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The procedure for obtaining human cells from hospitals was approved by the ethics committee of School of Stomatology Capital Medical University (Approval Number: CMUSH-IRB-KJ-PJ-2023-06; Title: m6A methylation regulates the regeneration of apical papilla stem cells; Date of approval: 02\/13\/2023). Informed consent was signed prior to the study. All the animal experiments are performed at Beijing Laboratory of Oral Health and approved under the project of \u201cm6A methylation regulates the regeneration of apical papilla stem cells\u201d by the Ethic Committee of School of Stomatology Capital Medical University. 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