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The informed consents were obtained prior to tissue collection. The project was approved by ethical committee: Title of the approved project: \u201chuman Mesenchymal Stromal Cells (MSCs) loaded with drugs and derived Extracellular Vesicles: production process optimization and drug product characterization\u201d. Name of the institutional approval committee: Institutional Review Board of the IRCCS Neurological Institute C. Besta Foundation. Approval number: 15. Date of approval: March 29, 2023. Human cell lines MSTO-211\u00a0H and NCI H2052 were purchased from a commercial vendor, ATCC. The company has confirmed that there was initial ethical approval for the collection of human materials and the derivation of cell lines and that the donors had signed informed consent. See for details: ; .","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to partecipate"}},{"value":"The authors declare that they have no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. The authors declare that they have not use AI-generated work in this manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"307"}}