{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:09:10Z","timestamp":1788779350256,"version":"build-2803163510"},"reference-count":172,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7242211"],"award-info":[{"award-number":["7242211"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174056"],"award-info":[{"award-number":["82174056"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82474161"],"award-info":[{"award-number":["82474161"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"DOI":"10.1186\/s13287-025-04549-2","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T22:54:13Z","timestamp":1755644053000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Multi-function of adipose-derived stem cells on gut disorder: from bench to bedside"],"prefix":"10.1186","volume":"16","author":[{"given":"Jiatong","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzi","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weikai","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boya","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongxuan","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yize","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingdong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,20]]},"reference":[{"issue":"10","key":"4549_CR1","doi-asserted-by":"publisher","first-page":"2523","DOI":"10.3390\/ijms20102523","volume":"20","author":"L Mazini","year":"2019","unstructured":"Mazini L, Rochette L, Amine M, Malka G. Regenerative capacity of adipose derived stem cells (ADSCs), comparison with mesenchymal stem cells (MSCs). Int J Mol Sci. 2019;20(10):2523.","journal-title":"Int J Mol Sci"},{"issue":"2","key":"4549_CR2","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1002\/jcp.21200","volume":"213","author":"AI Caplan","year":"2007","unstructured":"Caplan AI. Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. J Cell Physiol. 2007;213(2):341\u20137.","journal-title":"J Cell Physiol"},{"issue":"9","key":"4549_CR3","doi-asserted-by":"publisher","first-page":"17986","DOI":"10.3390\/ijms140917986","volume":"14","author":"HJ Jin","year":"2013","unstructured":"Jin HJ, Bae YK, Kim M, Kwon SJ, Jeon HB, Choi SJ, et al. Comparative analysis of human mesenchymal stem cells from bone marrow, adipose tissue, and umbilical cord blood as sources of cell therapy. Int J Mol Sci. 2013;14(9):17986\u20138001.","journal-title":"Int J Mol Sci"},{"issue":"4","key":"4549_CR4","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.patbio.2008.04.010","volume":"57","author":"M Vall\u00e9e","year":"2009","unstructured":"Vall\u00e9e M, C\u00f4t\u00e9 JF, Fradette J. Adipose-tissue engineering: taking advantage of the properties of human adipose-derived stem\/stromal cells. Pathol Biol (Paris). 2009;57(4):309\u201317.","journal-title":"Pathol Biol (Paris)"},{"issue":"6","key":"4549_CR5","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1097\/01.prs.0000185606.03222.a9","volume":"116","author":"YY Shi","year":"2005","unstructured":"Shi YY, Nacamuli RP, Salim A, Longaker MT. The osteogenic potential of adipose-derived mesenchymal cells is maintained with aging. Plast Reconstr Surg. 2005;116(6):1686\u201396.","journal-title":"Plast Reconstr Surg"},{"issue":"1","key":"4549_CR6","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.jocit.2014.12.001","volume":"2","author":"Q Zhao","year":"2016","unstructured":"Zhao Q, Ren H, Han Z. Mesenchymal stem cells: Immunomodulatory capability and clinical potential in immune diseases. J Cell Immunotherapy. 2016;2(1):3\u201320.","journal-title":"J Cell Immunotherapy"},{"key":"4549_CR7","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.reth.2023.09.014","volume":"24","author":"L Dong","year":"2023","unstructured":"Dong L, Li X, Leng W, Guo Z, Cai T, Ji X, et al. Adipose stem cells in tissue regeneration and repair: from bench to bedside. Regen Ther. 2023;24:547\u201360.","journal-title":"Regen Ther"},{"issue":"1","key":"4549_CR8","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1007\/s12015-023-10641-y","volume":"20","author":"Y Cao","year":"2024","unstructured":"Cao Y, Yan J, Dong Z, Wang J, Jiang X, Cui T, et al. Adipose-derived mesenchymal stem cells are ideal for the Cell-based treatment of refractory wounds: strong potential for angiogenesis. Stem Cell Reviews Rep. 2024;20(1):313\u201328.","journal-title":"Stem Cell Reviews Rep"},{"issue":"2","key":"4549_CR9","first-page":"125","volume":"35","author":"S Al-Ghadban","year":"2020","unstructured":"Al-Ghadban S, Bunnell BA. Adipose Tissue-Derived stem cells: Immunomodulatory effects and therapeutic potential. Physiol (Bethesda). 2020;35(2):125\u201333.","journal-title":"Physiol (Bethesda)"},{"key":"4549_CR10","doi-asserted-by":"crossref","unstructured":"Skrypnyk M. Current progress and limitations of research regarding the therapeutic use of adipose-derived stem cells: literature review. J Umm Al-Qura Univ Appl Sci. 2024:1\u201313.","DOI":"10.1007\/s43994-024-00147-9"},{"issue":"12","key":"4549_CR11","doi-asserted-by":"publisher","first-page":"4279","DOI":"10.1091\/mbc.e02-02-0105","volume":"13","author":"PA Zuk","year":"2002","unstructured":"Zuk PA, Zhu M, Ashjian P, De Ugarte DA, Huang JI, Mizuno H, et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell. 2002;13(12):4279\u201395.","journal-title":"Mol Biol Cell"},{"issue":"2\u20133","key":"4549_CR12","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/S0165-2478(03)00108-1","volume":"89","author":"DA De Ugarte","year":"2003","unstructured":"De Ugarte DA, Alfonso Z, Zuk PA, Elbarbary A, Zhu M, Ashjian P, et al. Differential expression of stem cell mobilization-associated molecules on multi-lineage cells from adipose tissue and bone marrow. Immunol Lett. 2003;89(2\u20133):267\u201370.","journal-title":"Immunol Lett"},{"issue":"1","key":"4549_CR13","doi-asserted-by":"publisher","first-page":"3","DOI":"10.4049\/jimmunol.1900868","volume":"204","author":"C Lu","year":"2020","unstructured":"Lu C, Amin MA, Fox DA. CD13\/Aminopeptidase N is a potential therapeutic target for inflammatory disorders. J Immunol. 2020;204(1):3\u201311.","journal-title":"J Immunol"},{"issue":"5","key":"4549_CR14","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.ceb.2011.08.005","volume":"23","author":"C Margadant","year":"2011","unstructured":"Margadant C, Monsuur HN, Norman JC, Sonnenberg A. Mechanisms of integrin activation and trafficking. Curr Opin Cell Biol. 2011;23(5):607\u201314.","journal-title":"Curr Opin Cell Biol"},{"issue":"1","key":"4549_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1182\/blood.V87.1.1.1","volume":"87","author":"DS Krause","year":"1996","unstructured":"Krause DS, Fackler MJ, Civin CI, May WS. CD34: structure, biology, and clinical utility. Blood. 1996;87(1):1\u201313.","journal-title":"Blood"},{"issue":"5","key":"4549_CR16","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1634\/stemcells.18-5-320","volume":"18","author":"R Kronenwett","year":"2000","unstructured":"Kronenwett R, Martin S, Haas R. The role of cytokines and adhesion molecules for mobilization of peripheral blood stem cells. Stem Cells. 2000;18(5):320\u201330.","journal-title":"Stem Cells"},{"issue":"3","key":"4549_CR17","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1084\/jem.173.3.599","volume":"173","author":"K Miyake","year":"1991","unstructured":"Miyake K, Weissman IL, Greenberger JS, Kincade PW. Evidence for a role of the integrin VLA-4 in lympho-hemopoiesis. J Exp Med. 1991;173(3):599\u2013607.","journal-title":"J Exp Med"},{"issue":"1\u20132","key":"4549_CR18","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3109\/10428199209049814","volume":"8","author":"M Maio","year":"1992","unstructured":"Maio M, Del Vecchio L. Expression and functional role of CD54\/Intercellular adhesion Molecule-1 (ICAM-1) on human blood cells. Leuk Lymphoma. 1992;8(1\u20132):23\u201333.","journal-title":"Leuk Lymphoma"},{"key":"4549_CR19","doi-asserted-by":"publisher","first-page":"705260","DOI":"10.3389\/fimmu.2021.705260","volume":"12","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Liu Q, Yang S, Liao Q. CD58 immunobiology at a glance. Front Immunol. 2021;12:705260.","journal-title":"Front Immunol"},{"issue":"8","key":"4549_CR20","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1007\/s10875-020-00851-1","volume":"40","author":"AH Aljohani","year":"2020","unstructured":"Aljohani AH, Al-Mousa H, Arnaout R, Al-Dhekri H, Mohammed R, Alsum Z, et al. Clinical and immunological characterization of combined immunodeficiency due to TFRC mutation in eight patients. J Clin Immunol. 2020;40(8):1103\u201310.","journal-title":"J Clin Immunol"},{"issue":"6","key":"4549_CR21","doi-asserted-by":"publisher","first-page":"6689","DOI":"10.1096\/fj.201802224R","volume":"33","author":"A Saalbach","year":"2019","unstructured":"Saalbach A, Anderegg U. Thy-1: more than a marker for mesenchymal stromal cells. Faseb J. 2019;33(6):6689\u201396.","journal-title":"Faseb J"},{"issue":"11","key":"4549_CR22","doi-asserted-by":"publisher","first-page":"2739","DOI":"10.1634\/stemcells.2007-0197","volume":"25","author":"G Chamberlain","year":"2007","unstructured":"Chamberlain G, Fox J, Ashton B, Middleton J. Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells. 2007;25(11):2739\u201349.","journal-title":"Stem Cells"},{"issue":"4","key":"4549_CR23","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1016\/S0016-5085(99)70070-3","volume":"116","author":"M Sans","year":"1999","unstructured":"Sans M, Pan\u00e9s J, Ardite E, Elizalde JI, Arce Y, Elena M, et al. VCAM-1 and ICAM-1 mediate leukocyte-endothelial cell adhesion in rat experimental colitis. Gastroenterology. 1999;116(4):874\u201383.","journal-title":"Gastroenterology"},{"issue":"2","key":"4549_CR24","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1006\/bbrc.2001.6013","volume":"289","author":"F Barry","year":"2001","unstructured":"Barry F, Boynton R, Murphy M, Haynesworth S, Zaia J. The SH-3 and SH-4 antibodies recognize distinct epitopes on CD73 from human mesenchymal stem cells. Biochem Biophys Res Commun. 2001;289(2):519\u201324.","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"4549_CR25","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1182\/blood.V78.1.55.55","volume":"78","author":"PJ Simmons","year":"1991","unstructured":"Simmons PJ, Torok-Storb B. Identification of stromal cell precursors in human bone marrow by a novel monoclonal antibody, STRO-1. Blood. 1991;78(1):55\u201362.","journal-title":"Blood"},{"key":"4549_CR26","doi-asserted-by":"publisher","first-page":"822","DOI":"10.3332\/ecancer.2018.822","volume":"12","author":"VV Miana","year":"2018","unstructured":"Miana VV, Gonz\u00e1lez EAP. Adipose tissue stem cells in regenerative medicine. Ecancermedicalscience. 2018;12:822.","journal-title":"Ecancermedicalscience"},{"issue":"2","key":"4549_CR27","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1089\/107632701300062859","volume":"7","author":"PA Zuk","year":"2001","unstructured":"Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, Katz AJ, et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng. 2001;7(2):211\u201328.","journal-title":"Tissue Eng"},{"key":"4549_CR28","first-page":"149","volume":"8","author":"V Feisst","year":"2015","unstructured":"Feisst V, Meidinger S, Locke MB. From bench to bedside: use of human adipose-derived stem cells. Stem Cells Cloning. 2015;8:149\u201362.","journal-title":"Stem Cells Cloning"},{"issue":"6","key":"4549_CR29","first-page":"1229","volume":"31","author":"A Tsekouras","year":"2017","unstructured":"Tsekouras A, Mantas D, Tsilimigras DI, Moris D, Kontos M, Zografos GC. Comparison of the viability and yield of Adipose-Derived stem cells (ASCs) from different donor areas. Vivo. 2017;31(6):1229\u201334.","journal-title":"Vivo"},{"key":"4549_CR30","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.amsu.2017.07.018","volume":"20","author":"E Raposio","year":"2017","unstructured":"Raposio E, Simonacci F, Perrotta RE. Adipose-derived stem cells: comparison between two methods of isolation for clinical applications. Ann Med Surg (Lond). 2017;20:87\u201391.","journal-title":"Ann Med Surg (Lond)"},{"issue":"2","key":"4549_CR31","first-page":"88","volume":"29","author":"P Tragoonlugkana","year":"2024","unstructured":"Tragoonlugkana P, Chitchongyingcharoen N, Pruksapong C, Hassan S, Ngamkham K, Kamprom W, et al. The use of human platelet lysate as a coating substance for Adipose-Derived stem cell expansion. FBL. 2024;29(2):88.","journal-title":"FBL"},{"issue":"3","key":"4549_CR32","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1007\/s12015-021-10252-5","volume":"18","author":"C Li","year":"2022","unstructured":"Li C, Wei S, Xu Q, Sun Y, Ning X, Wang Z. Application of ADSCs and their exosomes in Scar prevention. Stem Cell Rev Rep. 2022;18(3):952\u201367.","journal-title":"Stem Cell Rev Rep"},{"issue":"23","key":"4549_CR33","first-page":"12408","volume":"24","author":"HW Hou","year":"2020","unstructured":"Hou HW, Xue P, Wang Y, Li YK. Liraglutide regulates proliferation, differentiation, and apoptosis of preosteoblasts through a signaling network of notch\/wnt\/hedgehog signaling pathways. Eur Rev Med Pharmacol Sci. 2020;24(23):12408\u201322.","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"2","key":"4549_CR34","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1080\/03008207.2017.1313248","volume":"59","author":"EJ Tsang","year":"2018","unstructured":"Tsang EJ, Wu B, Zuk P. MAPK signaling has stage-dependent osteogenic effects on human adipose-derived stem cells in vitro. Connect Tissue Res. 2018;59(2):129\u201346.","journal-title":"Connect Tissue Res"},{"issue":"5","key":"4549_CR35","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1097\/PRS.0000000000006159","volume":"144","author":"AK Alverdy","year":"2019","unstructured":"Alverdy AK, Pakvasa M, Zhao C, Mostafa S, Liu W, Luo W, et al. Imiquimod acts synergistically with BMP9 through the Notch pathway as an osteoinductive agent in vitro. Plast Reconstr Surg. 2019;144(5):1094\u2013103.","journal-title":"Plast Reconstr Surg"},{"issue":"11","key":"4549_CR36","doi-asserted-by":"publisher","first-page":"3790","DOI":"10.3390\/ijms21113790","volume":"21","author":"G Hutchings","year":"2020","unstructured":"Hutchings G, Janowicz K, Moncrieff L, Dompe C, Strauss E, Kocherova I, et al. The proliferation and differentiation of Adipose-Derived stem cells in neovascularization and angiogenesis. Int J Mol Sci. 2020;21(11):3790.","journal-title":"Int J Mol Sci"},{"issue":"14","key":"4549_CR37","doi-asserted-by":"publisher","first-page":"14830","DOI":"10.18632\/aging.103547","volume":"12","author":"GM Lu","year":"2020","unstructured":"Lu GM, Rong YX, Liang ZJ, Hunag DL, Wu FX, Ma YF, et al. FGF2-induced PI3K\/Akt signaling evokes greater proliferation and adipogenic differentiation of human adipose stem cells from breast than from abdomen or thigh. Aging. 2020;12(14):14830\u201348.","journal-title":"Aging"},{"issue":"1","key":"4549_CR38","first-page":"1540905","volume":"2020","author":"X Liu","year":"2020","unstructured":"Liu X, Li Z, Liu H, Zhu Y, Xia D, Wang S, et al. Flufenamic acid inhibits adipogenic differentiation of mesenchymal stem cells by antagonizing the PI3K\/AKT signaling pathway. Stem Cells Int. 2020;2020(1):1540905.","journal-title":"Stem Cells Int"},{"issue":"20","key":"4549_CR39","doi-asserted-by":"publisher","first-page":"3939","DOI":"10.1007\/s00018-019-03191-5","volume":"76","author":"R Chijimatsu","year":"2019","unstructured":"Chijimatsu R, Saito T. Mechanisms of synovial joint and articular cartilage development. Cell Mol Life Sci. 2019;76(20):3939\u201352.","journal-title":"Cell Mol Life Sci"},{"issue":"12","key":"4549_CR40","doi-asserted-by":"publisher","first-page":"e115191","DOI":"10.1371\/journal.pone.0115191","volume":"9","author":"L Zhao","year":"2014","unstructured":"Zhao L, Yang G, Zhao X. Rho-associated protein kinases play an important role in the differentiation of rat adipose-derived stromal cells into cardiomyocytes in vitro. PLoS ONE. 2014;9(12):e115191.","journal-title":"PLoS ONE"},{"issue":"9","key":"4549_CR41","first-page":"1247","volume":"36","author":"LJ Fan","year":"2016","unstructured":"Fan LJ, Xiao QR, Lin KS, Wang SY, Li ZF, Li CZ, et al. [Comparison of endothelial differentiation capacity of adipose-derived stem cells and bone marrow mesenchymal stem cells from rats]. Nan Fang Yi Ke Da Xue Xue Bao. 2016;36(9):1247\u201354.","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"issue":"3","key":"4549_CR42","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s12565-009-0026-1","volume":"84","author":"M Hirashima","year":"2009","unstructured":"Hirashima M. Regulation of endothelial cell differentiation and arterial specification by VEGF and Notch signaling. Anat Sci Int. 2009;84(3):95\u2013101.","journal-title":"Anat Sci Int"},{"issue":"1","key":"4549_CR43","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s00441-014-1996-4","volume":"359","author":"NC Inestrosa","year":"2015","unstructured":"Inestrosa NC, Varela-Nallar L. Wnt signalling in neuronal differentiation and development. Cell Tissue Res. 2015;359(1):215\u201323.","journal-title":"Cell Tissue Res"},{"issue":"7","key":"4549_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10571-021-01089-0","volume":"42","author":"C Li","year":"2022","unstructured":"Li C, Xie Z, Xing Z, Zhu H, Zhou W, Xie S, et al. The Notch signaling pathway regulates differentiation of NG2 cells into oligodendrocytes in demyelinating diseases. Cell Mol Neurobiol. 2022;42(7):1\u201311.","journal-title":"Cell Mol Neurobiol"},{"issue":"1","key":"4549_CR45","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1038\/s41467-017-02171-2","volume":"8","author":"Y Shi","year":"2017","unstructured":"Shi Y, He G, Lee WC, McKenzie JA, Silva MJ, Long F. Gli1 identifies osteogenic progenitors for bone formation and fracture repair. Nat Commun. 2017;8(1):2043.","journal-title":"Nat Commun"},{"key":"4549_CR46","doi-asserted-by":"publisher","first-page":"170","DOI":"10.3389\/fcell.2018.00170","volume":"6","author":"KS Houschyar","year":"2018","unstructured":"Houschyar KS, Tapking C, Borrelli MR, Popp D, Duscher D, Maan ZN, et al. Wnt pathway in bone repair and Regeneration - What do we know so Far. Front Cell Dev Biol. 2018;6:170.","journal-title":"Front Cell Dev Biol"},{"issue":"10","key":"4549_CR47","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1007\/s11886-022-01756-8","volume":"24","author":"D Li","year":"2022","unstructured":"Li D, Sun J, Zhong TP. Wnt signaling in heart development and regeneration. Curr Cardiol Rep. 2022;24(10):1425\u201338.","journal-title":"Curr Cardiol Rep"},{"issue":"2","key":"4549_CR48","doi-asserted-by":"publisher","first-page":"a022210","DOI":"10.1101\/cshperspect.a022210","volume":"10","author":"MJ Goumans","year":"2018","unstructured":"Goumans MJ, Ten Dijke P. TGF-\u03b2 signaling in control of cardiovascular function. Cold Spring Harb Perspect Biol. 2018;10(2):a022210.","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"4549_CR49","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.3389\/fimmu.2018.01642","volume":"9","author":"M Waldner","year":"2018","unstructured":"Waldner M, Zhang W, James IB, Allbright K, Havis E, Bliley JM, et al. Characteristics and Immunomodulating functions of Adipose-Derived and bone Marrow-Derived mesenchymal stem cells across defined human leukocyte antigen barriers. Front Immunol. 2018;9:1642.","journal-title":"Front Immunol"},{"issue":"27","key":"4549_CR50","doi-asserted-by":"publisher","first-page":"2652","DOI":"10.1056\/NEJMra2002697","volume":"383","author":"JT Chang","year":"2020","unstructured":"Chang JT. Pathophysiology of inflammatory bowel diseases. N Engl J Med. 2020;383(27):2652\u201364.","journal-title":"N Engl J Med"},{"key":"4549_CR51","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1146\/annurev-immunol-042718-041728","volume":"37","author":"K Bassler","year":"2019","unstructured":"Bassler K, Schulte-Schrepping J, Warnat-Herresthal S, Aschenbrenner AC, Schultze JL. The myeloid cell Compartment-Cell by cell. Annu Rev Immunol. 2019;37:269\u201393.","journal-title":"Annu Rev Immunol"},{"issue":"2","key":"4549_CR52","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.3390\/ijms24021526","volume":"24","author":"A Saez","year":"2023","unstructured":"Saez A, Herrero-Fernandez B, Gomez-Bris R, S\u00e1nchez-Martinez H, Gonzalez-Granado JM. Pathophysiology of inflammatory bowel disease: innate immune system. Int J Mol Sci. 2023;24(2):1526.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"4549_CR53","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.autrev.2013.06.004","volume":"13","author":"A Geremia","year":"2014","unstructured":"Geremia A, Biancheri P, Allan P, Corazza GR, Di Sabatino A. Innate and adaptive immunity in inflammatory bowel disease. Autoimmun Rev. 2014;13(1):3\u201310.","journal-title":"Autoimmun Rev"},{"issue":"9","key":"4549_CR54","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1038\/ni1488","volume":"8","author":"L Zhou","year":"2007","unstructured":"Zhou L, Ivanov II, Spolski R, Min R, Shenderov K, Egawa T, et al. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol. 2007;8(9):967\u201374.","journal-title":"Nat Immunol"},{"issue":"2","key":"4549_CR55","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.alit.2021.02.001","volume":"70","author":"K Hirahara","year":"2021","unstructured":"Hirahara K, Aoki A, Nakayama T. Pathogenic helper T cells. Allergol Int. 2021;70(2):169\u201373.","journal-title":"Allergol Int"},{"issue":"8","key":"4549_CR56","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1038\/nm0804-801","volume":"10","author":"A O\u2019Garra","year":"2004","unstructured":"O\u2019Garra A, Vieira P. Regulatory T cells and mechanisms of immune system control. Nat Med. 2004;10(8):801\u20135.","journal-title":"Nat Med"},{"issue":"1","key":"4549_CR57","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1182\/blood-2005-11-4567","volume":"108","author":"X Valencia","year":"2006","unstructured":"Valencia X, Stephens G, Goldbach-Mansky R, Wilson M, Shevach EM, Lipsky PE. TNF downmodulates the function of human CD4\u2009+\u2009CD25hi T-regulatory cells. Blood. 2006;108(1):253\u201361.","journal-title":"Blood"},{"issue":"9","key":"4549_CR58","doi-asserted-by":"publisher","first-page":"4773","DOI":"10.4049\/jimmunol.165.9.4773","volume":"165","author":"L Gorelik","year":"2000","unstructured":"Gorelik L, Fields PE, Flavell RA. Cutting edge: TGF-beta inhibits Th type 2 development through Inhibition of GATA-3 expression. J Immunol. 2000;165(9):4773\u20137.","journal-title":"J Immunol"},{"issue":"1","key":"4549_CR59","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1034\/j.1600-065X.2001.1820115.x","volume":"182","author":"B Singh","year":"2001","unstructured":"Singh B, Read S, Asseman C, Malmstr\u00f6m V, Mottet C, Stephens LA, et al. Control of intestinal inflammation by regulatory T cells. Immunol Rev. 2001;182(1):190\u2013200.","journal-title":"Immunol Rev"},{"issue":"8","key":"4549_CR60","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1002\/ibd.21229","volume":"16","author":"Z Li","year":"2010","unstructured":"Li Z, Arijs I, De Hertogh G, Vermeire S, Noman M, Bullens D, et al. Reciprocal changes of Foxp3 expression in blood and intestinal mucosa in IBD patients responding to Infliximab. Inflamm Bowel Dis. 2010;16(8):1299\u2013310.","journal-title":"Inflamm Bowel Dis"},{"issue":"6","key":"4549_CR61","doi-asserted-by":"publisher","first-page":"667","DOI":"10.3727\/096368910X508762","volume":"19","author":"H Yagi","year":"2010","unstructured":"Yagi H, Soto-Gutierrez A, Parekkadan B, Kitagawa Y, Tompkins RG, Kobayashi N, et al. Mesenchymal stem cells: mechanisms of Immunomodulation and homing. Cell Transpl. 2010;19(6):667\u201379.","journal-title":"Cell Transpl"},{"issue":"1","key":"4549_CR62","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1634\/stemcells.2007-0554","volume":"26","author":"Z Selmani","year":"2008","unstructured":"Selmani Z, Naji A, Zidi I, Favier B, Gaiffe E, Obert L, et al. Human leukocyte antigen-G5 secretion by human mesenchymal stem cells is required to suppress T lymphocyte and natural killer function and to induce CD4\u2009+\u2009CD25highFOXP3\u2009+\u2009regulatory T cells. Stem Cells. 2008;26(1):212\u201322.","journal-title":"Stem Cells"},{"key":"4549_CR63","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/j.1600-065X.2011.01039.x","volume":"243","author":"TB Clarke","year":"2011","unstructured":"Clarke TB, Weiser JN. Intracellular sensors of extracellular bacteria. Immunol Rev. 2011;243:9\u201325.","journal-title":"Immunol Rev"},{"issue":"4","key":"4549_CR64","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","volume":"124","author":"S Akira","year":"2006","unstructured":"Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell. 2006;124(4):783\u2013801.","journal-title":"Cell"},{"issue":"1","key":"4549_CR65","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.jcmgh.2021.03.002","volume":"12","author":"B Drury","year":"2021","unstructured":"Drury B, Hardisty G, Gray RD, Ho GT. Neutrophil extracellular traps in inflammatory bowel disease: pathogenic mechanisms and clinical translation. Cell Mol Gastroenterol Hepatol. 2021;12(1):321\u201333.","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"3","key":"4549_CR66","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/nm.4294","volume":"23","author":"SK Jorch","year":"2017","unstructured":"Jorch SK, Kubes P. An emerging role for neutrophil extracellular traps in noninfectious disease. Nat Med. 2017;23(3):279\u201387.","journal-title":"Nat Med"},{"key":"4549_CR67","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.matbio.2018.01.019","volume":"68\u201369","author":"P Pakshir","year":"2018","unstructured":"Pakshir P, Hinz B. The big five in fibrosis: macrophages, myofibroblasts, matrix, mechanics, and miscommunication. Matrix Biol. 2018;68\u201369:81\u201393.","journal-title":"Matrix Biol"},{"issue":"36","key":"4549_CR68","doi-asserted-by":"publisher","first-page":"eaau6571","DOI":"10.1126\/sciimmunol.aau6571","volume":"4","author":"B Bernshtein","year":"2019","unstructured":"Bernshtein B, Curato C, Ioannou M, Thaiss CA, Gross-Vered M, Kolesnikov M, et al. IL-23-producing IL-10R\u03b1-deficient gut macrophages elicit an IL-22-driven Proinflammatory epithelial cell response. Sci Immunol. 2019;4(36):eaau6571.","journal-title":"Sci Immunol"},{"issue":"2","key":"4549_CR69","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s10620-017-4892-4","volume":"63","author":"P Giuffrida","year":"2018","unstructured":"Giuffrida P, Corazza GR, Di Sabatino A. Old and new lymphocyte players in inflammatory bowel disease. Dig Dis Sci. 2018;63(2):277\u201388.","journal-title":"Dig Dis Sci"},{"key":"4549_CR70","doi-asserted-by":"publisher","first-page":"1171680","DOI":"10.3389\/fimmu.2023.1171680","volume":"14","author":"Y Guo","year":"2023","unstructured":"Guo Y, Liu Y, Rui B, Lei Z, Ning X, Liu Y, et al. Crosstalk between the gut microbiota and innate lymphoid cells in intestinal mucosal immunity. Front Immunol. 2023;14:1171680.","journal-title":"Front Immunol"},{"issue":"6","key":"4549_CR71","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1159\/000362959","volume":"33","author":"X Hu","year":"2014","unstructured":"Hu X, Zhou Y, Dong K, Sun Z, Zhao D, Wang W, et al. Programming of the development of Tumor-Promoting neutrophils by mesenchymal stromal cells. Cell Physiol Biochem. 2014;33(6):1802\u201314.","journal-title":"Cell Physiol Biochem"},{"key":"4549_CR72","doi-asserted-by":"publisher","first-page":"38308","DOI":"10.1038\/srep38308","volume":"6","author":"AB Vasandan","year":"2016","unstructured":"Vasandan AB, Jahnavi S, Shashank C, Prasad P, Kumar A, Prasanna SJ. Human mesenchymal stem cells program macrophage plasticity by altering their metabolic status via a PGE(2)-dependent mechanism. Sci Rep. 2016;6:38308.","journal-title":"Sci Rep"},{"issue":"4","key":"4549_CR73","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1016\/j.bbrc.2014.07.001","volume":"450","author":"Y Liu","year":"2014","unstructured":"Liu Y, Yin Z, Zhang R, Yan K, Chen L, Chen F, et al. MSCs inhibit bone marrow-derived DC maturation and function through the release of TSG-6. Biochem Biophys Res Commun. 2014;450(4):1409\u201315.","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"4549_CR74","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1089\/scd.2018.0015","volume":"28","author":"Y Fan","year":"2018","unstructured":"Fan Y, Herr F, Vernochet A, Mennesson B, Oberlin E, Durrbach A. Human fetal liver mesenchymal stem cell-Derived exosomes impair natural killer cell function. Stem Cells Dev. 2018;28(1):44\u201355.","journal-title":"Stem Cells Dev"},{"issue":"1","key":"4549_CR75","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/cei.13155","volume":"193","author":"LS Taams","year":"2018","unstructured":"Taams LS. Inflammation and immune resolution. Clin Exp Immunol. 2018;193(1):1\u20132.","journal-title":"Clin Exp Immunol"},{"issue":"2","key":"4549_CR76","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1111\/apt.13864","volume":"45","author":"C Gr\u00e9goire","year":"2017","unstructured":"Gr\u00e9goire C, Lechanteur C, Briquet A, Baudoux \u00c9, Baron F, Louis E, et al. Review article: mesenchymal stromal cell therapy for inflammatory bowel diseases. Aliment Pharmacol Ther. 2017;45(2):205\u201321.","journal-title":"Aliment Pharmacol Ther"},{"issue":"8","key":"4549_CR77","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1136\/gutjnl-2012-302152","volume":"62","author":"P Anderson","year":"2013","unstructured":"Anderson P, Souza-Moreira L, Morell M, Caro M, O\u2019Valle F, Gonzalez-Rey E, et al. Adipose-derived mesenchymal stromal cells induce Immunomodulatory macrophages which protect from experimental colitis and sepsis. Gut. 2013;62(8):1131\u201341.","journal-title":"Gut"},{"issue":"6","key":"4549_CR78","doi-asserted-by":"publisher","first-page":"7204","DOI":"10.18632\/oncotarget.23208","volume":"9","author":"L Chen","year":"2018","unstructured":"Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, et al. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2018;9(6):7204\u201318.","journal-title":"Oncotarget"},{"issue":"14","key":"4549_CR79","doi-asserted-by":"publisher","first-page":"2130","DOI":"10.1182\/blood.2021012295","volume":"139","author":"A Margraf","year":"2022","unstructured":"Margraf A, Lowell CA, Zarbock A. Neutrophils in acute inflammation: current concepts and translational implications. Blood. 2022;139(14):2130\u201344.","journal-title":"Blood"},{"issue":"5663","key":"4549_CR80","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1126\/science.1092385","volume":"303","author":"V Brinkmann","year":"2004","unstructured":"Brinkmann V, Reichard U, Goosmann C, Fauler B, Uhlemann Y, Weiss DS, et al. Neutrophil extracellular traps kill bacteria. Science. 2004;303(5663):1532\u20135.","journal-title":"Science"},{"issue":"9","key":"4549_CR81","doi-asserted-by":"publisher","first-page":"2052","DOI":"10.1097\/MIB.0000000000000460","volume":"21","author":"TB Bennike","year":"2015","unstructured":"Bennike TB, Carlsen TG, Ellingsen T, Bonderup OK, Glerup H, B\u00f8gsted M, et al. Neutrophil extracellular traps in ulcerative colitis: A proteome analysis of intestinal biopsies. Inflamm Bowel Dis. 2015;21(9):2052\u201367.","journal-title":"Inflamm Bowel Dis"},{"issue":"12","key":"4549_CR82","doi-asserted-by":"publisher","first-page":"3950","DOI":"10.4049\/jimmunol.1701643","volume":"200","author":"I Angelidou","year":"2018","unstructured":"Angelidou I, Chrysanthopoulou A, Mitsios A, Arelaki S, Arampatzioglou A, Kambas K, et al. REDD1\/Autophagy pathway is associated with Neutrophil-Driven IL-1\u03b2 inflammatory response in active ulcerative colitis. J Immunol. 2018;200(12):3950\u201361.","journal-title":"J Immunol"},{"key":"4549_CR83","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.jaut.2019.01.003","volume":"98","author":"M Ribon","year":"2019","unstructured":"Ribon M, Seninet S, Mussard J, Sebbag M, Clavel C, Serre G, et al. Neutrophil extracellular traps exert both pro- and anti-inflammatory actions in rheumatoid arthritis that are modulated by C1q and LL-37. J Autoimmun. 2019;98:122\u201331.","journal-title":"J Autoimmun"},{"issue":"5","key":"4549_CR84","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1038\/nm.3547","volume":"20","author":"C Schauer","year":"2014","unstructured":"Schauer C, Janko C, Munoz LE, Zhao Y, Kienh\u00f6fer D, Frey B, et al. Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines. Nat Med. 2014;20(5):511\u20137.","journal-title":"Nat Med"},{"issue":"8","key":"4549_CR85","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1038\/s41419-020-02914-y","volume":"11","author":"Q Shang","year":"2020","unstructured":"Shang Q, Chu Y, Li Y, Han Y, Yu D, Liu R, et al. Adipose-derived mesenchymal stromal cells promote corneal wound healing by accelerating the clearance of neutrophils in cornea. Cell Death Dis. 2020;11(8):707.","journal-title":"Cell Death Dis"},{"issue":"1","key":"4549_CR86","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1038\/s41598-024-51931-w","volume":"14","author":"H Yu","year":"2024","unstructured":"Yu H, Zhang B, Zhan Y, Yi Y, Jiang Q, Zhang Q, et al. Neutrophil extracellular trap-related mechanisms in acne vulgaris inspire a novel treatment strategy with adipose-derived stem cells. Sci Rep. 2024;14(1):1521.","journal-title":"Sci Rep"},{"issue":"2","key":"4549_CR87","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/cdd.2013.158","volume":"21","author":"S Ma","year":"2014","unstructured":"Ma S, Xie N, Li W, Yuan B, Shi Y, Wang Y. Immunobiology of mesenchymal stem cells. Cell Death Differ. 2014;21(2):216\u201325.","journal-title":"Cell Death Differ"},{"issue":"8","key":"4549_CR88","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/s41581-018-0023-5","volume":"14","author":"Y Shi","year":"2018","unstructured":"Shi Y, Wang Y, Li Q, Liu K, Hou J, Shao C, et al. Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases. Nat Rev Nephrol. 2018;14(8):493\u2013507.","journal-title":"Nat Rev Nephrol"},{"issue":"14","key":"4549_CR89","doi-asserted-by":"publisher","first-page":"8407","DOI":"10.1073\/pnas.1432929100","volume":"100","author":"LA Ortiz","year":"2003","unstructured":"Ortiz LA, Gambelli F, McBride C, Gaupp D, Baddoo M, Kaminski N, et al. Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc Natl Acad Sci U S A. 2003;100(14):8407\u201311.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"23","key":"4549_CR90","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.lfs.2008.09.016","volume":"83","author":"F Tanaka","year":"2008","unstructured":"Tanaka F, Tominaga K, Ochi M, Tanigawa T, Watanabe T, Fujiwara Y, et al. Exogenous administration of mesenchymal stem cells ameliorates dextran sulfate sodium-induced colitis via anti-inflammatory action in damaged tissue in rats. Life Sci. 2008;83(23):771\u201379.","journal-title":"Life Sci"},{"issue":"10","key":"4549_CR91","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/gt.2008.39","volume":"15","author":"E Spaeth","year":"2008","unstructured":"Spaeth E, Klopp A, Dembinski J, Andreeff M, Marini F. Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells. Gene Ther. 2008;15(10):730\u201338.","journal-title":"Gene Ther"},{"issue":"3","key":"4549_CR92","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1002\/jcp.30968","volume":"238","author":"Q Zhang","year":"2023","unstructured":"Zhang Q, Piao C, Xu J, Wang Y, Liu T, Ma H, et al. ADSCs-exo attenuates hepatic ischemia-reperfusion injury after hepatectomy by inhibiting Endoplasmic reticulum stress and inflammation. J Cell Physiol. 2023;238(3):659\u201369.","journal-title":"J Cell Physiol"},{"issue":"2","key":"4549_CR93","doi-asserted-by":"publisher","first-page":"10264","DOI":"10.1080\/21655979.2021.1990193","volume":"12","author":"W Jiang","year":"2021","unstructured":"Jiang W, Zhang J, Zhang X, Fan C, Huang J. VAP-PLGA microspheres (VAP-PLGA) promote adipose-derived stem cells (ADSCs)-induced wound healing in chronic skin ulcers in mice via PI3K\/Akt\/HIF-1\u03b1 pathway. Bioengineered. 2021;12(2):10264\u201384.","journal-title":"Bioengineered"},{"key":"4549_CR94","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.mam.2017.11.007","volume":"62","author":"N Papadopoulos","year":"2018","unstructured":"Papadopoulos N, Lennartsson J. The PDGF\/PDGFR pathway as a drug target. Mol Aspects Med. 2018;62:75\u201388.","journal-title":"Mol Aspects Med"},{"issue":"2","key":"4549_CR95","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/j.jss.2013.05.017","volume":"185","author":"S Komiyama","year":"2013","unstructured":"Komiyama S, Sakakura C, Murayama Y, Komatsu S, Shiozaki A, Kuriu Y, et al. Adipose-derived stem cells enhance tissue regeneration of gastrotomy closure. J Surg Res. 2013;185(2):945\u201352.","journal-title":"J Surg Res"},{"issue":"6","key":"4549_CR96","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1002\/ibd.20382","volume":"14","author":"Y Ando","year":"2008","unstructured":"Ando Y, Inaba M, Sakaguchi Y, Tsuda M, Quan GK, Omae M, et al. Subcutaneous adipose tissue\u2013derived stem cells facilitate colonic mucosal recovery from 2,4,6-trinitrobenzene sulfonic acid (TNBS)\u2013induced colitis in rats. Inflamm Bowel Dis. 2008;14(6):826\u201338.","journal-title":"Inflamm Bowel Dis"},{"issue":"10","key":"4549_CR97","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1161\/01.CIR.0000121425.42966.F1","volume":"109","author":"J Rehman","year":"2004","unstructured":"Rehman J, Traktuev D, Li J, Merfeld-Clauss S, Temm-Grove CJ, Bovenkerk JE, et al. Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation. 2004;109(10):1292\u20138.","journal-title":"Circulation"},{"issue":"6","key":"4549_CR98","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1164\/ajrccm.156.6.9611057","volume":"156","author":"M Yaekashiwa","year":"1997","unstructured":"Yaekashiwa M, Nakayama S, Ohnuma K, Sakai T, Abe T, Satoh K, et al. Simultaneous or delayed administration of hepatocyte growth factor equally represses the fibrotic changes in murine lung injury induced by bleomycin. A morphologic study. Am J Respir Crit Care Med. 1997;156(6):1937\u201344.","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"4549_CR99","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.stem.2020.09.014","volume":"27","author":"S Yamanaka","year":"2020","unstructured":"Yamanaka S. Pluripotent stem cell-Based cell Therapy-Promise and challenges. Cell Stem Cell. 2020;27(4):523\u201331.","journal-title":"Cell Stem Cell"},{"issue":"5","key":"4549_CR100","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1111\/odi.12703","volume":"24","author":"L Hu","year":"2018","unstructured":"Hu L, Liu Y, Wang S. Stem cell-based tooth and periodontal regeneration. Oral Dis. 2018;24(5):696\u2013705.","journal-title":"Oral Dis"},{"issue":"1","key":"4549_CR101","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.mayocp.2018.09.013","volume":"94","author":"GP Ramos","year":"2019","unstructured":"Ramos GP, Papadakis KA. Mechanisms of disease: inflammatory bowel diseases. Mayo Clin Proc. 2019;94(1):155\u201365.","journal-title":"Mayo Clin Proc"},{"issue":"9853","key":"4549_CR102","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1016\/S0140-6736(12)60150-0","volume":"380","author":"I Ord\u00e1s","year":"2012","unstructured":"Ord\u00e1s I, Eckmann L, Talamini M, Baumgart DC. Sandborn WJ. Ulcerative colitis. Lancet. 2012;380(9853):1606\u201319.","journal-title":"Lancet"},{"issue":"1","key":"4549_CR103","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/imr.12182","volume":"260","author":"T Pelaseyed","year":"2014","unstructured":"Pelaseyed T, Bergstr\u00f6m JH, Gustafsson JK, Ermund A, Birchenough GM, Sch\u00fctte A, et al. The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the Gastrointestinal tract and interact with the immune system. Immunol Rev. 2014;260(1):8\u201320.","journal-title":"Immunol Rev"},{"issue":"37","key":"4549_CR104","doi-asserted-by":"publisher","first-page":"e35020","DOI":"10.1097\/MD.0000000000035020","volume":"102","author":"M Guo","year":"2023","unstructured":"Guo M, Wang X. Pathological mechanism and targeted drugs of ulcerative colitis: A review. Med (Baltim). 2023;102(37):e35020.","journal-title":"Med (Baltim)"},{"issue":"3","key":"4549_CR105","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1159\/000430225","volume":"37","author":"NN Liu","year":"2015","unstructured":"Liu NN, Zhao N, Cai N. The effect and mechanism of celecoxib in hypoxia-induced survivin up-regulation in HUVECs. Cell Physiol Biochem. 2015;37(3):991\u20131001.","journal-title":"Cell Physiol Biochem"},{"issue":"1","key":"4549_CR106","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/s41572-020-0156-2","volume":"6","author":"G Roda","year":"2020","unstructured":"Roda G, Chien Ng S, Kotze PG, Argollo M, Panaccione R, Spinelli A, et al. Crohn\u2019s disease. Nat Rev Dis Primers. 2020;6(1):22.","journal-title":"Nat Rev Dis Primers"},{"issue":"10080","key":"4549_CR107","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1016\/S0140-6736(16)31711-1","volume":"389","author":"J Torres","year":"2017","unstructured":"Torres J, Mehandru S, Colombel J-F, Peyrin-Biroulet L. Crohn\u2019s disease. Lancet. 2017;389(10080):1741\u201355.","journal-title":"Lancet"},{"issue":"1","key":"4549_CR108","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1136\/gut.2006.094375","volume":"56","author":"S Zeissig","year":"2007","unstructured":"Zeissig S, B\u00fcrgel N, G\u00fcnzel D, Richter J, Mankertz J, Wahnschaffe U, et al. Changes in expression and distribution of Claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active crohn\u2019s disease. Gut. 2007;56(1):61\u201372.","journal-title":"Gut"},{"issue":"5","key":"4549_CR109","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.cell.2008.07.021","volume":"134","author":"A Kaser","year":"2008","unstructured":"Kaser A, Lee AH, Franke A, Glickman JN, Zeissig S, Tilg H, et al. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell. 2008;134(5):743\u201356.","journal-title":"Cell"},{"issue":"10","key":"4549_CR110","doi-asserted-by":"publisher","first-page":"2985","DOI":"10.1084\/jem.20162041","volume":"214","author":"S Hosomi","year":"2017","unstructured":"Hosomi S, Grootjans J, Tschurtschenthaler M, Krupka N, Matute JD, Flak MB, et al. Intestinal epithelial cell Endoplasmic reticulum stress promotes MULT1 up-regulation and NKG2D-mediated inflammation. J Exp Med. 2017;214(10):2985\u201397.","journal-title":"J Exp Med"},{"issue":"3","key":"4549_CR111","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1097\/MIB.0b013e31828028ad","volume":"19","author":"TA Willson","year":"2013","unstructured":"Willson TA, Jurickova I, Collins M, Denson LA. Deletion of intestinal epithelial cell STAT3 promotes T-lymphocyte STAT3 activation and chronic colitis following acute dextran sodium sulfate injury in mice. Inflamm Bowel Dis. 2013;19(3):512\u201325.","journal-title":"Inflamm Bowel Dis"},{"issue":"1","key":"4549_CR112","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1053\/j.gastro.2005.05.013","volume":"129","author":"AL Hart","year":"2005","unstructured":"Hart AL, Al-Hassi HO, Rigby RJ, Bell SJ, Emmanuel AV, Knight SC, et al. Characteristics of intestinal dendritic cells in inflammatory bowel diseases. Gastroenterology. 2005;129(1):50\u201365.","journal-title":"Gastroenterology"},{"issue":"1","key":"4549_CR113","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1186\/s13075-018-1639-3","volume":"20","author":"EH Regner","year":"2018","unstructured":"Regner EH, Ohri N, Stahly A, Gerich ME, Fennimore BP, Ir D, et al. Functional intraepithelial lymphocyte changes in inflammatory bowel disease and spondyloarthritis have disease specific correlations with intestinal microbiota. Arthritis Res Ther. 2018;20(1):149.","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"4549_CR114","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1186\/s13287-022-02940-x","volume":"13","author":"R Zhang","year":"2022","unstructured":"Zhang R, Zhang Q, Chen Y, Zhao Q, Zhang B, Wang L, et al. Combined treatment with Rg1 and adipose-derived stem cells alleviates DSS-induced colitis in a mouse model. Stem Cell Res Ther. 2022;13(1):272.","journal-title":"Stem Cell Res Ther"},{"key":"4549_CR115","doi-asserted-by":"publisher","first-page":"822772","DOI":"10.3389\/fcell.2022.822772","volume":"10","author":"X Wu","year":"2022","unstructured":"Wu X, Mu Y, Yao J, Lin F, Wu D, Ma Z. Adipose-Derived stem cells from patients with ulcerative colitis exhibit impaired immunosuppressive function. Front Cell Dev Biol. 2022;10:822772.","journal-title":"Front Cell Dev Biol"},{"issue":"5","key":"4549_CR116","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/s00384-003-0490-3","volume":"18","author":"D Garc\u00eda-Olmo","year":"2003","unstructured":"Garc\u00eda-Olmo D, Garc\u00eda-Arranz M, Garc\u00eda LG, Cuellar ES, Blanco IF, Prianes LA, et al. Autologous stem cell transplantation for treatment of rectovaginal fistula in perianal crohn\u2019s disease: a new cell-based therapy. Int J Colorectal Dis. 2003;18(5):451\u201354.","journal-title":"Int J Colorectal Dis"},{"issue":"18","key":"4549_CR117","doi-asserted-by":"publisher","first-page":"9967","DOI":"10.3390\/ijms22189967","volume":"22","author":"E Buscail","year":"2021","unstructured":"Buscail E, Le Cosquer G, Gross F, Lebrin M, Bugarel L, Deraison C, et al. Adipose-Derived stem cells in the treatment of perianal fistulas in crohn\u2019s disease: rationale, clinical results and perspectives. Int J Mol Sci. 2021;22(18):9967.","journal-title":"Int J Mol Sci"},{"issue":"8","key":"4549_CR118","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.1053\/j.gastro.2019.02.005","volume":"156","author":"A Dige","year":"2019","unstructured":"Dige A, Hougaard HT, Agnholt J, Pedersen BG, Tencerova M, Kassem M, et al. Efficacy of injection of freshly collected autologous adipose tissue into perianal fistulas in patients with crohn\u2019s disease. Gastroenterology. 2019;156(8):2208\u2013e161.","journal-title":"Gastroenterology"},{"key":"4549_CR119","doi-asserted-by":"publisher","first-page":"1423069","DOI":"10.3389\/fimmu.2024.1423069","volume":"15","author":"HX Liao","year":"2024","unstructured":"Liao HX, Mao X, Wang L, Wang N, Ocansey DKW, Wang B, et al. The role of mesenchymal stem cells in attenuating inflammatory bowel disease through ubiquitination. Front Immunol. 2024;15:1423069.","journal-title":"Front Immunol"},{"issue":"5","key":"4549_CR120","doi-asserted-by":"publisher","first-page":"607","DOI":"10.3390\/ph17050607","volume":"17","author":"Y Qiao","year":"2024","unstructured":"Qiao Y, Tang X, Liu Z, Ocansey DKW, Zhou M, Shang A, et al. Therapeutic prospects of mesenchymal stem cell and their derived exosomes in the regulation of the gut microbiota in inflammatory bowel disease. Pharmaceuticals (Basel). 2024;17(5):607.","journal-title":"Pharmaceuticals (Basel)"},{"issue":"16","key":"4549_CR121","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.21037\/atm-21-3746","volume":"9","author":"J Ren","year":"2021","unstructured":"Ren J, Kong W, Lu F, Li Y. Adipose-derived stem cells (ADSCs) inhibit the expression of anti-apoptosis proteins through up-regulation of ATF4 on breast cancer cells. Ann Transl Med. 2021;9(16):1300.","journal-title":"Ann Transl Med"},{"key":"4549_CR122","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.bbrc.2023.09.022","volume":"680","author":"H Suzuki","year":"2023","unstructured":"Suzuki H, Yokoi A, Uno K, Yoshida K, Kitagawa M, Asano-Inami E, et al. Small extracellular vesicles from adipose-derived stem cells suppress cell proliferation by delivering the let-7 family of MicroRNAs in ovarian cancer. Biochem Biophys Res Commun. 2023;680:211\u201319.","journal-title":"Biochem Biophys Res Commun"},{"issue":"10","key":"4549_CR123","doi-asserted-by":"publisher","first-page":"6794","DOI":"10.1002\/jcp.29574","volume":"235","author":"YW Chan","year":"2020","unstructured":"Chan YW, So C, Yau KL, Chiu KC, Wang X, Chan FL, et al. Adipose-derived stem cells and cancer cells fuse to generate cancer stem cell-like cells with increased tumorigenicity. J Cell Physiol. 2020;235(10):6794\u2013807.","journal-title":"J Cell Physiol"},{"issue":"1","key":"4549_CR124","doi-asserted-by":"publisher","first-page":"15437","DOI":"10.1038\/s41598-022-19290-6","volume":"12","author":"YY Wang","year":"2022","unstructured":"Wang YY, Hung AC, Wu YC, Lo S, Chen HD, Chen YK, et al. ADSCs stimulated by resistin promote breast cancer cell malignancy via CXCL5 in a breast cancer coculture model. Sci Rep. 2022;12(1):15437.","journal-title":"Sci Rep"},{"issue":"6","key":"4549_CR125","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1038\/s41388-018-0477-8","volume":"38","author":"H Goto","year":"2019","unstructured":"Goto H, Shimono Y, Funakoshi Y, Imamura Y, Toyoda M, Kiyota N, et al. Adipose-derived stem cells enhance human breast cancer growth and cancer stem cell-like properties through adipsin. Oncogene. 2019;38(6):767\u201379.","journal-title":"Oncogene"},{"issue":"16","key":"4549_CR126","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1177\/15353702211023846","volume":"246","author":"W Zhang","year":"2021","unstructured":"Zhang W, Torres-Rojas C, Yue J, Zhu BM. Adipose-derived stem cells in ovarian cancer progression, metastasis, and chemoresistance. Exp Biol Med (Maywood). 2021;246(16):1810\u201315.","journal-title":"Exp Biol Med (Maywood)"},{"key":"4549_CR127","doi-asserted-by":"publisher","first-page":"447","DOI":"10.3389\/fcell.2020.00447","volume":"8","author":"A Papait","year":"2020","unstructured":"Papait A, Stefani FR, Cargnoni A, Magatti M, Parolini O, Silini AR. The multifaceted roles of MSCs in the tumor microenvironment: interactions with immune cells and exploitation for therapy. Front Cell Dev Biol. 2020;8:447.","journal-title":"Front Cell Dev Biol"},{"issue":"2","key":"4549_CR128","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.immuni.2004.07.017","volume":"21","author":"GP Dunn","year":"2004","unstructured":"Dunn GP, Old LJ, Schreiber RD. The immunobiology of cancer immunosurveillance and immunoediting. Immunity. 2004;21(2):137\u201348.","journal-title":"Immunity"},{"issue":"12","key":"4549_CR129","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.trecan.2016.10.010","volume":"2","author":"GJ Yuen","year":"2016","unstructured":"Yuen GJ, Demissie E, Pillai S. B lymphocytes and cancer: a love-hate relationship. Trends Cancer. 2016;2(12):747\u201357.","journal-title":"Trends Cancer"},{"key":"4549_CR130","doi-asserted-by":"publisher","first-page":"113181","DOI":"10.1016\/j.intimp.2024.113181","volume":"142","author":"H Zhang","year":"2024","unstructured":"Zhang H, Cao X, Gui R, Li Y, Zhao X, Mei J, et al. Mesenchymal stem\/stromal cells in solid tumor microenvironment: orchestrating NK cell remodeling and therapeutic insights. Int Immunopharmacol. 2024;142:113181.","journal-title":"Int Immunopharmacol"},{"key":"4549_CR131","doi-asserted-by":"publisher","first-page":"4015039","DOI":"10.1155\/2017\/4015039","volume":"2017","author":"CM Rivera-Cruz","year":"2017","unstructured":"Rivera-Cruz CM, Shearer JJ, Figueiredo Neto M, Figueiredo ML. The Immunomodulatory effects of mesenchymal stem cell polarization within the tumor microenvironment niche. Stem Cells Int. 2017;2017:4015039.","journal-title":"Stem Cells Int"},{"issue":"3","key":"4549_CR132","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1002\/sctm.18-0117","volume":"8","author":"S Fran\u00e7ois","year":"2019","unstructured":"Fran\u00e7ois S, Usunier B, Forgue-Lafitte ME, L\u2019Homme B, Benderitter M, Douay L, et al. Mesenchymal stem cell administration attenuates colon cancer progression by modulating the immune component within the colorectal tumor microenvironment. Stem Cells Transl Med. 2019;8(3):285\u2013300.","journal-title":"Stem Cells Transl Med"},{"issue":"2","key":"4549_CR133","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1093\/gastro\/goy017","volume":"7","author":"XB Zheng","year":"2019","unstructured":"Zheng XB, He XW, Zhang LJ, Qin HB, Lin XT, Liu XH, et al. Bone marrow-derived CXCR4-overexpressing MSCs display increased homing to intestine and ameliorate colitis-associated tumorigenesis in mice. Gastroenterol Rep (Oxf). 2019;7(2):127\u201338.","journal-title":"Gastroenterol Rep (Oxf)"},{"issue":"5","key":"4549_CR134","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1038\/leu.2008.384","volume":"23","author":"Y Zhu","year":"2009","unstructured":"Zhu Y, Sun Z, Han Q, Liao L, Wang J, Bian C, et al. Human mesenchymal stem cells inhibit cancer cell proliferation by secreting DKK-1. Leukemia. 2009;23(5):925\u201333.","journal-title":"Leukemia"},{"issue":"4","key":"4549_CR135","first-page":"e133934","volume":"13","author":"MJ Khodayar","year":"2022","unstructured":"Khodayar MJ, Rezaei Tazangi F, Samimi A, Alidadi H. Adipose-Derived mesenchymal stem cells secretome induces apoptosis in colon carcinoma HT-29 cells. Jentashapir J Cell Mol Biol. 2022;13(4):e133934.","journal-title":"Jentashapir J Cell Mol Biol"},{"issue":"10","key":"4549_CR136","doi-asserted-by":"publisher","first-page":"7713","DOI":"10.18632\/oncotarget.3481","volume":"6","author":"HJ Wei","year":"2015","unstructured":"Wei HJ, Zeng R, Lu JH, Lai WF, Chen WH, Liu HY, et al. Adipose-derived stem cells promote tumor initiation and accelerate tumor growth by interleukin-6 production. Oncotarget. 2015;6(10):7713\u201326.","journal-title":"Oncotarget"},{"issue":"12","key":"4549_CR137","doi-asserted-by":"publisher","first-page":"3447","DOI":"10.1002\/1878-0261.12998","volume":"15","author":"Z Liang","year":"2021","unstructured":"Liang Z, Liu H, Zhang Y, Xiong L, Zeng Z, He X, et al. Cyr61 from adipose-derived stem cells promotes colorectal cancer metastasis and vasculogenic mimicry formation via integrin \u03b1(V) \u03b2(5). Mol Oncol. 2021;15(12):3447\u201367.","journal-title":"Mol Oncol"},{"issue":"1","key":"4549_CR138","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s00018-024-05215-1","volume":"81","author":"C Zhu","year":"2024","unstructured":"Zhu C, Teng L, Lai Y, Yao X, Fang Y, Wang Z, et al. Adipose-derived stem cells promote Glycolysis and peritoneal metastasis via TGF-\u03b21\/SMAD3\/ANGPTL4 axis in colorectal cancer. Cell Mol Life Sci. 2024;81(1):189.","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"4549_CR139","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1186\/s12951-021-00888-3","volume":"19","author":"B Jing","year":"2021","unstructured":"Jing B, Qian R, Jiang D, Gai Y, Liu Z, Guo F, et al. Extracellular vesicles-based pre-targeting strategy enables multi-modal imaging of orthotopic colon cancer and image-guided surgery. J Nanobiotechnol. 2021;19(1):151.","journal-title":"J Nanobiotechnol"},{"issue":"4","key":"4549_CR140","first-page":"388","volume":"26","author":"E Pishavar","year":"2023","unstructured":"Pishavar E, Yazdian-Robati R, Abnous K, Hashemi M, Ebrahimian M, Feizpour R, et al. Aptamer-functionalized mesenchymal stem cells-derived exosomes for targeted delivery of SN38 to colon cancer cells. Iran J Basic Med Sci. 2023;26(4):388\u201394.","journal-title":"Iran J Basic Med Sci"},{"key":"4549_CR141","doi-asserted-by":"publisher","first-page":"122502","DOI":"10.1016\/j.lfs.2024.122502","volume":"341","author":"M Thandar","year":"2024","unstructured":"Thandar M, Yang X, Zhu Y, Zhang X, Chen Z, Huang S, et al. Dysbiosis of gut microbiota and metabolites is associated with radiation-induced colorectal fibrosis and is restored by adipose-derived mesenchymal stem cell therapy. Life Sci. 2024;341:122502.","journal-title":"Life Sci"},{"issue":"2","key":"4549_CR142","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1038\/s41401-022-00952-0","volume":"44","author":"L Qin","year":"2023","unstructured":"Qin L, Liu N, Bao CL, Yang DZ, Ma GX, Yi WH, et al. Mesenchymal stem cells in fibrotic diseases-the two sides of the same coin. Acta Pharmacol Sin. 2023;44(2):268\u201387.","journal-title":"Acta Pharmacol Sin"},{"issue":"6","key":"4549_CR143","doi-asserted-by":"publisher","first-page":"2973","DOI":"10.1007\/s10787-023-01350-6","volume":"31","author":"MA Didamoony","year":"2023","unstructured":"Didamoony MA, Soubh AA, Atwa AM, Ahmed LA. Innovative preconditioning strategies for improving the therapeutic efficacy of extracellular vesicles derived from mesenchymal stem cells in Gastrointestinal diseases. Inflammopharmacology. 2023;31(6):2973\u201393.","journal-title":"Inflammopharmacology"},{"issue":"2","key":"4549_CR144","doi-asserted-by":"publisher","first-page":"G157","DOI":"10.1152\/ajpgi.90463.2008","volume":"296","author":"Y Kamada","year":"2009","unstructured":"Kamada Y, Yoshida Y, Saji Y, Fukushima J, Tamura S, Kiso S, et al. Transplantation of basic fibroblast growth factor-pretreated adipose tissue-derived stromal cells enhances regression of liver fibrosis in mice. Am J Physiology-Gastrointestinal Liver Physiol. 2009;296(2):G157\u201367.","journal-title":"Am J Physiology-Gastrointestinal Liver Physiol"},{"issue":"12","key":"4549_CR145","doi-asserted-by":"publisher","first-page":"2753","DOI":"10.3727\/096368912X652959","volume":"21","author":"H-J Harn","year":"2012","unstructured":"Harn H-J, Lin S-Z, Hung S-H, Subeq Y-M, Li Y-S, Syu W-S, et al. Adipose-Derived stem cells can abrogate Chemical-Induced liver fibrosis and facilitate recovery of liver function. Cell Transplant. 2012;21(12):2753\u201364.","journal-title":"Cell Transplant"},{"issue":"9","key":"4549_CR146","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1089\/cbr.2011.1150","volume":"27","author":"W Zhao","year":"2012","unstructured":"Zhao W, Ren G, Zhang L, Zhang Z, Liu J, Kuang P, et al. Efficacy of mesenchymal stem cells derived from human adipose tissue in inhibition of hepatocellular carcinoma cells in vitro. Cancer Biotherapy Radiopharmaceuticals. 2012;27(9):606\u201313.","journal-title":"Cancer Biotherapy Radiopharmaceuticals"},{"issue":"5","key":"4549_CR147","doi-asserted-by":"publisher","first-page":"567","DOI":"10.3748\/wjg.v25.i5.567","volume":"25","author":"R Serhal","year":"2019","unstructured":"Serhal R, Saliba N, Hilal G, Moussa M, Hassan GS, El Atat O, et al. Effect of adipose-derived mesenchymal stem cells on hepatocellular carcinoma: in vitro Inhibition of carcinogenesis. World J Gastroenterol. 2019;25(5):567\u201383.","journal-title":"World J Gastroenterol"},{"key":"4549_CR148","doi-asserted-by":"publisher","first-page":"267","DOI":"10.3389\/fcell.2019.00267","volume":"7","author":"L Wu","year":"2019","unstructured":"Wu L, Tang Q, Yin X, Yan D, Tang M, Xin J, et al. The therapeutic potential of adipose Tissue-Derived mesenchymal stem cells to enhance radiotherapy effects on hepatocellular carcinoma. Front Cell Dev Biol. 2019;7:267.","journal-title":"Front Cell Dev Biol"},{"issue":"2","key":"4549_CR149","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1002\/path.2277","volume":"214","author":"T Wynn","year":"2008","unstructured":"Wynn T. Cellular and molecular mechanisms of fibrosis. J Pathol. 2008;214(2):199\u2013210.","journal-title":"J Pathol"},{"issue":"20","key":"4549_CR150","doi-asserted-by":"publisher","first-page":"11269","DOI":"10.3390\/ijms222011269","volume":"22","author":"M G\u00f3mez-Ferrer","year":"2021","unstructured":"G\u00f3mez-Ferrer M, Amaro-Prellezo E, Dorronsoro A, S\u00e1nchez-S\u00e1nchez R, Vicente \u00c1, Cos\u00edn-Roger J, et al. HIF-Overexpression and Pro-Inflammatory priming in human mesenchymal stromal cells improves the healing properties of extracellular vesicles in experimental crohn\u2019s disease. Int J Mol Sci. 2021;22(20):11269.","journal-title":"Int J Mol Sci"},{"issue":"4","key":"4549_CR151","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.3390\/ijms22041790","volume":"22","author":"B Usunier","year":"2021","unstructured":"Usunier B, Brossard C, L\u2019Homme B, Linard C, Benderitter M, Milliat F, et al. HGF and TSG-6 released by mesenchymal stem cells attenuate colon Radiation-Induced fibrosis. Int J Mol Sci. 2021;22(4):1790.","journal-title":"Int J Mol Sci"},{"issue":"4","key":"4549_CR152","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1002\/path.4590","volume":"237","author":"R Bessout","year":"2015","unstructured":"Bessout R, Demarquay C, Moussa L, Ren\u00e9 A, Doix B, Benderitter M, et al. TH17 predominant T-cell responses in radiation-induced bowel disease are modulated by treatment with adipose-derived mesenchymal stromal cells. J Pathol. 2015;237(4):435\u201346.","journal-title":"J Pathol"},{"key":"4549_CR153","doi-asserted-by":"publisher","first-page":"340257","DOI":"10.1155\/2014\/340257","volume":"2014","author":"B Usunier","year":"2014","unstructured":"Usunier B, Benderitter M, Tamarat R, Chapel A. Management of fibrosis: the mesenchymal stromal cells breakthrough. Stem Cells Int. 2014;2014:340257.","journal-title":"Stem Cells Int"},{"issue":"3","key":"4549_CR154","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s13205-020-2090-0","volume":"10","author":"J Zhao","year":"2020","unstructured":"Zhao J, Zhang Z, Cui Q, Zhao L, Hu Y, Zhao S. Human adipose-derived mesenchymal stem cells inhibit proliferation and induce apoptosis of human gastric cancer HGC-27 cells. 3 Biotech. 2020;10(3):129.","journal-title":"3 Biotech"},{"issue":"104","key":"4549_CR155","first-page":"1382","volume":"57","author":"BC Zhao","year":"2010","unstructured":"Zhao BC, Zhao B, Han JG, Ma HC, Wang ZJ. Adipose-derived stem cells promote gastric cancer cell growth, migration and invasion through SDF-1\/CXCR4 axis. Hepatogastroenterology. 2010;57(104):1382\u20139.","journal-title":"Hepatogastroenterology"},{"issue":"4","key":"4549_CR156","doi-asserted-by":"publisher","first-page":"106","DOI":"10.4252\/wjsc.v5.i4.106","volume":"5","author":"A Chapel","year":"2013","unstructured":"Chapel A, Francois S, Douay L, Benderitter M, Voswinkel J. New insights for pelvic radiation disease treatment: multipotent stromal cell is a promise mainstay treatment for the restoration of abdominopelvic severe chronic damages induced by radiotherapy. World J Stem Cells. 2013;5(4):106\u201311.","journal-title":"World J Stem Cells"},{"key":"4549_CR157","doi-asserted-by":"publisher","first-page":"3010342","DOI":"10.1155\/2019\/3010342","volume":"2019","author":"J Wei","year":"2019","unstructured":"Wei J, Wang B, Wang H, Meng L, Zhao Q, Li X, et al. Radiation-Induced normal tissue damage: oxidative stress and epigenetic mechanisms. Oxid Med Cell Longev. 2019;2019:3010342.","journal-title":"Oxid Med Cell Longev"},{"issue":"10","key":"4549_CR158","doi-asserted-by":"publisher","first-page":"9068","DOI":"10.3390\/ijms24109068","volume":"24","author":"C Helissey","year":"2023","unstructured":"Helissey C, Cavallero S, Guitard N, Th\u00e9ry H, Chargari C. Fran\u00e7ois S. Revolutionizing radiotoxicity management with mesenchymal stem cells and their derivatives: A focus on Radiation-Induced cystitis. Int J Mol Sci. 2023;24(10):9068.","journal-title":"Int J Mol Sci"},{"key":"4549_CR159","doi-asserted-by":"publisher","first-page":"8810813","DOI":"10.1155\/2020\/8810813","volume":"2020","author":"J Zhang","year":"2020","unstructured":"Zhang J, Liu Y, Chen Y, Yuan L, Liu H, Wang J, et al. Adipose-Derived stem cells: current applications and future directions in the regeneration of multiple tissues. Stem Cells Int. 2020;2020:8810813.","journal-title":"Stem Cells Int"},{"key":"4549_CR160","doi-asserted-by":"publisher","first-page":"1400347","DOI":"10.3389\/fcell.2024.1400347","volume":"12","author":"\u010cesnik AB,\u0160vajger U","year":"2024","unstructured":"\u010cesnik AB,\u0160vajger U. The issue of heterogeneity of MSC-based advanced therapy medicinal products-a review. Front Cell Dev Biol. 2024;12:1400347.","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"4549_CR161","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s13287-017-0483-8","volume":"8","author":"J Varghese","year":"2017","unstructured":"Varghese J, Griffin M, Mosahebi A, Butler P. Systematic review of patient factors affecting adipose stem cell viability and function: implications for regenerative therapy. Stem Cell Res Ther. 2017;8(1):45.","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"4549_CR162","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1186\/s12967-024-05816-1","volume":"22","author":"T Kawamura","year":"2024","unstructured":"Kawamura T, Yoshioka D, Kawamura A, Misumi Y, Taguchi T, Mori D, et al. Safety and therapeutic potential of allogeneic adipose-derived stem cell spray transplantation in ischemic cardiomyopathy: a phase I clinical trial. J Translational Med. 2024;22(1):1091.","journal-title":"J Translational Med"},{"issue":"11","key":"4549_CR163","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1056\/NEJMoa1609583","volume":"376","author":"AE Kuriyan","year":"2017","unstructured":"Kuriyan AE, Albini TA, Townsend JH, Rodriguez M, Pandya HK, Leonard RE 2, et al. Vision loss after intravitreal injection of autologous stem cells for AMD. N Engl J Med. 2017;376(11):1047\u201353.","journal-title":"N Engl J Med"},{"issue":"9","key":"4549_CR164","first-page":"540","volume":"53","author":"L Bagher","year":"2015","unstructured":"Bagher L, Hamidreza A, Parisa G, Fereshteh M-J, Abbas N-J, Ahmad Reza D, et al. Clinical grade human adipose Tissue-Derived mesenchymal stem cell banking. Acta Medica Iranica. 2015;53(9):540\u201346.","journal-title":"Acta Medica Iranica"},{"issue":"1","key":"4549_CR165","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13287-020-02006-w","volume":"12","author":"L Mazini","year":"2021","unstructured":"Mazini L, Ezzoubi M, Malka G. Overview of current adipose-derived stem cell (ADSCs) processing involved in therapeutic advancements: flow chart and regulation updates before and after COVID-19. Stem Cell Res Ther. 2021;12(1):1.","journal-title":"Stem Cell Res Ther"},{"key":"4549_CR166","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/j.reth.2024.07.007","volume":"26","author":"Y Shimizu","year":"2024","unstructured":"Shimizu Y, Ntege EH, Takahara E, Matsuura N, Matsuura R, Kamizato K, et al. Adipose-derived stem cell therapy for spinal cord injuries: advances, challenges, and future directions. Regen Ther. 2024;26:508\u201319.","journal-title":"Regen Ther"},{"key":"4549_CR167","doi-asserted-by":"crossref","unstructured":"Malhotra A, Thebaud B, Paton MCB, Fleiss B, Papagianis P, Baker E et al. Advances in neonatal cell therapies: Proceedings of the First Neonatal Cell Therapies Symposium (2022). Pediatr Res. 2023;94(5):1631-38.","DOI":"10.1038\/s41390-023-02707-x"},{"issue":"7","key":"4549_CR168","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/j.jcyt.2016.04.008","volume":"18","author":"Y Zhao","year":"2016","unstructured":"Zhao Y, Zhang H. Update on the mechanisms of homing of adipose tissue\u2013derived stem cells. Cytotherapy. 2016;18(7):816\u201327.","journal-title":"Cytotherapy"},{"issue":"2","key":"4549_CR169","doi-asserted-by":"publisher","first-page":"e12404","DOI":"10.1002\/jev2.12404","volume":"13","author":"JA Welsh","year":"2024","unstructured":"Welsh JA, Goberdhan DCI, O\u2019Driscoll L, Buzas EI, Blenkiron C, Bussolati B, et al. Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches. J Extracell Vesicles. 2024;13(2):e12404.","journal-title":"J Extracell Vesicles"},{"issue":"1","key":"4549_CR170","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1186\/s12951-024-02603-4","volume":"22","author":"S Yang","year":"2024","unstructured":"Yang S, Sun Y, Yan C. Recent advances in the use of extracellular vesicles from adipose-derived stem cells for regenerative medical therapeutics. J Nanobiotechnol. 2024;22(1):316.","journal-title":"J Nanobiotechnol"},{"issue":"11","key":"4549_CR171","doi-asserted-by":"publisher","first-page":"e70075","DOI":"10.1002\/ctm2.70075","volume":"14","author":"L Clua-Ferr\u00e9","year":"2024","unstructured":"Clua-Ferr\u00e9 L, Suau R, Va\u00f1\u00f3-Segarra I, Gin\u00e9s I, Serena C, Many\u00e9 J. Therapeutic potential of mesenchymal stem cell-derived extracellular vesicles: A focus on inflammatory bowel disease. Clin Transl Med. 2024;14(11):e70075.","journal-title":"Clin Transl Med"},{"issue":"11","key":"4549_CR172","doi-asserted-by":"publisher","first-page":"5916","DOI":"10.3390\/ijms25115916","volume":"25","author":"KS Papadopoulos","year":"2024","unstructured":"Papadopoulos KS, Piperi C, Korkolopoulou P. Clinical applications of Adipose-Derived stem cell (ADSC) exosomes in tissue regeneration. Int J Mol Sci. 2024;25(11):5916.","journal-title":"Int J Mol Sci"}],"container-title":["Stem Cell Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-025-04549-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13287-025-04549-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-025-04549-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T09:24:42Z","timestamp":1757409882000},"score":1,"resource":{"primary":{"URL":"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/s13287-025-04549-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,20]]},"references-count":172,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4549"],"URL":"https:\/\/doi.org\/10.1186\/s13287-025-04549-2","relation":{},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,20]]},"assertion":[{"value":"15 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This systematic review synthesizes existing literature and excludes original research activities, including experiments or data collection involving human subjects or human-derived materials. Ethics approval and consent to participate are not applicable to this manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}}],"article-number":"444"}}