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The Fourth Affiliated Hospital of Jiangsu University confirmed that there was initial ethical approval for collection of hucMSCs, and the donors had signed informed consent. All experiments involving animals were approved by the Institutional Animal Care and Use Committee of Jiangsu University and were conducted in accordance with the ARRIVE guideline 2.0 (Project title: NMN-engineered hucMSC-sEV delays D-gal-induced skin aging in mice; Approval number: UJS-IACUC-2024070902; Approval date: July 9, 2024).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors confirm that there are no conflicts of interest regarding the publication of this article.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"339"}}