"4024_CR73","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1186\/s13287-019-1426-3","volume":"10","author":"R Zuo","year":"2019","unstructured":"Zuo R, Kong L, Wang M, et al. Exosomes derived from human CD34+ stem cells transfected with miR-26a prevent glucocorticoid-induced osteonecrosis of the femoral head by promoting angiogenesis and osteogenesis. Stem Cell Res Ther. 2019;10(1):321.","journal-title":"Stem Cell Res Ther"},{"issue":"41","key":"4024_CR74","doi-asserted-by":"publisher","first-page":"5508","DOI":"10.1038\/s41388-018-0359-0","volume":"37","author":"B Li","year":"2018","unstructured":"Li B, Xu H, Han H, et al. Exosome-mediated transfer of lncRUNX2-AS1 from multiple myeloma cells to MSCs contributes to osteogenesis. Oncogene. 2018;37(41):5508\u201319.","journal-title":"Oncogene"},{"issue":"2","key":"4024_CR75","doi-asserted-by":"publisher","first-page":"e22115","DOI":"10.1096\/fj.202101106RR","volume":"36","author":"L Ren","year":"2022","unstructured":"Ren L, Zeng F, Deng J, Bai Y, Chen K, Chen L, Sun L. Inflammatory osteoclasts-derived exosomes promote bone formation by selectively transferring lncRNA LIOCE into osteoblasts to interact with and stabilize Osterix. FASEB J. 2022;36(2):e22115.","journal-title":"FASEB J"},{"issue":"1","key":"4024_CR76","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s12951-023-01855-w","volume":"21","author":"Y Chen","year":"2023","unstructured":"Chen Y, Wu Y, Guo L, et al. Exosomal Lnc NEAT1 from endothelial cells promote bone regeneration by regulating macrophage polarization via DDX3X\/NLRP3 axis. J Nanobiotechnology. 2023;21(1):98.","journal-title":"J Nanobiotechnology"},{"key":"4024_CR77","doi-asserted-by":"crossref","unstructured":"ACOG Committee on Clinical Practice Guidelines-Gynecology. Management of Postmenopausal Osteoporosis: ACOG Clinical Practice Guideline No. 2. Obstet Gynecol. 2022;139(4):698\u2013717;","DOI":"10.1097\/AOG.0000000000004730"},{"issue":"1","key":"4024_CR78","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/s13287-021-02214-y","volume":"12","author":"F Zhi","year":"2021","unstructured":"Zhi F, Ding Y, Wang R, et al. Exosomal hsa_circ_0006859 is a potential biomarker for postmenopausal osteoporosis and enhances adipogenic versus osteogenic differentiation in human bone marrow mesenchymal stem cells by sponging miR-431-5p. Stem Cell Res Ther. 2021;12(1):157.","journal-title":"Stem Cell Res Ther"},{"issue":"3","key":"4024_CR79","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.3390\/ijms24032785","volume":"24","author":"S Ma","year":"2023","unstructured":"Ma S, Li S, Zhang Y, et al. BMSC-derived exosomal CircHIPK3 promotes osteogenic differentiation of MC3T3-E1 cells via mitophagy. Int J Mol Sci. 2023;24(3):2785.","journal-title":"Int J Mol Sci"},{"key":"4024_CR80","doi-asserted-by":"crossref","unstructured":"Perez MO, Pedro P, Lyrio AM, et al. Osteoporosis and fracture risk assessment: improving outcomes in postmenopausal women. Rev Assoc Med Bras (1992). 2023. 69(suppl 1): e2023S130;","DOI":"10.1590\/1806-9282.2023s130"},{"key":"4024_CR81","doi-asserted-by":"crossref","unstructured":"Ramchand SK, Leder BZ. Sequential therapy for the long-term treatment of postmenopausal osteoporosis. J Clin Endocrinol Metab. 2023: dgad496 [pii];","DOI":"10.1210\/clinem\/dgad496"},{"issue":"9","key":"4024_CR82","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1016\/j.clnu.2023.07.022","volume":"42","author":"Z Wang","year":"2023","unstructured":"Wang Z, Wu J, Li L, et al. Eicosapentaenoic acid supplementation modulates the osteoblast\/osteoclast balance in inflammatory environments and protects against estrogen deficiency-induced bone loss in mice. Clin Nutr. 2023;42(9):1715\u201327.","journal-title":"Clin Nutr"},{"issue":"6","key":"4024_CR83","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1002\/jor.25776","volume":"42","author":"F Li","year":"2024","unstructured":"Li F, Zhao X, Zhang Y, et al. Exosomal circFAM63Bsuppresses bone regeneration of postmenopausal osteoporosis via regulating miR-578\/HMGA2 axis. J Orthop Res. 2024;42(6):1244\u201353.","journal-title":"J Orthop Res"},{"issue":"1","key":"4024_CR84","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1080\/21655979.2021.2019871","volume":"13","author":"L Han","year":"2022","unstructured":"Han L, Liu H, Fu H, et al. Exosome-delivered BMP-2 and polyaspartic acid promotes tendon bone healing in rotator cuff tear via Smad\/RUNX2 signaling pathway. Bioengineered. 2022;13(1):1459\u201375.","journal-title":"Bioengineered"},{"issue":"1","key":"4024_CR85","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s10020-023-00649-y","volume":"29","author":"Y Li","year":"2023","unstructured":"Li Y, Wang X, Pan C, et al. Myoblast-derived exosomal Prrx2 attenuates osteoporosis via transcriptional regulation of lncRNA-MIR22HG to activate Hippo pathway. Mol Med. 2023;29(1):54.","journal-title":"Mol Med"},{"issue":"12","key":"4024_CR86","doi-asserted-by":"publisher","first-page":"3688","DOI":"10.3390\/nu12123688","volume":"12","author":"A Abate","year":"2020","unstructured":"Abate A, Cavagnetto D, Fama A, Maspero C, Farronato G. Relationship between breastfeeding and malocclusion: a systematic review of the literature. Nutrients. 2020;12(12):3688.","journal-title":"Nutrients"},{"issue":"33","key":"4024_CR87","doi-asserted-by":"publisher","first-page":"e29247","DOI":"10.1097\/MD.0000000000029247","volume":"101","author":"S Matsuda","year":"2022","unstructured":"Matsuda S, Yamaguchi T, Mikami S, et al. Can malocclusion provide clinicians with information for differential diagnosis of temporomandibular joint diseases? A review. Medicine (Baltimore). 2022;101(33):e29247.","journal-title":"Medicine (Baltimore)"},{"issue":"4","key":"4024_CR88","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.det.2020.05.002","volume":"38","author":"JM Laudenbach","year":"2020","unstructured":"Laudenbach JM, Kumar SS. Common dental and periodontal diseases. Dermatol Clin. 2020;38(4):413\u201320.","journal-title":"Dermatol Clin"},{"key":"4024_CR89","doi-asserted-by":"crossref","unstructured":"El-Angbawi A, McIntyre G, Fleming PS, et al. Non-surgical adjunctive interventions for accelerating tooth movement in patients undergoing orthodontic treatment. Cochrane Database Syst Rev. 2023;6(6):CD010887;","DOI":"10.1002\/14651858.CD010887.pub3"},{"key":"4024_CR90","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1177\/00220345211016285","volume":"101","author":"S Chaushu","year":"2022","unstructured":"Chaushu S, Klein Y, Mandelboim O, et al. Immune changes induced by orthodontic forces: a critical review. J Dent Res. 2022;101:11\u201320.","journal-title":"J Dent Res"},{"issue":"1","key":"4024_CR91","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s12951-023-01836-z","volume":"21","author":"P Pu","year":"2023","unstructured":"Pu P, Wu S, Zhang K, et al. Mechanical force induces macrophage-derived exosomal UCHL3 promoting bone marrow mesenchymal stem cell osteogenesis by targeting SMAD1. J Nanobiotechnology. 2023;21(1):88.","journal-title":"J Nanobiotechnology"},{"issue":"10","key":"4024_CR92","doi-asserted-by":"publisher","first-page":"e12890","DOI":"10.1111\/cpr.12890","volume":"53","author":"S Yang","year":"2020","unstructured":"Yang S, Guo S, Tong S, et al. Exosomal miR-130a-3p regulates osteogenic differentiation of Human Adipose-Derived stem cells through mediating SIRT7\/Wnt\/\u03b2-catenin axis. Cell Prolif. 2020;53(10):e12890.","journal-title":"Cell Prolif"},{"key":"4024_CR93","doi-asserted-by":"publisher","first-page":"109504","DOI":"10.1016\/j.cellsig.2019.109504","volume":"70","author":"JX Yang","year":"2020","unstructured":"Yang JX, Xie P, Li YS, et al. Osteoclast-derived miR-23a-5p-containing exosomes inhibit osteogenic differentiation by regulating Runx2. Cell Signal. 2020;70:109504.","journal-title":"Cell Signal"},{"issue":"18","key":"4024_CR94","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1042\/CS20181064","volume":"133","author":"W Liao","year":"2019","unstructured":"Liao W, Ning Y, Xu HJ, et al. BMSC-derived exosomes carrying microRNA-122-5p promote proliferation of osteoblasts in osteonecrosis of the femoral head. Clin Sci (Lond). 2019;133(18):1955\u201375.","journal-title":"Clin Sci (Lond)"},{"issue":"6","key":"4024_CR95","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1111\/jre.13187","volume":"58","author":"Z Zhang","year":"2023","unstructured":"Zhang Z, Wang P, Zheng Y, et al. Exosomal microRNA-223 from neutrophil-like cells inhibits osteogenic differentiation of PDLSCs through the cGMP-PKG signaling pathway. J Periodontal Res. 2023;58(6):1315\u201325.","journal-title":"J Periodontal Res"},{"issue":"1","key":"4024_CR96","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1186\/s13287-020-01815-3","volume":"11","author":"PY Lv","year":"2020","unstructured":"Lv PY, Gao PF, Tian GJ, et al. Osteocyte-derived exosomes induced by mechanical strain promote human periodontal ligament stem cell proliferation and osteogenic differentiation via the miR-181b-5p\/PTEN\/AKT signaling pathway. Stem Cell Res Ther. 2020;11(1):295.","journal-title":"Stem Cell Res Ther"},{"issue":"5","key":"4024_CR97","doi-asserted-by":"publisher","first-page":"e12669","DOI":"10.1111\/cpr.12669","volume":"52","author":"S Chen","year":"2019","unstructured":"Chen S, Tang Y, Liu Y, et al. Exosomes derived from miR-375-overexpressing human adipose mesenchymal stem cells promote bone regeneration. Cell Prolif. 2019;52(5):e12669.","journal-title":"Cell Prolif"},{"issue":"Pt B","key":"4024_CR98","doi-asserted-by":"publisher","first-page":"111190","DOI":"10.1016\/j.intimp.2023.111190","volume":"125","author":"Z Li","year":"2023","unstructured":"Li Z, Zhang B, Shang J, et al. Diabetic and nondiabetic BMSC-derived exosomes affect bone regeneration via regulating miR-17-5p\/SMAD7 axis. Int Immunopharmacol. 2023;125(Pt B):111190.","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"4024_CR99","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s12951-022-01267-2","volume":"20","author":"N Wang","year":"2022","unstructured":"Wang N, Liu X, Tang Z, et al. Increased BMSC exosomal miR-140-3p alleviates bone degradation and promotes bone restoration by targeting Plxnb1 in diabetic rats. J Nanobiotechnology. 2022;20(1):97.","journal-title":"J Nanobiotechnology"},{"issue":"1","key":"4024_CR100","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1186\/s13287-021-02438-y","volume":"12","author":"W Yang","year":"2021","unstructured":"Yang W, Zhu W, Yang Y, et al. Exosomal miR-100-5p inhibits osteogenesis of hBMSCs and angiogenesis of HUVECs by suppressing the BMPR2\/Smad1\/5\/9 signalling pathway. Stem Cell Res Ther. 2021;12(1):390.","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"4024_CR101","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s10020-021-00268-5","volume":"27","author":"Z Cao","year":"2021","unstructured":"Cao Z, Wu Y, Yu L, et al. Exosomal miR-335 derived from mature dendritic cells enhanced mesenchymal stem cell-mediated bone regeneration of bone defects in athymic rats. Mol Med. 2021;27(1):20.","journal-title":"Mol Med"},{"issue":"1","key":"4024_CR102","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1186\/s12951-021-00958-6","volume":"19","author":"D Wu","year":"2021","unstructured":"Wu D, Chang X, Tian J, et al. Bone mesenchymal stem cells stimulation by magnetic nanoparticles and a static magnetic field: release of exosomal miR-1260a improves osteogenesis and angiogenesis. J Nanobiotechnology. 2021;19(1):209.","journal-title":"J Nanobiotechnology"},{"issue":"18","key":"4024_CR103","doi-asserted-by":"publisher","first-page":"3727","DOI":"10.2147\/IJN.S413692","volume":"7","author":"L Pan","year":"2023","unstructured":"Pan L, Zhang C, Zhang H, et al. Osteoclast-derived exosomal miR-5134-5p interferes with alveolar bone homeostasis by targeting the JAK2\/STAT3 axis. Int J Nanomedicine. 2023;7(18):3727\u201344.","journal-title":"Int J Nanomedicine"},{"issue":"12","key":"4024_CR104","doi-asserted-by":"publisher","first-page":"831420","DOI":"10.3389\/fgene.2021.831420","volume":"3","author":"Y Yang","year":"2022","unstructured":"Yang Y, Miao L, Chang S, et al. Exosome-derived LncRNA TCONS_00072128 mediated osteogenic differentiation and inflammation by caspase 8 regulation. Front Genet. 2022;3(12):831420.","journal-title":"Front Genet"},{"key":"4024_CR105","unstructured":"Dong JC, Liao Y, Zhou W, et al. Porphyromonas gingivalis LPS-stimulated BMSC-derived exosome promotes osteoclastogenesis via miR-151\u20133p\/PAFAH1B1. Oral Dis;"},{"key":"4024_CR106","doi-asserted-by":"crossref","unstructured":"Xu J, Li D, Cai Z, et al. Exosomal lncRNAs NONMMUT000375.2 and NONMMUT071578.2 derived from titanium particle treated RAW264.7 cells regulate osteogenic differentiation of MC3T3-E1 cells. J Biomed Mater Res A. 2020;108(11):2251\u20132262;","DOI":"10.1002\/jbm.a.36983"},{"issue":"20","key":"4024_CR107","doi-asserted-by":"publisher","first-page":"8777","DOI":"10.18632\/aging.102264","volume":"11","author":"X Yang","year":"2019","unstructured":"Yang X, Yang J, Lei P, et al. LncRNA MALAT1 shuttled by bone marrow-derived mesenchymal stem cells-secreted exosomes alleviates osteoporosis through mediating microRNA-34c\/SATB2 axis. Aging (Albany NY). 2019;11(20):8777\u201391.","journal-title":"Aging (Albany NY)"},{"issue":"3","key":"4024_CR108","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1007\/s13577-023-00881-y","volume":"36","author":"W Li","year":"2023","unstructured":"Li W, Li L, Cui R, et al. Bone marrow mesenchymal stem cells derived exosomal Lnc TUG1 promotes bone fracture recovery via miR-22-5p\/Anxa8 axis. Hum Cell. 2023;36(3):1041\u201353.","journal-title":"Hum Cell"},{"issue":"8","key":"4024_CR109","doi-asserted-by":"publisher","first-page":"e493","DOI":"10.1002\/ctm2.493","volume":"11","author":"C Mo","year":"2021","unstructured":"Mo C, Huang B, Zhuang J, et al. LncRNA nuclear-enriched abundant transcript 1 shuttled by prostate cancer cells-secreted exosomes initiates osteoblastic phenotypes in the bone metastatic microenvironment via miR-205-5p\/runt-related transcription factor 2\/splicing factor proline- and glutamine-rich\/polypyrimidine tract-binding protein 2 axis. Clin Transl Med. 2021;11(8):e493.","journal-title":"Clin Transl Med"},{"issue":"2020","key":"4024_CR110","first-page":"6319395","volume":"28","author":"L Xie","year":"2020","unstructured":"Xie L, Guan Z, Zhang M, et al. Exosomal circLPAR1 promoted osteogenic differentiation of homotypic dental pulp stem cells by competitively binding to hsa-miR-31. Biomed Res Int. 2020;28(2020):6319395.","journal-title":"Biomed Res Int"},{"issue":"1","key":"4024_CR111","doi-asserted-by":"publisher","first-page":"397","DOI":"10.7150\/thno.50741","volume":"11","author":"Y Zha","year":"2021","unstructured":"Zha Y, Li Y, Lin T, et al. Progenitor cell-derived exosomes endowed with VEGF plasmids enhance osteogenic induction and vascular remodeling in large segmental bone defects. Theranostics. 2021;11(1):397\u2013409.","journal-title":"Theranostics"},{"issue":"1","key":"4024_CR112","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/s12951-022-01314-y","volume":"20","author":"X Chen","year":"2022","unstructured":"Chen X, Wan Z, Yang L, et al. Exosomes derived from reparative M2-like macrophages prevent bone loss in murine periodontitis models via IL-10 mRNA. J Nanobiotechnology. 2022;20(1):110.","journal-title":"J Nanobiotechnology"},{"issue":"2021","key":"4024_CR113","doi-asserted-by":"publisher","first-page":"5542241","DOI":"10.1155\/2021\/5542241","volume":"27","author":"Z Guo","year":"2021","unstructured":"Guo Z, Su W, Zhou R, et al. Exosomal MATN3 of urine-derived stem cells ameliorates intervertebral disc degeneration by antisenescence effects and promotes NPC proliferation and ECM synthesis by activating TGF-\u03b2. Oxid Med Cell Longev. 2021;27(2021):5542241.","journal-title":"Oxid Med Cell Longev"},{"key":"4024_CR114","doi-asserted-by":"publisher","first-page":"116933","DOI":"10.1016\/j.bone.2023.116933","volume":"178","author":"Y Leng","year":"2024","unstructured":"Leng Y, Li J, Long Z, et al. Osteoblast-derived exosomes promote osteogenic differentiation of osteosarcoma cells via URG4\/Wnt signaling pathway. Bone. 2024;178:116933.","journal-title":"Bone"},{"issue":"31","key":"4024_CR115","first-page":"192","volume":"12","author":"YK Zhou","year":"2023","unstructured":"Zhou YK, Han CS, Zhu ZL, et al. M2 exosomes modified by hydrogen sulfide promoted bone regeneration by moesin mediated endocytosis. Bioact Mater. 2023;12(31):192\u2013205.","journal-title":"Bioact Mater"},{"issue":"1","key":"4024_CR116","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s13287-023-03275-x","volume":"14","author":"Y Lu","year":"2023","unstructured":"Lu Y, Mai Z, Cui L, et al. Engineering exosomes and biomaterial-assisted exosomes as therapeutic carriers for bone regeneration. Stem Cell Res Ther. 2023;14(1):55.","journal-title":"Stem Cell Res Ther"},{"issue":"16","key":"4024_CR117","doi-asserted-by":"publisher","first-page":"e2201989","DOI":"10.1002\/adhm.202201989","volume":"12","author":"Y Yao","year":"2023","unstructured":"Yao Y, Jiang Y, Song J, et al. Exosomes as potential functional nanomaterials for tissue engineering. Adv Healthc Mater. 2023;12(16):e2201989.","journal-title":"Adv Healthc Mater"},{"issue":"12","key":"4024_CR118","doi-asserted-by":"publisher","first-page":"4266","DOI":"10.7150\/thno.84971","volume":"13","author":"Q Li","year":"2023","unstructured":"Li Q, Fu X, Kou Y, et al. Engineering strategies and optimized delivery of exosomes for theranostic application in nerve tissue. Theranostics. 2023;13(12):4266\u201386.","journal-title":"Theranostics"},{"issue":"1","key":"4024_CR119","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/s12951-023-01871-w","volume":"21","author":"Z Yang","year":"2023","unstructured":"Yang Z, Li X, Gan X, et al. Hydrogel armed with Bmp2 mRNA-enriched exosomes enhances bone regeneration. J Nanobiotechnology. 2023;21(1):119.","journal-title":"J Nanobiotechnology"},{"issue":"2","key":"4024_CR120","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.cell.2022.12.031","volume":"186","author":"L Biswas","year":"2023","unstructured":"Biswas L, Chen J, De Angelis J, et al. Lymphatic vessels in bone support regeneration after injury. Cell. 2023;186(2):382-397.e24.","journal-title":"Cell"},{"issue":"1","key":"4024_CR121","doi-asserted-by":"publisher","first-page":"426","DOI":"10.7150\/thno.34126","volume":"10","author":"Y Peng","year":"2020","unstructured":"Peng Y, Wu S, Li Y, et al. Type H blood vessels in bone modeling and remodeling. Theranostics. 2020;10(1):426\u201336.","journal-title":"Theranostics"},{"key":"4024_CR122","doi-asserted-by":"publisher","first-page":"106798","DOI":"10.1016\/j.phrs.2023.106798","volume":"192","author":"Q Zhu","year":"2023","unstructured":"Zhu Q, Tang Y, Zhou T, et al. Exosomes derived from mesenchymal stromal cells promote bone regeneration by delivering miR-182-5p-inhibitor. Pharmacol Res. 2023;192:106798.","journal-title":"Pharmacol Res"},{"issue":"15\u201316","key":"4024_CR123","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1089\/ten.tea.2018.0257","volume":"25","author":"SY Choi","year":"2019","unstructured":"Choi SY, Han EC, Hong SH, et al. Regulating osteogenic differentiation by suppression of exosomal microRNAs. Tissue Eng Part A. 2019;25(15\u201316):1146\u201354.","journal-title":"Tissue Eng Part A"},{"issue":"10","key":"4024_CR124","doi-asserted-by":"publisher","first-page":"3650","DOI":"10.1021\/acs.molpharmaceut.5b00364","volume":"12","author":"TN Lamichhane","year":"2015","unstructured":"Lamichhane TN, Raiker RS, Jay SM. Exogenous DNA loading into extracellular vesicles via electroporation is size-dependent and enables limited gene delivery. Mol Pharm. 2015;12(10):3650\u20137.","journal-title":"Mol Pharm"},{"issue":"17","key":"4024_CR125","doi-asserted-by":"publisher","first-page":"3111","DOI":"10.2174\/0929867328666210902142015","volume":"29","author":"Y Jiang","year":"2022","unstructured":"Jiang Y, Wang F, Wang K, et al. Engineered exosomes: a promising drug delivery strategy for brain diseases. Curr Med Chem. 2022;29(17):3111\u201324.","journal-title":"Curr Med Chem"},{"issue":"1","key":"4024_CR126","doi-asserted-by":"publisher","first-page":"5335","DOI":"10.1038\/s41598-019-41800-2","volume":"9","author":"GK Patel","year":"2019","unstructured":"Patel GK, Khan MA, Zubair H, et al. Comparative analysis of exosome isolation methods using culture supernatant for optimum yield, purity and downstream applications. Sci Rep. 2019;9(1):5335.","journal-title":"Sci Rep"},{"issue":"6","key":"4024_CR127","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1080\/07388551.2020.1785385","volume":"40","author":"J Donoso-Quezada","year":"2020","unstructured":"Donoso-Quezada J, Ayala-Mar S, Gonz\u00e1lez-Valdez J. State-of-the-art exosome loading and functionalization techniques for enhanced therapeutics: a review. Crit Rev Biotechnol. 2020;40(6):804\u201320.","journal-title":"Crit Rev Biotechnol"},{"issue":"10","key":"4024_CR128","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1038\/s41592-022-01487-2","volume":"19","author":"AF Nielsen","year":"2022","unstructured":"Nielsen AF, Bindereif A, Bozzoni I, et al. Best practice standards for circular RNA research. Nat Methods. 2022;19(10):1208\u201320.","journal-title":"Nat Methods"},{"key":"4024_CR129","doi-asserted-by":"publisher","first-page":"113775","DOI":"10.1016\/j.colsurfb.2024.113775","volume":"235","author":"S Zhang","year":"2024","unstructured":"Zhang S, Wang S, Chen J, et al. Human dental pulp stem cell-derived exosomes decorated titanium scaffolds for promoting bone regeneration. Colloids Surf B Biointerfaces. 2024;235:113775.","journal-title":"Colloids Surf B Biointerfaces"},{"key":"4024_CR130","doi-asserted-by":"crossref","unstructured":"Wu Z, Pu P, Su Z, et al. Schwann Cell-derived exosomes promote bone regeneration and repair by enhancing the biological activity of porous Ti6Al4V scaffolds. Biochem Biophys Res Commun. 2020;531(4):559\u2013565;","DOI":"10.1016\/j.bbrc.2020.07.094"},{"issue":"1","key":"4024_CR131","doi-asserted-by":"publisher","first-page":"130","DOI":"10.3892\/mmr.2023.13017","volume":"28","author":"F Yang","year":"2023","unstructured":"Yang F, Wu M, Chen H, et al. Combination therapy with BMSCs-exosomes and porous tantalum for the repair of femur supracondylar defects. Mol Med Rep. 2023;28(1):130.","journal-title":"Mol Med Rep"},{"issue":"23","key":"4024_CR132","doi-asserted-by":"publisher","first-page":"27486","DOI":"10.1021\/acsami.3c00898","volume":"15","author":"H Liu","year":"2023","unstructured":"Liu H, Gu R, Li W, et al. Engineering 3D-printed strontium-titanium scaffold-integrated highly bioactive serum exosomes for critical bone defects by osteogenesis and angiogenesis. ACS Appl Mater Interfaces. 2023;15(23):27486\u2013501.","journal-title":"ACS Appl Mater Interfaces"},{"issue":"4","key":"4024_CR133","first-page":"1113","volume":"5","author":"Z Shen","year":"2020","unstructured":"Shen Z, Kuang S, Zhang Y, et al. Chitosan hydrogel incorporated with dental pulp stem cell-derived exosomes alleviates periodontitis in mice via a macrophage-dependent mechanism. Bioact Mater. 2020;5(4):1113\u201326.","journal-title":"Bioact Mater"},{"issue":"9","key":"4024_CR134","doi-asserted-by":"publisher","first-page":"11973","DOI":"10.1021\/acsnano.0c05122","volume":"14","author":"J Fan","year":"2020","unstructured":"Fan J, Lee CS, Kim S, et al. Generation of small RNA-modulated exosome mimetics for bone regeneration. ACS Nano. 2020;14(9):11973\u201384.","journal-title":"ACS Nano"},{"key":"4024_CR135","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.addr.2019.08.006","volume":"146","author":"A Passi","year":"2019","unstructured":"Passi A, Vigetti D. Hyaluronan as tunable drug delivery system. Adv Drug Deliv Rev. 2019;146:83\u201396.","journal-title":"Adv Drug Deliv Rev"},{"key":"4024_CR136","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/j.ijbiomac.2021.08.140","volume":"189","author":"Y Fang","year":"2021","unstructured":"Fang Y, Shi L, Duan Z, et al. Hyaluronic acid hydrogels, as abiological macromolecule-based platform for stem cells delivery and their fate control: a review. Int J Biol Macromol. 2021;189:554\u201366.","journal-title":"Int J Biol Macromol"},{"issue":"1","key":"4024_CR137","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1055\/a-0991-7585","volume":"70","author":"E Ahmadian","year":"2020","unstructured":"Ahmadian E, Dizaj SM, Eftekhari A, et al. The potential applications of hyaluronic acid hydrogels in biomedicine. Drug Res (Stuttg). 2020;70(1):6\u201311.","journal-title":"Drug Res (Stuttg)"},{"key":"4024_CR138","doi-asserted-by":"publisher","first-page":"3393","DOI":"10.1039\/D2BM00397J","volume":"10","author":"YW Ding","year":"2022","unstructured":"Ding YW, Wang ZY, Ren ZW, et al. Advances in modified hyaluronic acid-based hydrogels for skin wound healing. Biomater Sci. 2022;10:3393\u2013409.","journal-title":"Biomater Sci"},{"key":"4024_CR139","doi-asserted-by":"publisher","first-page":"115640","DOI":"10.1016\/j.carbpol.2019.115640","volume":"230","author":"Y Zhou","year":"2020","unstructured":"Zhou Y, Gu Z, Liu J, et al. Arginine based poly (ester amide)\/hyaluronic acid hybrid hydrogels for bone tissue engineering. Carbohydr Polym. 2020;230:115640.","journal-title":"Carbohydr Polym"},{"issue":"25","key":"4024_CR140","doi-asserted-by":"publisher","first-page":"5441","DOI":"10.1039\/C9TB02796C","volume":"8","author":"Q Zhang","year":"2020","unstructured":"Zhang Q, Wei X, Ji Y, et al. Adjustable and ultrafast light-cured hyaluronic acid hydrogel: promoting biocompatibility and cell growth. J Mater Chem B. 2020;8(25):5441\u201350.","journal-title":"J Mater Chem B"},{"key":"4024_CR141","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.ijbiomac.2020.06.157","volume":"162","author":"B Ashwin","year":"2020","unstructured":"Ashwin B, Abinaya B, Prasith TP, et al. 3D-poly (lactic acid) scafolds coated with gelatin and mucic acid for bone tissue engineering. Int J Biol Macromol. 2020;162:523\u201332.","journal-title":"Int J Biol Macromol"},{"issue":"1","key":"4024_CR142","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s13036-022-00301-z","volume":"16","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Huo M, Wang Y, et al. A tailored bioactive 3D porous poly(lactic-acid)-exosome scaffold with osteo-immunomodulatory and osteogenic differentiation properties. J Biol Eng. 2022;16(1):22.","journal-title":"J Biol Eng"},{"issue":"18","key":"4024_CR143","first-page":"26","volume":"18","author":"Y Kang","year":"2022","unstructured":"Kang Y, Xu C, Meng L, et al. Exosome-functionalized magnesium-organic framework-based scaffolds with osteogenic, angiogenic and anti-inflammatory properties for accelerated bone regeneration. Bioact Mater. 2022;18(18):26\u201341.","journal-title":"Bioact Mater"},{"issue":"3","key":"4024_CR144","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1021\/acsbiomaterials.9b01363","volume":"6","author":"S Yang","year":"2020","unstructured":"Yang S, Zhu B, Yin P, et al. Integration of human umbilical cord mesenchymal stem cells-derived exosomes with hydroxyapatite-embedded hyaluronic acid-alginate hydrogel for bone regeneration. ACS Biomater Sci Eng. 2020;6(3):1590\u2013602.","journal-title":"ACS Biomater Sci Eng"},{"key":"4024_CR145","doi-asserted-by":"crossref","unstructured":"Qin Y, Sun R, Wu C, et al. Exosome: a novel approach to stimulate bone regeneration through regulation of osteogenesis and angiogenesis. Int J Mol Sci. 2016;17(5):712 mm","DOI":"10.3390\/ijms17050712"},{"issue":"3","key":"4024_CR146","doi-asserted-by":"publisher","first-page":"126","DOI":"10.3390\/jfb13030126","volume":"13","author":"X Luo","year":"2022","unstructured":"Luo X, Xiao D, Zhang C, Wang G. The roles of exosomes upon metallic ions stimulation in bone regeneration. J Funct Biomater. 2022;13(3):126.","journal-title":"J Funct Biomater"},{"issue":"24","key":"4024_CR147","doi-asserted-by":"publisher","first-page":"7123","DOI":"10.1007\/s00216-022-04253-7","volume":"414","author":"WZ Liu","year":"2022","unstructured":"Liu WZ, Ma ZJ, Kang XW. Current status and outlook of advances in exosome isolation. Anal Bioanal Chem. 2022;414(24):7123\u201341.","journal-title":"Anal Bioanal Chem"},{"issue":"19","key":"4024_CR148","doi-asserted-by":"publisher","first-page":"e2400293","DOI":"10.1002\/adhm.202400293","volume":"13","author":"F Zhu","year":"2024","unstructured":"Zhu F, Wang T, Wang G, et al. The exosome-mediated bone regeneration: an advanced horizon toward the isolation, engineering, carrying modalities, and mechanisms. Adv Healthc Mater. 2024;13(19):e2400293.","journal-title":"Adv Healthc Mater"},{"issue":"15","key":"4024_CR149","doi-asserted-by":"publisher","first-page":"e2103222","DOI":"10.1002\/advs.202103222","volume":"9","author":"JJ Lai","year":"2022","unstructured":"Lai JJ, Chau ZL, Chen SY, et al. Exosome processing and characterization approaches for research and technology development. Adv Sci (Weinh). 2022;9(15):e2103222.","journal-title":"Adv Sci (Weinh)"},{"issue":"3","key":"4024_CR150","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1007\/s11010-023-04756-6","volume":"479","author":"M Omrani","year":"2024","unstructured":"Omrani M, Beyrampour-Basmenj H, Jahanban-Esfahlan R, et al. Global trend in exosome isolation and application: an update concept in management of diseases. Mol Cell Biochem. 2024;479(3):679\u201391.","journal-title":"Mol Cell Biochem"},{"issue":"19","key":"4024_CR151","doi-asserted-by":"publisher","first-page":"4684","DOI":"10.3390\/ijms20194684","volume":"20","author":"N Ludwig","year":"2019","unstructured":"Ludwig N, Whiteside TL, Reichert TE. Challenges in exosome isolation and analysis in health and disease. Int J Mol Sci. 2019;20(19):4684.","journal-title":"Int J Mol Sci"},{"key":"4024_CR152","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.jconrel.2022.05.027","volume":"347","author":"I Kimiz-Gebologlu","year":"2022","unstructured":"Kimiz-Gebologlu I, Oncel SS. Exosomes: Large-scale production, isolation, drug loading efficiency, and biodistribution and uptake. J Control Release. 2022;347:533\u201343.","journal-title":"J Control Release"}],"container-title":["Stem Cell Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-024-04024-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13287-024-04024-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-024-04024-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T17:04:58Z","timestamp":1731431098000},"score":1,"resource":{"primary":{"URL":"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/s13287-024-04024-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,9]]},"references-count":152,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["4024"],"URL":"https:\/\/doi.org\/10.1186\/s13287-024-04024-4","relation":{},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,9]]},"assertion":[{"value":"16 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"407"}}