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(1) Title of the approved project: Extracellular vesicles from Hoffa\u00b4s fat pad- a new strategy for cartilage regeneration. (2) Name of the institutional approval committee: The ethics committee of Karl Landsteiner Private University, Austria. (3) Approval number: EK 1020\/2020. (4) Date of approval: 15\/07\/2020. Tissue samples were obtained from patients, following written informed consent for participation in the study and\/or the use of samples. Whole blood samples were collected in-house from healthy volunteers, after informed consent, with approval from the ethics committee of the University for Continuing Education Krems, Austria. (1) Title of the approved project: Collection of human whole blood for scientific purposes. (2) Name of the institutional approval committee: The ethics committee of the University for Continuing Education Krems, Austria. (3) Approval number: EK GZ 13\/2015\u20132018. (4) Date of approval: 14\/01\/2013 (confirmation of continuation 04\/04\/2022). The human THP-1 cell line ( #TIB-202 \u2122) used in this study was purchased from the American Type Culture Collection (ATCC). The original derivation of the THP-1 cell line was described by Tsuchiya et al. (1980, International Journal of Cancer) [\n                      \n                      ], where the establishment from a human donor was reported. While ATCC does not explicitly state details of ethical approval and informed consent for this cell line on their website, by standard practices ATCC requires that human-derived materials meet ethical sourcing requirements. No additional ethical approval was required for this study. A standard Material Transfer Agreement (MTA) was accepted as part of the purchase process from ATCC.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Zsombor Lacza is CEO of Orthosera GmbH, the other authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"578"}}