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NLRP3 deficiency improves bone healing of tooth extraction sockets through SMAD2\/3-RUNX2 mediated osteoblast differentiation. 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This study was adhered to the tenants of the Declaration of Helsinki. Human jaw bone were obtained with informed patient consent. The patients provided written informed consent for the use of the samples. The animal experiment was approved by the Animal Ethics Committee of the Beijing Stomatological Hospital of the Capital Medical University (Title: The effect and mechanism of LINC01013 in preventing bisphosphonate-related osteonecrosis of the jaw; Approval number: KQYY-202309-006; Date of approval: 2023-12-25).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declared no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"319"}}