{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T10:30:29Z","timestamp":1784716229203,"version":"3.55.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["LH2023C086"],"award-info":[{"award-number":["LH2023C086"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010009","name":"Heilongjiang Provincial Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["LBH-Z19088"],"award-info":[{"award-number":["LBH-Z19088"]}],"id":[{"id":"10.13039\/501100010009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011441","name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases","doi-asserted-by":"publisher","award":["RPJJ2020009"],"award-info":[{"award-number":["RPJJ2020009"]}],"id":[{"id":"10.13039\/501100011441","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008828","name":"Heilongjiang Bayi Agricultural University","doi-asserted-by":"publisher","award":["XYB201915"],"award-info":[{"award-number":["XYB201915"]}],"id":[{"id":"10.13039\/501100008828","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"DOI":"10.1186\/s13287-025-04466-4","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T12:39:31Z","timestamp":1751891971000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Adipose-derived stem cells alleviate acute pancreatitis by inhibiting ferroptosis and oxidative damage in canines"],"prefix":"10.1186","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4270-2716","authenticated-orcid":false,"given":"Yansong","family":"Ge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meilin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruxin","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiying","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enshuang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8082-1508","authenticated-orcid":false,"given":"Jiasan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"issue":"2","key":"4466_CR1","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1111\/jvim.15421","volume":"33","author":"D Fabr\u00e8s Virginie","year":"2019","unstructured":"Fabr\u00e8s Virginie D, Olivier R, Cl\u00e9mence, et al. Development and validation of a novel clinical scoring system for short-term prediction of death in dogs with acute pancreatitis[J]. J Vet Intern Med. 2019;33(2):499\u2013507.","journal-title":"J Vet Intern Med"},{"issue":"7","key":"4466_CR2","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1053\/j.gastro.2018.12.041","volume":"156","author":"K Garg Pramod","year":"2019","unstructured":"Garg Pramod K, Singh P, Vijay. Organ failure due to systemic injury in acute pancreatitis[J]. Gastroenterology. 2019;156(7):2008\u201323.","journal-title":"Gastroenterology"},{"issue":"6","key":"4466_CR3","doi-asserted-by":"publisher","first-page":"2084","DOI":"10.1111\/jvim.16897","volume":"37","author":"M Steiner Joerg","year":"2023","unstructured":"Steiner Joerg M, Chantal L, Yuya N, et al. Fuzapladib in a randomized controlled multicenter masked study in dogs with presumptive acute onset pancreatitis[J]. J Vet Intern Med. 2023;37(6):2084\u201392.","journal-title":"J Vet Intern Med"},{"issue":"3","key":"4466_CR4","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/cdd.2015.158","volume":"23","author":"Y Xie","year":"2016","unstructured":"Xie Y, Hou W, Song X, et al. Ferroptosis: process and function[J]. Cell Death Differ. 2016;23(3):369\u201379.","journal-title":"Cell Death Differ"},{"issue":"2","key":"4466_CR5","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","volume":"11","author":"J Li","year":"2020","unstructured":"Li J, Cao F, Yin He-liang, et al. Ferroptosis: past, present and future[J]. Cell Death Dis. 2020;11(2):88.","journal-title":"Cell Death Dis"},{"issue":"17","key":"4466_CR6","doi-asserted-by":"publisher","first-page":"2026","DOI":"10.1097\/CM9.0000000000002096","volume":"135","author":"H Li","year":"2022","unstructured":"Li H, Lin Y, Zhang L, et al. Ferroptosis and its emerging roles in acute pancreatitis[J]. Chin Med J. 2022;135(17):2026\u201334.","journal-title":"Chin Med J"},{"issue":"4","key":"4466_CR7","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/j.biotechadv.2018.03.011","volume":"36","author":"J Lucie Bacakova","year":"2018","unstructured":"Lucie Bacakova J, Zarubova M, Travnickova, et al. Stem cells: their source, potency and use in regenerative therapies with focus on adipose-derived stem cells\u2013a review[J]. Biotechnol Adv. 2018;36(4):1111\u201326.","journal-title":"Biotechnol Adv"},{"issue":"3","key":"4466_CR8","doi-asserted-by":"publisher","first-page":"e42","DOI":"10.4142\/jvs.2020.21.e42","volume":"21","author":"M-H Kang","year":"2020","unstructured":"Kang M-H, Park H-M. Challenges of stem cell therapies in companion animal practice[J]. J Vet Sci. 2020;21(3):e42.","journal-title":"J Vet Sci"},{"issue":"2","key":"4466_CR9","doi-asserted-by":"publisher","first-page":"297","DOI":"10.34172\/apb.2020.036","volume":"10","author":"T Kamal Abdolmohammadi","year":"2020","unstructured":"Kamal Abdolmohammadi T, Mahmoudi S, Nojehdehi, et al. Effect of hypoxia preconditioned adipose-derived mesenchymal stem cell conditioned medium on cerulein-induced acute pancreatitis in mice[J]. Adv Pharm Bull. 2020;10(2):297.","journal-title":"Adv Pharm Bull"},{"issue":"6","key":"4466_CR10","first-page":"3375","volume":"11","author":"J Na Wang","year":"2019","unstructured":"Na Wang J, Ma Y, Ren, et al. Secreted klotho from exosomes alleviates inflammation and apoptosis in acute pancreatitis[J]. Am J Translational Res. 2019;11(6):3375.","journal-title":"Am J Translational Res"},{"issue":"S1","key":"4466_CR11","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1017\/S096272860003178X","volume":"16","author":"J Reid","year":"2007","unstructured":"Reid J, Nolan AM, Hughes JML, et al. Development of the short-form Glasgow composite measure pain scale (CMPS-SF) and derivation of an analgesic intervention score[J]. Anim Welf. 2007;16(S1):97\u2013104.","journal-title":"Anim Welf"},{"issue":"6","key":"4466_CR12","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1016\/0016-5085(95)90158-2","volume":"108","author":"J-L Van Laethem","year":"1995","unstructured":"Van Laethem J-L, Marchant A, Delvaux A, et al. Interleukin 10 prevents necrosis in murine experimental acute pancreatitis[J]. Gastroenterology. 1995;108(6):1917\u201322.","journal-title":"Gastroenterology"},{"issue":"8","key":"4466_CR13","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/s41575-019-0158-2","volume":"16","author":"J Lee Peter","year":"2019","unstructured":"Lee Peter J, Papachristou Georgios. New insights into acute pancreatitis[J]. Nat Reviews Gastroenterol Hepatol. 2019;16(8):479\u201396.","journal-title":"Nat Reviews Gastroenterol Hepatol"},{"key":"4466_CR14","doi-asserted-by":"crossref","unstructured":"Brent RS et al. Friedmann Angeli Jos\u00e9 Pedro, H\u00fclya Bayir. Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease[J]. Cell. 2017;171(2):273\u2013285.","DOI":"10.1016\/j.cell.2017.09.021"},{"issue":"1","key":"4466_CR15","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3892\/ijmm.2022.5144","volume":"50","author":"J Yuqiang Shan","year":"2022","unstructured":"Yuqiang Shan J, Li A, Zhu, et al. Ginsenoside Rg3 ameliorates acute pancreatitis by activating the NRF2\/HO-1-mediated ferroptosis pathway[J]. Int J Mol Med. 2022;50(1):89.","journal-title":"Int J Mol Med"},{"issue":"2","key":"4466_CR16","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.jcmgh.2021.09.008","volume":"13","author":"J Ke Liu","year":"2022","unstructured":"Ke Liu J, Liu B, Zou, et al. Trypsin-mediated sensitization to ferroptosis increases the severity of pancreatitis in mice[J]. Cell Mol Gastroenterol Hepatol. 2022;13(2):483\u2013500.","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"4466_CR17","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.freeradbiomed.2021.07.009","volume":"173","author":"J Rong Fan","year":"2021","unstructured":"Rong Fan J, Sui X, Dong, et al. Wedelolactone alleviates acute pancreatitis and associated lung injury via GPX4 mediated suppression of pyroptosis and ferroptosis[J]. Free Radic Biol Med. 2021;173:29\u201340.","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"4466_CR18","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","volume":"22","author":"RS Xuejun Jiang","year":"2021","unstructured":"Xuejun Jiang RS, Brent. Marcus conrad. Ferroptosis: mechanisms, biology and role in disease[J]. Nat Rev Mol Cell Biol. 2021;22(4):266\u201382.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"4466_CR19","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1186\/s12974-022-02550-7","volume":"19","author":"D Wang","year":"2022","unstructured":"Wang D, Zhang S, Ge X, et al. Mesenchymal stromal cell treatment attenuates repetitive mild traumatic brain injury-induced persistent cognitive deficits via suppressing ferroptosis[J]. J Neuroinflamm. 2022;19(1):185.","journal-title":"J Neuroinflamm"},{"issue":"3","key":"4466_CR20","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.bbrc.2020.02.142","volume":"525","author":"Y Yang Liu","year":"2020","unstructured":"Yang Liu Y, Wang J, Liu, et al. The circadian clock protects against ferroptosis-induced sterile inflammation[J]. Biochem Biophys Res Commun. 2020;525(3):620\u20135.","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"4466_CR21","doi-asserted-by":"publisher","first-page":"6339","DOI":"10.1038\/s41467-020-20154-8","volume":"11","author":"E Dai","year":"2020","unstructured":"Dai E, Han L, Liu J, et al. Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173\/STING-dependent DNA sensor pathway[J]. Nat Commun. 2020;11(1):6339.","journal-title":"Nat Commun"},{"issue":"106","key":"4466_CR22","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.semcancer.2024.10.003","volume":"10","author":"Y Wang","year":"2024","unstructured":"Wang Y, Cao X, Yang C, et al. Ferroptosis and immunosenescence in colorectal cancer[J]. Sem Cancer Biol. 2024;10(106):156\u201365.","journal-title":"Sem Cancer Biol"},{"issue":"6","key":"4466_CR23","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1172\/JCI126428","volume":"129","author":"W Li","year":"2019","unstructured":"Li W, Feng G, Gauthier Jason M, et al. Ferroptotic cell death and TLR4\/Trif signaling initiate neutrophil recruitment after heart transplantation[J]. J Clin Investig. 2019;129(6):2293\u2013304.","journal-title":"J Clin Investig"},{"issue":"4","key":"4466_CR24","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.chembiol.2020.03.016","volume":"27","author":"C Alexia Belavgeni","year":"2020","unstructured":"Alexia Belavgeni C, Meyer J. Ferroptosis and necroptosis in the kidney[J]. Cell Chem Biology. 2020;27(4):448\u201362.","journal-title":"Cell Chem Biology"},{"key":"4466_CR25","doi-asserted-by":"publisher","first-page":"4880","DOI":"10.1007\/s12035-018-1403-3","volume":"56","author":"Y Abigail Weiland","year":"2019","unstructured":"Abigail Weiland Y, Wang W, Wu, et al. Ferroptosis and its role in diverse brain diseases[J]. Mol Neurobiol. 2019;56:4880\u201393.","journal-title":"Mol Neurobiol"},{"key":"4466_CR26","doi-asserted-by":"crossref","unstructured":"Tong Wu M, Ji T, Li et al. The molecular and metabolic landscape of ferroptosis in respiratory diseases: Pharmacological aspects[J].Journal of Pharmaceutical Analysis, 2025;15(1):101050.","DOI":"10.1016\/j.jpha.2024.101050"},{"key":"4466_CR27","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.freeradbiomed.2022.06.002","volume":"188","author":"J-H Chu","year":"2022","unstructured":"Chu J-H, Li L-X, Gao P-C, et al. Mercuric chloride induces sequential activation of ferroptosis and necroptosis in chicken embryo kidney cells by triggering ferritinophagy[J]. Free Radic Biol Med. 2022;188:35\u201344.","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"4466_CR28","doi-asserted-by":"publisher","first-page":"874","DOI":"10.7150\/ijbs.105455","volume":"21","author":"X Dai","year":"2025","unstructured":"Dai X, Xu Z, Lv X, et al. Cold atmospheric plasma potentiates ferroptosis via EGFR (Y1068)-mediated dual axes on GPX4 among triple negative breast cancer cells[J]. Int J Biol Sci. 2025;21(2):874.","journal-title":"Int J Biol Sci"},{"issue":"6","key":"4466_CR29","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1111\/jphp.13229","volume":"72","author":"ASK Vaishnavi Sundar","year":"2020","unstructured":"Vaishnavi Sundar ASK, Keerthic V, Manickam, et al. Current trends in pharmacological approaches for treatment and management of acute pancreatitis\u2013a review[J]. J Pharm Pharmacol. 2020;72(6):761\u201375.","journal-title":"J Pharm Pharmacol"},{"issue":"13","key":"4466_CR30","doi-asserted-by":"publisher","first-page":"12943","DOI":"10.18632\/aging.103378","volume":"12","author":"Z Hui Dong","year":"2020","unstructured":"Hui Dong Z, Qiang D, Chai, et al. Nrf2 inhibits ferroptosis and protects against acute lung injury due to intestinal ischemia reperfusion via regulating SLC7A11 and HO-1[J]. Aging. 2020;12(13):12943.","journal-title":"Aging"},{"key":"4466_CR31","doi-asserted-by":"publisher","first-page":"115643","DOI":"10.1016\/j.bcp.2023.115643","volume":"214","author":"C Chen","year":"2023","unstructured":"Chen C, Ding P. Pharmacological roles of LncRNAs in diabetic retinopathy with a focus on oxidative stress and inflammation[J]. Biochem Pharmacol. 2023;214:115643.","journal-title":"Biochem Pharmacol"},{"key":"4466_CR32","doi-asserted-by":"publisher","first-page":"114486","DOI":"10.1016\/j.bcp.2021.114486","volume":"186","author":"H Yuan","year":"2021","unstructured":"Yuan H, Pratte J. Ferroptosis and its potential as a therapeutic target[J]. Biochem Pharmacol. 2021;186:114486.","journal-title":"Biochem Pharmacol"},{"key":"4466_CR33","doi-asserted-by":"publisher","first-page":"118340","DOI":"10.1016\/j.lfs.2020.118340","volume":"261","author":"C Xiaoqiang Liang","year":"2020","unstructured":"Xiaoqiang Liang C. Dihydrokaempferol (DHK) ameliorates severe acute pancreatitis (SAP) via Keap1\/Nrf2 pathway[J]. Life Sci. 2020;261:118340.","journal-title":"Life Sci"},{"key":"4466_CR34","doi-asserted-by":"publisher","first-page":"113914","DOI":"10.1016\/j.intimp.2024.113914","volume":"146","author":"Y Xiaozhi Bai","year":"2025","unstructured":"Xiaozhi Bai Y, Liu J, Liu, et al. ADSCs-derived exosomes suppress macrophage ferroptosis via the SIRT1\/NRF2 signaling axis to alleviate acute lung injury in sepsis[J]. Int Immunopharmacol. 2025;146:113914.","journal-title":"Int Immunopharmacol"},{"key":"4466_CR35","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/j.omtn.2020.07.007","volume":"21","author":"H Huang","year":"2020","unstructured":"Huang H, Xu Z, Qi Y, et al. Exosomes from SIRT1-overexpressing ADSCs restore cardiac function by improving angiogenic function of EPCs[J]. Mol Therapy-nucleic Acids. 2020;21:737\u201350.","journal-title":"Mol Therapy-nucleic Acids"},{"issue":"1","key":"4466_CR36","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1186\/s13098-023-01119-5","volume":"15","author":"P Ren","year":"2023","unstructured":"Ren P, Qian F, Fu L, et al. Adipose-derived stem cell exosomes regulate Nrf2\/Keap1 in diabetic nephropathy by targeting FAM129B[J]. Diabetol Metab Syndr. 2023;15(1):149.","journal-title":"Diabetol Metab Syndr"},{"key":"4466_CR37","doi-asserted-by":"publisher","first-page":"102655","DOI":"10.1016\/j.redox.2023.102655","volume":"62","author":"X Kuo Shen","year":"2023","unstructured":"Kuo Shen X, Wang Y, Wang, et al. miR-125b-5p in adipose derived stem cells exosome alleviates pulmonary microvascular endothelial cells ferroptosis via Keap1\/Nrf2\/GPX4 in sepsis lung injury[J]. Redox Biol. 2023;62:102655.","journal-title":"Redox Biol"},{"issue":"7","key":"4466_CR38","doi-asserted-by":"publisher","first-page":"3678","DOI":"10.1007\/s12035-023-03297-9","volume":"60","author":"J Chen","year":"2023","unstructured":"Chen J, Li G, Liu X, et al. Delivery of miR-130a-3p through adipose-derived stem cell-secreted EVs protects against diabetic peripheral neuropathy via DNMT1\/NRF2\/HIF1\u03b1\/ACTA1 axis[J]. Mol Neurobiol. 2023;60(7):3678\u201394.","journal-title":"Mol Neurobiol"},{"key":"4466_CR39","doi-asserted-by":"publisher","first-page":"569977","DOI":"10.3389\/fcell.2020.569977","volume":"8","author":"L Xu","year":"2020","unstructured":"Xu L, Ji H, Jiang Y, et al. Exosomes derived from CircAkap7-modified adipose-derived mesenchymal stem cells protect against cerebral ischemic injury[J]. Front Cell Dev Biology. 2020;8:569977.","journal-title":"Front Cell Dev Biology"},{"key":"4466_CR40","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.3389\/fphys.2019.01445","volume":"10","author":"C-F Weng","year":"2019","unstructured":"Weng C-F, Wu C-F, Kao S-H, et al. Down-regulation of miR-34a-5p potentiates protective effect of adipose-derived mesenchymal stem cells against ischemic myocardial infarction by stimulating the expression of C1q\/tumor necrosis factor-related protein-9[J]. Front Physiol. 2019;10:1445.","journal-title":"Front Physiol"},{"key":"4466_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cytogfr.2019.04.002","volume":"46","author":"P Kumar","year":"2019","unstructured":"Kumar P, Kandoi S, Misra R, et al. The mesenchymal stem cell secretome: a new paradigm towards cell-free therapeutic mode in regenerative medicine[J]. Cytokine Growth Factor Rev. 2019;46:1\u20139.","journal-title":"Cytokine Growth Factor Rev"},{"issue":"3","key":"4466_CR42","doi-asserted-by":"publisher","first-page":"4142","DOI":"10.3390\/ijms15034142","volume":"15","author":"B Yu","year":"2014","unstructured":"Yu B, Zhang X, Li X. Exosomes derived from mesenchymal stem cells[J]. Int J Mol Sci. 2014;15(3):4142\u201357.","journal-title":"Int J Mol Sci"},{"key":"4466_CR43","doi-asserted-by":"crossref","unstructured":"Lu X, Lv C, Zhao Y, et al. TSG-6 released from adipose stem cells-derived small extracellular vesicle protects against spinal cord ischemia reperfusion injury by inhibiting Endoplasmic reticulum stress[J]. Stem Cell Res Ther. 2022;13(1):291.","DOI":"10.1186\/s13287-022-02963-4"},{"issue":"1","key":"4466_CR44","doi-asserted-by":"publisher","first-page":"8287227","DOI":"10.1155\/2022\/8287227","volume":"2022","author":"S Zhao","year":"2022","unstructured":"Zhao S, Huang M. Exosomes derived from baicalin-pretreated mesenchymal stem cells alleviate hepatocyte ferroptosis after acute liver injury via the Keap1\u2010NRF2 pathway[J]. Oxidative Med Cell Longev. 2022;2022(1):8287227.","journal-title":"Oxidative Med Cell Longev"}],"container-title":["Stem Cell Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-025-04466-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13287-025-04466-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-025-04466-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T14:03:06Z","timestamp":1751896986000},"score":1,"resource":{"primary":{"URL":"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/s13287-025-04466-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,7]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4466"],"URL":"https:\/\/doi.org\/10.1186\/s13287-025-04466-4","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-6218655\/v1","asserted-by":"object"}]},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,7]]},"assertion":[{"value":"20 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have no competing interests to declare.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"355"}}