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Human pluripotent stem cell experiments were approved by the Embryonic Stem Cell Oversight Committee at the Pennsylvania State University on November 5, 2020. Title of the approved project is \u201cDirected Differentiation of Human Pluripotent Stem Cells\u201d with an approval number 48399. The authors carried out experiments in accordance with the approved guidelines. Both H9 and 6\u20139-9 hPSC lines were obtained from WiCell. The H9 cells were obtained under the MTA # 16-W0407 between Penn State and WiCell. H9 cell line was reported in Thomson, et al., Science, 282(5391):1145\u20137, 1998. The 6\u20139-9 cells were obtained under the MTA # 20-W0024 between Penn State and WiCell. This line was first reported in Yu et al., Science, 324(5928):797\u2013801, 2009. These two source papers claimed the ethical approval for collection of human cells, and the donors had signed informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"32"}}