{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T04:19:31Z","timestamp":1794457171422,"version":"4.9.1"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T00:00:00Z","timestamp":1751760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T00:00:00Z","timestamp":1751760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["FONDEF ID21I10077"],"award-info":[{"award-number":["FONDEF ID21I10077"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["FONDECYT 1241624"],"award-info":[{"award-number":["FONDECYT 1241624"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["FONDECYT 1221522"],"award-info":[{"award-number":["FONDECYT 1221522"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["FONDEQUIP EQM170111"],"award-info":[{"award-number":["FONDEQUIP EQM170111"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"DOI":"10.1186\/s13287-025-04415-1","type":"journal-article","created":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T14:06:19Z","timestamp":1751810779000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Novel sponge formulation of mesenchymal stem cell secretome and hyaluronic acid: a safe and effective topical therapy for Psoriasis vulgaris"],"prefix":"10.1186","volume":"16","author":[{"given":"Estefan\u00eda","family":"Elgueta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina P.","family":"Prieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Carrillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constanza","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara","family":"Casas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Vergara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Valenzuela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Catal\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Lattus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Oyarzun-Ampuero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Palma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,6]]},"reference":[{"issue":"1","key":"4415_CR1","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1186\/s13287-024-03800-6","volume":"15","author":"A Jafarzadeh","year":"2024","unstructured":"Jafarzadeh A, Pour Mohammad A, Keramati H, Zeinali R, Khosravi M, Goodarzi A. Regenerative medicine in the treatment of specific dermatologic disorders: a systematic review of randomized controlled clinical trials. Stem Cell Res Ther. 2024;15(1):176. https:\/\/doi.org\/10.1186\/s13287-024-03800-6. PMID: 38886861; PMCID: PMC11184747.","journal-title":"Stem Cell Res Ther"},{"key":"4415_CR2","doi-asserted-by":"publisher","first-page":"m1590","DOI":"10.1136\/bmj.m1590","volume":"28","author":"R Parisi","year":"2020","unstructured":"Parisi R, Iskandar IYK, Kontopantelis E, Augustin M, Griffiths CEM, Ashcroft DM. Global psoriasis atlas. National, regional, and worldwide epidemiology of psoriasis: systematic analysis and modelling study. BMJ. 2020;28:369:m1590.","journal-title":"BMJ"},{"issue":"19","key":"4415_CR3","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1001\/jama.2020.4006","volume":"323","author":"AW Armstrong","year":"2020","unstructured":"Armstrong AW, Read C, Pathophysiology. Clinical presentation, and treatment of psoriasis: A review. JAMA. 2020;323(19):1945\u201360.","journal-title":"JAMA"},{"issue":"6","key":"4415_CR4","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1111\/1346-8138.15840","volume":"48","author":"F Yamazaki","year":"2021","unstructured":"Yamazaki F, Psoriasis. Comorbidities J Dermatol. 2021;48(6):732\u201340.","journal-title":"Comorbidities J Dermatol"},{"issue":"9583","key":"4415_CR5","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/S0140-6736(07)61128-3","volume":"370","author":"CE Griffiths","year":"2007","unstructured":"Griffiths CE, Barker JN. Pathogenesis and clinical features of psoriasis. Lancet. 2007;370(9583):263\u201371.","journal-title":"Lancet"},{"key":"4415_CR6","doi-asserted-by":"publisher","first-page":"788940","DOI":"10.3389\/fimmu.2021.788940","volume":"15","author":"P Hu","year":"2021","unstructured":"Hu P, Wang M, Gao H, Zheng A, Li J, Mu D, Tong J. The role of helper T cells in psoriasis. Front Immunol. 2021;15:12:788940.","journal-title":"Front Immunol"},{"issue":"1","key":"4415_CR7","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s40659-020-00316-0","volume":"53","author":"J Gao","year":"2020","unstructured":"Gao J, Chen F, Fang H, Mi J, Qi Q, Yang M. Daphnetin inhibits proliferation and inflammatory response in human HaCaT keratinocytes and ameliorates imiquimod-induced psoriasis-like skin lesion in mice. Biol Res. 2020;53(1):48.","journal-title":"Biol Res"},{"issue":"1","key":"4415_CR8","doi-asserted-by":"publisher","first-page":"29","DOI":"10.4103\/ijd.IJD_327_18","volume":"65","author":"B Kiafar","year":"2020","unstructured":"Kiafar B, Binabaj MM, Jafarian AH, Khazan Z, Hashemy SI. The relationship between tissue thioredoxin reductase activity and the psoriasis area and severity index. Indian J Dermatol. 2020;65(1):29\u201332.","journal-title":"Indian J Dermatol"},{"issue":"7","key":"4415_CR9","first-page":"651","volume":"11","author":"D Maroto-Morales","year":"2021","unstructured":"Maroto-Morales D, Montero-Vilchez T, Arias-Santiago S. Study of skin barrier function in psoriasis: the impact of emollients. Life (Basel). 2021;11(7):651.","journal-title":"Life (Basel)"},{"issue":"2","key":"4415_CR10","doi-asserted-by":"publisher","first-page":"359","DOI":"10.3390\/jcm10020359","volume":"10","author":"T Montero-Vilchez","year":"2021","unstructured":"Montero-Vilchez T, Segura-Fern\u00e1ndez-Nogueras MV, P\u00e9rez-Rodr\u00edguez I, et al. Skin barrier function in psoriasis and atopic dermatitis: transepidermal water loss and temperature as useful tools to assess disease severity. J Clin Med. 2021;10(2):359.","journal-title":"J Clin Med"},{"key":"4415_CR11","first-page":"306","volume":"1","author":"R Fitoussi","year":"2022","unstructured":"Fitoussi R, Faure MO, Beauchef G, Achard S. Human skin responses to environmental pollutants: A review of current scientific models. Environ Pollut. 2022;1:306\u2013119316.","journal-title":"Environ Pollut"},{"issue":"10","key":"4415_CR12","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1111\/exd.14635","volume":"31","author":"M Green","year":"2022","unstructured":"Green M, Feschuk AM, Kashetsky N, Maibach HI. Normal TEWL-how can it be defined? A systematic review. Exp Dermatol. 2022;31(10):1618\u201331.","journal-title":"Exp Dermatol"},{"issue":"11","key":"4415_CR13","doi-asserted-by":"publisher","first-page":"771","DOI":"10.2165\/00128071-200304110-00005","volume":"4","author":"M Lod\u00e9n","year":"2003","unstructured":"Lod\u00e9n M. Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. Am J Clin Dermatol. 2003;4(11):771\u201388.","journal-title":"Am J Clin Dermatol"},{"key":"4415_CR14","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1186\/s13287-022-03091-9","volume":"13","author":"M Yang","year":"2020","unstructured":"Yang M, Wang L, Chen Z, et al. Topical administration of the secretome derived from human amniotic epithelial cells ameliorates psoriasis-like skin lesions in mice. Stem Cell Res Ther. 2020;13:393.","journal-title":"Stem Cell Res Ther"},{"issue":"12","key":"4415_CR15","doi-asserted-by":"publisher","first-page":"10132","DOI":"10.3390\/ijms241210132","volume":"24","author":"N Cuesta-Gomez","year":"2023","unstructured":"Cuesta-Gomez N, Medina-Ruiz L, Graham GJ, Campbell JDM. IL-6 and TGF-\u03b2-Secreting Adoptively-Transferred murine mesenchymal stromal cells accelerate healing of Psoriasis-like skin inflammation and upregulate IL-17A and TGF-\u03b2. Int J Mol Sci. 2023;24(12):10132.","journal-title":"Int J Mol Sci"},{"issue":"7","key":"4415_CR16","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1111\/ced.14269","volume":"45","author":"A Paganelli","year":"2020","unstructured":"Paganelli A, Tarentini E, Benassi L, Kaleci S, Magnoni C. Mesenchymal stem cells for the treatment of psoriasis: a comprehensive review. Clin Exp Dermatol. 2020;45(7):824\u201330.","journal-title":"Clin Exp Dermatol"},{"issue":"1","key":"4415_CR17","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/s41392-022-01059-y","volume":"7","author":"L Cheng","year":"2022","unstructured":"Cheng L, Wang S, Peng C, Zou X, Yang C, Mei H, et al. Human umbilical cord mesenchymal stem cells for psoriasis: a phase 1\/2a, single-arm study. Signal Transduct Target Ther. 2022;7(1):263.","journal-title":"Signal Transduct Target Ther"},{"issue":"23","key":"4415_CR18","doi-asserted-by":"publisher","first-page":"15080","DOI":"10.3390\/ijms232315080","volume":"23","author":"F Diotallevi","year":"2022","unstructured":"Diotallevi F, Di Vincenzo M, Martina E, Radi G, Lariccia V, Offidani A, Orciani M, Campanati A. Mesenchymal stem cells and psoriasis: systematic review. Int J Mol Sci. 2022;23(23):15080.","journal-title":"Int J Mol Sci"},{"key":"4415_CR19","doi-asserted-by":"crossref","first-page":"683040","DOI":"10.3389\/fphar.2021.753140","volume":"12","author":"S Yoon","year":"2021","unstructured":"Yoon S, Kim H, Lee K, Park B, Choi J, Cho S. Adipose-Derived mesenchymal stem cell conditioned medium ameliorates skin lesions in atopic dermatitis model rats. Front Pharmacol. 2021;12:683040.","journal-title":"Front Pharmacol"},{"issue":"2","key":"4415_CR20","doi-asserted-by":"publisher","first-page":"e10443","DOI":"10.1002\/btm2.10443","volume":"8","author":"D Carrillo","year":"2023","unstructured":"Carrillo D, Edwards N, Arancibia-Altamirano D, Ot\u00e1rola F, Villarroel C, Prieto CP, Villamizar-Sarmiento MG, et al. Efficacy of stem cell secretome loaded in hyaluronate sponge for topical treatment of psoriasis. Bioeng Transl Med. 2023;8(2):e10443.","journal-title":"Bioeng Transl Med"},{"issue":"4","key":"4415_CR21","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.abd.2021.10.002","volume":"97","author":"PP Naik","year":"2022","unstructured":"Naik PP. Stem cell therapy as a potential treatment option for psoriasis. Bras Dermatol. 2022;97(4):471\u20137.","journal-title":"Bras Dermatol"},{"key":"4415_CR22","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1515\/pac-2016-1111","volume":"90","author":"S Orellana","year":"2018","unstructured":"Orellana S, Giacaman A, Vidal A, Morales C, Oyarzun-Ampuero F, Lisoni J, Henr\u00edquez-B\u00e1ez C, Mor\u00e1n-Trujillo L, Miguel C, Moreno-Villoslada I. Chitosan\/chondroitin sulfate aerogels with high polymeric electroneutralization degree: formation and mechanical properties. Pure Appl Chemi. 2018;90:901\u201311. https:\/\/doi.org\/10.1515\/pac-2016-1111.","journal-title":"Pure Appl Chemi"},{"key":"4415_CR23","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1097\/MJT.0b013e318235f309","volume":"20","author":"A Vidal","year":"2013","unstructured":"Vidal A, Giacaman A, Oyarzun-Ampuero FA, Orellana S, Aburto I, Pavicic MF, Sanchez A, Lopez C, Morales C, Caro M, et al. Therapeutic potential of a low-cost device for wound healing: A study of three cases of healing after lower-extremity amputation in patients with diabetes. Am J. 2013;20:394\u20138. https:\/\/doi.org\/10.1097\/MJT.0b013e318235f309.","journal-title":"Am J"},{"key":"4415_CR24","doi-asserted-by":"publisher","first-page":"13208","DOI":"10.1021\/acs.jpcb.5b05963","volume":"119","author":"L Sanhueza","year":"2015","unstructured":"Sanhueza L, Castro J, Urz\u00faa E, Barrientos L, Oyarzun-Ampuero F, Pesenti H, Shibue T, Sugimura N, Tomita W, Nishide H, et al. Photochromic solid materials based on Poly(decylviologen) complexed with alginate and Poly (sodium 4-styrenesulfonate. J Phys Chem B. 2015;119:13208\u201317. https:\/\/doi.org\/10.1021\/acs.jpcb.5b05963.","journal-title":"J Phys Chem B"},{"key":"4415_CR25","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.dyepig.2016.12.005","volume":"139","author":"JP Pino-Pinto","year":"2017","unstructured":"Pino-Pinto JP, Oyarzun-Ampuero F, Orellana SL, Flores ME, Nishide H, Moreno-Villoslada I. Aerogels containing 5,10,15,20-tetrakis-(4-sulfonatophenyl)-porphyrin with controlled state of aggregation. Dye Pigment. 2017;139:193\u2013200. https:\/\/doi.org\/10.1016\/j.dyepig.2016.12.005.","journal-title":"Dye Pigment"},{"key":"4415_CR26","doi-asserted-by":"publisher","first-page":"2464","DOI":"10.1002\/jbm.b.34038","volume":"106","author":"M Concha","year":"2018","unstructured":"Concha M, Vidal A, Giacaman A, Ojeda J, Pavicic F, Oyarzun-Ampuero FA, Torres C, Cabrera M, Moreno-Villoslada I, Orellana SL. Aerogels made of Chitosan and chondroitin sulfate at high degree of neutralization: biological properties toward wound healing. J Biomed Mater Res Part B Appl Biomater. 2018;106:2464\u201371. https:\/\/doi.org\/10.1002\/jbm.b.34038.","journal-title":"J Biomed Mater Res Part B Appl Biomater"},{"key":"4415_CR27","first-page":"576","volume":"85","author":"GS Ozbalci","year":"2014","unstructured":"Ozbalci GS, Tuncal S, Bayraktar K, Tasova V, Ali Akkus M. Is gentamicin-impregnated collagen sponge to be recommended in pilonidal sinus patient treated with marsupialization? A prospective randomized study. Ann Ital Chir. 2014;85:576\u201382.","journal-title":"Ann Ital Chir"},{"key":"4415_CR28","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s12663-013-0599-z","volume":"14","author":"M Singh","year":"2015","unstructured":"Singh M, Bhate K, Kulkarni D, Santhosh Kumar SN, Kathariya R. The effect of alloplastic bone graft and absorbable gelatin sponge in prevention of periodontal defects on the distal aspect of mandibular second molars, after surgical removal of impacted mandibular third molar: A comparative prospective study. J Maxillofac Oral Surg. 2015;14:101\u20136. https:\/\/doi.org\/10.1007\/s12663-013-0599-z.","journal-title":"J Maxillofac Oral Surg"},{"key":"4415_CR29","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1902\/jop.2015.150198","volume":"87","author":"B Femminella","year":"2016","unstructured":"Femminella B, Iaconi MC, Di Tullio M, Romano L, Sinjari B, D\u2019Arcangelo C, De Ninis P, Paolantonio M. Clinical comparison of Platelet-Rich fibrin and a gelatin sponge in the management of palatal wounds after epithelialized free gingival graft harvest: A randomized clinical trial. J Periodontol. 2016;87:103\u201313. https:\/\/doi.org\/10.1902\/jop.2015.150198.","journal-title":"J Periodontol"},{"key":"4415_CR30","doi-asserted-by":"publisher","first-page":"22","DOI":"10.12968\/jowc.2016.25.1.22","volume":"25","author":"V Joshi","year":"2016","unstructured":"Joshi V, Vaja R, Richens D. Cost analysis of gentamicin-impregnated collagen sponges in preventing sternal wound infection post cardiac surgery. J Wound Care. 2016;25:22\u20135. https:\/\/doi.org\/10.12968\/jowc.2016.25.1.22.","journal-title":"J Wound Care"},{"key":"4415_CR31","doi-asserted-by":"publisher","first-page":"2213","DOI":"10.3892\/etm.2016.3191","volume":"11","author":"Y Li","year":"2016","unstructured":"Li Y, Yao M, Wang X, Zhao Y. Effects of gelatin sponge combined with moist wound-healing nursing intervention in the treatment of phase III Bedsore. Exp Ther Med. 2016;11:2213\u20136. https:\/\/doi.org\/10.3892\/etm.2016.3191.","journal-title":"Exp Ther Med"},{"issue":"7","key":"4415_CR32","doi-asserted-by":"publisher","first-page":"944","DOI":"10.3390\/nano9070944","volume":"9","author":"MG Villamizar-Sarmiento","year":"2019","unstructured":"Villamizar-Sarmiento MG, Moreno-Villoslada I, Mart\u00ednez S, Giacaman A, Miranda V, Vidal A, Orellana SL, Concha M, Pavicic F, Lisoni JG, Leyton L, Oyarzun-Ampuero FA. Ionic nanocomplexes of hyaluronic acid and polyarginine to form solid materials: A green methodology to obtain sponges with biomedical potential. Nanomaterials (Basel). 2019;9(7):944. https:\/\/doi.org\/10.3390\/nano9070944. PMID: 31261871; PMCID: PMC6669755.","journal-title":"Nanomaterials (Basel)"},{"key":"4415_CR33","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s13287-017-0494-5","volume":"8","author":"CP Prieto","year":"2017","unstructured":"Prieto CP, Ortiz MC, Villanueva A, et al. Netrin-1 acts as a non-canonical angiogenic factor produced by human Wharton\u2019s jelly mesenchymal stem cells (WJ-MSC). Stem Cell Res Ther. 2017;8:43. https:\/\/doi.org\/10.1186\/s13287-017-0494-5","journal-title":"Stem Cell Res Ther"},{"key":"4415_CR34","doi-asserted-by":"crossref","unstructured":"Prieto CP, Casas BS, Falc\u00f3n P, Villanueva A, Lois P, Lattus J, Palma V. Downregulation of the Netrin-1 Receptor UNC5b Underlies Increased Placental Angiogenesis in Human Gestational Diabetes Mellitus. Int J Mol Sci. 2019; 20;20(6):1408.","DOI":"10.3390\/ijms20061408"},{"key":"4415_CR35","doi-asserted-by":"publisher","unstructured":"Edwards SS, Zavala G, Prieto CP et al. Functional analysis reveals angiogenic potential of human mesenchymal stem cells from Wharton\u2019s jelly in dermal regeneration. Angiogenesis 2014 17, 851\u201366. https:\/\/doi.org\/10.1007\/s10456-014-9432-7","DOI":"10.1007\/s10456-014-9432-7"},{"key":"4415_CR36","doi-asserted-by":"publisher","unstructured":"Th\u00e9ry C, Amigorena S, Raposo G, Clayton A. Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr Protoc Cell Biol. 2006;Chap. 3:Unit 3.22. https:\/\/doi.org\/10.1002\/0471143030.cb0322s30. PMID: 18228490.","DOI":"10.1002\/0471143030.cb0322s30"},{"issue":"4","key":"4415_CR37","first-page":"300","volume":"189","author":"C H\u00f6ller","year":"1990","unstructured":"H\u00f6ller C, Gundermann KO. Untersuchungen Zur quantitativen wiedergewinnung von Keimen Bei der instrumentendesinfektionsmitteltestung [The quantitative recovery of microbes during testing of disinfectants for instruments]. Zentralbl Hyg Umweltmed. 1990;189(4):300\u201311. German. PMID: 2180422.","journal-title":"Zentralbl Hyg Umweltmed"},{"key":"4415_CR38","doi-asserted-by":"publisher","unstructured":"Uyesugi BA, Sheehan MP. Patch Testing Pearls. Clin Rev Allergy Immunol. 2019;56(1):110\u2013118. https:\/\/doi.org\/10.1007\/s12016-018-8715-y. PMID: 30269296.","DOI":"10.1007\/s12016-018-8715-y"},{"key":"4415_CR39","doi-asserted-by":"publisher","unstructured":"Goldenberg A, Ehrlich A, Machler BC, Jacob SE. Patch Test Clinic Start-up: From Basics to Pearls. Dermatitis. 2020 Sep\/Oct;31(5):287\u2013296. https:\/\/doi.org\/10.1097\/DER.0000000000000559. PMID: 32091460.","DOI":"10.1097\/DER.0000000000000559"},{"key":"4415_CR40","doi-asserted-by":"crossref","unstructured":"Clausen B, Laman J. Inflammation - Methods and protocols. Springer International Publishing; 2017.","DOI":"10.1007\/978-1-4939-6786-5"},{"issue":"5","key":"4415_CR41","first-page":"12","volume":"13","author":"DS Patel","year":"2020","unstructured":"Patel DS, Veverka KA, Hansen JB, Yamauchi PS, Alonso-Llamazares J, Lebwohl M. Efficacy of Fixed-combination calcipotriene 0.005% and betamethasone dipropionate 0.064% foam for scalp plaque psoriasis: additional analysis of a phase II, randomized clinical study. J Clin Aesthet Dermatol. 2020;13(5):12\u20138.","journal-title":"J Clin Aesthet Dermatol"},{"issue":"3","key":"4415_CR42","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1159\/000444581","volume":"232","author":"DY Hsu","year":"2016","unstructured":"Hsu DY, Gniadecki R. Patient adherence to biologic agents in psoriasis. Dermatology. 2016;232(3):326\u201333.","journal-title":"Dermatology"},{"issue":"1","key":"4415_CR43","doi-asserted-by":"publisher","first-page":"326","DOI":"10.36849\/JDD.7372","volume":"22","author":"A Curcio","year":"2023","unstructured":"Curcio A, Kontzias C, Gorodokin B, Feldman S, Kircik L. Patient preferences in topical psoriasis treatment. J Drugs Dermatol. 2023;22(1):326\u201332.","journal-title":"J Drugs Dermatol"},{"issue":"5","key":"4415_CR44","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1111\/bjd.20517","volume":"185","author":"SM Lwin","year":"2021","unstructured":"Lwin SM, Snowden JA, Griffiths CEM. The promise and challenges of cell therapy for psoriasis. Br J Dermatol. 2021;185(5):887\u201398.","journal-title":"Br J Dermatol"},{"issue":"23","key":"4415_CR45","doi-asserted-by":"publisher","first-page":"6798","DOI":"10.12998\/wjcc.v9.i23.6798","volume":"9","author":"H Ahn","year":"2021","unstructured":"Ahn H, Lee SY, Jung WJ, Pi J, Lee KH. Psoriasis treatment using minimally manipulated umbilical cord-derived mesenchymal stem cells: A case report. World J Clin Cases. 2021;9(23):6798\u2013803.","journal-title":"World J Clin Cases"},{"key":"4415_CR46","doi-asserted-by":"publisher","unstructured":"De Jesus MM, Santiago JS, Trinidad CV, See ME, Semon KR, Fernandez MO Jr, Chung FS. Autologous Adipose-Derived Mesenchymal Stromal Cells for the Treatment of Psoriasis Vulgaris and Psoriatic Arthritis: A Case Report. Cell Transplant. 2016;25(11):2063\u20132069. https:\/\/doi.org\/10.3727\/096368916X691998. PMID: 27301844.","DOI":"10.3727\/096368916X691998"},{"key":"4415_CR47","doi-asserted-by":"publisher","first-page":"59","DOI":"10.2147\/IMCRJ.S163612","volume":"11","author":"K Comella","year":"2018","unstructured":"Comella K, Parlo M, Daly R, Dominessy K. First-in-man intravenous implantation of stromal vascular fraction in psoriasis: a case study. Int Med Case Rep J. 2018;11:59\u201364. https:\/\/doi.org\/10.2147\/IMCRJ.S163612. PMID: 29606893; PMCID: PMC5868735.","journal-title":"Int Med Case Rep J"},{"key":"4415_CR48","doi-asserted-by":"publisher","unstructured":"Seetharaman R. Mahmood, Anjum, Kshatriya, Prashant, Patel, Divyang, Srivastava, Anand, Mesenchymal Stem Cell Conditioned Media Ameliorate Psoriasis Vulgaris: A Case Study, Case Reports in Dermatological Medicine, 2019, 8309103, 5 pages, 2019. https:\/\/doi.org\/10.1155\/2019\/8309103","DOI":"10.1155\/2019\/8309103"},{"issue":"22","key":"4415_CR49","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.21037\/atm-21-5028","volume":"9","author":"D Yao","year":"2021","unstructured":"Yao D, Ye S, He Z, Huang Y, Deng J, Wen Z, Chen X, Li H, Han Q, Deng H, Zhao RC, Lu C. Adipose-derived mesenchymal stem cells (AD-MSCs) in the treatment for psoriasis: results of a single-arm pilot trial. Ann Transl Med. 2021;9(22):1653.","journal-title":"Ann Transl Med"},{"key":"4415_CR50","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/1479-5876-9-29","volume":"22","author":"CA Herberts","year":"2011","unstructured":"Herberts CA, Kwa MS, Hermsen HP. Risk factors in the development of stem cell therapy. J Transl Med. 2011;22:9:29.","journal-title":"J Transl Med"},{"key":"4415_CR51","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s12015-011-9345-4","volume":"9","author":"F Casiraghi","year":"2013","unstructured":"Casiraghi F, Remuzzi G, Abbate M, Perico N. Multipotent mesenchymal stromal cell therapy and risk of malignancies. Stem Cell Rev Rep. 2013;9:65\u201379. https:\/\/doi.org\/10.1007\/s12015-011-9345-4.","journal-title":"Stem Cell Rev Rep"},{"key":"4415_CR52","doi-asserted-by":"crossref","unstructured":"Lukomska B, Stanaszek L, Zuba-Surma E, Legosz P, Sarzynska S, Drela K. Challenges and controversies in human mesenchymal stem cell therapy. Stem Cells Int. 2019.","DOI":"10.1155\/2019\/9628536"},{"key":"4415_CR53","doi-asserted-by":"publisher","first-page":"34","DOI":"10.21037\/sci.2019.08.11","volume":"25","author":"P Saeedi","year":"2019","unstructured":"Saeedi P, Halabian R, Imani Fooladi AA. A revealing review of mesenchymal stem cells therapy, clinical perspectives and modification strategies. Stem Cell Investig. 2019;25:6:34.","journal-title":"Stem Cell Investig"},{"issue":"4","key":"4415_CR54","doi-asserted-by":"publisher","first-page":"e14557","DOI":"10.1111\/iwj.14557","volume":"21","author":"A Jafarzadeh","year":"2024","unstructured":"Jafarzadeh A, PourMohammad A, Goodarzi A. A systematic review of the efficacy, safety, and satisfaction of regenerative medicine treatments, including platelet-rich plasma, stromal vascular fraction and stem cell-conditioned medium for hypertrophic scars and keloids. Int Wound J. 2024;21(4):e14557. https:\/\/doi.org\/10.1111\/iwj.14557. Epub 2023 Dec 21. PMID: 38126221; PMCID: PMC10961894.","journal-title":"Int Wound J"},{"issue":"12","key":"4415_CR55","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1080\/02713683.2020.1762227","volume":"45","author":"S Jabbehdari","year":"2020","unstructured":"Jabbehdari S, Yazdanpanah G, Kanu LN, Chen E, Kang K, Anwar KN, et al. Therapeutic effects of lyophilized Conditioned-Medium derived from corneal mesenchymal stromal cells on corneal epithelial wound healing. Curr Eye Res. 2020;45(12):1490\u20136.","journal-title":"Curr Eye Res"},{"key":"4415_CR56","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.biocel.2019.05.010","volume":"112","author":"W Chen","year":"2019","unstructured":"Chen W, Wang S, Xiang H, Liu J, Zhang Y, Zhou S, Du T, Shan L. Exosomes derived from human Wharton\u2019s jelly mesenchymal stem cells ameliorate acute lung injury partly mediated by hepatocyte growth factor. Int J Biochem Cell Biol. 2019;112:114\u201322. Epub 2019 May 14. PMID: 31100425.","journal-title":"Int J Biochem Cell Biol"},{"issue":"4","key":"4415_CR57","first-page":"296","volume":"46","author":"MV Sarycheva","year":"2019","unstructured":"Sarycheva MV, Nadezhdina NA, Nadezhdin SV, et al. Effect of multipotent mesenchymal stromal cells secretome on imiquimod-induced psoriasis in rats. J Int Pharm Res. 2019;46(4):296\u2013301.","journal-title":"J Int Pharm Res"},{"issue":"5","key":"4415_CR58","doi-asserted-by":"publisher","first-page":"e280","DOI":"10.1111\/ijd.13197","volume":"55","author":"X Niu","year":"2016","unstructured":"Niu X, Chang W, Liu R, Hou R, Li J, Wang C, et al. Expression of pro-angiogenic genes in mesenchymal stem cells derived from dermis of patients with psoriasis. Int J Dermatol. 2016;55(5):e280\u20138.","journal-title":"Int J Dermatol"},{"issue":"2","key":"4415_CR59","doi-asserted-by":"publisher","first-page":"e104","DOI":"10.1002\/ski2.104","volume":"2","author":"M Green","year":"2022","unstructured":"Green M, Kashetsky N, Feschuk A, Maibach HI. Transepidermal water loss (TEWL): environment and pollution-A systematic review. Skin Health Dis. 2022;2(2):e104.","journal-title":"Skin Health Dis"},{"issue":"3","key":"4415_CR60","doi-asserted-by":"publisher","first-page":"267","DOI":"10.4103\/idoj.IDOJ_180_18","volume":"10","author":"VN Nikam","year":"2019","unstructured":"Nikam VN, Monteiro RC, Dandakeri S, Bhat RM. Transepidermal water loss in psoriasis: A Case-control study. Indian Dermatol Online J. 2019;10(3):267\u201371.","journal-title":"Indian Dermatol Online J"},{"key":"4415_CR61","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1001\/archderm.1985.01660050094022","volume":"121","author":"H Tagami","year":"1985","unstructured":"Tagami H, Yoshikuni K. Interrelationship between water- barrier and reservoir functions of pathologic stratum corneum. Arch Dermatol. 1985;121:642\u20135.","journal-title":"Arch Dermatol"},{"issue":"4","key":"4415_CR62","doi-asserted-by":"publisher","first-page":"449","DOI":"10.3390\/pharmaceutics16040449","volume":"16","author":"K Bodn\u00e1r","year":"2024","unstructured":"Bodn\u00e1r K, Feh\u00e9r P, Ujhelyi Z, B\u00e1cskay I, J\u00f3zsa L. Recent approaches for the topical treatment of psoriasis using nanoparticles. Pharmaceutics. 2024;16(4):449.","journal-title":"Pharmaceutics"},{"key":"4415_CR63","unstructured":"Bajouri A, Dayani D, Sharghi AT, Sc M, Karimi S. Subcutaneous injection of allogeneic adipose-derived mesenchymal stromal cells in psoriasis plaques. Clin Trial Phase I 2023;363\u201371."},{"key":"4415_CR64","doi-asserted-by":"publisher","unstructured":"Jafarzadeh A, Mohammad AP, Goodarzi A. A systematic review of case series and clinical trials investigating regenerative medicine for the treatment of vitiligo. J Cosmet Dermatol 2024 Nov 7. https:\/\/doi.org\/10.1111\/jocd.16660. Epub ahead of print. PMID: 39509558.","DOI":"10.1111\/jocd.16660"}],"container-title":["Stem Cell Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-025-04415-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13287-025-04415-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-025-04415-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T14:06:23Z","timestamp":1751810783000},"score":1,"resource":{"primary":{"URL":"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/s13287-025-04415-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,6]]},"references-count":64,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4415"],"URL":"https:\/\/doi.org\/10.1186\/s13287-025-04415-1","relation":{},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,6]]},"assertion":[{"value":"3 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have not used AI-generated work in this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare that they have no conflicts of interest in this publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"348"}}