{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T04:11:01Z","timestamp":1793506261654,"version":"4.5.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173524"],"award-info":[{"award-number":["82173524"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Res Ther"],"DOI":"10.1186\/s13287-025-04579-w","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T13:39:39Z","timestamp":1756215579000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Co-treatments of vitamin D and mesenchymal stem cells effectively alleviate the diabetic kidney disease through attenuating the SIRT1-mediated pathways"],"prefix":"10.1186","volume":"16","author":[{"given":"Xinfeng","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirui","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaru","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueqing","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kemin","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1310-1092","authenticated-orcid":false,"given":"Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"4579_CR1","doi-asserted-by":"publisher","first-page":"4563","DOI":"10.3390\/ijms25084563","volume":"25","author":"C Kourtidou","year":"2024","unstructured":"Kourtidou C, Tziomalos K. Advances in the pathogenesis of diabetic kidney disease. Int J Mol Sci. 2024;25:4563.","journal-title":"Int J Mol Sci"},{"key":"4579_CR2","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1038\/s12276-024-01257-4","volume":"56","author":"M Qiu","year":"2024","unstructured":"Qiu M, et al. Activation of the osteoblastic HIF-1\u03b1 pathway partially alleviates the symptoms of STZ-induced type 1 diabetes mellitus via RegIII\u03b3. Exp Mol Med. 2024;56:1574\u201390.","journal-title":"Exp Mol Med"},{"key":"4579_CR3","doi-asserted-by":"publisher","first-page":"111764","DOI":"10.1016\/j.diabres.2024.111764","volume":"213","author":"L Kugathasan","year":"2024","unstructured":"Kugathasan L, et al. Effect of hyperglycemia and empagliflozin on markers of cardiorenal injury and inflammation in patients with type 1 diabetes. Diabetes Res Clin Pract. 2024;213:111764.","journal-title":"Diabetes Res Clin Pract"},{"key":"4579_CR4","doi-asserted-by":"publisher","first-page":"5441","DOI":"10.1038\/s41467-024-49854-1","volume":"15","author":"Y Zhao","year":"2024","unstructured":"Zhao Y, et al. Podocyte OTUD5 alleviates diabetic kidney disease through deubiquitinating TAK1 and reducing podocyte inflammation and injury. Nat Commun. 2024;15:5441.","journal-title":"Nat Commun"},{"key":"4579_CR5","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.kint.2022.10.030","volume":"103","author":"S Rayego-Mateos","year":"2023","unstructured":"Rayego-Mateos S, et al. Targeting inflammation to treat diabetic kidney disease: the road to 2030. Kidney Int. 2023;103:282\u201396.","journal-title":"Kidney Int"},{"key":"4579_CR6","first-page":"751","volume":"99","author":"K McGrath","year":"2019","unstructured":"McGrath K, Edi R. Diabetic kidney disease: diagnosis, treatment, and prevention. Am Fam Physician. 2019;99:751\u20139.","journal-title":"Am Fam Physician"},{"key":"4579_CR7","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1002\/sctm.19-0419","volume":"10","author":"LJ Hickson","year":"2021","unstructured":"Hickson LJ, et al. A systematic review and meta-analysis of cell-based interventions in experimental diabetic kidney disease. Stem Cells Transl Med. 2021;10:1304\u201319.","journal-title":"Stem Cells Transl Med"},{"key":"4579_CR8","doi-asserted-by":"publisher","first-page":"e2404719","DOI":"10.1002\/adhm.202404719","volume":"14","author":"Y Chen","year":"2025","unstructured":"Chen Y, et al. Ultrasound-Guided functionalized extracellular vesicles for visualized, controlled, and efficient renal delivery for enhanced kidney repair. Adv Healthc Mater. 2025;14:e2404719.","journal-title":"Adv Healthc Mater"},{"key":"4579_CR9","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/s13287-025-04137-4","volume":"16","author":"T Xiao","year":"2025","unstructured":"Xiao T, et al. Ultrasound-guided renal subcapsular transplantation of mesenchymal stem cells for treatment of acute kidney injury in a minipig model: safety and efficacy evaluation. Stem Cell Res Ther. 2025;16:102.","journal-title":"Stem Cell Res Ther"},{"key":"4579_CR10","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1681\/ASN.0000000000000189","volume":"34","author":"N Perico","year":"2023","unstructured":"Perico N, et al. Safety and preliminary efficacy of mesenchymal stromal cell (ORBCEL-M) therapy in diabetic kidney disease: A randomized clinical trial (NEPHSTROM). J Am Soc Nephrol. 2023;34:1733\u201351.","journal-title":"J Am Soc Nephrol"},{"key":"4579_CR11","doi-asserted-by":"publisher","first-page":"112634","DOI":"10.1016\/j.nut.2024.112634","volume":"131","author":"CFF Moreira","year":"2025","unstructured":"Moreira CFF, et al. Prevalence and factors associated with vitamin D deficiency in children and adolescents with type 1 diabetes mellitus: baseline data from a clinical trial in Rio de Janeiro. Nutrition. 2025;131:112634.","journal-title":"Nutrition"},{"key":"4579_CR12","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.3390\/nu16071042","volume":"16","author":"Y Dadon","year":"2024","unstructured":"Dadon Y, et al. Vitamin D and Insulin-Dependent diabetes: A systematic review of clinical trials. Nutrients. 2024;16:1042.","journal-title":"Nutrients"},{"key":"4579_CR13","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1093\/abbs\/gmaa138","volume":"53","author":"X Hu","year":"2021","unstructured":"Hu X, et al. 1,25-(OH)2D3 protects pancreatic beta cells against H2O2-induced apoptosis through inhibiting the PERK-ATF4-CHOP pathway. Acta Biochim Biophys Sin (Shanghai). 2021;53:46\u201353.","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"4579_CR14","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1038\/s41467-018-03943-0","volume":"9","author":"N Cobo-Vuilleumier","year":"2018","unstructured":"Cobo-Vuilleumier N, et al. LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus. Nat Commun. 2018;9:1488.","journal-title":"Nat Commun"},{"key":"4579_CR15","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1093\/ndt\/gfae293","volume":"40","author":"HS J\u00f8rgensen","year":"2025","unstructured":"J\u00f8rgensen HS, et al. The role of nutritional vitamin D in CKD-MBD in children and adults with CKD, on Dialysis and after kidney transplantation-a European consensus statement. Nephrol Dial Transpl. 2025;40:797\u2013822.","journal-title":"Nephrol Dial Transpl"},{"key":"4579_CR16","doi-asserted-by":"publisher","first-page":"4689","DOI":"10.3390\/ijms24054689","volume":"24","author":"D Gallo","year":"2023","unstructured":"Gallo D, et al. How does vitamin D affect immune cells crosstalk in autoimmune diseases?? Int J Mol Sci. 2023;24:4689.","journal-title":"Int J Mol Sci"},{"key":"4579_CR17","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1016\/j.cmet.2024.05.009","volume":"36","author":"J Orlowski","year":"2024","unstructured":"Orlowski J. Nuclear SMAD5 dances to a different tune in regulating insulin secretion. Cell Metab. 2024;36:1169\u201371.","journal-title":"Cell Metab"},{"key":"4579_CR18","doi-asserted-by":"publisher","first-page":"769","DOI":"10.3390\/nu15030769","volume":"15","author":"G Renke","year":"2023","unstructured":"Renke G, et al. Effects of vitamin D on cardiovascular risk and oxidative stress. Nutrients. 2023;15:769.","journal-title":"Nutrients"},{"key":"4579_CR19","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1080\/10408398.2018.1546671","volume":"60","author":"MS Filgueiras","year":"2020","unstructured":"Filgueiras MS, et al. Vitamin D status, oxidative stress, and inflammation in children and adolescents: A systematic review. Crit Rev Food Sci Nutr. 2020;60:660\u20139.","journal-title":"Crit Rev Food Sci Nutr"},{"key":"4579_CR20","doi-asserted-by":"publisher","first-page":"111262","DOI":"10.1016\/j.isci.2024.111262","volume":"27","author":"Y Liang","year":"2024","unstructured":"Liang Y, et al. Vitamin D alleviates HFD-induced hepatic fibrosis by inhibiting DNMT1 to affect the TGF\u03b21\/Smad3 pathway. iScience. 2024;27:111262.","journal-title":"iScience"},{"key":"4579_CR21","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s11255-024-04162-x","volume":"57","author":"W Wang","year":"2025","unstructured":"Wang W, et al. The role of SIRT1 in kidney diseases. Int Urol Nephrol. 2025;57:147\u201358.","journal-title":"Int Urol Nephrol"},{"key":"4579_CR22","doi-asserted-by":"publisher","first-page":"111588","DOI":"10.1016\/j.nut.2022.111588","volume":"96","author":"A Raji-Amirhasani","year":"2022","unstructured":"Raji-Amirhasani A, et al. Comparison of the effects of different dietary regimens on susceptibility to experimental acute kidney injury: the roles of SIRT1 and TGF-\u03b21. Nutrition. 2022;96:111588.","journal-title":"Nutrition"},{"key":"4579_CR23","doi-asserted-by":"publisher","first-page":"2303396","DOI":"10.1080\/0886022X.2024.2303396","volume":"46","author":"H Liu","year":"2024","unstructured":"Liu H, et al. Placenta-derived mesenchymal stem cells protect against diabetic kidney disease by upregulating autophagy-mediated SIRT1\/FOXO1 pathway. Ren Fail. 2024;46:2303396.","journal-title":"Ren Fail"},{"key":"4579_CR24","doi-asserted-by":"publisher","first-page":"610","DOI":"10.7150\/ijbs.78785","volume":"19","author":"J Chen","year":"2023","unstructured":"Chen J, et al. 1,25-Dihydroxyvitamin D deficiency accelerates Aging-related osteoarthritis via downregulation of Sirt1 in mice. Int J Biol Sci. 2023;19:610\u201324.","journal-title":"Int J Biol Sci"},{"key":"4579_CR25","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.jot.2023.04.003","volume":"40","author":"P Wang","year":"2023","unstructured":"Wang P, et al. Sirt1 protects against intervertebral disc degeneration induced by 1,25-dihydroxyvitamin D insufficiency in mice by inhibiting the NF-\u03baB inflammatory pathway. J Orthop Translat. 2023;40:13\u201326.","journal-title":"J Orthop Translat"},{"key":"4579_CR26","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1186\/s13287-024-03860-8","volume":"15","author":"P Li","year":"2024","unstructured":"Li P, et al. Imbalance of early-life vita min D intake targets ROS-mediated crosstalk between mitochondrial dysfunction and differentiation potential of MSCs associated the later obesity. Stem Cell Res Ther. 2024;15:252.","journal-title":"Stem Cell Res Ther"},{"key":"4579_CR27","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/s41401-021-00721-5","volume":"43","author":"XQ Liu","year":"2022","unstructured":"Liu XQ, et al. Wogonin protects glomerular podocytes by targeting Bcl-2-mediated autophagy and apoptosis in diabetic kidney disease. Acta Pharmacol Sin. 2022;43:96\u2013110.","journal-title":"Acta Pharmacol Sin"},{"key":"4579_CR28","doi-asserted-by":"publisher","first-page":"e165654","DOI":"10.1172\/JCI165654","volume":"133","author":"S Mohandes","year":"2023","unstructured":"Mohandes S, et al. Molecular pathways that drive diabetic kidney disease. J Clin Invest. 2023;133:e165654.","journal-title":"J Clin Invest"},{"key":"4579_CR29","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s13148-021-01079-5","volume":"13","author":"W Zheng","year":"2021","unstructured":"Zheng W, Guo J, Liu ZS. Effects of metabolic memory on inflammation and fibrosis associated with diabetic kidney disease: an epigenetic perspective. Clin Epigenetics. 2021;13:87.","journal-title":"Clin Epigenetics"},{"key":"4579_CR30","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1038\/s41419-024-06833-0","volume":"15","author":"X Fan","year":"2024","unstructured":"Fan X, et al. Mitochondrial metabolic reprogramming in diabetic kidney disease. Cell Death Dis. 2024;15:442.","journal-title":"Cell Death Dis"},{"key":"4579_CR31","doi-asserted-by":"publisher","first-page":"484","DOI":"10.7150\/ijbs.78654","volume":"19","author":"C Lu","year":"2023","unstructured":"Lu C, et al. Novel role of the SIRT1 in endocrine and metabolic diseases. Int J Biol Sci. 2023;19:484\u2013501.","journal-title":"Int J Biol Sci"},{"key":"4579_CR32","doi-asserted-by":"publisher","first-page":"1465849","DOI":"10.3389\/fimmu.2024.1465849","volume":"15","author":"H Sun","year":"2024","unstructured":"Sun H, et al. The relationship between SIRT1 and inflammation: a systematic review and meta-analysis. Front Immunol. 2024;15:1465849.","journal-title":"Front Immunol"},{"key":"4579_CR33","doi-asserted-by":"publisher","first-page":"e14163","DOI":"10.1111\/apha.14163","volume":"240","author":"H Li","year":"2024","unstructured":"Li H, et al. Resistance exercise upregulates Irisin expression and suppresses myocardial fibrosis following myocardial infarction via activating AMPK-Sirt1 and inactivating TGF\u03b21-Smad2\/3. Acta Physiol (Oxf). 2024;240:e14163.","journal-title":"Acta Physiol (Oxf)"},{"key":"4579_CR34","doi-asserted-by":"publisher","first-page":"3265","DOI":"10.1002\/ptr.7499","volume":"36","author":"R Wang","year":"2022","unstructured":"Wang R, et al. Resveratrol ameliorates muscle atrophy in chronic kidney disease via the axis of SIRT1\/Foxo1. Phytother Res. 2022;36:3265\u201375.","journal-title":"Phytother Res"},{"key":"4579_CR35","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.ajpath.2016.09.016","volume":"187","author":"Y Zhang","year":"2017","unstructured":"Zhang Y, et al. Sirtuin 1 activation reduces transforming growth Factor-\u03b21-Induced fibrogenesis and affords organ protection in a model of progressive, experimental kidney and associated cardiac disease. Am J Pathol. 2017;187:80\u201390.","journal-title":"Am J Pathol"},{"key":"4579_CR36","doi-asserted-by":"publisher","first-page":"153919","DOI":"10.1016\/j.phymed.2021.153919","volume":"98","author":"HY Ni","year":"2022","unstructured":"Ni HY, et al. Seed oil of Rosa Roxburghii Tratt against non-alcoholic fatty liver disease in vivo and in vitro through PPAR\u03b1\/PGC-1\u03b1-mediated mitochondrial oxidative metabolism. Phytomedicine. 2022;98:153919.","journal-title":"Phytomedicine"},{"key":"4579_CR37","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1093\/hmg\/ddad166","volume":"33","author":"L Wei","year":"2024","unstructured":"Wei L, et al. Multi-omics analysis reveals the potential pathogenesis and therapeutic targets of diabetic kidney disease. Hum Mol Genet. 2024;33:122\u201337.","journal-title":"Hum Mol Genet"},{"key":"4579_CR38","doi-asserted-by":"publisher","first-page":"2381597","DOI":"10.1080\/0886022X.2024.2381597","volume":"46","author":"Y Wang","year":"2024","unstructured":"Wang Y, et al. Mesenchymal stem cell-derived exosomes ameliorate diabetic kidney disease through NOD2 signaling pathway. Ren Fail. 2024;46:2381597.","journal-title":"Ren Fail"},{"key":"4579_CR39","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1186\/s13287-019-1424-5","volume":"10","author":"MN Islam","year":"2019","unstructured":"Islam MN, et al. Human mesenchymal stromal cells broadly modulate high glucose-induced inflammatory responses of renal proximal tubular cell monolayers. Stem Cell Res Ther. 2019;10:329.","journal-title":"Stem Cell Res Ther"},{"key":"4579_CR40","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1186\/s12951-024-02613-2","volume":"22","author":"C Ji","year":"2024","unstructured":"Ji C, et al. Single-cell RNA transcriptomic reveal the mechanism of MSC derived small extracellular vesicles against DKD fibrosis. J Nanobiotechnol. 2024;22:339.","journal-title":"J Nanobiotechnol"},{"key":"4579_CR41","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s13287-023-03269-9","volume":"14","author":"X Bian","year":"2023","unstructured":"Bian X, et al. Diabetic kidney disease induces transcriptome alterations associated with angiogenesis activity in human mesenchymal stromal cells. Stem Cell Res Ther. 2023;14:49.","journal-title":"Stem Cell Res Ther"},{"key":"4579_CR42","doi-asserted-by":"publisher","first-page":"10540","DOI":"10.3390\/ijms251910540","volume":"25","author":"J Cheng","year":"2024","unstructured":"Cheng J, Zhang C. Mesenchymal stem cell therapy: therapeutic opportunities and challenges for diabetic kidney disease. Int J Mol Sci. 2024;25:10540.","journal-title":"Int J Mol Sci"},{"key":"4579_CR43","doi-asserted-by":"publisher","first-page":"112667","DOI":"10.1016\/j.intimp.2024.112667","volume":"139","author":"Q Li","year":"2024","unstructured":"Li Q, et al. Small extracellular vesicles-shuttled miR-23a-3p from mesenchymal stem cells alleviate renal fibrosis and inflammation by inhibiting KLF3\/STAT3 axis in diabetic kidney disease. Int Immunopharmacol. 2024;139:112667.","journal-title":"Int Immunopharmacol"},{"key":"4579_CR44","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s13287-020-02108-5","volume":"12","author":"W Lin","year":"2021","unstructured":"Lin W, et al. Administration of mesenchymal stem cells in diabetic kidney disease: a systematic review and meta-analysis. Stem Cell Res Ther. 2021;12:43.","journal-title":"Stem Cell Res Ther"},{"key":"4579_CR45","doi-asserted-by":"publisher","first-page":"e2107354","DOI":"10.1002\/smll.202107354","volume":"18","author":"Y Liu","year":"2022","unstructured":"Liu Y, et al. Inflammation-Stimulated MSC-Derived small extracellular vesicle miR-27b-3p regulates macrophages by targeting CSF-1 to promote temporomandibular joint condylar regeneration. Small. 2022;18:e2107354.","journal-title":"Small"},{"key":"4579_CR46","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.2147\/IJN.S355366","volume":"17","author":"S Wang","year":"2022","unstructured":"Wang S, et al. Targeted therapy for inflammatory diseases with mesenchymal stem cells and their derived exosomes: from basic to clinics. Int J Nanomed. 2022;17:1757\u201381.","journal-title":"Int J Nanomed"},{"key":"4579_CR47","first-page":"1271","volume":"57","author":"HJ Lee","year":"2021","unstructured":"Lee HJ, et al. Vitamin D enhanced the osteogenic differentiation of cell spheroids composed of bone marrow stem cells. Med (Kaunas). 2021;57:1271.","journal-title":"Med (Kaunas)"},{"key":"4579_CR48","doi-asserted-by":"publisher","first-page":"106373","DOI":"10.1016\/j.jsbmb.2023.106373","volume":"233","author":"J Huovinen","year":"2023","unstructured":"Huovinen J, et al. 1,25(OH)2D3 and its analogue calcipotriol inhibit the migration of human synovial and mesenchymal stromal cells in a wound healing model-A comparison with glucocorticoids. J Steroid Biochem Mol Biol. 2023;233:106373.","journal-title":"J Steroid Biochem Mol Biol"},{"key":"4579_CR49","doi-asserted-by":"publisher","first-page":"3027","DOI":"10.1016\/j.apsb.2023.05.007","volume":"13","author":"L Sun","year":"2023","unstructured":"Sun L, et al. A novel mesenchymal stem cell-based regimen for acute myeloid leukemia differentiation therapy. Acta Pharm Sin B. 2023;13:3027\u201342.","journal-title":"Acta Pharm Sin B"},{"key":"4579_CR50","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1080\/10408398.2017.1406333","volume":"59","author":"SM Barbalho","year":"2019","unstructured":"Barbalho SM, Goulart RA, Gasparini RG. Associations between inflammatory bowel diseases and vitamin D. Crit Rev Food Sci Nutr. 2019;59:1347\u201356.","journal-title":"Crit Rev Food Sci Nutr"},{"key":"4579_CR51","doi-asserted-by":"publisher","first-page":"3570","DOI":"10.1186\/s12889-024-21133-0","volume":"24","author":"P Yunpeng","year":"2024","unstructured":"Yunpeng P, et al. The U-shaped correlation between serum VD concentration and systemic immune-inflammatory index: results from the NHANES database prospective cohort study. BMC Public Health. 2024;24:3570.","journal-title":"BMC Public Health"},{"key":"4579_CR52","doi-asserted-by":"publisher","first-page":"6686","DOI":"10.3390\/ijms22136686","volume":"22","author":"S Cruciani","year":"2021","unstructured":"Cruciani S, et al. Metformin and vitamin D modulate inflammation and autophagy during Adipose-Derived stem cell differentiation. Int J Mol Sci. 2021;22:6686.","journal-title":"Int J Mol Sci"}],"container-title":["Stem Cell Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-025-04579-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13287-025-04579-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13287-025-04579-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T18:50:13Z","timestamp":1757443813000},"score":1,"resource":{"primary":{"URL":"https:\/\/stemcellres.biomedcentral.com\/articles\/10.1186\/s13287-025-04579-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,26]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4579"],"URL":"https:\/\/doi.org\/10.1186\/s13287-025-04579-w","relation":{},"ISSN":["1757-6512"],"issn-type":[{"value":"1757-6512","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,26]]},"assertion":[{"value":"16 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The animal experimental protocols were performed with the guidelines of National Institutes of Health Guide for care and use of Laboratory Animals, which was then approved by the Ethics of Animal Experiments from the Academy of Military Medical Sciences in China (Title: Peri-pregnancy stem cell resources and clinical medical record collection, Name of the institutional approval committee: animal experiments in the Academy of Military Medical Sciences in China, Approval No: IACUC-DWZX-2019-704, Date of Approval: January 1st, 2020).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The authors declare that they have not used the AI-generated work in this manuscript.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Use of AI"}}],"article-number":"451"}}